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    Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

    Published 2025-02-01
    “…Xiuqi Li,1,* Shupeng Liu,1,* Mengyang Yu,1 Wanlin Xi,1 Xiaofei Wu,1 Dan Liu,2 Aijing Liu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyun Wang, Email wanghy@pumch.cnBackground: Proton pump inhibitors (PPIs) and potassium competitive acid blockers (P-CABs) are widely used to treat acid-related diseases (ARDs). …”
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    The Prediction Model of High-Frequency Ultrasound Combined with Artificial Intelligence-Assisted Scoring System Improved the Diagnosis of Sclerosing Adenosis and Early Breast Cance... by Ma B, Wu G, Zhu H, Liu Y, Hu W, Zhao J, Liu Y, Liu Q

    Published 2025-02-01
    “…Bingxin Ma,1 Gang Wu,1 Haohui Zhu,1 Yifei Liu,1 Wenjia Hu,1 Jing Zhao,1 Yinlong Liu,1 Qiuyu Liu2 1Department of Ultrasound, Henan Provincial People’s Hospital, Zhengzhou, 450000, People’s Republic of China; 2Department of Pathology, Henan Provincial People’s Hospital, Zhengzhou, 450000, People’s Republic of ChinaCorrespondence: Gang Wu, Email drwugang325@126.com; Haohui Zhu, Email zhh761126@163.comObjective: The study aimed to apply an artificial intelligence (AI)-assisted scoring system, and improve the diagnostic efficiency of Sclerosing adenosis and early breast cancer.Methods: This study retrospectively collected adenopathy patients (156 cases) and early breast cancer patients (150 cases) in Henan Provincial People’s Hospital from August 2020 to April 2023.Results: The area under the curve of the model constructed by clinical ultrasound features and combined AI features to predict and identify the two in the training group was 0.89 and 0.94, respectively. …”
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