What was Killing Babies in Ipswich Between 1872 and 1909? by Eilidh Garrett, Alice Reid

“…While water-food borne diseases killed large numbers in the summer months, it was the ever-present airborne diseases which carried off a greater number of small victims. …”
Get full text

SOMATIC AND PSYCHIATRIC MORBIDITY OF ELDERLY DRIVERS KILLED IN MOTOR VEHICLE ACCIDENTS IN FINLAND DURING 22-YEAR FOLLOW-UP by JENNY TYNI, PIRKKO RIIPINEN, HELINÄ HAKKO, NIINA SIHVOLA, LIISA KANTOJÄRVI

Get full text

Does a biological invasion modify host immune responses to parasite infection? by Gregory P. Brown, Richard Shine, Lee A. Rollins

“…Infected toads also exhibited lower bacteria-killing ability, perhaps reflecting a trade-off of resources towards defences that are more specifically anthelminthic. …”
Get full text

Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxici... by Hazal Aslan Rejeski, Hazal Aslan Rejeski, Anne Hartz, Anne Hartz, Elias Rackl, Elias Rackl, Lin Li, Lin Li, Christoph Schwepcke, Christoph Schwepcke, Kai Rejeski, Kai Rejeski, Christoph Schmid, Christoph Schmid, Andreas Rank, Andreas Rank, Jörg Schmohl, Doris Kraemer, Peter Bojko, Helga Maria Schmetzer, Helga Maria Schmetzer

Get full text

Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

Get full text

Semifield Evaluation of Improved Passive Outdoor Host Seeking Device (POHD) for Outdoor Control of Anopheles arabiensis Mosquitoes by Stella T. Kessy, Bruno A. Nyundo, Ladslaus L. Mnyone, Issa N. Lyimo

Get full text

The Use of Granular Cyclopentanone as Alternative to Artificial Source of Carbon Dioxide in Improved Passive Outdoor Host Seeking Device (POHD) by Stella T. Kessy, Bruno A. Nyundo, Ladslaus L. Mnyone, Issa N. Lyimo

Get full text

PREVENTING VIOLENCE CRIMES (KIDNAPPING, ARMED ROBBERY, BRIGANDAGE OR COMMUNITY MASSACRE) WITH DRONES: AN EFFECTIVE ALTERNATIVE TO VEHICULAR PATROLS IN NIGERIA by GABRIEL SALIFU, DANIEL OLASUNKANMI OLADAPO

“…In the 21st century, the families off springs are endangered with multiple social vices that range from internet fraud (yahoo yahoo), kidnapping, lesbianism, drug abuse, homosexuality, bestiality, incest, ritual killing and others. …”
Get full text

The Molecular Imaging of Natural Killer Cells by Mariya Shapovalova, Sean R. Pyper MD, PhD, Branden S. Moriarity PhD, Aaron M. LeBeau PhD

“…Natural killer cells are cytotoxic lymphocytes that mediate the direct killing of transformed cells with reduced or absent major histocompatibility complex (MHC) and are the effector cells in antibody-dependent cell-mediated cytotoxicity. …”
Get full text

Transition Yet Energy Consuming for Tumor Growth Regulated by the Colored Microenvironment by Leiyan Chen, Yan Wang, Qingqing Li, Haohua Wang

“…Moreover, by reconstructing the reaction network from the mesoscopic scale, we further show that AT of multiplicative noise can increase energy consumption, and there exists a trade-off between NS and AT of additive noise. We also show that the energy consumption is monotonically decreasing with increasing the CT but the CS can amplify the difference of this dependence. …”
Get full text

Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies by Yan-Ruide Li, Ying Fang, Siyue Niu, Yichen Zhu, Yuning Chen, Zibai Lyu, Enbo Zhu, Yanxin Tian, Jie Huang, Valerie Rezek, Scott Kitchen, Tzung Hsiai, Jin J. Zhou, Pin Wang, Wanxing Chai-Ho, Sunmin Park, Christopher S. Seet, Caspian Oliai, Lili Yang

“…Furthermore, CAR-NKT cells synergize with hypomethylating agents, enhancing tumor-killing efficacy. These cells also show minimal off-tumor toxicity, reduced graft-versus-host disease and cytokine release syndrome risks, and resistance to allorejection, highlighting their substantial therapeutic potential for treating myeloid malignancies.…”
Get full text

Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…TCEs function by binding to cell surface receptors on T cells, frequently CD3, with one arm of the bispecific antibody while the other arm binds to cell surface antigens on cancer cells. On-target, off-tumor toxicity can arise when the target antigen is also present on healthy cells. …”
Get full text

Comparative analysis of lactaptin activity when produced in bacterial or eukaryotic expression systems by O. A. Koval, O. Y. Volkova, A. A. Gorchakov, S. V. Kulemzin, A. V. Tkachenko, A. A. Nushtaeva, E. V. Kuligina, V. A. Richter, A. V. Taranin

“…Taken together, our results provide an opportunity for developing armored immune cells as an “off-the-shelf” platform for targeted delivery of lactaptin to cancer cells.…”
Get full text

A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

“…Furthermore, compared to IL15 alone, it was able to induce higher levels of NKG2D- and NKp30-activating receptors and restore NK-mediated direct killing in the CLL patient-derived samples. The preliminary data presented in this work suggest that IL15’s targeting of NK cells via scFvB1 potentiates the effects of IL15 and that scFvB1IL15 can be a useful agent for overcoming NK functional gaps and contribute to NK-cell-based immunotherapies.…”
Get full text

Efficacy and safety of pseudolaric acid B against Echinococcus multilocularis in vitro and in a murine infection model by Zhuo-ma Dawa, Zhuo-ma Dawa, Ting Zhai, Ting Zhai, Chuan-chuan Liu, Chuan-chuan Liu, Hai-ning Fan, Hai-ning Fan

“…Scanning electron microscopy revealed that the microvilli structure of the protoscolex was destroyed and the rostellar hooks had fallen off. PAB induced. The release of PGI from the metacestode vesicles, leading to the structural destruction of the inner surfaces. …”
Get full text

TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…To generate an ‘off-the-shelf’ multitargeting Ag-scaffold product of relevance to patients with metastatic melanoma, we identified the 30 most frequently recognized shared HLA-A0201-restricted melanoma epitopes in a cohort of 87 patients. …”
Get full text

Passive Outdoor Host Seeking Device (POHD): Designing and Evaluation against Outdoor Biting Malaria Vectors by Stella T. Kessy, Ladslaus L. Mnyone, Bruno A. Nyundo, Issa N. Lyimo

Get full text

Pan-caspase inhibitors induce secretion of HIV-1 latency reversal agent lymphotoxin-alpha from cytokine-primed NK cells by Zamaneh Hajikhezri, Ioannis Zygouras, Anders Sönnerborg, Robert van Domselaar

“…Abstract The persistence of HIV-1 latency reservoirs in CD4+ T cells is a significant obstacle for curing HIV-1. Shock-and-kill strategies, which aim to reactivate latent HIV-1 followed by cytotoxic clearance, have shown limited success in vivo due to insufficient efficacy of latency reversal agents (LRAs) and off-target effects. …”
Get full text

Study of an arginine- and tryptophan-rich antimicrobial peptide in peri-implantitis by Qian Zhang, Yalei Jiang, Xiaotong He, Liwei Liu, Xi Zhang

“…Therefore, VR-12 may be a good option for both warding off and treatmenting peri-implantitis.…”
Get full text

Engineered Perfluorochemical Cancer-Derived Exosomes Loaded with Indocyanine Green and Camptothecin Provide Targeted Photochemotherapy for Effective Cancer Treatment by Lee YH, Huang CY

“…After 5 min of NIR exposure and 24 h of in vitro culture, ICFESs encapsulating ≥ 10/10 μM [ICG]/[CPT] effectively killed more than 70% of the cancer cells, inducing greater mortality than that caused by a 4-fold higher dose of CPT alone. …”
Get full text