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Inhibition of RAC1 activator DOCK2 ameliorates cholestatic liver injury via regulating macrophage polarisation and hepatic stellate cell activation
Published 2025-02-01Subjects: Get full text
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La efectividad del Programa de Estímulos a la Innovación (PEI) en Sonora. ¿Qué factores influyen en el impacto del programa Rodríguez sobre la innovación y la competitividad de las...
Published 2019-01-01“…Para la selección del modelo se usa el criterio de información de Akaike (AIC). Resultados: El impacto neto del programa sobre los insumos de innovación es definido por la calidad de las propuestas y la capacidad de asimilación del conocimiento, principalmente; mientras que los efectos netos sobre los productos son moderados por la existencia de departamento interno de I+D, la vinculación, la calidad de los proyectos y la capacidad de absorción del conocimiento.Limitaciones: El tamaño de la muestra es muy reducido, lo que tiene implicaciones sobre el nivel de generalización de los hallazgos; los datos se basan en la percepción de los beneficiarios, por los que pueden estar sujetos a sesgos; el modelo no contempla variables de tipo contextual, como la intensidad tecnológica de los sectores.Conclusiones: Se encontró evidencia de un efecto de contribución neta de los subsidios otorgados por el PEI a los recursos de investigación, desarrollo e innovación (I+D+i) de las empresas beneficiarias, por un lado, a los indicadores de desempeño empresarial y desempeño en innovación, por el otro. …”
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Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice
Published 2025-01-01“…Additionally, COS inhibited ferroptosis by modulating the SLC7A11/GSH/GPX4 pathway and the expression of FTH1 and FLC proteins, thereby reducing lipid peroxidation accumulation and iron overload. …”
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Parent’s Perspective on Continuity of Care in the Maternity Care and Child Health Services Continuum: A Qualitative Systematic Review
Published 2025-01-01“…Conclusion: Ideally, (a) parents enter the postnatal period well-prepared, and well-informed about self-care, PCHC and possible postnatal carepathways, (b) number of caretransfers is limited, (c) by overlapping maternity care and PCHC, parents are provided with an opportunity to maintain meaningful relationships with their care providers, and (d) information is consistent, family-centred, and tailored.…”
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Utvrđivanje standardne transverzalne maksilarne dimenzije na studijskim modelima korištenjem omjera intermolarne i interkanine širine: pan-indijska studija
Published 2024-01-01“…Svrha rada: Procjena maksilarne širine klinički je veoma važna u prepoznavanju razvojnih anomalija, ortodontskoj dijagnostici i planiranju terapije, pružanju podataka specifičnih za etničku pripadnost i u forenzici. …”
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Trends and factors associated with skilled birth attendance in a post-Ebola context: DHS Guinea 2018
Published 2025-01-01“…Factors associated with skilled birth attendance in post-Ebola were: having no level of education (odds ratio [OR] = 0.39; confidence interval [CI]: 0.31–0.77), performing four or more antenatal care (ANC) (OR = 12.10; CI: 8.24–17.77), residing in a rural area (OR = 0.25 [0.17–0.37]), having a spouse who was a trader or manual worker, belonging to a household with an intermediate or poor wealth index and residing in the Labé region. …”
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Establishment and Clinical Application of Rh Blood Group Bank in the East China Region
Published 2025-02-01“…Yiming Jin,1,* Xiaoyan Fu,2,* Shuhong Xie,3 Zhen Liu,1 Zihao Xu,1 Mingyuan Wang,1 Yihan Wang,1 Rong Lu,1 Lingling Wang1 1Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China; 2Department of Blood Screening Test, Tai Cang Blood Branch Station, Tai Cang, People’s Republic of China; 3Division of Transfusion Medicine, Suzhou Blood Center, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingling Wang; Rong Lu, Department of Blood Screening Test, Suzhou Blood Center, Suzhou, People’s Republic of China, Email linglingwang0716@163.com; cv-25a@163.comPurpose: To investigate the expression and distribution of Rh phenotypes (C, c, D, E, e) among voluntary blood donors in a specific region of East China, to establish a regional Rh phenotype database, and to enhance the precision and efficacy of clinical blood transfusions.Patients and Methods: A total of 28979 blood samples were collected from voluntary donors at a central blood station in East China between May 2023 and December 2023. …”
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Expectativas acerca das atividades síncronas na formação a distância do Programa Mais Médicos para o Brasil
Published 2025-02-01“…Objetivo: Este estudo investigou as expectativas de estudantes e tutores do PMMB acerca das atividades síncronas previstas no curso de especialização lato sensu em MFC, oferecido pela Fundação Oswaldo Cruz (Fiocruz) de Mato Grosso do Sul e pela Universidade Aberta do Sistema Único de Saúde (UNA-SUS). …”
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Effects of dietary chlorogenic acid supplementation on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens
Published 2025-12-01“…Additionally, 600 and 800 mg/kg CGA treatment significantly decreased serum TG, T-CHO, and LDL-C levels, as well as liver TG and T-CHO levels, while increasing serum lipoprotein lipase activity. …”
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Prevalence and antimicrobial resistance of three clones (ST1223, ST2198, ST2250) of Staphylococcus argenteus clinical isolates in northern Japan
Published 2025-01-01“…Three genotypes, ST1223-coa-XV, ST2198-coa-XIV, and ST2250-coa-XId were identified, with ST2250 being dominant (49%) and exhibiting an increasing trend. …”
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Floquet operator engineering for quantum state stroboscopic stabilization
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Impacto sobre el cambio climático del ciclo de vida de las tarimas de madera elaboradas en la región Huetar Norte de Costa Rica
Published 2021-01-01Subjects: “…Cambio climático; Evaluación de Impacto de Ciclo de Vida (EICV); huella de carbono de producto (HCP); Inventario de Ciclo de Vida (ICV); productos biogénicos; productos de madera recolectada (PMR); productos forestales.…”
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Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls
Published 2025-03-01“…Meanwhile, the serum and ovarian matrix total antioxidant capacity (T-AOC) level decreased with increasing age, whereas the ovarian matrix malondialdehyde (MDA) level showed the opposite trend. …”
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New anti-friction self-lubricating composite based on EP975 nickel alloy powder with CaF2 solid lubricant – Thermal and dilatometric behavior
Published 2025-04-01“…The authors analyzed the thermal, mechanical, wear structural and chemical phenomena of the new high-temperature antifriction composite developed to operate at high temperatures (800˗900 °C). Samples were tested with triple heating up to 1000 °C at different heating rates. …”
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