Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization by Yang Fu, Xinwang Duan, Wei Zhou

“…Single nucleotide polymorphisms (SNPs) significantly associated with PAH at the genome-wide significance threshold (P < 1 × 10−6) were selected as instrumental variables (IVs). Inverse-variance weighted (IVW) was used as the primary method for MR analysis, with sensitivity analyses including tests for heterogeneity and horizontal pleiotropy. …”
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Tracing pistachio nuts’ origin and irrigation practices through hyperspectral imaging by Raquel Martínez-Peña, Salvador Castillo-Gironés, Sara Álvarez, Sergio Vélez

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Causal Relationship Between Cerebrospinal Fluid Metabolites and Intervertebral Disc Disease: A Bidirectional Mendelian Randomization Study by Jiheng Xiao, Tianyi Xia, Xianglong Zhou, Xin Xing, Yanbin Zhu, Yingze Zhang, Liming Xiong

“…MR analysis employed single nucleotide polymorphisms (SNPs) closely associated with disease as instrumental variables (IVs). …”
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Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization by Weisheng Li, Baoguo Xia, Weixin Chu, Likui Lu, Xuedong Liu

“…Results Two-sample Mendelian randomization analysis indicated that CX3CL1 was inversely associated with PCa risk. …”
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PHENOTYPIC FEATURES OF ENDOMETRIAL CANCER AND MSI IN COLON AND BLOOD SERUM by S. M. Kartashov, E. M. Oleshko

“…A similar pattern was observed also in cases with MSI+ tumour phenotype (MSI frequency in colonic mucosal lining made 12.2 %, whereas in blood serum – 29.6 %, p <0.01). Analysis of indices in cases with MSI- tumour phenotype demonstrated inverse relation, i.e. genome microsatellite instability was more frequently observed in the colonic mucosal lining than in blood serum (p<0.05). …”
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The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study by Zong Jiang, Xiaoling Yao, Yuzheng Yang, Fang Tang, Wukai Ma, Xueming Yao, Weiya Lan

“…Abstract Background It has been shown that low testosterone levels are associated with the development of osteoarthritis (OA). In our study, we aimed to investigate a bidirectional causal relationship between bioavailable testosterone levels and OA using Mendelian randomization (MR) analysis. …”
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High-Precision Remote Sensing Monitoring of Extent, Species, and Production of Cultured Seaweed for Korean Peninsula by Shuangshuang Chen, Zhanjiang Ye, Runjie Jin, Junjie Zhu, Nan Wang, Yuhan Zheng, Junyu He, Jiaping Wu

“…During the 2022–2023 cultivation season, South Korea’s farms comprised 78% laver and 22% kelp, while North Korea’s showed an inverse distribution. A strong correlation (r² = 0.99) between acreage and seaweed production enabled us to estimate annual seaweed production in North Korea, effectively addressing data gaps in regions with limited statistics. …”
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Duration of rheumatoid arthritis changes blood levels of angiotensin and aldosterone by Boris A. Rebrov, Elena B. Komarova, Antonina K. Knyazeva

“…Further mathematical processing of data using multiple regression analysis and determination of correlations showed the presence of a linear inverse relationship between the ATII level and the duration of the disease (R=-0.44, p<0.001; F=10.98, p=0.001). …”
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Assessing the causal effect of inflammation‐related genes on myocarditis: A Mendelian randomization study by Huazhen Xiao, Hongkui Chen, Wenjia Liang, Yucheng Liu, Kaiyang Lin, Yansong Guo

“…Five algorithms [MR‐Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode regression] were employed for the MR analysis, with IVW as the primary method, and sensitivity analysis was conducted. …”
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The gut microbiota and diabetic nephropathy: an observational study review and bidirectional Mendelian randomization study by Yi Zhen Han, Yang Zhi Yuan Wang, Xing Yu Zhu, Bo Xuan Du, Yao Xian Wang, Xue Qin Zhang, Jia Meng Jia, Wei Jing Liu, Hui Juan Zheng

“…The primary method for analysis was the inverse variance weighted (IVW) approach. …”
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The Possible Influence of Atmospheric Circulation and North Atlantic Sea Surface Temperature Anomaly on the Winter Cold Wave Frequency in the Southern China by Feng JIANG, Liping LI

“…Based on the daily minimum temperature station data provided by the National Meteorological Information Centre from 1980 to 2022， the month-by-month reanalysis data of the NCEP/NCAR， and the monthly Sea Surface Temperature （SST） data from the NOAA， by using EOF， simple linear regression and T-N wave flux methods， the main anomalous spatial and temporal characteristics of winter cold wave frequency in the southern China are studied， and the influence mechanisms of atmospheric circulation and winter Atlantic Sea Surface Temperature Anomaly （SSTA） on it are also analyzed.The results show that： （1） The large value areas of winter cold wave frequency are mainly located in the eastern and central of the southern China， with an approximately "inverse C" distribution.There are three main frequency anomalous modes， namely， regionally consistent anomaly， north-south antiphase anomaly and tripole anomaly patterns according to the EOF analysis， among which the regionally consistent anomaly reflects the overall anomalous spatial and temporal characteristics of the winter cold wave frequency in the southern China.（2） The negative phase of the North Atlantic Oscillation （NAO）， the strong Caspian Sea - Tibetan Plateau ridge and the East Asian Trough located to the north and to the east， the weak in the north and strong in the south of the Siberian High， the strong temperate jet and the weak subtropical jet are the key circulation systems affect the winter cold wave frequency in the southern China.The cold air pool is located in the Western Siberia.The high and low level circulation systems cooperate together to make the cold air from Western Siberia move southward to the vicinity of the Caspian Sea， and then transport eastward along the northern side of the Tibetan Plateau， then move southward into the southern China along the eastern side of the Tibetan Plateau， resulting in the increase of the winter cold wave frequency in the whole southern China.（3）In winter， the “+”“-”“+” tripolar SSTA in the North Atlantic can stimulate the -NAO atmospheric circulation anomalies through the exchange of heat fluxes between air and sea and the Rossby wave energy anomalies.The Rossby wave energy propagates from the North Atlantic to East Asia along the south and north two paths， and stimulates the corresponding anomalous waves， which enhance the key circulation systems in the north and south affecting the cold wave frequency in the southern China.When the North Atlantic SSTA exhibits an inverse "C" anomaly in spring， and there is a trend of developing into a “+”“-”“+” tripolar pattern in summer and autumn， the winter cold wave frequency in the southern China can be predicted to more.…”
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Telomere Length as Both Cause and Consequence in Type 1 Diabetes: Evidence from Bidirectional Mendelian Randomization by Guanping Wei, Ruiping Chen, Shupeng Liu, Shenhua Cai, Zhijun Feng

“…However, the causal relationship between diabetes and TL remains unclear, particularly whether cellular homeostasis imbalance acts as a consequence of diabetic complications or a precipitating factor in disease development. <b>Methods:</b> We performed a bidirectional Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data. …”
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APOE ε4‐independent pathways predominate in the association between retinal nerve fiber layer thinning and 12‐year incident dementia by Yuzhuo Wang, Xiaoxi Ma, Haoze Cen, Jie Wang, Jie Wu, Ding Ding, Yiqin Xiao, Qianhua Zhao

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Spatial and Temporal Variation of Main Air Pollutants and Their Concentrations in Relation to Meteorological Conditions in the Industrialized City of Kocaeli by Burak Kotan, Arzu Erener

“…One of the interpolation methods employed was the inverse distance weighted technique (IDW). Pollution maps for the winter, spring, summer, and fall seasons of 2008, 2014, and 2019 were developed for Kocaeli by providing data continuity with the produced values. …”
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Longitudinal association of sleep duration with possible sarcopenia: evidence from CHARLS by Ping Lin, Xiaoling Lv, Wenjia Peng, Bingbing Jia, Zhouxin Yang

“…Hence, this study aimed to investigate the associations of sleep duration with possible sarcopenia and its defining components based on the China Health and Retirement Longitudinal Study (CHARLS).Design A retrospective cohort study.Setting This study was conducted on participants aged over 45 years applying the 2011 baseline and 2015 follow-up survey from CHARLS covering 450 villages, 150 counties and 28 provinces.Participants Data from 5036 individuals (2568 men and 2468 women) free of possible sarcopenia at baseline were analysed.Primary and secondary outcome measures The dose-response relationship between sleep duration and possible sarcopenia.Results During 4 years of follow-up, 964 (19.14%) participants developed possible sarcopenia. …”
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Causal relationship between type I diabetes mellitus and atrial fibrillation: A Mendelian randomization study by Yongkai Li, Shasha Liu, Yiming Dong, Jianzhong Yang, Yingping Tian

“…Background: Patients with type 1 diabetes mellitus have been at heightened risk for developing atrial fibrillation. We aimed to investigate whether this association is causal using Mendelian randomization. …”
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Does capital efficiency influence economic growth in Bangladesh? Application of the Harrod-Domar model by Sakib Bin Amin, Bismi Iqbal Samia, Farhan Khan

“…Design/methodology/approach – We use annual data from 1980 to 2019 for this paper. Three steps are taken in the data analysis. …”
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Psychological, social factors, and smoking behavior mediated the effects of cannabis use on personality disorders: A Mendelian randomization study by Yao Ni, Juanmei Li, Zitian Tang, Youqian Zhang, Yanyan Feng

“…Although links between CU and personality disorders (PDs) are documented, their causality remains uncertain.MethodsEmploying Genome-Wide Association Studies (GWAS) data, this study investigated the causal relationship between cannabis use disorder (CUD) and lifetime cannabis use (LCU) with 9 types of PD risk through Mendelian randomization (MR) analysis. …”
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The Association between Baseline, Changes in Uric Acid, and Renal Failure in the Elderly Chinese Individuals: A Prospective Study with a 3-Year Follow-Up by Xiuxiu Lai, Bo Gao, Gongmin Zhou, Qingyan Zhu, Yan Zhu, Haijia Lai

“…In the multivariable analysis, the odds ratio (OR) for the development of CKD increased with the increase in SUA quartiles at baseline (1.00 vs. 1.79 (95% CI, 1.00–3.22), 3.4 (95% CI, 1.79–6.47), and 6.79 (95% CI, 3.45–13.75), respectively; P for linear trend <0.001), and a per unit increase in baseline SUA levels gave an OR of 1.76 (95% CI, 1.45–2.14) for renal failure. …”
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Cathepsins and neurological diseases: a Mendelian randomization study by Haitao Sun, Qingqing Tang, Xue Yan, Wanying Xie, Yueshan Xu, Weimin Zhang

“…To address this, we utilized a two-sample Mendelian randomization (MR) approach to assess the potential causal effect of cathepsins on the development of neurological diseases.MethodsThis study conducted a two-sample two-way MR study using pooled data from published genome-wide association studies to evaluate the relationship between 10 cathepsins (B, D, E, F, G, H, L2, O, S, and Z) and 7 neurological diseases, which included ischemic stroke, cerebral hemorrhage, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and epilepsy. …”
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