Protease and <i>Bacillus coagulans</i> Supplementation in a Low-Protein Diet Improves Broiler Growth, Promotes Amino Acid Transport Gene Activity, Strengthens Intestinal Barriers,... by Junlong Niu, Yingying Qiao, Xiaopeng Yang, Xiaoshuang Chen, Hongfei Li, Yongpeng Guo, Wei Zhang, Zhixiang Wang

“…Both PRO and PAB diets significantly enhanced the expression of amino acid transport genes and tight junction genes (<i>p</i> < 0.05) and optimized the composition of the intestinal microbiota. Overall, LPRO diets have a detrimental effect on the growth of broiler chickens, while the PRO and PAB diets effectively counteract these negative effects by improving protein digestion, amino acid absorption, and intestinal health.…”
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Dysbiosis of gut microbiota with enriched pro-inflammatory species in children with idiopathic short stature: a case-control study by Qin Zeng, Xianqiong Feng, Yanling Hu, Shaoyu Su, Bi Ru Luo, Jing Chen

“…We explored the prevalence, variability, organization, and contribution of gut microbiota in children affected by ISS. This study selected 58 ISS individuals aged 6–12, serving as the experimental group, 58 non-ISS children constituted the control group. …”
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A dynamic simulation model for digestion, gut transit, and absorption in the ballan wrasse, Labrus bergylta by T.S. Silva, L.E.C. Conceição, Ø. Sæle, I. Rønnestad

“…The model overestimated protein digestibility/absorption (Apparent Digestibility Coefficient; ADC) in the first intestinal segment (S1) but showed good compliance for the rest of the intestine. …”
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Tetrastigma hemsleyanum as a feed additive: modulating gut microbiota for enhancing nutritional transport and growth performance in Jinhua yellow chickens by Chao Lu, Yun Xiang, Kewei Xu, Fengrui Gao, Shaofeng Zhu, Fangfang Lou, Lu Liu, Xin Peng

“…Furthermore, qPCR analysis results preliminarily verified that dietary TH not only enhanced intestinal amino acids (rBAT and EAAT3) and peptides (PepT1 and APN) transport but also alleviated the inflammation (IL-1β, IL-6 and IFN-γ), thus thereby improved intestinal development and growth performance in Jinhua yellow chickens. …”
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Integrated 16S rDNA-Seq and metabolomics reveal seasonal dynamics of gut microbial–SCFA–immune crosstalk in diarrheic calves by Qianqian Wang, Qicheng Lu, Yaqin Tang, Qiuyan Li, Peiyun Gao, Shaoyang Pang, Wenju Zhang, Cunxi Nie, Junli Niu, Xiaoling Ma

“…This study investigated body weight and size, immune function, intestinal permeability, rectal microbiota, and short-chain fatty acid (SCFA) levels in diarrheal and healthy lactating calves across seasons.MethodsTen lactating healthy and ten diarrhea calves were selected in each season, blood and rectal contents samples were collected. …”
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A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors by John C. Y. Chen, Lech Kaczmarczyk, Lech Kaczmarczyk, Walker S. Jackson, Walker S. Jackson, Max Larsson

“…The mouse showed high recombination efficiency (97%) and selectivity (93%) in dorsal root ganglia. Reporter-expressing fibers were observed in a variety of peripheral tissues, including skin, skeletal muscle, genitalia, bladder and intestines. …”
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The in ovo screening of 27 single essential oils showed selective effects on hatchability, performance and gene expression relevant to gut functions in broilers at hatch by Asad A. Khaskheli, Shahram Niknafs, Mila M.Y. Meijer, Xinle Tan, Peter R. Ferket, Eugeni Roura

“…Hatchability, body weight and organ weights (residual yolk, gizzard-proventriculus, intestines, liver, and heart) were measured at hatch. …”
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Selection of Lactobacillus strains from native chicken feces for the fermentation of purple onion (Allium cepa L.) as an antibiotic alternative against Salmonella spp. in chickens by Phan Vu Hai, Hoang Thi Anh Phuong, Pham Hoang Son Hung, Tran Thi Na, Ngo Huu Lai, Nguyen Dinh Thuy Khuong, Tran Ngoc Liem, Nguyen Xuan Hoa

“…In vivo studies in chicks were conducted to assess the safety and intestinal persistence of LFOE. Results: From an initial pool of 68 Lactobacillus strains, six promising candidates (L. plantarum 1582, L. plantarum WCFS1, L. plantarum JDM1, L. acidophilus NCFM, L. agilis DSM 20509, and L. agilis La3) were selected based on their antibacterial activity and high survival rate in OE. …”
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Case report: Vedolizumab in Oral Crohn’s disease: the downsides of a gut-specific therapy for a multi-site disease by Molly Harte, John Macken, John Macken, Lifong Zou, Farida Fortune, Farida Fortune, Farida Fortune

“…Clinicians should be aware that vedoluzimab may be beneficial for intestinal CD, but does not target inflammation in oral tissues due to its gut-specific action. …”
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β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool by Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou

“…This study explores the crosstalk between gut microbiota and intestinal stem cells (ISCs) in intestinal mucositis triggered by CPT11 chemotherapy. …”
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Excretory/secretory products from Hymenolepis nana adult worms alleviate ulcerative colitis in mice via tuft/IL-13 signaling pathway by Rong Mou, Xuanyin Cui, Hongyan Wang, Zhenfen Zhang, Yi Cheng, Wenlan Wu, Jinfu Li, Ke Zhang

“…Conclusions In conclusion, H. nana-derived ESPs intervention facilitates healing of intestinal mucosa to alleviate UC in mice, enriching the feasibility and selectivity of “helminthic therapy.” …”
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VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy. by Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu, Jiahuan Zhang, Hongyu Li, Ke Zeng, Wenqiang Peng, Cheng Yang, Junsheng Huang, Zelong Han, Xiaochun Bai, Xiao Yu

“…Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation, but the underlying mechanisms remain elusive. …”
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Positioning Guselkumab in The Treatment Algorithm of Patients with Crohn&amp;rsquo;s Disease by D'Amico F, Bencardino S, Magro F, Dignass A, Gutiérrez Casbas A, Verstockt B, Hart A, Armuzzi A, Peyrin-Biroulet L, Danese S

“…Unlike conventional therapies, guselkumab offers a different mechanism of action by selectively inhibiting IL-23, a key cytokine implicated in the pathogenesis of CD. …”
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The state of cancer care in Russia: cancer of the small intestine (C17). Survival of patients, median survival, survival of patients according to tumor localization, histological p... by V. M. Merabishvili

“…To calculate the survival rates for patients with small intestine cancer, we selected 1922 patients from the database of the pcr of the Northwestern Federal district of the Russian Federation, for the period from 2000 to 2018. …”
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Nematodes exposed to furfural acetone exhibit a species-specific vacuolar H+-ATPase response by Wanli Cheng, Wei Dai, Wen Chen, Hua Xue, Zhengzheng Zhao, Zhengbing Jiang, Huanan Li, Jiashu Liu, Feng Huang, Minmin Cai, Longyu Zheng, Ziniu Yu, Donghai Peng, Jibin Zhang

“…In contrast, it exhibited weak activity against the free-living nematode C. elegans, suggesting its potential as a selective nematicide. Our investigation unveiled that FAc binds to the vacuolar H+-ATPase subunits VHA-12 and VHA-13, accelerating intestinal cell necrosis and leading to the death of C. elegans. …”
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Inflammatory bowel disease and multiple sclerosis by M. Dominguez-Gallego, V. Meca-Lallana, C. Ana Belén

“…Resumen: Introducción: La enfermedad inflamatoria intestinal (EII), que incluye principalmente la enfermedad de Crohn y la colitis ulcerosa, se caracteriza por producir una inflamación crónica en el tracto gastrointestinal, que se inicia y perpetua por alteraciones en la respuesta inmunitaria. …”
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Evaluation of post-market adverse events of lubiprostone: a real-world adverse event analysis from the FAERS database by Qingqing Li, Jijun Zhang, Chuanli Yang, Xiushan Dong, Yan Wang

“…Abstract Objective Lubiprostone is a selective intestinal chloride channel activator approved for treating chronic idiopathic constipation and constipation-predominant irritable bowel syndrome in adults. …”
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Using the digital archive of pathological reports of stomach cancer as internal quality control of coding according to the ICD-O system by O. I. Kit, Yu. A. Fomenko, N. S. Karnaukhov, T. O. Lapteva, M. V. Voloshin, G. Yu. Vakulenko, S. Zh-P. Bosenko, I. A. Suhar, K. S. Eremin, G. V. Kaminskij, M. A. Kuznecova

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Immunological and clinical overlap between autoimmune gastritis and autoimmune liver diseases: a prospective cohort study by Sara Massironi, Giulia Dispinzieri, Giulia Dispinzieri, Alberto Rossi, Laura Cristoferi, Marco Vincenzo Lenti, Marco Vincenzo Lenti, Alessio Gerussi, Alessio Gerussi, Alessandra Elvevi, Marco Carbone, Marco Carbone, Alessandra Bonfichi, Alessandra Bonfichi, Antonio Di Sabatino, Antonio Di Sabatino, Silvio Danese, Silvio Danese, Pietro Invernizzi, Pietro Invernizzi

“…Among APCA-positive individuals, histological confirmation of AIG was achieved in 91.3%, with a high rate of intestinal metaplasia (95.7%) and variable OLGA stages of gastric atrophy. …”
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Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects by P.S. Kheoane, K.C. Mokhetho, S. Mokhele, K.C. Mbara, C.M. Leonard, T.H. Gadaga, C. Tarirai

“…P-gp and CYP3A4 show analogous substrate specificities and work together to establish an intestinal absorption barrier against xenobiotics. This study investigated the ex vivo p-glycoprotein inhibition and the in vitro inhibition of cytochrome P450 3A4 (CYP3A4) isoezyme by selected wild edible plants to identify potential food/herb-drug interactions. …”
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