Discovery of Specific Inhibitors for Intestinal E. coli  β-Glucuronidase through In Silico Virtual Screening by Ta-Chun Cheng, Kuo-Hsiang Chuang, Steve R. Roffler, Kai-Wen Cheng, Yu-Lin Leu, Chih-Hung Chuang, Chien-Chaio Huang, Chien-Han Kao, Yuan-Chin Hsieh, Long-Sen Chang, Tian-Lu Cheng, Chien-Shu Chen

“…Compound 4041  (IC50=2.8 μM) shows a higher inhibiting ability than compound 7145  (IC50=31.6 μM) against eβG. …”
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LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumber Apostichopus japonicus by Fang Su, Igor Yu. Dolmatov, Tianming Wang, Hongsheng Yang, Kui Ding, Libin Zhang, Lina Sun

“…However, studies on the role of non-coding RNAs, particularly long non-coding RNA (lncRNA), in intestinal regeneration remain limited. In this study, we identified and performed differential expression analysis of lncRNAs in both normal intestines and intestines at 3 days post evisceration (dpe). …”
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Regulation of intestinal health by Lactobacillus rhamnosus GG during fasting-induced molting in laying hens by Zhixuan Luo, Yujie Gong, Qiang Li, Mengyan Zhang, Jun Zhang, Hao Zhang, Qingduo Zeng, Yidan Zhu, Yujie Guo, Donghua Li, Yadong Tian, Xiangtao Kang, Ruirui Jiang

“…Compared with NC group, TBF group significantly increased the activity of antioxidant enzymes in serum during fasting, enhanced of the body's immune function, and also improved the intestinal barrier function, reduced intestinal inflammation and the content of oxidase, and further enhanced the digestion and absorption ability of FIM laying hens. …”
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Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity by Wen-lin Pang, Wen-lin Pang, Tian-gang Li, Tian-gang Li, Yin-ying Wang, Yin-ying Wang, Li-yun Song, Li-yun Song, Li Li, Li Li, Xiao-ya Li, Xiao-ya Li, Yong Qiu, Yong Qiu, Zhong-shan Yang, Zhong-shan Yang

“…In addition, analysis of 16S rRNA gene sequencing indicated that SC reduced harmful bacterial populations, such as Proteobacteria, while simultaneously enhancing the levels of beneficial bacteria like Lactobacillus, thereby contributing to the improvement of UC pathology.ConclusionThis study highlights the therapeutic potential of SC in managing UC through its ability to attenuate inflammatory responses, restore intestinal barrier functionality, and modulate gut microbiota composition, which findings offer insights into potential strategies for advancing UC treatment.…”
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Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions by Yichen Wang, Minghui Shi, Jiahui Wu, Xiangyu Han, Mengqi Li, Yining Wu, Yuanlin Jiang, Haonan Zhang, Shuqiang Liu, Defu Hu

“…In addition, the PICRUSt (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States) function prediction results indicated that FSD were less capable than FRD and FWLD in the functional category of nutrient metabolism, and FWLD were less capable than FSD and FRD in the functional category of intestinal absorption. These results indicated that there may be differences in the nutritional adaptation abilities of the three deer species under different feeding conditions. …”
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TiO2 – do we have to worry about it? One of the important aetiological factors in inflammatory bowel disease by Sara Jarmakiewicz-Czaja, Aneta Sokal, Jacek Tabarkiewicz, Rafał Filip

“…A change in the composition of the host’s intestinal microflora is also observed after exposure to high doses of TiO2. …”
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Enhancing the antibacterial ability of Ligilactobacillus salivarius through ARTP mutagenesis breeding: an effective strategy to improve its probiotic properties by Hetian Zhou, Hetian Zhou, Hetian Zhou, Yunping Du, Guolian Yu, Wei Liu, Juanjuan Zeng, Bin Wang, Bin Wang, Maojin Chen, Yujue Wang, Wenbo Zhang, Xiaona Wei, Xiaona Wei

“…Following ARTP mutagenesis and positively screened for its antibacterial ability, the mutant strain 30s-37 was obtained. By comparing the effects of the parental (D428) and mutant (30s-37) strains on broiler growth performance and intestinal microbiota, their probiotic properties performance was evaluated.ResultsThe results indicated that the use of L. salivarius strains improved the growth performance and increased the richness and diversity of cecal probiotic microbial communities, with the mutagenized strain 30s-37 exhibiting more pronounced effects.DiscussionThese findings underscore mutagenesis breeding as an effective strategy for probiotic strain optimization, justifying its expanded application in future strain development programs.…”
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Transcriptome Analysis Reveals the Molecular Mechanism of <i>Pseudomonas</i> with Different Adhesion Abilities on <i>Tilapia</i> Decay by Liumin Zhuang, Chen Song, Yunru Wei, Jinzhi Han, Li Ni, Chengxu Ruan, Wen Zhang

“…LP-3, with high adhesion ability, was observed to promote a relative increase in <i>Nocardioides</i> and <i>Cloacibacterium</i> in fish intestines. …”
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Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction. by Ryan D Pardy, Katelyn A Walzer, Bethan A Wallbank, Jessica H Byerly, Keenan M O'Dea, Ian S Cohn, Breanne E Haskins, Justin L Roncaioli, Eleanor J Smith, Gracyn Y Buenconsejo, Boris Striepen, Christopher A Hunter

“…The production of IFN-γ is crucial for control of multiple enteric infections, but its impact on intestinal epithelial cells (IEC) is not well understood. …”
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Spontaneous Intestinal Tumorigenesis in Apc/Min+ Mice Requires Altered T Cell Development with IL-17A by Wook-Jin Chae, Alfred L. M. Bothwell

“…Taken together, our results suggest that both T cell development in a functional thymus and IL-17A control the ability of Treg to inhibit intestinal tumorigenesis in Apc/Min+ mice.…”
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Simulator of the Human Intestinal Microbial Ecosystem (SHIME^®): Current Developments, Applications, and Future Prospects by Wei Zhu, Xiaoyong Zhang, Dong Wang, Qinghua Yao, Guang-Lei Ma, Xiaohui Fan

“…The continuous and real-time monitoring hallmarks, along with the programmatically flexible setup, bestow SHIME^® with the ability to mimic the entire human intestinal ecosystem with high dynamics and stability, allowing the evaluation of various treatments on the bowel microbiota in a controlled environment. …”
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Regulatory effects of Xihu Longjing tea on the intestinal flora of mice fed with high-fat and high-fructose diet by HU Liquan, TU Linyue, ZHAO Yueling, XIE Hengtong, XU An’an, XU Ping, ZHOU Jihong, WANG Yuefei

“…The results provide a theoretical basis for Longjing tea to regulate fat accumulation by improving intestinal flora disorders, and provide theoretical support for the ability of tea consumption to improve intestinal health and play a role in fat reduction and body mass loss.…”
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A Bioconjugate Vaccine Against Extra-Intestinal Pathogenic <i>Escherichia coli</i> (ExPEC) by Linhui Hao, Wenhua Huang, Yan Guo, Xiankai Liu, Jun Wu, Li Zhu, Chao Pan, Hengliang Wang

“…<b>Background</b>: Extra-intestinal pathogenic <i>Escherichia coli</i> (ExPEC) represents a major global public health challenge due to its ability to cause diverse clinical infections, including urinary tract infections, bacteremia, neonatal meningitis, and sepsis. …”
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Bacillus subtilis supplementation enhances the growth performance, immune indicators, and stability of the intestinal flora of Cherax quadricarinatus by Duanduan Chen, Shouquan Wang, Kai An, Xiujuan Feng, Yubao Li, Hui Wang

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Effects of drinking slightly acidic electrolyzed water on the growth health, blood physiology, and intestinal development in mice by Zhifang Shi, Lei Xi, ShuiLin Gao, ZhengYang Shi, XiaoTong Wang, Zhangying Ye, Pu Cheng

“…Furthermore, SAEW promoted the morphological development of the small intestine and increased the activities of amylase, lipase, and protease. …”
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MODELING OF EX VIVO INTERNALIZATION METHOD OF WATER- SOLUBLE ANTICANCER DRUGS IN SMALL INTESTINE USING CHEMILUMINESCENCE by H. M. Treshalina, N. V. Andronova, J. R. Tcherkassova, E. Yu. Klinski, G. Babayeva, E. V. Lukasheva, M. I. Treshchalin, S. A. Tsurkan

“…Introduction. the ability of the small intestine (internalization) to absorb water-soluble anticancer cytostatics determines the possibility of their oral administration. the ex-vivo express method that simulates the internalization of substances using a modified technique of an isolated «inverted» segment of the rat small intestine with flash chemiluminescence is adequate to solve the problem. …”
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Different doses of hydroxychloroquine regulate the structure of intestinal flora and glycosyltransferase activity in rats with IgA nephropathy by Lingling Bao, Xueyan Bian, Liling Ren, Sizeng Bao, Aiwei Zhang

“…Background: Hydroxychloroquine (HCQ), by virtue of its ability to reduce proteinuria, is an alternative therapy for Immunoglobulin A nephropathy (IgAN). …”
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A modified multi-angle suture training module for laparoscopic training curriculum on emergency intestinal surgery by Jiliang Shen, Chengcheng Wu, Xiaochen Zhang, Yaoting Xue, Jin Yang

“…Twelve residents were randomly divided at a 1:1 ratio into the traditional suture group and the multi-angle suture group according to their basic laparoscopic surgical ability. After training, they were required to perform laparoscopic end-to-end anastomosis surgery on isolated swine intestines. …”
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Enterobacteriaceae and Bacteroidaceae provide resistance to travel-associated intestinal colonization by multi-drug resistant Escherichia coli by Matthew Davies, Gianluca Galazzo, Jarne M. van Hattem, Maris S. Arcilla, Damian C. Melles, Menno D. de Jong, Constance Schultsz, Petra Wolffs, Alan McNally, Willem van Schaik, John Penders

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Malic enzyme 3 mediated the effects of malic acid on intestinal redox status and feed efficiency in broilers by Hongfeng Jiang, Genghui Li, Xue Yang, Xiaohua Feng, Penglin Li, Huisi Yang, Demin Cai, Qingyan Jiang, Gang Shu

“…We then constructed a mouse colitis model to explore malic acid (MA) ability to alleviate intestinal inflammation. We further used controlled release technology to coat MA and investigated its effects on the intestinal redox status and FE in vivo. …”
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