Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

“…Keywords: acute myocardial infarction, allicin, gut microbiota, metabolomics, intestinal barrier, pyroptosis…”
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A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA by Ilaria D’Amato, Enrico Ganguzza, Enrico Ganguzza, Guido Basilisco, Alessia Strippoli, Erika Salvi, Elkadia Mehmeti, Federica Chiappori, Grazia Devigili, Maurizio Vecchi, Maurizio Vecchi, Giuseppe Lauria, Giuseppe Lauria, Margherita Marchi

“…The mutation was localized in the N-terminus of the FLNA long isoform, a critical region for smooth muscle contractility and intestinal motility. Structural modeling of the mutant Filamin A suggested that the p.Gly19Val substitution alters the local protein folding and may interfere with the protein ability to cross-link actin filaments, potentially impairing cytoskeletal dynamics in visceral smooth muscle cells. …”
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Combination of p-coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice by Yan Zhou, Yitian Sun, Hui Guo, Yanzi Liang, Siyuan Zhu, Yu Sha, Zhongxiao Wan, Jiaying Xu, Jianrong Jiang, Liqiang Qin, Yunhong Li

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Alleviating <i>Clostridium perfringens</i>-Induced Intestinal Lesions in Chickens Using the Xylanase <i>Cb</i>Xyn10C and Its Binary Cocktail with a Protease by Wenjing Zhang, Zhenzhen Hao, Daoxin Yang, Wangli Ji, Kairui Guo, Xianhua Sun, Shuai Wang, Shuyan Yang, Jianshuang Ma, Tong Wang, Huiying Luo, Bin Yao, Meiling Zhang, Yuan Wang, Huoqing Huang, Xiaoyun Su

“…Not unexpectedly, feeding enzymes influenced the abundance of <i>Lactobacillus</i> and <i>Butyricicoccus</i> bacteria in the intestine. These results indicated that <i>Cb</i>Xyn10C and protease can be used to alleviate intestinal damage caused by <i>C. perfringens</i> infection.…”
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Consortium of <i>Lactobacillus crispatus</i> 2029 and <i>Ligilactobacillus salivarius</i> 7247 Strains Shows In Vitro Bactericidal Effect on <i>Campylobacter jejuni</i> and, in Com... by Vyacheslav M. Abramov, Igor V. Kosarev, Andrey V. Machulin, Evgenia I. Deryusheva, Tatiana V. Priputnevich, Alexander N. Panin, Irina O. Chikileva, Tatiana N. Abashina, Ashot M. Manoyan, Olga E. Ivanova, Tigran T. Papazyan, Ilia N. Nikonov, Nataliya E. Suzina, Vyacheslav G. Melnikov, Valentin S. Khlebnikov, Vadim K. Sakulin, Vladimir A. Samoilenko, Alexey B. Gordeev, Gennady T. Sukhikh, Vladimir N. Uversky, Andrey V. Karlyshev

“…<b>Methods:</b> A complex of microbiological, immunological, and molecular biological methods was used. The ability of the LC2029 and LS7247 consortium to promote intestinal homeostasis in vitro was assessed by the effectiveness of controlling CJ-induced TLR4 activation, secretion of pro-inflammatory cytokines, development of intestinal barrier dysfunction, and production of intestinal alkaline phosphatase (IAP). …”
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Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release by Yuanyuan Wu, Xinyue Huang, Qianbei Li, Chaoqun Yang, Xixin Huang, Hualongyue Du, Bo Situ, Lei Zheng, Zihao Ou

“…Probiotics have shown promise in managing IBD due to their ability to modulate the gut microbiota, enhance intestinal barrier function, and exert anti-inflammatory effects. …”
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Surgery of «low» rectal cancer — prospects of modern oncoproctology by G. K. Zherlov, C. P. Bashirov, I. V. Pankratov, D. G. Chepezubov

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Predisposing factors contributing to the development of renal dysfunction in acute infectious diarrhea associated with hemocolitis (AIDH) by L. N. Tuychiev, M. D. Ahkmedova, I. A. Imamova, N. U. Ibragimova, S. D. Igamberdieva

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Time-restricted feeding promotes glucagon-like peptide-1 secretion and regulates appetite via tryptophan metabolism of gut Lactobacillus in pigs by Qiuke Li, Ding Tan, Shijie Xiong, Kaifan Yu, Yong Su, Weiyun Zhu

“…In vitro studies with pig intestinal organoids showed the Lactobacillus metabolite ILA enhanced GLP-1 secretion through the promotion of intestinal stem cell differentiation into EECs, rather than activating the ability of EECs to secrete GLP-1. …”
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Expression of recombination antimicrobial protein PIL22-PBD-2 in Pichia pastoris and verification of its biological function in vitro by Xian Li, Pengfei Qiu, Menglong Yue, Ying Zhang, Congshang Lei, Jingyu Wang, Xiwen Chen, Xuefeng Qi

“…Additionally, given its strong ability to repair intestinal epithelial damage and maintain intestinal mucosal barrier function, porcine interleukin-22 (PIL-22) is a potential feed additive to combat intestinal damage caused by intestinal pathogens in piglets. …”
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Effects of Dendrobium officinale Kimura & Migo flower flavonoids on cognitive function by regulating gut microbiota by Nanzhi Hu, Nanzhi Hu, Kaiyue Wang, Xing Ge, Xin Zhang, Xiaojie Zheng, Shifang Sun

“…The Y-maze experiment was used to test the cognitive ability of mice, the expression of related synaptic protein was detected by WB, and Iba-1 was labeled by immunofluorescence to study the effects of DOFF on inflammatory response and cognitive function by regulating intestinal microbiota.ResultsThe results showed that DOFF intervention could regulate the relative abundance of intestinal flora in D-gal mice, including the relative abundance of Akkermansia, down-regulate the ratio of Firmicutes/Bacteroidetes, up-regulate the expression of ZO-1, and improve the colonic tissue injury. …”
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Effects of Astragalus–Ginseng Dietary Supplementation on the Growth and Stress Resistance of Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Wenkai Lin, Haijing Xu, Xinlan Ma, Zifeng Yin, Aimin Wang, Junqiang Qiu, Mingyou Li

“…Astragalus and ginseng, esteemed as traditional Chinese herbal medicines, have demonstrated the ability to bolster physical health and enhance the immune function of organisms. …”
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Epidemiology of Giardia intestinalis in non-human primates and their caregivers: A study from Czech zoos by Kristýna Brožová, Anna Šejnohová, Monika Koutenská, Zuzana Pavlíčková, Milan Jirků, Eliška Zimmelová, Oldřiška Kadlecová, Klára J. Petrželková, Kateřina Jirků

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Tea Polyphenol Protects the Immune Barrier and Inhibits TLR2/NF-κB/MLCK Signal Activation to Prevent Inflammatory Injury in the Intestines of Common Carp (<i>Cyprinus carpio</i> L.... by Man Qian, Jie Yang, Yao Xue, Jiawei Wu, Ziyi Li, Jilong Luo, Bing Zhao, Xuejiao Gao

“…In summary, the present study indicated that TP improved immune ability and inhibited the activation of the TLR2/NF-κB/MLCK pathway to attenuate LPS-induced inflammatory injury in the intestines of common carp.…”
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Dynamics of cumulating of metronidazole in the gut wall on a model of mechanical ileus. by V. V. Nepomniashchyi, T. I. Tamm, D. P. Polianskyi, O. A. Shakalova, O. P. Zakharchuk

“…The frequency of acute intestinal obstruction in relation to urgent surgical diseases in Ukraine remains high and reaches 3.8-6%. …”
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Cpx‐mediated amino acid sensing diversifies gastrointestinal colonization of Klebsiella pneumoniae by Danyang Li, Qiucheng Shi, Liuqing He, Jianhua Luo, Huajie Zhu, Xiaoting Hua, Yunsong Yu, Yan Jiang, Liang Tao

“…In this study, we identified three cpxA mutations in K. pneumoniae that experimentally evolved to show reduced adhesive ability. CpxA is a sensor histidine kinase that rendered reduced surface adhesion and gut colonization ability in K. pneumoniae. …”
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The predictive value of FAH model for the occurrence of colorectal cancer by Zhixuan Ma, Zhixuan Ma, Qing Wu, Qingming Wu

“…A model was constructed based on independent risk factors, and its accuracy and sensitivity were verified. The discriminative ability, calibration, and clinical utility of the predictive model were evaluated using the Receiver Operating Characteristic curve, bootstrap resampling method, the Hosmer–Lemeshow goodness-of-fit test, and Decision Curve Analysis (DCA).ResultsFatty liver (F), carotid atherosclerosis (A), HDL-C (H), and intestinal dysbiosis (D) were identified as independent risk factors for CRC. …”
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The Metabolites Produced by Lactic Acid Bacteria and Their Role in the Microbiota–Gut–Brain Axis by Yulma Lizbeth Aguirre-Garcia, Neftiti Carolina Cerda-Alvarez, Rosa María Santiago-Santiago, Adriana Rocío Chantre-López, Sarahi Del Carmen Rangel-Ortega, Raúl Rodríguez-Herrera

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Mechanism of hedysari radix praeparata cum melle and curcumae rhizoma herb pair in colitis-associated colorectal cancer through the MAPK/NF-κB signaling pathway: an investigation i... by Ting Liu, Ting Liu, Yugui Zhang, Yugui Zhang, Feiyun Gao, Feiyun Gao, Zhuanhong Zhang, Zhuanhong Zhang, Maomao Wang, Maomao Wang, Cui Ma, Cui Ma, Yanjun Wang, Yanjun Wang, Dingcai Ma, Dingcai Ma, Zhe Wang, Zhe Wang, Xingke Yan, Yuefeng Li, Yuefeng Li

“…The expressions of the intestinal permeability proteins, such as Claudin-1, Occludin, and ZO-1, were detected via immunohistochemical (IHC) analysis. …”
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Human milk oligosaccharides in infant formula: yesterday, today, tomorrow by I. V. Gmoshinsky, V. А. Skvortsova, T. Е. Borovik, O. А. Bokovskaya

“…So, numerous studies have shown a variety of beneficial effects of breast milk oligosaccharides in the development of the child's body, which includes a stimulating effect on the formation of a normal microbiome of the colon, the ability to form an effectively functioning protective intestinal barrier, binding and neutralizing a large number of pathogenic microorganisms and viruses, immunoregulatory action. …”
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