Cryofibrinogen-associated glomerulonephritis with paraproteinemia by Xuanli Tang, Mengya Jiang, Huaqin Zhang, Peng Bi, Jun Wang, Tian Ye, Jie Zheng, Mengli Tong, Xingyu Zhu, Xiaotao Hou, Shuhua Bao, Yi Lin, Xue Jiang, Hongyu Chen, Feng Wan, Haichun Yang

“…Cryofibrinogen was detectable under cold conditions, and monoclonal immunoglobulin (MIg) was exclusively identified within cryoprecipitates. …”
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Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion by Hanwool Park, Jong-Hyuk Lee, Ji Hoon Sim, Jihoon Park, Seong-Soo Choi, Jeong Gil Leem

“…One day after the final drug administration, we performed behavioral tests to measure responses of rats to mechanical, heat, cold, and acetone-induced cold stimuli. After behavioral tests, pJNK expression in the DRG was evaluated using western blot assay and immunohistochemistry. …”
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Dynamics of heart rate variability in rats with streptozotocin-induced diabetes by Maria P. Morozova, Svetlana A. Gavrilova, Evgeniy V. Ivanov, Anna M. Gorbacheva, Ekaterina M. Rzhavina, Aleksey K. Erdyakov, Zera N. Dzhemilova, Ekaterina V. Artemova, Alla Y. Tokmakova, Vladimir B. Koshelev, Gagik R. Galstyan

“…Materials and methods: DM in rats was induced by injection of streptozotocin at a dose of 65 mg/kg in citrate buffer (DM group). …”
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Effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF by Qin Xie, Xueyi Jiang, Ming Zhao, Yating Xie, Yong Fan, Lun Suo, Yanping Kuang

“…However, many studies reported that cryopreservation might have adverse effects on sperm DNA integrity, motility, and fertilization, probably due to cold shock, intra- and extracellular ice crystals, and excess reactive oxygen species (ROS). …”
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A four-week study on the toxicity of repeated intramuscular administration of plant-based BA-CoV2-0301 vaccine against SARS-CoV-2 in Sprague-Dawley rats by Sang-Jin Park, Seonghyeon Kim, Eun-Young Gu, Heejin Park, Wan‑Jung Im, Seung Eui Min, Bo-Hwa Choi, NamHyung Kim, Min Seong Jang, Yoongi Kim, Kang-Hyun Han, Kyong-Cheol Ko, Eui-Ju Hong, Yong-Bum Kim

“…However, the high cost, cold storage requirements, and scalability challenges associated with mRNA vaccines have necessitated alternative vaccine technologies. …”
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The Long-Term Immunity of a Microneedle Array Patch of a SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice by Eun Kim, Muhammad S. Khan, Juyeop Shin, Shaohua Huang, Alessandro Ferrari, Donghoon Han, Eunjin An, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Dohyeon Jeong, Andrea Gambotto

“…Methods: The rS1RS09 vaccine was administered via MAP or intramuscular injection in murine models. The immune responses of the MAP with and without gamma irradiation as terminal sterilization were assessed at doses of 5, 15, and 45 µg, alongside neutralizing antibody responses to Wuhan, Delta, and Omicron variants. …”
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Chemotherapeutic drug scavenger-based combination therapy toward treating triple-negative breast cancer by Qingqing Yin, Yutong Zhong, Mengchun Chen, Weian Mao, Yuan Yang, Li Li, Dongyan Tian, Shuangshuang Liu, Ying Chen, Jiale Quan, Shiyu Li, Deli Zhuge, Xufei Zhang, Ledan Wang, Fang Wang, Yiming Chen, Xiaosheng Lu, Xiaoji Lin, Yijie Chen, Linzhi Yan

“…Further, tumor exposure to high Dox amounts could convert the 4T1 tumor microenvironment from ‘cold’ to ‘hot’, leading to improved infiltration of immune cells, including T cells, dendritic cells, and macrophages. …”
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CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. by Aleksandar Lj Obradovic, Sung Mi Hwang, Joseph Scarpa, Sung Jun Hong, Slobodan M Todorovic, Vesna Jevtovic-Todorovic

“…When administered intraperitoneally (i.p.), at clinically relevant doses, mibefradil effectively alleviated heat, cold and mechanical hypersensitivities in STZ-treated diabetic rats in a dose-dependent manner. …”
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Tirzepatide safety in type 2 diabetes: a disproportionality analysis of adverse events using the FDA FAERS database by Zhenpo Zhang, Jiangxiong Li, Jingping Zheng, Yankun Liang, Lin Ma, Ling Su

“…Common events included gastrointestinal disorders (nausea and diarrhea) and injection-site reactions. The strongest signals were injection-site coldness and belching. …”
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Functional Anatomy of the kidney of the Buffaloes by Alaa A.Sawad

“…Th‘ f wtionrll with latex and Cold cure solution injected vascular and in excI‘et0TY 035” " u‘ ‘ significance of the renal apparatus was discussed…”
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Lemnaceae as a resilient crop to improve food security under climate extremes: global warming and post-catastrophic cooling scenarios by P. V. Femeena, R. A. Brennan

“…It is capable of growing in extreme hot or cold conditions, where conventional crops struggle. …”
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Sick Day Management for Adults with Diabetes Who Take Insulin by Nancy J. Gal, Linda B. Bobroff

“… When people have type 1 diabetes or type 2 diabetes and take multiple daily insulin injections, getting a cold or another minor illness can cause their blood glucose levels to go very high. …”
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Cosmic-Ray-driven Galactic Winds with Resolved Interstellar Medium and Ion-neutral Damping by Brandon Sike, Timon Thomas, Mateusz Ruszkowski, Christoph Pfrommer, Matthias Weber

“…Baryons can be cycled through stars, which inject energy into the interstellar medium in supernova explosions, fueling multiphase galactic winds. …”
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Sick Day Management for Adults with Diabetes Who Take Insulin by Nancy J. Gal, Linda B. Bobroff

“… When people have type 1 diabetes or type 2 diabetes and take multiple daily insulin injections, getting a cold or another minor illness can cause their blood glucose levels to go very high. …”
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Sick Day Management for Adults with Diabetes Who Take Insulin by Nancy Gal, Linda B. Bobroff

“… When people have type 1 or type 2 diabetes and take multiple daily insulin injections, their blood glucose levels can rise drastically due to a cold or another minor illness. …”
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Sick Day Management for Adults with Diabetes Who Take Insulin by Nancy Gal, Linda B. Bobroff

“… When people have type 1 or type 2 diabetes and take multiple daily insulin injections, their blood glucose levels can rise drastically due to a cold or another minor illness. …”
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TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy by Qiliang Teng, Niu Wang, Hanqi Lei, Tongyu Tong, Yupeng Guan, Mengjun Huang, Fei Cao, Bin Xu, Jia Yang, Yimian Huo, Wenping Chen, Ran Bi, Xuanqi Wang, Zhenyu Wang, Fu-Ying Tian, Bo Zhao, Jun Pang

“…Abstract Background Prostate cancer (PCa) has previously been established as a cold tumor with highly complex tumor environment. …”
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Diagnosis and treatment of nocturnal enuresis throughout the ages by Pieter Dik, Mohammad Sajjad Rahnama’i

“…Throughout​ the ages therapies for bedwetting were tried varying from drinking wine with shaved down testicle of a hare, flogging with nettles, cold showers, injections with strychnine, application of metal devices and electrical pulses until eventually the discovery of the pad and bell alarm was made. …”
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Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization by Jay A Berzofsky, William Becker, Noriko Seishima, Purevdorj B Olkhanud, Paloma A Moreno, Katherine C Goldfarbmuren, Hoyoung M Maeng

“…Background Despite advances in checkpoint inhibitor (CPI) therapy for cancer treatment, many cancers remain resistant. Tumors deemed “cold” based on lack of T cell infiltration show reduced potential for CPI therapy. …”
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Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat by Duo Su, Tingting Jiang, Yulong Song, Die Li, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Li Li, Hongping Zhang, Linjie Wang

“…In vivo, lentivirus-mediated repression of Ucp1-En4 was injected into iBAT, resulting in impacted iBAT thermogenic capacity and impaired iBAT mitochondrial function under cold acclimation conditions. …”
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