Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging by Erkan Cagliyan, Samican Ozmen, Sureyya Saridas Demir, Ceren Aydin, Egehan Bilen, Handan Guleryuz, Elif Yasar, Derya Ercal, Elcin Bora, Tufan Cankaya

“…The results of genetic diagnostic tests were evaluated retrospectively. Postpartum information of the cases was obtained from the hospital records and neurodevelopmental development of the newborns was recorded. …”
Get full text

Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes by Sadegh Faramarzi, Arianna Bassan, Kevin P. Cross, Xinning Yang, Glenn J. Myatt, Donna A. Volpe, Lidiya Stavitskaya

“…The 2020 FDA drug-drug interaction (DDI) guidance includes a consideration for metabolites with structural alerts for potential mechanism-based inhibition (MBI) and describes how this information may be used to determine whether in vitro studies need to be conducted to evaluate the inhibitory potential of a metabolite on CYP enzymes. …”
Get full text

Molecular response to multiple trace element contamination of the European sardine by Beauvieux, Anaïs, Fromentin, Jean-Marc, Saraux, Claire, Romero, Diego, Couffin, Nathan, Brown, Adrien, Metral, Luisa, Bertile, Fabrice, Schull, Quentin

“…Since 2008, this species has been experiencing a significant crisis in the region, prompting numerous studies to investigate the potential factors behind the dramatic decline in sardines size, age, and body condition. However, thorough information on chemical contamination by trace elements and its physiological impact on this species was lacking. …”
Get full text

Comprehensive Assessment of Specific Patient-Reported Outcome Measures for Hand and Wrist Conditions in Adults: A Scoping Review by S. Iskander, G. Halbesma, M.M. Hoogbergen, D. Young-Afat, I.J. Veldhuizen

“…The objective is to provide healthcare professionals with an up-to-date overview of the available PROMs, empowering them to make informed decisions in selecting the most appropriate PROM to support personalized care for their patients. …”
Get full text

Mastalgia Assesment and Hormonal Correlations in Patients with Polycystic Ovary Syndrome by Emel Kıyak Çağlayan, Levent Seçkin, Ayşe Yeşim Göçmen, Aylin Okur, Ergin Arslan, Halil İbrahim Serin, Kasım Çağlayan, Yaprak Engin Üstün

“…STUDY DESIGN: 141 patients who are admitted to our clinic were included in this study after taking their informed consent. 78 patients who were diagnosed as PCOS according to the Rotterdam Criteria constitute the patient group. 63 patients who are admitted for routine control and had no hormonal pathology constitute the control group. …”
Get full text

Versatile on-chip polarization-sensitive detection system for optical communication and artificial vision by Zhilin Liu, Mingxiu Liu, Liujian Qi, Nan Zhang, Bin Wang, Xiaojuan Sun, Rongjun Zhang, Dabing Li, Shaojuan Li

“…Abstract Polarization is an important attribute of light and can be artificially modulated as a versatile information carrier. Conventional polarization-sensitive photodetection relies on a combination of polarizing optical elements and standard photodetectors, which requires a substantial amount of space and manufacturing expenses. …”
Get full text

Identification and Quantification of Emission Hotspots of Air Pollutants over Bhubaneswar: A Smart City in Eastern India by Saroj Kumar Sahu, Pallavi Sahoo, Poonam Mangaraj, Gufran Beig, Bhishma Tyagi, Basanta Samal, Ashirbad Mishra, Ravi Yadav

“…The inventory involves detailed activity data with ~0.4 km × ~0.4 km resolution covering the city using a Geographical Information System (GIS) based statistical approach. …”
Get full text

What is the near-natural catchment? An application of hydrological signatures assessment by Huan Xu, Hao Wang, Pan Liu, Xiaojing Zhang, Weibo Liu, Chutian Zhou, Hao Ye, Hongxuan Lei, Yang Liu

“…The sensitivity of the eight signatures to HA are calculated using a causal inference method instead of directly calculating linear correlation coefficients to avoid spurious relationships. …”
Get full text

Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures by Tijana Hanauske, Carolin Christina Koretz, Tassilo Jungenitz, Jochen Roeper, Alexander Drakew, Thomas Deller

“…However, the threshold for AP firing in single GCs varied based on the stimulus light intensity and the expression levels of ChR2. This information allowed us to calibrate light intensity for chronic stimulations. …”
Get full text

New findings into the genetic population structure of two commercially valuable and threatened sharks, Mustelus mustelus (Linnaeus, 1758) and M. punctulatus (Risso, 1827), allow re... by Matteo Barbato, Matteo Barbato, Matteo Barbato, Sara Bonanomi, Sara Bonanomi, Diego Borme, Ilija Ćetković, Francesco Colloca, Manfredi Di Lorenzo, Manfredi Di Lorenzo, Ilaria A. M. Marino, Ilaria A. M. Marino, Carlotta Mazzoldi, Carlotta Mazzoldi, Carlotta Mazzoldi, Ana Pešić, Antonello Sala, Lorenzo Zane, Lorenzo Zane, Lorenzo Zane, Massimo Mezzavilla

“…In such exploited species, information on genetic diversity and connectivity is lacking and should be collected to identify management units. …”
Get full text

Feasibility Study of the Development of a Drinking Water Supply System (SPAM) Investment of Cibulakan Springs Perumda Drinking Water Tirta Rahaja Bandung District – West Java by Hari Sundana, Wateno Oetomo, Risma Marleno

“…An NPV value that is positive or greater than (> 0) indicates that the income is greater than the value invested. The results of the Break Even Point (BEP) investment assessment showed that the return value occurred in the 14th year with the accumulation of negative profits being marked as positive after the 14th year. …”
Get full text

DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…The search for innovative therapeutic strategies remains critical in addressing cancer, one of the leading global health challenges. …”
Get full text

Diversity of bacterial symbionts associated with the tropical plant bug Monalonion velezangeli (Hemiptera: Miridae) revealed by high-throughput 16S-rRNA sequencing by Navarro-Escalante, Lucio, Benavides, Pablo, Acevedo, Flor E.

“…The tropical plant bug Monalonion velezangeli (Hemiptera: Miridae) is a polyphagous herbivore considered an important insect pest for several economically relevant tropical crops, but information about the composition of its bacterial microbiota was missing. …”
Get full text

Strategic enhancement of joint strength in dissimilar Al/Mg alloys: a workable approach for aerospace application by S. Suresh, Elango Natarajan, Kalaimani Markandan, S. Sudhagar, Gnanasambandam Anbuchezhiyan, R. Elayaraja

“…However, the challenges associated with joining these dissimilar metals necessitate innovative solutions. This study explores the role of silicon carbide (SiC) nanoparticles in enhancing the friction stir spot welding (FSSW) of dissimilar alloys AA6061 and AZ31B. …”
Get full text

An open data collection of 3D tool and equipment models for neonatology by Serena Bardelli, Gianpaolo Coro, Rosa T. Scaramuzzo, Massimiliano Ciantelli, Armando Cuttano

“…Virtual Simulation (VS) offers an elegant and effective solution to the current need for innovation in medical education, thanks to the possibility of creating low-cost, realistic training environments for repetitive practice without compromising patient safety. …”
Get full text

The Impact of Movement Control Order (MCO) during Pandemic COVID-19 on Local Air Quality in an Urban Area of Klang Valley, Malaysia by Mohd Shahrul Mohd Nadzir, Maggie Chel Gee Ooi, Kemal Maulana Alhasa, Mohd Aftar Abu Bakar, Anis Asma Ahmad Mohtar, Mohd Fadzil Firdzaus Mohd Nor, Mohd Talib Latif, Haris Hafizal Abd Hamid, Sawal Hamid Md Ali, Noratiqah Mohd Ariff, Johary Anuar, Fatimah Ahamad, Azliyana Azhari, Norfazrin Mohd Hanif, Mohammed Ahmed Subhi, Murnira Othman, Mohd Zaim Mohd Nor

“…This air quality level information showed that the reduction of air pollutants can be achieved if traffic and industry emissions are strictly controlled.…”
Get full text

Changes in the nutrient composition of top-selling packaged foods and beverages in Colombia between 2016 to 2021 by Luis Carlos Forero, Luis F. Gómez, Mercedes Mora-Plazas, María Parra-Murillo, María Parra-Murillo, Sara Toquica, Lindsey Smith Taillie

“…While a previous study examined the changes in the nutritional composition of beverage and food products offered in Colombia between 2016 and 2018, it is necessary to update this information to understand whether the industry anticipated labeling and tax regulations by reformulating products.MethodsThis study carried out a comparison of the content of selected nutrients of concern and non-nutritive sweeteners (NNS) from the nutritional panels of 164 matched pairs of packaged foods and beverages from the top selling brands in Colombia in 2021 compared to 2016. …”
Get full text

Relationship between personality traits and spontaneous coronary artery dissection risk: evidence from Mendelian randomization by Kun Zheng, Kun Zheng, Mengdi Wu, Junhua Wang, Junhua Wang, Jinjin Sun, Yuqian Li, Peng Wang, Zhiyue Zhang, Xiuming Pan, Yifeng Yang, Tianqi Li, Yujie Guo

“…Besides, data regarding SCAD and personality were extracted from expansive genome-wide association studies (GWAS), and rigorous statistical inferences were made using inverse variance weighting (IVW) and ancillary methodologies. …”
Get full text

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…Furthermore, this study also aims to highlight the efforts made in exploiting the structural information in conjunction with molecular modeling techniques to discern the mechanism of action of the fusion inhibitors and to assist the design and interpretation of structure-activity relationships of novel lead compounds will be highlighted. …”
Get full text

Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions by Syamand Ahmed Qadir, Qausar Hamed ALKaisy, Abdulbasit F. Hasan, Farhang Hameed Awlqadr, Ammar B. Altemimi, Aryan Mahmood Faraj, Angelo Maria Giuffrè, Mohammed N. Saeed, Sherzad Rasul Abdalla

“… Fecal microbiota transplantation (FMT) is revolutionizing the treatment of gastrointestinal disorders by leveraging the gut microbiome in innovative ways. This systematic review evaluates the clinical effectiveness and safety of FMT across various medical conditions, offering insights into its therapeutic potential and limitations. …”
Get full text