Obesity and Mechanisms of its Negative Impact on the Cardiovascular System by S. V. Miklishanskaya, L. V. Solomasova, M. A. Mazur

“…Obesity has a direct negative impact on the heart and blood vessels, which can be considered not only as an appropriate response to an increase in the volume of circulating blood due to an increase in body weight, but also as a side tissue reaction of the myocardium to hormonal and metabolic changes inherent in obesity. …”
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Calcium phosphate bions: towards a pathogenetic concept by A. G. Kutikhin

“…Upon an excess of serum calcium and phosphate, mineral chaperone fetuin-A aggregates mineral ions into calcium phosphate bions (CPB, alternatively termed calciprotein particles), which are irreversibly internalised by endothelial cells causing lysosome membrane permeabilisation, non-specific inflammatory response and cell death. Altogether, these processes contribute to pathological microenvironment potentiating endothelial dysfunction, osteochondrogenic differentiation of vascular smooth muscle cells, and adventitial inflammation which in turn culminate into intimal hyperplasia and medial arterial calcification. …”
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The association of intolerance to non-steroidal anti-inflammatory drugs, bronchial asthma and nasal polyps: Clinical aspects and treatment strategies in Poland by Maria Zofia Lisiecka

“…Pharmacotherapy included the use of inhaled corticosteroids to reduce airway inflammation, antihistamines to control allergic symptoms, and monoclonal antibodies to modify the immune response. …”
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GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis by Teresa Rubio-Tomás, David Martí-Aguado, Delia Blaya, Silvia Ariño, Beatriz Aguilar-Bravo, Raquel A. Martínez García de la Torre, Marc Miravet-Marti, Raquel Ferrer-Lorente, Laura Zanatto, Zengqing Xu, Laura Garcia-Tercero, Carlos Mateos-Sánchez, Juan José Lozano, Isabella Dotti, Johanne Poisson, Marion Tanguy, Azucena Salas, Pierre-Emmanuel Rautou, Ramon Bataller, Pau Sancho-Bru

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IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA

“…Bioactive factors secreted by stem and stromal cells -either as soluble molecules or within extracellular vesicles (EVs)- can reshape immune responses, not just by reducing inflammation but by actively promoting pro-resolving, regenerative profiles. …”
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Oral MIB‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID‐19 and Acute Kidney Injury: A Randomiz... by Karol M. Pencina, David E. Leaf, Rodrigo J. Valderrabano, Sushrut S. Waikar, Tapan S. Mehta, Yili Valentine Shang, Nancy K. Latham, Tejossy John, Elena Volpi, Dahlene Fusco, Yusnie Memish‐Beleva, Shobana Krishnamurthy, Siva Lavu, Salma Karmi, David J. Livingston, Shalender Bhasin

“…ABSTRACT Nicotinamide adenine dinucleotide (NAD+) plays an important role in the innate immune response and is depleted during SARS‐CoV‐2 infection due to increased turnover. …”
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Take charge during treatment: a protocol for a pilot study to evaluate the impact of exercise on cardiovascular biomarkers among black and white breast cancer patients undergoing t... by Natalia Do Couto, Mary Hidde, Georgios Grigoriadis, Rodney Sparapani, Matt Durand, Michael Widlansky, Courtney Jankowski, Madeline Berendt, Bethany Canales, Sarah Golus, Laura E. Norwood Toro, Purushottam Laud, Amanda Kong, Kent Hoskins, David Lewandowski, Shane A. Phillips, David D. Gutterman, Alison J. Kriegel, Kirsten M. M. Beyer, Andreas M. Beyer, Melinda Stolley

“…The Discovery and Elimination of Cardio-Oncology Disparities for Equity in the Heartland (DECODE Heartland) Center addresses these gaps with three overarching goals to: (1) Test the feasibility and efficacy of the Take Charge during Treatment (TCT) exercise intervention designed to mitigate the adverse effects of CTx; (2) Quantify differences on exercise capacity and quality of life (QoL), endothelial function and molecular differences in inflammation in NHB versus NHW BC patients before and following CTx; and (3) Examine the influence of socio-ecological factors (individual, interpersonal, systemic, environmental) on inflammation, microvascular endothelial function, QoL in response to the exercise intervention. …”
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Phantom tumour: inflammatory pseudotumour of the liver: a rare case report and review of literature by Jesheen Mann, Akash Shukla, Biswa Ranjan Patra

“…Since there is potential for spontaneous regression or response to corticosteroids, early histopathological confirmation is helpful to prevent unindicated hepatic resection. …”
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Lactiplantibacillus plantarum P101 Ameliorates TiO2 NP-Induced Bone Injury in Young Rats by Remodeling the Gut Microbiota and Inhibiting the Production of Pro-Inflammatory Cytokine... by Xie L, Feng L, Tang X, Xu Y, Xu H, Liu Y

“…Through a P101 supplementation experiment, we found that P101 ameliorated the inflammation and osteoporosis on bone caused by TiO2 NPs.Conclusion: This study showed that the mechanism by which P101 alleviates bone damage caused by TiO2 NPs may be through restoring intestinal microbial homeostasis and inhibiting inflammatory response. …”
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Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation by Chenyang Cui, Jiaze Tang, Jie Chen, Beining Zhang, Ruonan Li, Qiang Zhang, Chunjing Qiu, Rongchen Chen, Geng Min, Zhaowei Sun, Haibo Weng

“…This system shows superior affinity to inflammation-related cells due to the Lactobacillus acidophilus EVs can maintain immune homeostasis by regulating the secretion of cytokines in vitro. siRNA can specifically target the key inflammatory TNF-α in UC and silence its gene expression, thereby regulating the process of inflammatory response. …”
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Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity by Dayanira Alsina‐Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González‐Romero, Ester Díaz‐Mora, Ana Risco, Miguel A Martín‐Serrano, Carlos del Fresno, Jorge Dominguez‐Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz‐Ezquerro, Ana Cuenda

“…Here, we show that p38γ and p38δ regulate the innate immune response to C. albicans. We describe a new TAK1‐TPL2‐MKK1‐ERK1/2 pathway in macrophages, which is activated by Dectin‐1 engagement and positively regulated by p38γ/p38δ. …”
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Postnatal epigenetic differences in calves following transient fetal infection with bovine viral diarrhea virus by Jessica N. Kincade, Terry E. Engle, Marcela Henao-Tamayo, Jordan M. Eder, Erin M. McDonald, Darcy M. Deines, Brie M. Wright, Dilyara Murtazina, Jeanette V. Bishop, Thomas R. Hansen, Hana Van Campen

“…Genes containing differential methylation were associated with inflammation, reactive oxygen species (ROS) production, and metabolism. …”
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Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report by Panagiotis Paliogiannis, Angelo Zinellu, Valentina Scano, Giulia Mulas, Giacomo De Riu, Rosa M Pascale, Luigi B Arru, Ciriaco Carru, Pietro Pirina, Arduino A Mangoni, Alessandro G Fois

“…In further analysis of the COVID-19 group, the neutrophil count, neutrophil to lymphocyte ratio (NLR), derived NLR, systemic inflammation response index and De Ritis ratio, were significantly higher in non survivors than in survivors, while the number of platelets was significantly lower in non survivors. …”
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BLOOD MONOCYTE SUBPOPULATIONS DURING UNCOMPLICATED CORONARY ARTERY BYPASS SURGERY by A. S. Golovkin, V. G. Matveeva, I. V. Kudryavtsev, E. V. Grigoriev, E. A. Velikanova, Yu. V. Bairakova

“…The changes in monocyte subsets in blood of patients with and absence of post-surgical septic complications reflected severity of inflammatory response, and development of systemic inflammatory syndrome. …”
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The Importance of Antihypertensive and Lipid-Lowering Therapy in the Treatment of Patients with a New Coronavirus Infection COVID-19 by V. I. Podzolkov, A. I. Tarzimanova

“…One of the most severe consequences of COVID- 19 is the defeat of the cardiovascular system, which has a variety of mechanisms: dysregulation of the renin-angiotensin-aldosterone system; pathological systemic inflammatory response; direct action of the virus on the myocardium with the development of myocarditis; respiratory failure with hypoxia, leading to damage to cardiomyocytes; microvascular damage due to hypoperfusion, increased vascular permeability, angiospasm and the direct damaging effect of the virus on the endothelium of the coronary arteries; thrombotic complications due to the procoagulant and prothrombogenic effect of systemic inflammation. …”
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Asthma and obesity in children: what do we know? by G. A. Novik, E. G. Khaleva, S. G. Makarova, M. V. Zhdanova

“…The review highlights the mechanisms of development of the so-called obese asthma: morphological changes in the respiratory tract, systemic inflammation, adipokine production, impaired glucose and insulin metabolism, genetic and epigenetic factors, changes in the microbiome of the respiratory tract and(or) intestines. …”
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Parvovirus B19 NS1 protein induces synovitis mimicking rheumatoid arthritis by Chang-Yi Yen, Chia-Chun Tseng, Chia‐Hui Lin, Yuan‐Zhao Lin, Ruei‐Nian Li, Pin-Yi Wang, Kuan-Yu Chen, Cheng-Chin Wu, Tsan-Teng Ou, Chung-Jen Chen, Yu-Peng Liu, Jeng-Hsien Yen

“…Pathway analysis and comparison of pathway status between this study and GEO datasets were performed, demonstrating that acute phase response signaling, NRF2-mediated oxidative stress response, and mTOR signaling pathways were activated after the transduction of LEX-NS1 into the SW982 cell line, although the interferon signaling pathway was inhibited. …”
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Options for correction of local immune status in patients with chronic endometritis by I. O. Borovikov, E. I. Kravcova, V. P. Bulgakova, O. I. Borovikova, M. I. Biryukova

“…Chronic endometritis with impaired receptivity of uterine cavity epithelium (the “thin” endometrium) is considered the most common cause of recurrent implantation failures during in vitro fertilization (IVF). Chronic inflammation, accompanied by autoimmune mucosal reactions, may lead to a perverse immune response of lymphocytic cells with altered cascade of cytokine reactions, thus preventing efficiency of decontamination therapy, followed by potential inability to perform reproductive function in the patients. …”
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Case Report: Combined Autoimmune Pancreatitis, Ulcerative Colitis and Sclerosing Cholangitis in 28-y.o. Patient by A. R. Khurmatullina, A. V. Okhlobystin, L. N. Androsova, R. T. Rzayev, A. S. Tertychnyy, A. P. Kiryukhin, O. Z. Okhlobystina, M. S. Zharkova, O. S. Shifrin, V. T. Ivashkin

“…Colonic lesions that initially had low grade of inflammation were resistant to immunosuppressive therapy.Key points. …”
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Aberrant regulation of the GSK‐3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy by Pablo Ranea‐Robles, Nathalie Launay, Montserrat Ruiz, Noel Ylagan Calingasan, Magali Dumont, Alba Naudí, Manuel Portero‐Otín, Reinald Pamplona, Isidre Ferrer, M Flint Beal, Stéphane Fourcade, Aurora Pujol

“…Here, we identify an impaired NRF2 response caused by aberrant activity of GSK‐3β. We find that GSK‐3β inhibitors can significantly reactivate the blunted NRF2 response in patients’ fibroblasts. …”
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