Inflammatory Mechanisms in the Management and Treatment of Retinal Detachment by Pablo Redruello-Guerrero, María Gómez-Tomás, Tomás Rechi-Sierra, Laura Molinero-Sicilia, Nadia Galindo-Cabello, Ricardo Usategui-Martín, Salvador Pastor-Idoate

“…Several studies have demonstrated the critical role of cytokines in retinal inflammation, highlighting their importance in regulating the immune response following RD. …”
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In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model by Nupur Sharma, Sadam H. Bhat, Shweta Chaudhary, Babu Mathew, Sushmita Pandey, Sanju Yadav, Manisha Yadav, Vasundhra Bindal, Gaurav Tripathi, Neha Sharma, Vipul Sharma, Abhishak Gupta, Ranjan Nanda, Anupama Kumari, Shvetank Sharma, Jaswinder Singh Maras

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Intrauterine administration of peripheral blood mononuclear cells helps manage recurrent implantation failure by normalizing dysregulated gene expression including estrogen-respons... by Yoshimi Kitawaki, Akihito Horie, Asami Ikeda, Shimpei Shitanaka, Akihiro Yanai, Tsutomu Ohara, Baku Nakakita, Yusuke Sagae, Asuka Okunomiya, Hirohiko Tani, Masaki Mandai

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Ziziphus nummularia extract attenuates inflammatory markers in RAW 264.7 macrophages by Rola Abdallah, Serene Badran, Adnan Badran, Joelle Edward Mesmar, Elias Baydoun

“…Abstract While inflammation is a vital immune response to harmful stimuli, chronic inflammation has been associated with several diseases such as arthritis, cardiovascular disorders, and cancers. …”
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Topical glucocorticoids and the skin-mechanisms of action: an update by A. Ahluwalia

“…Current understanding of the molecular mechanism s of GC action has advanced significantly over the past decade with the realisation that multiple systems are responsible for transduction of GC effects at a molecular level. …”
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Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments by Yuehong Li, Qingzheng Zhang, Zongtai Liu, Weiguo Xu, Changfeng Fu

“…Deterioration of the microenvironments, including oxidative stress, inflammation, and excitotoxicity, exacerbates SCI. However, due to the complexity of these microenvironments, synergistic modulation of multiple factors remains challenging. …”
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THE ROLE OF GENETICALLY DETERMINED BODY RESISTANCE OF WARM-BLOODED ANIMALS TO HYPOXIA IN THE REALIZATION OF EFFECTOR FUNCTIONS OF NEUTROPHILS IN THE MODEL OF ADJUVANT-INDUCED RHEUM... by Elena Georgievna Pukhaeva, Alibek Kirilovich Badtiev, Fatima Elbrusovna Salamova, Stanislav Georgievich Dzgoev, Alina Muratbekovna Kupeeva

“…Rats from the experimental groups of the HR/SmY and LR/SmY lines were induced to develop immune responses in a model of rheumatoid arthritis (RA). …”
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Drug Repurposing to Inhibit Oncostatin M in Crohn’s Disease by Faranak Bahramimehr, Axel Guthart, Stefanie Kurz, Yuanping Hai, Mona Dawood, Rümeysa Yücer, Nasim Shahhamzehei, Ralf Weiskirchen, Wilfried Roth, Wolfgang Stremmel, Gerhard Bringmann, Thomas Efferth

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Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization by Jianshui Mao, Liangliang Chen, Genying Zhuang, Zhiqiang Jin, Shoukun Wu, Mingshuai Ying, Lingchao Sheng, Jianwei Lv, Qiuchen Bi, Jingjia Ye

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Recent advances in injectable hydrogels for osteoarthritis treatments by Jiayi Chen, Mingcong Deng, Jiangliang Wang, Yuanwen Liu, Ziran Hu, Feifan Luan, Huifeng Zhu, Chenxiao Zheng

“…We further discuss the advantages and limitations of natural, synthetic, and composite hydrogels, as well as innovative cross-linking strategies and stimuli-responsive behaviors. Thermosensitive, pH-responsive, enzyme-responsive, and multi-responsive hydrogels are highlighted for their potential to achieve intelligent drug delivery, inhibit cartilage degradation, and reduce inflammation. …”
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C-reactive protein-triglyceride glucose index and heart failure in US adults from NHANES 2001–2010 by Ningyi Cheng, Zhicheng Ma, Yukun Chen, Lei Jin, Liangwan Chen

“…Smooth curve fitting analyzed dose-response relationships, while subgroup analyses explored effect heterogeneity. …”
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Tubulointerstitial nephritis in cases of lupus nephritis: An experience from a tertiary care referral center of Eastern India by Keya Basu, Subhrajyoti Karmakar, Abhirup Bhunia, Soma Addya, Moumita Sengupta, Arpita Roy Chowdhury

“…Tubulointerstitial nephritis (TIN) includes interstitial inflammation, tubulitis, tubular atrophy (TA), and interstitial fibrosis. …”
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Porphyromonas gingivalis infection of oral keratinocytes drives the release of pro-inflammatory extracellular vesicles by Pierre-Yves Gegout, Benjamin Mary, Céline Stutz, Vincent Hyenne, Ofir Ginesin, Hadar Zigdon-Giladi, Olivier Huck

“…Recent studies have identified extracellular vesicles (EVs) as potential mediators of inflammation. This study aimed to evaluate the pro-inflammatory properties and miRNA content of EVs secreted in response to Porphyromonas gingivalis infection. …”
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Protection of chickens from Mycoplasma gallisepticum through the MAPK/ERK/JNK pathway by a compound of ten Chinese medicine formulas by Tengfei Wang, Changyong Fan, Yufei Xiao, Shan Lü, Guangyang Jiang, Mengyun Zou, Yingjie Wang, Qiao Guo, Zhenghao Che, Xiuli Peng

“…A mechanism-based study showed that in vitro and in vivo treatment with the TCM significantly reduced the expression of key proteins, including early growth response gene 1 (EGR1), p-ERK, p-JNK, and p-JUN. Altogether, TCM improved body weight gain, inhibited pro-inflammation responses, and alleviated tissue damage by inhibiting the MAPK/ERK/JNK signaling pathway to protect the performance and immune system of MG-infected chickens.…”
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Investigating Natural Product Inhibitors of IKKα: Insights from Integrative In Silico and Experimental Validation by Muhammad Yasir, Jinyoung Park, Eun-Taek Han, Jin-Hee Han, Won Sun Park, Jongseon Choe, Wanjoo Chun

“…Nuclear factor-κB (NF-κB) signaling plays a pivotal role in regulating immune responses and is strongly implicated in cancer progression and inflammation-related diseases. …”
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Bisphenol F exposure induced vascular toxicity through intestinal microbiota imbalance by Jianlong Yan, Yanbin Pan, Huadong Liu, Jie Yuan, Jie Chen, Yannan Gao, Chaolan Lin, Feng Lin, Rongning Wang, Yaqiong He, Caiping Wang, Cong Xu, Tangzhiming Li, Peng Zhang, Yu Lan, Wenming Shao, Xinli Pang, Da Yin, Xin Sun, Weixiang Luo

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Serum L-selectin levels as predictive markers for chronic major depressive disorder progression by Yeeun Yun, Sora Mun, Seungyeon Lee, Hee-Gyoo Kang, Jiyeong Lee

“…This marker offers insights into changes in leukocyte-mediated inflammatory responses characteristic of chronic depression. Consequently, it may forecast the transition from acute to chronic inflammation in depressive patients.…”
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Transcriptomics reveals the underlying mechanism of Prostaglandin E1 in improving severe pneumonia by Wentong Ma, Jingxin Zhou, Ying Qian, Su Zhang, Chuanlu Han, Jing Su, Haijun Sun

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Chinese massage therapy (Tuina) inhibits motor neuron apoptosis in rats with sciatic nerve injury by regulating the cPLA2 and RhoA/ROCK2 signaling pathways by Jiawei Sun, Yingqi Zhang, Zhifeng Liu, Hanyu Zhang, Jiayue Liu, Yue Xu, Rentuya Na, Hongzheng Zhang, Jiawang Yan, Tianyuan Yu

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Spectral immune cell profiling reveals modulations in immune cell response to repetitive inhaled organic dust exposure in a high omega-3 fatty acid mouse model by Logan S. Dean, Maëlis Wahl, Alissa N. Threatt, Morgan Pauly, Melea Barahona, Emmanuel O. Oyewole, Tara M. Nordgren

“…Fat-1 mice demonstrated a monocyte-dominant response compared to WT in both the airway and the lung tissue. …”
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