Research of <i>PNPLA3</i> I148M Gene Polymorphism in Patients with Non-Alcoholic Fatty Liver Disease, with Liver Cirrhosis and with Hepatocellular Carcinoma by V. V. Petkau, G. A. Tsaur, E. N. Bessonova, A. A. Karimova

“…The study was conducted according to the “case-control” design, three main groups were formed: a group with NAFLD (n = 46), a group with LC (n = 61), a group with HCC (n = 50), as well as a control group (n = 70), for all groups we performed genotyping of the rs738409 polymorphism of the PNPLA3 gene. …”
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Laguna de fracasos by Lagunaries

“…We perform theories, we investigate modes of escaping the lineal narrativity, using polyphonic and choral forms of thinking / moving / saying / existing. We inhabit the irony of a virtuality that imposes a distance on us and at the same time it hacks all geographical borders. …”
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Analisis Forensik Digital untuk Investigasi Kasus Cyberbullying pada Media Sosial Tiktok by Halimah Septya Mikayla, Ari Kusyanti, Primantara Hari Trisnawan

“…Abstract TikTok is currently a widely popular social media platform among users and is also a media where various forms of cyberbullying are encountered. Cases of cyberbullying on TikTok can be subject to legal prosecution through digital forensic investigations. …”
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Results of Selective Biochemical Screening for Lysosomal Acid Lipase Deficiency and Sequencing of the <i>LIPA</i> Gene in the Risk Group Patients by S. V. Shtykalova, A. A. Egorova, O. S. Glotov, A. V. Kiselev, I. Yu. Kogan

“…Samples from 2805 patients are collected as dried blood spots on filter paper test forms. Biochemical study of the lysosomal acid lipase (LAL) enzyme activity was carried out according to Hamilton’s protocol of, using 4-methylumbelliferyl palmitate as a substrate and LAL inhibitor Lalistat-2. …”
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Fuzzy Inference System Mamdani dalam Prediksi Produksi Kain Tenun Menggunakan Rule Berdasarkan Random Tree by Tundo Tundo, Shoffan Saifullah

“…This method uses the concept of a random tree decision tree in forming rules. The rules are made based on the criteria in determining the amount of woven fabric production, including production costs, demand, and stock. …”
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Межмуниципальный анализ структуры и эффективности формирования бюджетов by Мария Александровна Печенская-Полищук

“…Cross-Municipal Analysis of Budget Structure and Forming Effectiveness // Research in Economic and Financial Problems. 2024. № 4. …”
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Antagonism of Eucalyptus endophytic fungi against some important crop fungal diseases by Parmida Aleahmad, Leila Ebrahimi, Naser Safaie, Hassan Reza Etebarian

“…Endophytic fungi colonize plants without causing symptoms, throughout or at least a significant part of their life cycle, forming a plant-fungal association. In this study, endophytic fungi were isolated from Eucalyptus camaldulensis trees, and their antifungal activity was evaluated against four significant plant pathogens namely Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, Macrophomina phaseolina, and Rhizoctonia solani. …”
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Distribution of Aeromonas bacterial population in water, sediment and Nile tilapia in fish culture pond, Guder, Ethiopia by Bekele Lema, Natarajan Pavanasam, Kassaye Balkew, Zufan Bedewi

“…The level of bacterial population in water, sediment and fish tissue were done by following standard methods and expressed as colony-forming units (CFU) in water per milliliter (CFU ml-1), sediment and fish tissues(CFU g-1).The results revealed more bacterial population in sediment (3.43 x106 to 5.54 x 106 CFU g-1) than in water (1.45x106 to 4.0x106 CFU ml-1) and  fish tissues (1.06 ± 1.10x104 to 1.74 ± 10.8x104 CFU g-1in gill filaments; 1.62 ± 11.2x104 to 2.82 ± 13.0x104 CFU g−1 in intestine from; and 0.82 ± 5.9x104 to 1.60 ± 12.1.6x104 CFU g-1; in kidney from 0.48 ± 5.0 to 0.77 ± 4.1x104 CFU g-1. in skin). …”
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Assessing the Suitability of Snail-Shell Powder as a Partial Replacement of Cement in Concrete Production. by Mukundane, Ivan

“…It makes any shape when cast in any formwork and forms a solid mass when cured at a suitable temperature and humidity This research titled “Assessing the suitability of snail-shell powder as partial replacement of cement in concrete” aims at the utilization of snail shells as a partial replacement of ordinary Portland cement. …”
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Severe primary graft failure: Are there lasting impacts? Analysis from the PHTS Database by Jennifer Conway, MD, Tara Pidborochynski, MSc, James K. Kirklin, MD, Ryan Cantor, PhD, Hong Zhao, PhD, Aryaz Sheybani, MD, Jacqueline Lamour, MD, Lakshmi Gokanapudy Hahn, MD, Leslie Collins, MD, Jessica Laks, MD, Darren H. Freed, MD, PhD

“…Understanding the impact of milder forms of PGF on survival and long-term outcomes is still needed. …”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…Our study provides evidence that the complex formed by the hERG1 potassium channel and the β1 subunit of integrin receptors preferentially localizes in Lipid Rafts (LRs) in Pancreatic Ductal Adenocarcinoma (PDAC) cell lines and primary samples. …”
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Developing a risk score using liquid biopsy biomarkers for selecting Immunotherapy responders and stratifying disease progression risk in metastatic melanoma patients by Amalia Azzariti, Simona De Summa, Tommaso M. Marvulli, Ivana De Risi, Giuseppe De Palma, Roberta Di Fonte, Rossella Fasano, Simona Serratì, Sabino Strippoli, Letizia Porcelli, Michele Guida

“…Identifying biomarkers to predict patient response is crucial, ideally through non-invasive methods such as liquid biopsy. Methods Soluble forms of PD1, PD-L1, LAG-3, CTLA-4, CD4, CD73, and CD74 were quantified using ELISA assay in plasma of a cohort of 110 MM patients, at baseline, to investigate possible correlations with clinical outcomes. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Intriguingly, we identified two parallel signaling cascades impacted by FNDC5 in cardiomyocytes: the ROS-driven intrinsic mitochondrial apoptosis pathway and the ROS-independent Ataxia Telangiectasia and Rad3-Related Protein (ATR)/Checkpoint Kinase 1 (Chk1) pathway. In fact, FNDC5 forms a co-precipitable complex with Chk1 alluding to possible intracellular actions for this canonically membrane-associated protein. …”
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Effect of Reforestation Tree Species on the Distribution and Stability of Purple Soil Aggregates by ZHONG Yujian, HE Feng, HAN Guangzhong, ZHAO Xia, YANG Fan

“…[Conclusion] The weathering of purple soil following afforestation provides the material foundation for aggregate formation, while the humus formed in the soil of artificial forests acts as a binding agent, promoting the formation of large aggregates and the maintenance of their stability.…”
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Geological characteristics and main enrichment controlling factors of coalbed methane in Nanchuan area, southeastern Sichuan Basin by Xipeng HE, Kaiming WANG, Wei LUO, Yuqiao GAO, Nana LIU, Tao GUO, Yatong ZHOU, Didi WU

“…It is characterized by "high gas content, abundant free gas, and oversaturation", and its gas content increases with burial depth. (4) The in-situ stress in the study area is moderate (35 to 60 MPa), with a small two-way horizontal stress difference coefficient (< 0.1) and good roof and floor plates, forming effective stress shielding favorable for fracturing transformation. (5) The main controlling factors for CBM methane enrichment in the Nanchuan area include the sedimentary environment, which determines coal-bearing formations; the degree of coal evolution, which determines the intensity of hydrocarbon generation; and the preservation conditions, which govern CBM enrichment.…”
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Jianpi Yiqi Busui prescription alleviates myasthenia gravis by regulating Th17 through the TAK1/P38 MAPK/eIF-4E signaling pathway by Zhuming Chen, Jing Lu, Tianying Chang, Dongmei Zhang, Yibin Zhang, Miao Liu, Tong Wu, Peng Xv, Jian Wang

“…Western blot and immunofluorescence staining were used to detect the expression levels of key proteins and their phosphorylated forms, such as transforming growth factor beta-activated kinase 1 (TAK1), P38 mitogen-activated protein kinase (P38 MAPK), and eukaryotic initiation factor 4E (eIF-4E). …”
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Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro by Han T, Jia T, Wang J

“…Polymerase chain reaction assays and sequencing techniques were performed to detect well-known molecular determinants related to linezolid resistance, including the expression of optrA and cfr, mutations of 23S rRNA gene and ribosomal protein (L3, L4, L22) encoding genes (rplC, rplD, rplV).Results: After induction with sequentially increasing concentrations of linezolid, all four MRSA strains (L914, L860, L1096, and L2875) evolved into linezolid-resistant strains over various induction times (480, 384, 288, and 240 h) and universally formed small colony variants. A new mutation in the domain V region of 23S rRNA gene (C2404T) and one mutation in amino acid sequences of ribosomal protein (Met208Thr) were firstly identified among linezolid-resistant strains. …”
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Investigation of Potential Profiles and Influencing Factors of Voice Behavior among Chinese Nurses by Shuangying Huang, Hanwen Chen, Liyan Zhang, Xianming Weng, Lingming Zhou, Xiaoqin Ma, Weiyi Wang

“…By analyzing the potential profile of nurses' voice behavior, three potential categories were formed: low voice behavior group(C1, 21.1% of the total population), medium voice behavior group(C2, 60.9% of the total population), and high voice behavior group(C3, 18.0% of the total population). …”
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DIGITAL TOOLS FOR MATCHING QUALIFICATIONS TO THE LEVELS OF THE NATIONAL QUALIFICATIONS FRAMEWORK by Volodymyr Kovtunets, Sergiy Londar, Serhii Melnyk, Oles Kovtunets

“…Therefore, a user should be capable of forming at most four matrices of judgments and computing the main eigenvectors with some level of accuracy. …”
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Laser Based ¹³C-urea Breath Test in Quantitative Assessment of Bacterial Colonization, Severity of Inflammation and Atrophy in Gastric Mucosa by E. V. Stepanov, V. T. Ivashkin

“…A total of 525 patients (301 men and 224 women) aged 15–80 years (median 39.8 ± 15.1 years) were examined. 239 (45.5 %) patients were diagnosed with chronic gastritis, chronic duodenitis (including erosive forms). In 286 (54.5 %) patients, peptic ulcer was diagnosed with localization in the stomach — in 42 (8 %), in the duodenum – in 238 (45.3 %), combined lesions — in 9 (1.7 %) cases. …”
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