Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…Being on antipsychotics, antidepressants and antidiabetic drugs was associated with increased risk of higher anticholinergic burden.ConclusionIn conclusion, the anticholinergic burden might play a significant role as a risk factor for developing more severe BPSD in patients with cognitive decline, independently from their degree of cognitive impairment.…”
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The effects of citral on the intestinal health and growth performance of American bullfrogs (Aquarana catesbeiana) by Xiaoting Zheng, Qiuyu Chen, Xueying Liang, Jingyi Xie, Alfredo Loor, Hongbiao Dong, Jinlong Yang, Jiasong Zhang

“…Growth performance analysis revealed that 4 mL/kg citral supplementation significantly improved weight gain rate (WGR), specific growth rate (SGR), carcass weight (CW), and feed efficiency (FE), while survival rates declined at 16 mL/kg (P < 0.05). A linear regression model determined the optimal dietary citral concentration to be 3.216–3.942 mL/kg. …”
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Pengembangan Knowledge Management System Ukiran Kayu Khas Bali Berbasis Artificial Intelligence by I Putu Restu Indrawan Prabawa, Ariq Cahya Wardhana

“…Mereka bekerja dengan konsisten dan penuh dedikasi untuk menciptakan karya yang terbaik dan berkualitas tinggi. Selain itu, mereka selalu menyertakan filosofi spiritual yang mendalam dalam hasil karyanya. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…Among the remaining 62 eligible donors, 44 families/next-of-kin declined consent for solid-organ donation, resulting in a consent rate of 29% (n=18). …”
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Perancangan Spesifikasi Keamanan untuk Pengembangan Aplikasi Secure Chat Berdasarkan Common Criteria For It Security Evaluation by Amiruddin Amiruddin, Muhammad Faqih Rohmani

“…Messenger belum menerapkan disain keamanan yang baik, misalnya kita tidak dapat memverifikasi identitas kontak kita. Selain itu, Yahoo! Messenger tidak menerapkan perfect forward secrecy. …”
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Impacts of National Reimbursement Drug Price Negotiation on drug accessibility, utilization, and cost in China: a systematic review by Zheng Zhu, Jiawei Zhang, Zhihu Xu, Quan Wang, Yu Qi, Li Yang

“…Methods We searched the electronic databases PubMed (which includes MEDLINE), Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP for all associated studies published in English or Chinese between January 2016 and December 2023. …”
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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus by Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim

“…Methods To test this, first we screened the antibiotic properties of representative G4-binding ligands against hypervirulent and MDR S. aureus USA300 and determined the in vitro and in vivo antibacterial activity; and proposed the mechanism of action by applying various microbiological, infection, microscopic, and biophysicochemical techniques. Results Herein, among screened G4-binding ligands, N-methyl mesoporphyrin IX (NMM) showed the highest antibacterial activity against S. aureus USA300. …”
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Barriers and enablers to implementing clinical practice guidelines in primary care: an overview of systematic reviews by Tao Wang, Xian-Liang Liu, Jing-Yu (Benjamin) Tan, Isabella Zhao

“…Objectives To identify the barriers and enablers to implementing clinical practice guidelines (CPGs) recommendations in primary care and to provide recommendations that could facilitate the uptake of CPGs recommendations.Design An overview of systematic reviews.Data sources Nine electronic databases (PubMed, Cochrane Library, CINAHL, MEDLINE, PsycINFO, Web of Science, Journals @Ovid Full Text, EMBase, JBI) and three online data sources for guidelines (Turning Research Into Practice, the National Guideline Clearinghouse and the National Institute for Health and Care Excellence) were searched until May 2021.Eligibility criteria Systematic reviews, meta-analyses or other types of systematic synthesis of quantitative, qualitative or mixed-methods studies on the topic of barriers and/or enablers for CPGs implementation in primary care were included.Data extraction and synthesis Two authors independently screened the studies and extracted the data using a predesigned data extraction form. …”
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Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination. by Marcin Nowicki, Marzena Nowakowska, Katarzyna Nowak, Wojciech Szczechura, Piotr Kaminski

“….), a crucial vegetable crop of global importance, face unique challenges in seed germination and seedling development due to their complex pollination biology and outcrossing reproduction mode with severe inbreeding depression if selfed. …”
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Pengujian Rule-Based pada Dataset Log Server Menggunakan Support Vector Machine Berbasis Linear Discriminat Analysis untuk Deteksi Malicious Activity by Kurnia Adi Cahyanto, Muhammad Anis Al Hilmi, Muhamad Mustamiin

“…Dari informasi pada log, dapat dipakai untuk keperluan pengamanan sistem, salah satunya dengan cara melakukan analisis menggunakan data mining terhadap aktifitas klien yang tercatat pada log server. Selain itu, jika terdapat file yang diunggah pengguna, dapat juga dikaitkan dalam analisis log server dalam mengenali pola aktifitas dan malicious file. …”
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Metabolomics, network pharmacology, and microbiome analyses uncover the mechanisms of the Chinese herbal formula for the improvement of meat quality in spent hens by Zhihua Li, Md. Abul Kalam Azad, Chengwen Meng, Xiangfeng Kong, Jue Gui, Wenchao Lin, Yadong Cui, Wei Lan, Qinghua He

“…Abstract Background Meat originating from the spent hen is an important source of poultry meat production; however, multiple factors cause the decline in the meat quality of spent hens. Chinese herbs have been widely used as medicine for a long time to prevent diseases and as nutrient supplements to improve the product quality. …”
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Exploring proteomic immunoprofiles: common neurological and immunological pathways in multiple sclerosis and type 1 diabetes mellitus by Fátima Cano-Cano, Almudena Lara-Barea, Álvaro Javier Cruz-Gómez, Francisco Martín-Loro, Laura Gómez-Jaramillo, María Carmen González-Montelongo, María Mar Roca-Rodríguez, Lucía Beltrán-Camacho, Lucía Forero, Javier J. González-Rosa, Mª Carmen Durán-Ruiz, Ana I. Arroba, Manuel Aguilar-Diosdado

“…Methods We conducted a proteomic analysis of PBMCs from patients with T1DM and relapsing remitting Multiple Sclerosis (herein forth MS) patients (n = 9 per condition), using a label-free quantitative proteomics approach. …”
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Student perceptions of the socialization and implementation Merdeka Belajar Kampus Merdeka program by Tridelvy Sensony, Dadang Sukirman, Ahmad Fajar Fadlillah

“…Artinya sebagian besar responden setuju bahwa melalui sosialisasi mereka menjadi tahu tentang keberadaan program dan mengikutinya. Selain itu, minat belajar dikategorikan "sangat positif". …”
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The use of radar-optical remote sensing data and geographic information system–analytical hierarchy process–multicriteria decision analysis techniques for revealing groundwater rec... by Wang Yuxia, Han Yanzhong, Guo Yujiao, Wang Jingwei, Wang Nana, Abdelkareem Mohamed

“…Consequently, identifying groundwater prospective zones (GWPZs) has become essential for securing water resources. The study aims to delineate and predict the best areas of groundwater prospection and abstraction by implementing the analytical hierarchy process-geographic information system (GIS) techniques in a rough terrain that occupies ∼70% of fractured hard rocks including ∼34% of the basaltic flow sheet of Wadi Marawani, Saudi Arabia. …”
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CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

“…Further, membrane CD22 inhibited Amyloid β (Aβ) induced-NFκB signaling pathway and mechanistic study delineated that suciraslimab suppressed Aβ-induced IL-1β secretion in human microglia and PBMC. …”
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Sources and Radiative Impact of Carbonaceous Aerosols Using Four Years Ground-Based Measurements over the Central Himalayas by Priyanka Srivastava, Manish Naja, T. R. Seshadri

“…Here, we report the first simultaneous high-resolution delineation of primary organic carbon (POC) and secondary organic carbon (SOC) content and quantify the contributions of fossil fuel combustion and biomass burning over the Central Himalayas using four-year (2014–2017) online observations. …”
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Blood pressure, gallstones, and age at first cholecystectomy in U.S. adults: a cross-sectional study by Yue Zhang, Ruifeng Duan, Xin Chen, Lijuan Wei

“…Additionally, this study employed generalized additive models (GAM) and smooth-fitting curves to delineate the relationships. The two-piecewise linear regression model and logarithmic likelihood ratio test elucidated the inflection point of systolic blood pressure (SBP) on the age at first cholecystectomy. …”
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Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages by Fred Owino, Fred Owino, Fred Owino, Caroline Kijogi, Caroline Kijogi, Caroline Kijogi, Omu Anzala, Omu Anzala, Edwin Walong, Obiero Jael, Steven G. Nyanjom, Agola Lelo Eric, Bernard N. Kanoi, Bernard N. Kanoi, Jesse Gitaka, Jesse Gitaka

“…The expression of surface markers CD68, CD80, CD86, CD163, CD206, and CD209, was used to delineate the macrophage populations. For gene expression profiling, macrophages were isolated from the placental immune cells and the expression level of transcription factors STAT-1, IRF-5, STAT-6, c-Maf and angiogenic factors ANG-1, ANG-2 and VEGF determined by qPCR.Results and DiscussionWe found no difference in the total macrophage populations and M1 and M2 macrophage profiles between uninfected and infected placentas, however, M2 macrophages were significantly higher compared to their M1 counterparts regardless of infection status. …”
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Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations by Zhensheng Li, Jie Ma, Hongmin Bai, Bingmei Deng, Jian Lin, Weimin Wang

“…The subtypes of the parahippocampal connectomes exhibited resemblances to those of the hippocampus.ConclusionWe have constructed the brain local connectomes of the MTL parcellations and acquired the network parameters to delineate the hubs distribution through graph theory analysis. …”
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The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradati... by Quan Yuan, Mingwei Wang, Zhaoxiang Zhang, Ruofei Wang, Dechao Wang, Zichun Sang, Pu Zhao, Xiaoli Liu, Xiaoying Zhu, Gaofeng Liang, Hua Fan, Dongmei Wang

“…Therefore, this study aims to explore whether melatonin can mitigate BDE-47-elicited cognitive impairment via suppressing ferroptosis, and further delineate the underlying mechanisms. Our results found that melatonin administration effectively inhibited BDE-47-induced ferroptosis in mice hippocampi and murine hippocampal neuronal HT-22 cells. …”
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