Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…Pancreatic ductal adenocarcinoma (PDAC) remains one of the most feared diseases worldwide owing to its poor prognosis, negligible therapeutic advances, and high mortality. Herein, multifunctional enzyme-responsive micelles for the controlled delivery of paclitaxel (PTX) were prepared to circumvent its current clinical challenges. …”
Get full text

Detection and decontamination of Mycoplasma in cultured cells and viral strains by Glaucia Prado de Andrade, Natália Hettwer Pedroso, Alice Becker, Vinicius Soares dos Santos, Juciane Bonella, José Valter Joaquim Silva Júnior, Rudi Weiblen, Eduardo Furtado Flores

“…ABSTRACT: Contamination of biological products with Mycoplasma spp. represents a major problem for laboratories and vaccine industry. Herein, we investigated Mycoplasma spp. contamination in cell cultures and viral strains maintained at the Virology Section of the Universidade Federal de Santa Maria and evaluated drugs and protocols for decontamination. …”
Get full text

Penggunaan Metode Eklektik Dan Mentoring Untuk Meningkatkan Kemampuan Berbahasa Inggris Lisan Tenaga Pendidik Dan Kependidikan by Erniwati

“…Metode eklektik yang digunakan dalam penelitian ini merupakan gabungan dari teori behavioristik, teori kognitif, dan teori konstruktivistik. Selain itu, untuk mendukung ketiga teori tersebut peneliti juga menggunakan strategi Communicative Language Teaching dan Cooperative Language Learning. …”
Get full text

Analisis Masalah Dan Solusi Live Streaming Shopping: Tinjauan Literatur Sistematis by Nandhita Zefania Maharani, Betty Purwandari, Imairi Eitiveni, Erisva Hakiki Purwaningsih

“…Hasil penelitian ini akan menampilkan tabel yang merangkum teori yang digunakan, dampak yang menjadi fokus penelitian, serta masalah dan solusi yang terkait dengan lima proses utama dalam live streaming shopping, yaitu product promotion, merchant’s proposition, platform features, purchase decision, dan policy development. Selain itu, penelitian ini juga akan mengusulkan strategi pemasaran yang dapat diadopsi oleh penjual berdasarkan temuan dari penelitian sebelumnya. …”
Get full text

Does a Provider Contact Wristband Reduce Emergency Department Visit Rates Following Hip or Knee Arthroplasty? by David C. Hein, MD, Ajay K. Srivastava, MD, Seann E. Willson, MD, Paul M. Telehowski, MD, Patrick J. Atkinson, PhD, Theresa S. Atkinson, PhD

“…Nearly half (48.1%) of the calls were received during weekday work hours when the patients had been directed to call the office. While ED visits declined after the implementation of the wristband at both 2 and 3 years, these reductions were not statistically significant (30 days: 5.1% before, 4.1% after; 90 days: 8.1% before, 7.1% after). …”
Get full text

Lower respiratory tract infection admissions and deaths among children under 5 years in public sector facilities in the Western Cape Province, South Africa, before and during the C... by K Kehoe, E Morden, N Zinyakatira, A Heekes, H E Jones, S R Walter, T Jacobs, J Murray, H Buys, M T Redaniel, M-A Davies

“…The COVID‐19 surges and their associated measures were linked to declining LRTI admissions and in‐facility deaths, likely driven by a combination of reduced infectious disease transmission and reduced use of healthcare services, with effects diminishing over time. …”
Get full text

‘An Important Exercise of Care and Attention’: How the International Geological Expedition Was Established in Mongolia by Narma A. Kamandzhaev

“…In this regard, a number of initiatives were put forward by CMEA, one be discussed herein. Goals. The article examines how CMEA bodies would coordinate the making of the International Geological Expedition in Mongolia. …”
Get full text

Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster by Yi Pan, Ke Fan, Linhao Zong, Yantao Luo, Xin Ni, Dong Chen, Jinjun Qian, Fei Ma, Jie Cheng, Miao Guan

“…Firstly, our observations on the number of eggs laid, pupae formed, and adult flies emerged on the directly exposed generation (F0) confirmed a dose-dependent decline in fecundity. Transcriptome analysis revealed that, Cd-induced oxidative stress and ion transport disruption in the F0 generation could underlie synaptic dysfunction and impaired follicle cell development, impacting reproductive behavior and oocyte fertility. …”
Get full text

Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus-2 infection: a systematic review by Jiacai Cho, Joanne Lee, Ching-Hui Sia, Chieh Sian Koo, Benjamin YQ Tan, Weizhen Hong, Ellie Choi, Xueying Goh, Louis Chai, Nisha Suyien Chandran, Horng Ruey Chua, Bernard PL Chan, Mark Muthiah, Ting Ting Low, Eng Soo Yap, Manjari Lahiri

“…Methods: We searched the MEDLINE and Embase databases for SARS-CoV-2-related studies. …”
Get full text

Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-exp... by Michael A. Deaney, Katherine C. Shihadeh, Alexandra Craig, Margaret M. Cooper, Paul D. Paratore, Timothy C. Jenkins

“…Interrupted time series analysis showed a reduction in the median duration of therapy (–2.3 days, P = .0016), with a sustained decline (slope change –0.2103, P = .005) post-intervention. …”
Get full text

Simultaneous determination of 11 kinds of siloxanes in drinking water and source water using solid-phase microextraction combined with gas chromatography-mass spectrometry by Sijie Liu, Jie Ma, Su Jiang

“…Therefore, in order to protect human health, it is urgent to establish a method for the determination of siloxane content in drinking water and source water.MethodsHerein, this paper proposes a precise, fast, and selective method using solid-phase microextraction combined with gas chromatography-mass spectrometry (GC-MS/MS) method for the simultaneous detection of 11 kinds of siloxanes in drinking water and source water. …”
Get full text

Caesarean sections and private insurance: systematic review and meta-analysis by Ilir Hoxha, Medina Braha, Lamprini Syrogiannouli, David C Goodman, Peter Jüni, Bruno R da Costa

“…We therefore sought to determine the association of private insurance and odds of caesarean section.Design Systematic review and meta-analysis.Data sources MEDLINE, Embase and The Cochrane Library from the first year of records through August 2016.Eligibility criteria We included studies that reported data to allow the calculation of OR of caesarean section of privately insured as compared with publicly insured women.Outcomes The prespecified primary outcome was the adjusted OR of births delivered by caesarean section of women covered with private insurance as compared with women covered with public insurance. …”
Get full text

Public perceptions on the application of artificial intelligence in healthcare: a qualitative meta-synthesis by Jing Gao, Xinyu Chen, Xiaolian Jiang, Chenxi Wu, Huiqiong Xu, Dingxi Bai

“…Here, a meta-synthesis was conducted to analyse and summarise the public’s understanding of the application of AI in the healthcare field, to provide recommendations for future use and management of AI in medical practice.Design This was a meta-synthesis of qualitative studies.Method A search was performed on the following databases to identify studies published in English and Chinese: MEDLINE, CINAHL, Web of science, Cochrane library, Embase, PsycINFO, CNKI, Wanfang and VIP. …”
Get full text

Kidney transplant utilising donors after circulatory death: The first report from the African continent by T du Toit, K Manning, L Bertels, G Hoffman, D Thomson, Z A Barday

“…At Groote Schuur Hospital in Cape Town, South Africa, the number of deceased organ donors has declined over the past 2 decades, necessitating a more liberal approach to donor selection. …”
Get full text

Strategic control of excess tellurium to achieve high figure-of-merit in Te-rich Bi0.5Sb1.5Te3 by Ranu Bhatt, Rishikesh Kumar, Pramod Bhatt, Pankaj Patro, Shovit Bhattacharya, Mani Navaneethan, Soumen Samanta, Ajay Singh

“…Abstract Increasing the Te content in stoichiometric Bi0.5Sb1.5Te3 facilitates effective control over the anti-site defects and nanostructure; however, arresting excess Te in the host matrix is challenging. Herein, we report the success of a saturation-annealing treatment in a vacuum, followed by air-quenching as a promising approach for synthesizing high figure-of-merit (zT) Bi0.5Sb1.5Te3+xTe (x = 0, 2, 5 and 10 wt%) materials. …”
Get full text

Caveolin Gene, a Possible Risk Factor for Metabolic Syndrome in Humans: A Systematic Review and Meta-Analysis by Mohadeseh Arefian, Sadegh Mazaheri-Tehrani, Maryam Yazdi, Roya Kelishadi

“…Methods: A systematic literature search was done on electronic databases including Embase, Scopus, Medline (PubMed), and Web of Science until September 2023 and updated until June 2024. …”
Get full text

Immediate and short-term effects of neurodynamic techniques on hamstring flexibility: A systematic review with meta-analysis. by Sergio Núñez de Arenas-Arroyo, Vicente Martínez-Vizcaíno, Ana Torres-Costoso, Sara Reina-Gutiérrez, Bruno Bizzozero-Peroni, Iván Cavero-Redondo

“…<h4>Methods</h4>We systematically searched the Cochrane, MEDLINE(via PubMed), Scopus, Web of Science and Sportdiscus databases for RCTs comparing neurodynamic interventions with control intervention or with static stretching exercises for HF in adults with limited HF. …”
Get full text

Impact and perceptions of Active Learning Classrooms on reducing sedentary behaviour and improving physical and mental health and academic indicators in children and adolescents: A... by Mairena Sánchez-López, Jesús Violero-Mellado, Vicente Martínez-Vizcaíno, Arto Laukkanen, Arja Sääkslahti, María Eugenia Visier-Alfonso

“…Databases research included MEDLINE (PubMed), ERIC, SCOPUS and ProQuest Education. …”
Get full text

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling by Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

“…Microvascular dysfunction has been proposed to drive HFpEF, likely via endothelial cell (EC) dysfunction, yet the role of the mural cells herein has never been explored. Methods We used the diabetic db/db mouse given 1% salt as a new model of HFpEF and crossed then with PDGFRβtg/tg-CreERT2-EYFPtg/tg mice to label the mural cells. …”
Get full text

Biology of selective caries removal: a systematic scoping review protocol by Helge Knüttel, Matthias Widbiller, Rita Weiler, Kerstin M Galler, Wolfgang Buchalla, Konstantin J Scholz

“…In the course of phase I, a total of 100 systematic reviews related to selective caries removal were searched in MEDLINE and information or theories on the biological processes were extracted. …”
Get full text