Therapeutics for Sarcopenia and Functional Disabilities in Older Adults: A Review of Phase 4 Clinical Trials by Alorfi NM, Alshehri FS, Ashour AM

“…Data on therapeutic agents, trial outcomes, and their effects on muscle mass, strength, and disability prevention were collected from clinicaltrials.gov database.Results: Several therapeutic agents, including whey protein powder, eldecalcitol, testosterone enanthate, and Denosumab, have been tested in Phase 4 trials for their ability to enhance muscle mass and function in older adults with sarcopenia. …”
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Assessment Of The Impact Of Alcohol Intake On Cognition – A Cohort Study by Deekshitha Alla

“…The deleterious impact of alcoholism is a major public health issue worldwide due to its consequential long-term, social and economic damage. …”
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Frame Structure and Engineering Applications of the Multisource System Cloud Service Platform of Monitoring of the Soft Rock Tunnel by Fengnian Wang, Songyang Yin, Aipeng Guo, Zhicai Wang, Meng Mi, Gan Qi, Juan Ma, Haijiang Zhang

“…Therefore, structural health monitoring not only ensures accurate construction management but also provides a basis for dynamic adjustment of the support structure. …”
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Associations between non-traditional lipid parameters and normoglycemic reversion in Chinese adults with prediabetes: a retrospective analysis by Cheng Huang, Yuhang Zhang, Xiaoqing Yang, Guofeng Li, Zhichao Gao

“…BackgroundPrediabetes is a critical precursor to type 2 diabetes and poses an increasing global health challenge, particularly in China. While many individuals with prediabetes can revert to normoglycemia through lifestyle interventions, the impact of non-traditional lipid parameters on this process requires further investigation. …”
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Emotion-Aware Embedding Fusion in Large Language Models (Flan-T5, Llama 2, DeepSeek-R1, and ChatGPT 4) for Intelligent Response Generation by Abdur Rasool, Muhammad Irfan Shahzad, Hafsa Aslam, Vincent Chan, Muhammad Ali Arshad

“…The system can be integrated into existing mental health platforms to generate personalized responses based on retrieved therapy session data. …”
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Friedelin induces apoptosis in oral cancer: Insights from in vitro and in silico studies by Ramya Sekar, Monisha Prasad, Manikandan Alagumuthu

“…Background: Oral cancer is a major health issue in the world because of its high morbidity and mortality rates. …”
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Association of LDL‐C/HDL‐C Ratio With Hyperuricemia: A National Cohort Study by Yanyu Zhang, Xiaoyi Liu, Deyun Luo, Bingli Chen, Chenyi Lai, Chenyu He, Luo Yan, Haifeng Ding, Shiyang Li

“…We extracted data from the China Health and Retirement Longitudinal Study (CHARLS) database from 2011 to 2016. …”
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Impact of obesity on life expectancy among different European countries: secondary analysis of population-level data over the 1975–2012 period by Nikoletta Vidra, Sergi Trias-Llimós, Fanny Janssen

“…The differences found in this impact between countries and the sexes can be linked to contextual factors, as well as to differences in people’s ability and capacity to adopt healthier lifestyles.…”
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A fine-tuned convolutional neural network model for accurate Alzheimer’s disease classification by Muhammad Zahid Hussain, Tariq Shahzad, Shahid Mehmood, Kainat Akram, Muhammad Adnan Khan, Muhammad Usman Tariq, Arfan Ahmed

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Relationship of METS-IR with cardiometabolic multimorbidity in China: a nationwide longitudinal cohort study by Chunyan Zhou, Yanyu Zhang, Xiaoyi Liu, Chenyu He, Shiyang Li, Shiyang Li

“…BackgroundCardiometabolic multimorbidity (CMM) has emerged as a global health challenge with a high mortality risk. This study aimed to explore the association between the metabolic score for insulin resistance (METS-IR) and the incidence of CMM.MethodsThis study included 6,977 individuals in the CHARLS database. …”
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A systematic review and meta-analysis of acoustic stimulation in the treatment of insomnia by Mengchen Wang, Shuai Fan, Zixu Wang, Jixiang Ren

“…Acoustic stimulation, a promising non-pharmacological treatment, has gained significant attention due to its ability to improve sleep quality without the adverse effects of drugs. …”
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Global trends in the value of simulation as a pedagogical tool in oncology: a bibliometric analysis from 2010 to 2024 by Ouissam Al Jarroudi, Ahmed Rhassane El Adib, Hind Chibani, Said Afqir, Mohammed Mouhaoui

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Identification and selection of potential TNF-α inhibitors as anti-encephalitis candidates by using in silico assisted drug design by Pawan Kumar Gupta, Shashi Bhooshan Tiwari

“…Abstract Background Encephalitis, an inflammatory disorder of the brain caused by infections or autoimmune responses, is still a major global health concern due to its high morbidity, mortality, and long-term neurological consequences. …”
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A novel prognostic risk score associated with resistance to docetaxel chemotherapy for predicting biochemical recurrence-free survival in patients with prostate cancer by Desheng Zhu, Hongbin Zhu, Ting Huang, Wentao Fan

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Advanced lung cancer inflammation index is associated with mortality in critically ill patients with heart failure by Xiaoqian Sun, Xinyu Zhang, Rui Tang, Jiangyue Tian, Ying Li, Xiaoxia Hu, Ziru Sun, Anhu Wu, Jie Xiao, Mei Dong, Guihua Yao, Huixia Lu

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Advanced lung cancer inflammation index and its predictive value for all-cause and cardiovascular mortality among osteoarthritis patients: a NHANES-based study from 2001 to 2018 by Guiyou Wu, Guiyou Wu, Dongqiang Gu, Dongqiang Gu, Haigang Jia, Haigang Jia, Lei Hong, Lei Hong, Xishun Wang

“…This research seeks to delineate the link between ALI and the risk of mortality, whether from universal causes or cardiovascular disease (CVD), particularly in the OA-affected population.MethodsThis research drew upon the National Health and Nutrition Examination Survey (NHANES) database from 2001 to 2018. …”
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Development and Validation of a Dynamic Real-Time Risk Prediction Model for Intensive Care Units Patients Based on Longitudinal Irregular Data: Multicenter Retrospective Study by Zhuo Zheng, Jiawei Luo, Yingchao Zhu, Lei Du, Lan Lan, Xiaobo Zhou, Xiaoyan Yang, Shixin Huang

“…MethodsA time-aware bidirectional attention-based long short-term memory (TBAL) model was developed using EMR data from the MIMIC-IV (Medical Information Mart for Intensive Care) and eICU Collaborative Research Database (eICU-CRD) databases, comprising 176,344 ICU stays. …”
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Does Area Deprivation Index Predict Worse Initial Preoperative Patient-Reported Outcomes in Patients Who Underwent Microfracture for Osteochondral Lesions of the Talus? by Warren Austin, Kenzo M. Cotton BS, Garcia Findlay BS, Marfred Munoz Umanes MS, Richard Michael Smith MD, Cortes Brown MD, Warren Austin, Lauren Lewis MD MPH, Jarrett D. Cain DPM MSc, Macalus V. Hogan MD, MBA

“…An institution-based registry was created with foot and ankle patient data from three surgeons that were prospectively collected and retrospectively analyzed. The database was queried for patients who underwent talar dome OCL microfracture and completed preoperative Foot and Ankle Ability Measure Activities of Daily Living (FAAM ADL) questionnaires between September 2013 and February 2024. …”
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Meta-analysis of machine learning models for the diagnosis of central precocious puberty based on clinical, hormonal (laboratory) and imaging data by Yilin Chen, Xueqin Huang, Lu Tian

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Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

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