Examining How Technology Supports Shared Decision-Making in Oncology Consultations: Qualitative Thematic Analysis by Alan Yung, Tim Shaw, Judy Kay, Anna Janssen

“…Key issues such as data integration and interoperability between systems negatively impact the ability of digital technologies to support SDM. …”
Get full text

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells by Viktor Glaser, Christian Flugel, Jonas Kath, Weijie Du, Vanessa Drosdek, Clemens Franke, Maik Stein, Axel Pruß, Michael Schmueck-Henneresse, Hans-Dieter Volk, Petra Reinke, Dimitrios L. Wagner

“…Combining Cas12a Ultra for CAR knock-in and a Cas9-derived base editor enables the efficient generation of triple-edited CAR T cells with a translocation frequency comparable to unedited T cells. …”
Get full text

New Insights into Heavy Metal Sequestration Through Metal‐Phenolic Network‐Confined Nano‐HFO: Overlooking Iron Utilization and Modulating Electron Density by Manyu Zhang, Xiaolin Du, Zhanqi Liu, Yujia Yang, Shuo Wang, Ningyi Chen, Yulin Wang, Yaran Song, Keju Sun, Qingrui Zhang

“…Herein, we present a novel strategy to enhance HFO utilization by in situ confinement of nano‐HFO within polystyrene beads using a tannic acid‐zirconium (TA‐Zr) metalphenolic network, forming PS‐Fe@TA‐Zr. The TAZr network generates a highly negative microenvironment with tunable electron density at oxygen sites, facilitating Pb(II) enrichment and activating inner‐layer Fe sites. …”
Get full text

Inter- and intra-bacterial strain diversity remains the “elephant in the (living) room” by Adam Valcek, Carsten Kröger, Rubén de Dios, Ronan R. McCarthy, Tom Coenye, M. Stephen Trent, Nabil Karah, Bernt Eric Uhlin, Annika Y. Classen, Paul G. Higgins, Ingo Ebersberger, Maria-Halima Laaberki, Xavier Charpentier, Paolo Visca, Philip N. Rather, Charles Van der Henst

“…Abstract Acinetobacter baumannii is an opportunistic Gram-negative bacterial pathogen responsible for severe nosocomial infections worldwide. …”
Get full text

Turning Waste into Treasure: Functionalized Biomass‐Derived Carbon Dots for Superselective Visualization and Eradication of Gram‐Positive Bacteria by Ke‐Fei Xu, Zihao Wang, Macheng Cui, Yuhan Jiang, Chengcheng Li, Zi‐Xi Wang, Ling‐Yi Li, Chenyang Jia, Lijie Zhang, Fu‐Gen Wu

“…Strikingly, CDFs achieve superselective visualization of Gram‐positive bacteria even in the presence of mammalian cells and Gram‐negative bacteria. Furthermore, protoporphyrin (PpIX) molecules are conjugated onto BCDs to yield PpIX‐modified BCDs (termed CDPs), which can induce bacterial aggregation and in situ generate singlet oxygen for realizing enhanced antibacterial photodynamic therapy (PDT). …”
Get full text

Expression of Recombinant Human Alpha-Lactalbumin in the Milk of Transgenic Goats Using a Hybrid Pomoter/Enhancer by Yu-Guo Yuan, Liyou An, Baoli Yu, Shaozheng Song, Feng Zhou, Liqing Zhang, Yinyin Gu, Minghui Yu, Yong Cheng

“…We also describe the generation of transgenic goats expressing rhLA by somatic cell nuclear transfer (SCNT). …”
Get full text

Cross-neutralization of Influenza A by SARS-CoV-2 specific neutralizing antibodies and polyclonal plasma: Is pre-exposure to SARS-CoV-2 protective against Influenza A? by Mohammad Mamun Alam, Asma Salauddin, Sayra Moni, Md Belayet Hasan Limon, Raisha Musarrat, Sagar Bosu, Mohammad Enayet Hossain, Mohammed Ziaur Rahman, Mustafizur Rahman

“…In addition, SARS-CoV-2 antibody-positive but Influenza antibody-negative samples (n = 16) were investigated to determine the SARS-CoV-2 antibody-neutralizing potential against influenza viruses by microneutralization (MN) assay. …”
Get full text

Patient Transfer Process From Pre‐Hospital to the Hospital Emergency Department: A Grounded Theory Study by Maryam Jamsahar, Fazlollah Ahmadi, Mitra Khoobi, Mojtaba Vaismoradi

“…While successful strategies can inform practical guidelines, negative consequences highlight the need for more efficient and effective approaches. …”
Get full text

Noninvasive imaging biomarker reveals invisible microscopic variation in acute ischaemic stroke (≤ 24 h): a multicentre retrospective study by Kui Sun, Rongchao Shi, Xinxin Yu, Ying Wang, Wei Zhang, Xiaoxia Yang, Mei Zhang, Jian Wang, Shu Jiang, Haiou Li, Bing Kang, Tong Li, Shuying Zhao, Yu Ai, Jianfeng Qiu, Haiyan Wang, Ximing Wang

“…However, receiving a negative result was reported by radiologists according to the NCCT images. …”
Get full text

Optimization of antibacterial and antifungal activities in Moroccan saffron by-products using mixture design and simplex centroid methodology by Abdellah Baraich, Amine Elbouzidi, Naoufal El Hachlafi, Mohamed Taibi, Mounir Haddou, Sanae Baddaoui, Reda Bellaouchi, Mohamed Addi, Redouane Benabbes, Abdeslam Asehraou, Bassem Jaouadi, Ammar AL-Farga, Saleh M. Al-Maaqar, Ennouamane Saalaoui

“…Compared to other natural alternatives, saffron by-products offer distinct advantages, including a unique combination of phenolic compounds (e.g., ellagic acid, rutin) and carotenoids (e.g., crocin) that act synergistically against both Gram-positive and Gram-negative bacteria, as well as fungi. Additionally, these by-products represent a sustainable solution, with approximately 63 kg of agricultural waste generated per kg of saffron spice. …”
Get full text

Polar lights optimizer: A novel algorithm for accurate parameter estimation in proton exchange membrane fuel cells by Mohammad Aljaidi, Pradeep Jangir, Arpita, Sunilkumar P. Agrawal, Sundaram B. Pandya, Anil Parmar, G. Gulothungan, Ali Fayez Alkoradees, Mohammad Khishe, Reena Jangid

“…Proton Exchange Membrane Fuel Cells play a key role in sustainable power systems by delivering both superior energy conversion efficiency and eco-friendly operation. The complex multivariate structure together with nonlinear behavior of these systems makes it parameter estimation a challenging task, which negatively affects operational reliability and system lifespan. …”
Get full text

Modelado predictivo de actitudes y comportamientos ético-profesionales en médicos latinoamericanos mediante redes neuronales by Alberto Guevara Tirado, Raul Emilio Real Delor

“…Conclusions: The multilayer perceptron neural network was efficient for analyzing ethical and professional attitudes and behaviors in medical practice.…”
Get full text

Feasible and Rapid Screening of <i>IDH1/2</i> and <i>FLT3-TKD2</i> Mutations by High-Resolution Melting for Patients with Acute Myeloid Leukemia by José Vicente Gil, Sandra de las Heras, Alberto Miralles, Claudia Sargas, Marta Llop, Rebeca Rodríguez-Veiga, Laura Torres-Miñana, Blanca Boluda, Isabel Cano-Ferri, Evelyn Acuña-Cruz, Irene Navarro, Pilar Lloret-Madrid, Pau Montesinos, Eva Barragán

“…The method was applied to a cohort of 1363 AML patients, and its performance, including turnaround time, was evaluated through comparison with next-generation sequencing (NGS) results. <b>Results</b>: The PCR-HRM method demonstrated a positive percent agreement of 98%, 98%, and 92% for <i>IDH1</i>, <i>IDH2</i>, and <i>FLT3-TKD2</i>, respectively, and a negative percent agreement of 100% for all three genes compared to NGS. …”
Get full text

Comparison of wind-farm control strategies under realistic offshore wind conditions: wake quantities of interest by K. Brown, G. Yalla, L. Cheung, J. Frederik, D. Houck, N. deVelder, E. Simley, P. Fleming

“…This is done by using turbine settings such as the yaw angle, blade pitch angles, or generator torque to manipulate the wake that negatively affects downstream turbines in the farm. …”
Get full text

Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer by Lin Shen, Xiaochen Zhao, Zhenghang Wang, Yuezong Bai, Feilong Zhao, Zhi Peng, Jinping Cai, Tong Xie, Shuang Tong, Xiaofan Wei

“…Additionally, EBV-encoded RNA (EBER) in situ hybridization (ISH), the traditional method to detect EBV, could cause false-positive/false-negative results and not allow for characterizing other molecular biomarkers recommended by standard treatment guidelines for GC. …”
Get full text

Cytokines as potential biomarkers for the diagnosis of Mycobacterium bovis infection in Mediterranean buffaloes (Bubalus bubalis) by Giulia Franzoni, Federica Signorelli, Piera Mazzone, Anna Donniacuo, Giovanna De Matteis, Francesco Grandoni, Lorena Schiavo, Susanna Zinellu, Silvia Dei Giudici, Javier Bezos, Javier Bezos, Esterina De Carlo, Giorgio Galiero, Francesco Napolitano, Alessandra Martucciello

“…Mycobacterium bovis (M. bovis) is the primary agent of bovine tuberculosis (TB) in Mediterranean buffalo, which has a negative economic impact on buffalo herds. Improving TB diagnostic performance in this species represents a key step to eradicate efficiently this disease. …”
Get full text

High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform by Sascha D. Braun, Sascha D. Braun, Martin Reinicke, Martin Reinicke, Celia Diezel, Celia Diezel, Elke Müller, Elke Müller, Katrin Frankenfeld, Thomas Schumacher, Hugo Arends, Stefan Monecke, Stefan Monecke, Ralf Ehricht, Ralf Ehricht, Ralf Ehricht

“…The validated antibody pairs are directly applicable to ELISA or lateral flow test formats and provide a strong foundation for next-generation diagnostics capable of detecting an evolving panel of carbapenemases in clinical settings.…”
Get full text

Effects of pharmacological and non-pharmacological interventions for the management of sleep problems in people with fibromyalgia: a multi-methods evidence synthesis by Mari Imamura, Clare Robertson, Jemma Hudson, Daniel Whibley, Lorna Aucott, Katie Gillies, Marcus Beasley, Martin J Stevens, Paul Manson, Debra Dulake, Abhishek Abhishek, Nicole KY Tang, Gary J Macfarlane, Miriam Brazzelli

“…Insufficient sleep was reported to increase pain and fatigue, with a consequent negative impact on activities of daily living. Poor sleep was also described as having a negative impact on cognitive functioning, mental health and fibromyalgia symptom ‘flare-ups’. …”
Get full text

The Circular Kitchen by Bas Jansen

“…Additionally, the decision to make these investments coincided with unforeseen negative feedback received after placing demonstrator kitchens in several homes. …”
Get full text

Modeling and finite element simulation of temperature field in rail abrasive belt grinding by Haipeng WANG, Jianyong LI, Chaoyue ZHAO, Yueming LIU

“…However, during the grinding process, a large amount of grinding heat will be generated in the grinding area between the sand belt and the rail, causing the temperature of the rail to rise. …”
Get full text