N-of-1 medicine by Peter Wang, Qiao Ying Leong, Ni Yin Lau, Wei Ying Ng, Siong Peng Kwek, Lester Tan, Shang-Wei Song, Kui You, Li Ming Chong, Isaiah Zhuang, Yoong Hun Ong, Nigel Foo, Xavier Tadeo, Kirthika Senthil Kumar, Smrithi Vijayakumar, Yoann Sapanel, Marlena Natalia Raczkowska, Alexandria Remus, Agata Blasiak, Dean Ho

“…Therefore, it is important to define each domain and delineate their commonalities and differences in an effort to develop novel clinical trial designs, streamline workflow development, rethink regulatory considerations, create value in healthcare and economics assessments, and other factors. …”
Get full text

Fully automated extraction of high-quality total nucleic acids from FFPE specimens for comprehensive genomic profiling of solid tumors by Kristopher Amirault, Michael Collins, Luca Beker, Brandon Mills, Martina Werner, Jonathan Andreas, Daniel Hartman, Jordan Dargert, Vanessa Process, Sean Cederlund, Thuy Dao, Linnea Menin, Molly Ferrara, Andrew Briggs, Joshua Shreve, Daniel Metzger, Angela Stout, Erin Deblasi, Jie An, Taylor Jensen, Shengle Zhang, Vinesh Rana, Bryn Burlingame, Ulrich Thomann, Durga Prasad Dash, Sha Liao, Jeffrey M. Conroy, Eugenio Daviso

Get full text

Conceptos sobre infraestructura tecnológica de un canal de televisión y su aplicación al diseño by Leonardo Andrés Carvajal Álvarez

Subjects: “…transmisión de video por redes de datos (video streaming)…”
Get full text

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…However, the PTPRD-expressing hepatic cell types, signalling pathways responsive to PTPRD and their role in non-viral liver disease are largely unknown.Methods We studied PTPRD expression in single-cell and bulk liver transcriptomic data from mice and humans, and established a Ptprd-deficient mouse model for metabolic dysfunction-associated steatohepatitis (MASH). …”
Get full text

Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MI... by Fiona McNicholas, Dieter Wolke, Jason Madan, Jatinder Singh, Federico Fiori, Paramala Santosh, Jane Warwick, Helena Tuomainen, Swaran Singh, Laura Adams, Mathilde Mastroianni, Natalie Heaney, Kate Lievesley, Ilyas Sagar-Ouriaghli, Giovanni Allibrio, Rebecca Appleton, Nikolina Davidović, Giovanni de Girolamo, Gwen Dieleman, Katarina Dodig-Ćurković, Tomislav Franić, Charlotte Gatherer, Suzanne Gerritsen, Elisa Gheza, Lidia Manenti, Athanasios Maras, Francesco Margari, Adriana Pastore, Moli Paul, Diane Purper-Ouakil, Francesco Rinaldi, Vehbi Sakar, Ulrike Schulze, Giulia Signorini, Cathy Street, Priya Tah, Sabine Tremmery, Amanda Tuffrey, Frank Verhulst, Anna Wilson

“…The objective of this study was to develop and validate the Transition Readiness and Appropriateness Measure (TRAM) for assessing a young person’s readiness for transition, and their outcomes at the transfer boundary.Design MILESTONE prospective study.Setting Eight European Union (EU) countries participating in the EU-funded MILESTONE study.Participants The first phase (MILESTONE validation study) involved 100 adolescents (pre-transition), young adults (post-transition), parents/carers and both CAMHS and AMHS clinicians. The second phase (MILESTONE cohort study and nested cluster randomised trial) involved over 1000 young people.Results The development of the TRAM began with a literature review on transitioning and a review of important items regarding transition by a panel of 34 mental health experts. …”
Get full text

Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…Objectives To reliably quantify the radiographic severity of COVID-19 pneumonia with the Radiographic Assessment of Lung Edema (RALE) score on clinical chest X-rays among inpatients and examine the prognostic value of baseline RALE scores on COVID-19 clinical outcomes.Setting Hospitalised patients with COVID-19 in dedicated wards and intensive care units from two different hospital systems.Participants 425 patients with COVID-19 in a discovery data set and 415 patients in a validation data set.Primary and secondary outcomes We measured inter-rater reliability for RALE score annotations by different reviewers and examined for associations of consensus RALE scores with the level of respiratory support, demographics, physiologic variables, applied therapies, plasma host–response biomarkers, SARS-CoV-2 RNA load and clinical outcomes.Results Inter-rater agreement for RALE scores improved from fair to excellent following reviewer training and feedback (intraclass correlation coefficient of 0.85 vs 0.93, respectively). …”
Get full text

cigFacies: a massive-scale benchmark dataset of seismic facies and its application by H. Gao, X. Wu, X. Sun, M. Hou, M. Hou, H. Gao, G. Wang, H. Sheng

“…Earth System Science Data…”
Get full text

A comprehensive global mapping of offshore lighting by C. D. Elvidge, T. Ghosh, N. Chatterjee, N. Chatterjee, M. Zhizhin, M. Zhizhin, P. C. Sutton, M. Bazilian

“…Earth System Science Data…”
Get full text

HOLSEA-NL: a Holocene water level and sea level indicator dataset for the Netherlands by K. de Wit, K. M. Cohen, R. S. W. van de Wal, R. S. W. van de Wal

“…Earth System Science Data…”
Get full text

EARice10: a 10 m resolution annual rice distribution map of East Asia for 2023 by M. Song, M. Song, M. Song, L. Xu, L. Xu, J. Ge, J. Ge, J. Ge, H. Zhang, H. Zhang, H. Zhang, L. Zuo, L. Zuo, J. Jiang, J. Jiang, J. Jiang, Y. Ding, Y. Ding, Y. Ding, Y. Xie, Y. Xie, Y. Xie, F. Wu, F. Wu

“…Earth System Science Data…”
Get full text

A China dataset of soil properties for land surface modelling (version 2, CSDLv2) by G. Shi, W. Sun, W. Shangguan, Z. Wei, H. Yuan, L. Li, X. Sun, Y. Zhang, H. Liang, D. Li, F. Huang, Q. Li, Q. Li, Y. Dai

“…Earth System Science Data…”
Get full text

GravIS: mass anomaly products from satellite gravimetry by C. Dahle, E. Boergens, I. Sasgen, I. Sasgen, T. Döhne, S. Reißland, H. Dobslaw, V. Klemann, M. Murböck, M. Murböck, R. König, R. König, R. Dill, M. Sips, U. Sylla, A. Groh, M. Horwath, F. Flechtner, F. Flechtner

“…Earth System Science Data…”
Get full text

Calm ocean, stormy sea: atmospheric and oceanographic observations of the Atlantic during the Atlantic References and Convection (ARC) ship campaign by L. Köhler, L. Köhler, J. Windmiller, D. Baranowski, M. Brennek, M. Ciuryło, L. Hayo, D. Kȩpski, S. Kinne, B. Latos, B. Lobo, T. Marke, T. Nischik, D. Paul, P. Stammes, A. Szkop, O. Tuinder

“…Earth System Science Data…”
Get full text

A dataset of drip patterns for teaching and research purposes in forensic bloodstain pattern analysisBorealis by Shaijieni Kannan, Stanard M. Pachong, Peter R. Lewis, Theresa Stotesbury

“…Data in Brief…”
Get full text

Multiomics-based assessment of the impact of airflow on diverse plant callus cultures by June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita, Masami Yokota Hirai

“…Scientific Data…”
Get full text

Prokaryotic cellulase gene clusters derived from 2,305 metagenomes by Bing Song, Fernando D. K. Tria, Josip Skejo

“…Scientific Data…”
Get full text

Reach&Grasp: a multimodal dataset of the whole upper-limb during simple and complex movements by Dario Di Domenico, Inna Forsiuk, Simon Müller-Cleve, Simone Tanzarella, Florencia Garro, Andrea Marinelli, Michele Canepa, Matteo Laffranchi, Michela Chiappalone, Chiara Bartolozzi, Lorenzo De Michieli, Nicolò Boccardo, Marianna Semprini

“…Scientific Data…”
Get full text