Designing a broad-spectrum multi-epitope subunit vaccine against leptospirosis using immunoinformatics and structural approaches by Guneswar Sethi, Guneswar Sethi, Young Kyu Kim, Su-Cheol Han, Jeong Ho Hwang, Jeong Ho Hwang

“…The physicochemical properties of the vaccine were assessed, including antigenicity, immunogenicity, allergenicity, and conservation. The vaccine’s 3D structure was modeled, optimized, and validated. …”
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Describing viewpoints on human‐nature relationships to unveil socio‐environmental conflicts and support community‐based projects by Beatriz Demasi, Nina Garcia de Almeida Prado, Flávia Pereira Lima, Charbel N. El‐Hani, Renata Pardini

“…Abstract Socio‐environmental changes are threatening Indigenous peoples and local communities (IP&LC), hampering conservation efforts, jeopardizing biocultural diversity and escalating environmental injustice. …”
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Effects of Mycoplasma ovipneumoniae, abundance, and climate conditions on bighorn sheep lamb:ewe ratios in New Mexico by Colton J. Padilla, Caitlin Q. Ruhl, James W. Cain III, Matthew E. Gompper

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Integrative proteomic-transcriptomic analysis revealed the lifestyles of Lactobacillus paracasei H4-11 and Kluyveromyces marxianus L1-1 under co-cultivation conditions by Na Liu, Likang Qin, Haiying Zeng, Anyan Wen, Song Miao

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Associations of the Need for Surgery in Emergency Department Patients with Small Bowel Obstructions by Daniel J. Berman, Alexander W. Mahler, Ryan C. Burke, Andrew E. Bennett, Nathan I. Shapiro, Leslie A. Bilello

“…Objectives: Management strategies for small bowel obstruction (SBO) vary from conservative approaches to surgical intervention. A known complication of surgery is the subsequent adhesions that can cause recurrent SBOs, longer hospital stays, and higher treatment costs. …”
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F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1. by Zhongjiao Liu, Kexuan Ma, Panpan Zhang, Siqi Zhang, Xin Song, Yuqi Qin

“…Most of PoFbx23 is present in free form within the nucleus. A small portion of PoFbx23 associates with Skp1 to form PoFbx23-Skp1 heterodimer or assembles with the three invariable core components (Skp1, Cul1, and Rbx1) of SCF to form the SCFFbx23 complex. …”
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dataFishing: An efficient Python tool and user-friendly web-form for mining mitochondrial and chloroplast sequences, taxonomic, and biodiversity data by Luan Rabelo, Davidson Sodré, Oscar David Albito Balcázar, Murilo Furtado do Rosário, Aurycéia Jaquelyne Guimarães-Costa, Grazielle Gomes, Iracilda Sampaio, Marcelo Vallinoto

“…Moreover, it allows the retrieval of DNA sequences, common names, synonyms, conservation status, and species occurrence points. This tool is free and will enable a more systematized and time-efficient search, which tends to facilitate such data inquiries.…”
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Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors by Estela Regina Ramos Figueira, Julia Fray Ribeiro, Thiago Costa Ribeiro, Ricardo Jureidini, Guilherme Naccache Namur, Thiago Nogueira Costa, Telesforo Bacchella, Ivan Cecconello

“…The median TNM stage was IIa (range, I–IV). The disease-free and patient survival rates were 87.5% and 100% at 3 years and 43.75% and 75% at 10 years, respectively. …”
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Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…Previously established tumoroid lines were also transitioned to OncoPro medium and exhibited, on average, similar growth rates and conserved donor-specific characteristics when compared to original media systems. …”
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In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

“…Surface-exposed proteins that were antigenic, non-allergenic, and non-homologous to human proteins were selected for further analysis. The conserved domains of the selected proteins were analyzed, and their presence was examined across 68 genomes. …”
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ApWD40a, a Member of the WD40-Repeat Protein Family, Is Crucial for Fungal Development, Toxin Synthesis, and Pathogenicity in the Ginseng Alternaria Leaf Blight Fungus <i>Alternari... by Jinling Lan, Shengjie Mei, Yingxue Du, Meili Chi, Jiayi Yang, Shuliu Guo, Mingliang Chu, Ronglin He, Jie Gao

“…WD40 repeat-containing proteins are evolutionarily conserved proteins with diverse functions between different organisms. …”
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TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…Additionally, loss of p63γ shortens the lifespan of tumor-free mice potentially via increased cellular senescence. …”
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Widely Targeted Metabolomics Analysis Reveals Key Quality-Related Metabolites in Kernels of Sweet Corn by Ruichun Yang, Yunfeng Li, Yuanyuan Zhang, Jun Huang, Junjie Liu, Zimei Lin, Qinqin Yu, Aimin Wu, Bo Wang

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Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress by Chao Du, Xinyu Ni, Mengjiao Yan, Qinghan Meng, Junying He

“…Levels of hydrogen peroxide and oxygen free radicals remained relatively stable under osmotic stress. …”
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Building a near-infrared (NIR) soil spectral dataset and predictive machine learning models using a handheld NIR spectrophotometerZenodo by Colleen Partida, Jose Lucas Safanelli, Sadia Mannan Mitu, Mohammad Omar Faruk Murad, Yufeng Ge, Richard Ferguson, Keith Shepherd, Jonathan Sanderman

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Temperature Is a Key Factor Affecting Total Phosphorus and Total Nitrogen Concentrations in Northeastern Lakes Based on Sentinel-2 Images and Machine Learning Methods by Haoming Qin, Chong Fang, Ge Liu, Kaishan Song, Zhuoshi Li, Sijia Li, Hui Tao, Zhaojiang Yan

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Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1... by Wangcheng Hu, Hui Luo, Yuekun Yang, Qiong Wang, Ni Hong, Guoping Wang, Aiming Wang, Liping Wang

“…To investigate the role of RNA-silencing in B. dothidea defense, we constructed four small RNA libraries and sequenced B. dothidea micro-like RNAs (Bd-milRNAs) produced in response to BdCV1 and BdPV1 infection. Among these, 167 conserved and 68 candidate novel Bd-milRNAs were identified, of which 161 conserved and 20 novel Bd-milRNA were differentially expressed. …”
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Soil porosity as a key factor of soil aggregate stability: insights from restricted grazing by Yi Yang, Yi Yang, Yi Yang, Zhongju Meng, Zhongju Meng, Zhongju Meng, Haonian Li, Haonian Li, Haonian Li, Yue Gao, Yue Gao, Yue Gao, Tianyang Li, Tianyang Li, Tianyang Li, Lei Qin

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Spatial predictors of landowners' engagement in the restoration of the Brazilian Atlantic Forest by Thomas Pienkowski, Anna Freni Sterrantino, Anazelia M. Tedesco, Matt Clark, Pedro H. S. Brancalion, Arundhati Jagadish, Alex Mendes, Ludmila Pugliese de Siqueira, Morena Mills

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Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

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