Regression of left ventricular hypertrophy in patients with resistant hypertension after renal denervation: the role of hemodynamic and antifibrotic effects by E. I. Solonskaya, O. V. Mochula, V. F. Mordovin, I. V. Zyubanova, M. A. Manukyan, V. A. Lichikaki, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, A. М. Gusakova, S. Kh. Arsanova, K. V. Zavadovsky, A. Yu. Falkovskaya

“…After 1 year, a significant decrease in the levels of hsCRP from 2,05 (1,04; 3,28) to 1,64 (0,96; 2,25) mg/l (p=0,045) and MMP-2 from 278,2 (240,9; 353,4) to 265,2 (221,2; 293,2) ng/ml (p=0,018) was detected. There was a trend towards an increase in TIMP-1 and a decrease in MMP-9. …”
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Classifying Dry Eye Disease Patients from Healthy Controls Using Machine Learning and Metabolomics Data by Sajad Amouei Sheshkal, Morten Gundersen, Michael Alexander Riegler, Øygunn Aass Utheim, Kjell Gunnar Gundersen, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Hugo Lewi Hammer

“…Metabolomics, a method for analyzing biological systems, has been found helpful in identifying distinct metabolites in patients and in detecting metabolic profiles that may indicate dry eye disease at early stages. …”
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Photosynthetic pigments and phenolic potential of Rhodiola rosea L. from plant communities of different ecology and geography by Sergeeva Irina Yu., Zaushintsena Alexandra V., Bryukhachev Evgeniy N.

“…The photosynthetic pigments were detected using the spectrophotometric method. The obtained data underwent a statistical analysis based on Statistica 6.0 software. …”
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Painting the Portrait of Fibro-osseous Lesions: An In-vitro Study on Staining Duel of Modified Gallego versus Hematoxylin and Eosin (H&E) Staining by Akash Shegaonkar, Shilpa Patel, Jigna Pathak, Niharika Swain, Rashmi Hosalkar, Rutuj Waghmare

“…Introduction: Oral cavity tumours involve a mix of soft and hard tissues, with varying levels of calcification posing diagnostic challenges. Detecting the presence or absence of calcification in connective tissue tumours, whether central or peripheral, benign or malignant, is particularly challenging. …”
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Molecular characterization and expression profiles of cytochrome P450 reductase gene in Sogatella furcifera (Hemiptera: Delphacidae) by YU Hang, LIU Su, ZHU Qingzi, ZHOU Wenwu, LIANG Qingmei, SHI Xiaoxiao, ZHU Zijie, ZHU Zengrong

“…Real-time quantitative PCR showed that the expression of SfCPR was detectable in all developmental stages and the level in adults was the highest. …”
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Anxiety-depressive syndrome in patients with arterial hypertension and chronic obstructive pulmonary disease with frequent exaccations by L. A. Shpagina, I. S. Shpagin, L. D. Khidirova, A. A. Vasilenko

“…To reveal psychosomatic features of the course of arterial hypertension in chronic obstructive pulmonary disease with frequent exacerbations.Materials and methods. …”
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Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits by Ashiq Hussain, Salah Laaraj, Tusneem Kausar, Aziz Tikent, Hanane Azzouzi, Samina Kauser, Qurat Ul An, Aqsa Iqbal, Saima Akram, Rizwan Nisar, Ayesha Najam, Haya Fatima, Shazia Yaqub, Kaoutar Elfazazi

“…In the current work, orange seed powder replaced wheat flour at 0, 2.5, 5, 7.5, and 10% levels, to observe changes in physicochemical features of developed biscuits. Proximate analysis of orange seed powder and wheat flour revealed that orange seed powder has high fat, fiber, protein, and ash contents as compared to wheat flour, whereas moisture contents in wheat flour were high. …”
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Clinical implications of proximal tubular multicilia in glomerular diseases by Bohye Kim, Boram Weon, Evonne Kim, Sohee Park, Wencheng Jin, Nayeon Shin, Yun Kyu Oh, Chun Soo Lim, Jung Pyo Lee, Obin Kwon, Jeonghwan Lee

“…The relationship between the MCC ratio and kidney disease-related clinical features was then analyzed. Results: MCCs were exclusively detected in patients with glomerular diseases (68.3 %), not those in the control group. …”
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Langerhans cells infiltration in lymph nodes of patients with systemic lupus erythematosus by Lei Li, Chengde Yang, Yue Yang, Jialin Teng, Hui Shi, Yuying Fan, Jing Lv, Haoyu Pan, Jinyi Qian, Yingjie Jiang, Qianchen Ma, Xiaohan Wei, Zhixia Yang, Shuyi Yu, Aifei Zhang

“…Immunohistochemical analysis revealed a scattered (58.6%) or focal (41.4%) distribution of LCs. …”
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HEROIC: a 5-year observational cohort study aimed at identifying novel factors that drive diabetic kidney disease: rationale and study protocol by Neil Ashman, Ben Caplin, David Wheeler, Tahseen Ahmad Chowdhury, Kieran Mccafferty, Sinead Knight, Paul Hockings, Stanley L Fan, Johannes Hulthe, Robert Kleta, Vasilios Papastefanou, Hemal Mehta, Alan Salama, Sinela Hadzovic, Lisa Jarl, Robert Unwin, Benjamin Challis, Anna K Sundgren, Muhammad Magdi Yaqoob

“…Our primary objective is to identify histological features of DKD associated with kidney endpoints in a cohort of patients diagnosed with type 1 and type 2 DM, proteinuria and kidney impairment.Methods and analysis HEROIC is a longitudinal observational study that aims to recruit 500 patients with DKD at high-risk of renal and cardiovascular events. …”
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Molecular mechanism of DdSOC1 gene regulating flower bud initiation in Diospyros deyangensis by WAN Jianqi, DING Yu, REN Han, LI Wenxia, YANG Yong, HUANG Jinmeng, GUAN Changfei

“…QRT-PCR was used to examine the expression features of DdSOC1. On the one-deficient and three-deficient plates, the self-toxicity and self-activation of DdSOC1 were explored. …”
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A Novel Perspective on Tubular C4d Positivity in BK Polyomavirus Nephropathy by Tong Wu, Fangzhou Guo, Shicong Yang, Zeying Jiang, Xianghong He, Qihua Wang, Zhixin Huang, Jue Wang, Zhenyu Xu, Meiyi Song, Xiaotao Hou, Gang Huang, Wenfang Chen

“…C4d was assessed using immunohistochemistry (IHC) and compared with frozen tissue to evaluate its correlation with clinicopathological features. Immunofluorescence (IF) for Ig and complement components and electron microscopy were performed to assess complement activation. …”
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Elucidating the interplay between metabolites and microorganisms in the spermosphere of common bean (Phaseolus vulgaris L.) seeds by Chandrodhay Saccaram, Marie Simonin, Stéphanie Boutet, Céline Brosse, Shuang Peng, Tracy François, Boris Collet, François Perreau, Delphine Sourdeval, Coralie Marais, Matthieu Barret, Loïc Rajjou, Massimiliano Corso

“…Through an integrated approach, we explored the metabolomic and microbiota composition in the spermosphere of germinating common bean seeds and elucidated their environmental and genotype regulation. We detected and analyzed 2,467 metabolite features (Mf) through untargeted metabolomics categorized into fourteen metabolic categories, highlighting the prevalence of amino acids, flavonoids, and terpenoids. …”
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High Trop-2 expression in pulmonary sarcomatoid carcinoma reveals antibody–drug conjugate targeting Trop-2 is a promising therapeutic approach by Xiaoying Qian, Chuanhong Luo, Chen Fang, Yongbin Wu, Weiwei Hong, Biao Yu, Guizhen Qin, Yan Yin, Xinyuan Yao, Xin Ye, Bingbiao Zhou, Chengsi Shu, Dengying Chen, Zhaoqing Li, Shanshan Wang, Yong Wang, Yong Li

“…Materials and methods Surgical tissue specimens diagnosed with PSC from January 2015 to May 2023 were retrospectively collected to detect Trop-2 expression using immunohistochemistry. …”
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The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…The most promising extract was subjected to GC–MS analysis to determine the phytochemical composition. …”
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Characterization of the small RNAs carried by outer membrane vesicles produced by hlyF-positive Shiga toxin-producing Escherichia coli by Giorgia Barbieri, Giorgia Barbieri, Alessia Stefano, Agostina Pietrantoni, Federica Fratini, Serena Cavallero, Rosangela Tozzoli, Paola Chiani, Arianna Boni, Stefano Morabito, Valeria Michelacci

“…The OMVs collected were analyzed by Nanoparticle Tracking Analysis (NTA) and Electron Microscopy (EM) to define their morphology, size and concentration. …”
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Hederasaponin C ameliorates chronic obstructive pulmonary disease pathogenesis by targeting TLR4 to inhibit NF-κB/MAPK signaling pathways by Yujie Ning, Liting Huang, Qin-Qin Wang, Lina Liu, Xinghua Ni, Xiaoyun Xie, Jingyu Liu, Qian Su, Shilin Yang, Renyikun Yuan, Hongwei Gao

“…Binding affinity between HSC and TLR4 was evaluated using molecular docking, SPR analysis, and CETSA. DNA methylation at MUC-5B chr11:1243469 position was detected using an Agilent 2100 Bioanalyzer. …”
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Aquaporins modulate the cold response of Haemaphysalis longicornis via changes in gene and protein expression of fatty acids by Han Wang, Ruwei Bai, Tingwei Pei, Jianglei Meng, Chuks F. Nwanade, Yuchao Zhang, Xiujie Liang, Yunsheng Tang, Jingze Liu, Zhijun Yu

“…Quantitative real-time PCR (qPCR) was used to detect different expressions of H. longicornis genes under different cold treatment conditions. …”
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Metallurgical Waste for Sustainable Agriculture: Converter Slag and Blast-Furnace Sludge Increase Oat Yield in Acidic Soils by Olga V. Zakharova, Peter A. Baranchikov, Svetlana P. Chebotaryova, Gregory V. Grigoriev, Nataliya S. Strekalova, Tatiana A. Grodetskaya, Igor N. Burmistrov, Sergey V. Volokhov, Denis V. Kuznetsov, Alexander A. Gusev

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Peri-coronary adipose tissue attenuation and its association with plaque vulnerability and clinical outcomes in coronary artery disease using combined CCTA and OCT by Caifeng Yang, Chancui Deng, Jie Xia, Sha Wang, Long Zhang, Zhijiang Liu, Wei Zhang, Yi Deng, Shiwan Lu, Guanxue Xu, Bei Shi

“…In conclusion, the high-attenuation group exhibited more OCT-detected features indicative of vulnerable plaques and a higher frequency of MACE events relative to the low-attenuation group. …”
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