Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem Cell/Human Umbilical Vein Endothelial Cell Com... by Xiayi Wu, Chunxin Xu, Junming Feng, Shiyu Wu, Runheng Liu, Wei Qiao, Xin Luo, Shoucheng Chen, Zhipeng Li, Zhuofan Chen

“…The extraction solutions of FPHA0.25 and FPHA0.50 promoted the formation of capillary-like tubes by human umbilical vein endothelial cells (HUVECs), with FPHA0.25 significantly upregulating <i>vegf</i> mRNA and VEGF protein levels in co-cultured human bone marrow mesenchymal stem cells (HBMSCs). …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Patients reported low confidence in their ability to recover, and a need for more continuity in their care. …”
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Advances and applications of empirical mode decomposition and its variants in hydrology: A review by CHEN Yunfei, LIU Zuyu, LIU Xiuhua, HE Junqi, ZHENG Ce, MA Yandong

“…Empirical Mode Decomposition (EMD) has garnered increasing attention due to its ability to analyze non-linear and non-stationary data. …”
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7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B by Fengxiao Hao, Fengxiao Hao, Mengnan Zeng, Mengnan Zeng, Bing Cao, Bing Cao, Xiwen Liang, Zhiyou Hao, Zhiyou Hao, Kaili Ye, Kaili Ye, Xinmian Jiao, Xinmian Jiao, Weisheng Feng, Weisheng Feng, Xiaoke Zheng, Xiaoke Zheng

“…Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline. 7-α-O-Methylmorroniside (MorA), an iridoid glycoside extracted from Cornus officinalis Sieb. et Zucc., has been shown to have neuroprotective effects, but the mechanism of its anti-AD effect has not been clarified. …”
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Cathepsin-K Targeted by Sanggenol L Induces Lethal Autophagy through ROS-Dependent AMPK/mTOR Signaling in Gastric Cancer by Kui Zhang, Xin Hu, Jingjing Su, Guangzhao Pan, Abhimanyu Thakur, Natalia Baran, Anne Dijkstra, Isha Gaurav, Zhijun Yang, Hongjuan Cui

“…Methods: The study delved into the antitumor characteristics of Sanggenol L, a natural derivative extracted from the root bark of mulberry (Morus alba L.) trees. …”
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APPLICATION OF LEUKOCYTE FILTERS TO OBTAIN A PREPARATION OF CYTOKINE-INDUCED KILLER CELLS by Yu. V. Gelm, L. Yu. Grivtsova, E. V. Sayapina, N. S. Semenova, T. Yu. Mushkarina, S. A. Ivanov, A. D. Kaprin

“…AbstractThe ability of CIK cells to recognize and lyse tumor cells has been demonstrated in preclinical studies in vitro. …”
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Lactiplantibacillus plantarum (CECT7484 and CECT7485) and Pedioccoccus acidilactici (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability al... by Maria Raffaella Barbaro, Francesca Bianco, Cesare Cremon, Giovanni Marasco, Francesca Bonomini, Marta Palombo, Cecilia Delprete, Marta Perez, Jordi Espadaler-Mazo, Vincenzo Stanghellini, Simone Guglielmetti, Giovanni Barbara

“…Paracellular permeability was assessed by evaluating the amount of sulfonic-acid-conjugated to fluorescein passing through the Caco-2 monolayer. RNA was extracted from Caco-2 cells and used to perform qPCR analyses, to evaluate the expression of ZO-1 and β-actin, and RNAseq to evaluate the transcriptomic profile. …”
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Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis by Marc Kaethner, Pascal Zumstein, Joachim Müller, Matías Preza, Philipp Grossenbacher, Anissa Bartetzko, Laura Vetter, Martin Lochner, Stefan Schürch, Clement Regnault, Daniel Villalobos Ramírez, Britta Lundström-Stadelmann

“…EmTDH was enzymatically active in metacestode vesicle extracts. The compounds disulfiram, myricetin, quercetin, sanguinarine, and seven quinazoline carboxamides were evaluated for their ability to inhibit recombinantly expressed EmTDH. …”
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Exploring the Correlation between GCSI Score and GES in Type 2 Diabetic Patients—Proposing a GCSI Cut-off Score for Guiding GES Utilization: A Record-centric Research Approach by Rifika Bansal, Ravi Kant, Vandana K Dhingra, Manisha Naithani, Mukesh Darshan, Mukesh Bairwa, Ashwin Parchani, Balachandra Routhu

“…Gastroparesis cardinal symptom index scores, laboratory parameters, and GES findings were extracted from the records. Data analysis was done utilizing Chi-square tests and correlation coefficients with <i>p</i> < 0.05 considered statistically significant. …”
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Evaluasi Kinerja MLLIB APACHE SPARK pada Klasifikasi Berita Palsu dalam Bahasa Indonesia by Antonius Angga Kurniawan, Metty Mustikasari

“…The four algorithms were chosen because of their proven ability to classify and several algorithms that are rarely used but have good abilities in terms of classification. …”
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How do we measure dysarthria after stroke? A systematic review to guide the core outcome set for dysarthria by Jamie J Kirkham, Claire Mitchell, Audrey Bowen, Joshua Cheyne, Paul Conroy, Sabrina El Kouaissi, Martha Duncan-Zaleski, Brooke-Mai Whelan, Sarah J Jane Wallace

“…Psychometric data were extracted, by two authors, from included studies and methodological quality was evaluated using Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) and Core Outcome Measures in Effectiveness Trials (COMET) guidance. …”
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A study on early diagnosis for fracture non-union prediction using deep learning and bone morphometric parameters by Hui Yu, Qiyue Mu, Zhi Wang, Yu Guo, Jing Zhao, Guangpu Wang, Qingsong Wang, Xianghong Meng, Xiaoman Dong, Shuo Wang, Jinglai Sun

“…On day 14, the early diagnosis model achieved an AUC of 0.995, demonstrating its ability to diagnose fracture non-union during the soft-callus phase.ConclusionThis study proposed the VM-TE-UNet for fracture areas segmentation, extracted micro-CT indices, and established an early diagnostic model for fracture non-union. …”
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Integrative radiomics of intra- and peri-tumoral features for enhanced risk prediction in thymic tumors: a multimodal analysis of tumor microenvironment contributions by Liang zhu, Jiamin Li, Xuefeng Wang, Yan He, Siyuan Li, Shuyan He, Biao Deng

“…A custom Python algorithm was then used to automatically expand the peri-tumoral area, extracting features within 1 mm, 2 mm, and 3 mm zones surrounding the tumor. …”
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Pharmacokinetics and tissue distribution analysis of ginsenoside Rh3 in rats using a novel LC-MS/MS quantification strategy by Cong Hu, Cong Hu, Yuheng Wang, Yu Liu, Xiaojing Wang, Peifang Song, Hong Ma, Ling Yang, Ling Yang

“…Tissue samples (intestine, stomach, liver, brain, etc.) were collected at the time corresponding to the maximum plasma concentration for distribution analysis.Results:The LC-MS/MS method showed excellent precision, accuracy, and extraction recovery (≥ 85%), with minimal matrix effects. …”
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Comparative Genomics of Rhamnolipid Synthesis and Monoaromatic Hydrocarbon Tolerance Genes in Environmental Pseudomonas aeruginosa strains [version 2; peer review: 2 approved] by Sandro B. Martel-Torres, Camila Castillo-Vilcahuaman, ROGER A. PALOMINO HUARCAYA, Susana M. Gutiérrez Moreno, Fernando A. Merino Rafael

“…Each strain were able to degrade hydrocarbon and tolerate heavy metals. DNA extraction, sequencing, and quality-controlled assembly, functional genome annotation was performed using BAKTA. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…IntroductionWhile the adjustment of intracranial volume (ICV) is reported to have a significant influence in the outcomes of the analyses of brain structural measures, our study offers a paradigm shift, positing that adjusting for lateral ventricle (LV) inter-individual variability may reveal more atrophic patterns that might be overlooked in analyses without this adjustment,—and such LV-adjusted atrophic patterns may reduce discrepancies observed in earlier studies and better elucidate complex conditions associated with HIV, such as HAND.MethodsTo test this hypothesis, we employed a number of adjustment strategies on MRI T1-image-derived data extracted using deep learning models and compared their ability to identify the presence and extent of HIV-specific atrophic patterns based on statistical measures and strength.ResultsOur results show that both ICV adjustments may be effective to identify atrophic patterns associated with either aging or HIV in areas of the thalamus, basal ganglia, ventral DC and lateral ventricle, some of which may be overlooked without these adjustments. …”
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Engineered bone-targeting apoptotic vesicles as a minimally invasive nanotherapy for heterotopic ossification by Like Tang, Yuchen Wang, Shihua Mao, Zhou Yu, Yitong Chen, Xiaoqiao Xu, Wenjin Cai, Kaichen Lai, Guoli Yang, Tingben Huang

“…Briefly, apoEVs were extracted from hard palate mucosa and engineered with bone-targeting peptide SDSSD to treat HO. …”
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Neutrophil membrane-coated PLGA nanoparticles promoting the repair of myocardial ischemia-reperfusion injury in mice by Jing CHEN, Yanan SONG, Zheyong HUANG, Junbo GE

“…Neutrophil membranes were extracted and fused with PLGA nanoparticles to construct biomimetic Neu-NP. …”
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Evaluation of Shear Bond Strength and Marginal Adaptation of Calcium Silicate-based Cements and Premixed Bioceramics When Restored with Glass Ionomer Cement: An <i>In Vitro</i> Stu... by Megha C Patel, Malayka H Shah, Disha Makwani, Khushi Rathod, Sarchi Patel, Prachi Patel

“…The biocompatibility, sealing ability, and adaptability of these materials to the overlying restoration play an important role in the outcome of pulpotomy. …”
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Prediction of solid pseudopapillary tumor invasiveness of the pancreas based on multiphase contrast-enhanced CT radiomics nomogram by Dabin Ren, Liqiu Liu, Aiyun Sun, Yuguo Wei, Tingfan Wu, Yongtao Wang, Xiaxia He, Zishan Liu, Jie Zhu, Guoyu Wang

“…In addition, the radiomics nomogram combining radiomics signature and traditional CT signs can further improve classification ability.…”
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