IoC2 monitoring versus standard practice in reducing opioid consumption in elderly patients undergoing laparoscopic colorectal surgery: a study protocol for a randomised controlled... by Zhe Li, Jing Zhao, Xiaowen Liu, Huamei Cai, Yun Yan

“…While these technologies show promise in initial applications, the effectiveness of IoC2 in guiding pain management during anaesthesia, particularly in elderly patients who require precise opioid use, remains unclear. This study aims to evaluate the effectiveness of IoC2 in guiding intraoperative opioid use in elderly patients.Methods and analysis We will conduct a prospective, randomised, controlled, single-blind, single-centre study with recruitment carried out from 1 February to 30 November 2025. …”
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Delving into female breast cancer: Distinct disease-specific survival outcomes between invasive lobular and ductal carcinomas revealed by propensity score matching. by Wu Zhang, Yuquan Huang, Ye Zhou, Jiaojiao Xue, Shan Gao, Lin Kang, Jian Shi, Tao Zhou, Yalong Duan, Sihan Guo, Qingxia Li

“…<h4>Results</h4>Following PSM, the covariate differences between the IDC and ILC groups were significantly reduced. The survival analysis revealed a significantly better prognosis for the IDC group than the ILC group (Log-rank test p < 0.001), with a 28.0% increased risk observed in the ILC group.…”
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Single cell transcriptomics in blood of patients with chronic obstructive pulmonary disease by Yeonjeong Heo, Jeeyoung Kim, Seok-Ho Hong, Woo Jin Kim

“…We compared the scRNA-seq data between the COPD and control groups using computational analysis. …”
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Mapping mad maps and recovery tools developed by mental health service users and survivors of psychiatry: a scoping review by Hernán María Sampietro, Viviana R Carmona, J Emilio Rojo, J Gómez-Benito

“…All of them, but one, evaluated group workshops implementations. The most common objective was to evaluate symptom improvement. …”
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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

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Risk Factors of Diarrhoea among Children Under Five Years in Southwest Nigeria by Harriet U. Ugboko, Obinna C. Nwinyi, Solomon U. Oranusi, Fasina F. Fagbeminiyi

“…The majority of the mothers belonged to the age group 30–34. Multivariate analysis showed that the mother's level of education (95% CI for OR = 11.45; P=0.0001) and family income (95% CI for OR = 7.61, P=0.0001) were the most significant risk factors for diarrhoea among children. …”
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Metacognitions of substance-addicted patients compared to individuals without a diagnosis of a psychiatric disorder by Huseyin Unubol, Havva Ozen

“…The Kolmogorov-Smirnov distribution test was used for evaluating whether the data conform to a normal distribution. …”
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Primary sources in online history learning: enhancing engagement and retention by Fahruddin Fahruddin, Arif Saefudin

“…The data analysis employed descriptive statistics, ANOVA to examine differences in engagement levels, and the Kruskal-Wallis test to evaluate retention scores. …”
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The impact of teaching approach on horse and rider biomechanics during riding lessons by Anna Byström, Agneta Egenvall, Marie Eisersiö, Maria Terese Engell, Sigrid Lykken, Susanne Lundesjö Kvart

“…The teachers were interviewed, teacher-student interactions were analysed using conversation analysis. Biomechanical data were analysed in mixed models.S1 and N2 spent about a third of their lessons preparing the students while S2 and N1 began with straight-line walk-trot transitions early on. …”
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Differences between frequent emergency department users in a secondary rural hospital and a tertiary suburban hospital in central Japan: a prevalence study by Makoto Kaneko, Masashi Okubo, Michael D Fetters, Machiko Inoue, Allison K Cullen Furgal, Benjamin F Crabtree

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Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting by Mekonnen Feyissa Senbu, Dereje Gulilat, Hiwot Tadesse Habtamu

“…Methods and materials A retrospective study was conducted on 112 patients who underwent pneumonectomy. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) version 25. …”
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Implementing injury prevention training in youth handball (I-PROTECT) in Sweden: study protocol for a cluster randomised trial by Per Nilsen, Alex Donaldson, Eva Ageberg, Sofia Bunke, Jennie Linnéll, Karin Moesch, Karolina Lucander, Axel Ström, Robert Wedberg, Per Ekberg

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Alternative healthcare delivery arrangements in Nepal: a systematic review of comparative effectiveness, safety and cost-effectiveness studies by Rachelle Buchbinder, Shyam Sundar Budhathoki, Denise A O’Connor, Ilana Ackerman, Pramila Rai

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Comparison of glycosylated fibronectin versus soluble fms-like tyrosine kinase/placental growth factor ratio testing for the assessment of pre-eclampsia: protocol for a multicentre... by Marcus Green, Chao Wang, Sarah Fisher, Amarnath Bhide, Ramesh Ganapathy, Basky Thilaganathan, Nouran Elbarbary

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Association between visceral adiposity index and prostate cancer in men aged 40 years and older: a nationwide cross-sectional study by Wentao Yao, Jiacheng Wu, Hongzhi Wang, Zongming Jia, Yinyi Zhou, Chendi Yang, Feng Xu, Ying Kong, Yuhua Huang

“…Objectives This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.Methods Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. …”
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The use of topical antiseptic solutions in the healing process of post-surgical skin wounds in dogs (Canis lupus familiaris) by Thomás Souza e Silva, Soke Gninlome Cedril Hounkonnou, Hiasmin Marcia de Souza Lima, Joana Luiza Crispiano Cunha Santos, Fábio de Souza Mendonça, Rinaldo Florencio-Silva, Ricardo dos Santos Simões, Fabrício Bezerra da Sá, Joaquim Evêncio-Neto

“…Data were subjected to statistical analysis (p 0.05) Results: No significant differences in the macroscopic evaluation of the wounds and hematological parameters were observed among groups, in the healing of clean elective surgical wounds. …”
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Predictors of Young Adult Women’s Psychological Well-Being in Romantic Relationships by Elif Yöyen, Süreyya Çalık, Tülay Güneri Barış

“…Independent group <i>t</i>-test, one-way analysis of variance (ANOVA), Pearson correlation analysis, and regression analysis were used to analyse the data. …”
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Revealing the role of natural killer cells in ankylosing spondylitis: identifying diagnostic biomarkers and therapeutic targets by Yuling Chen, Yan Li, Yuan Xu, Qing Lv, Yuanchun Ye, Jieruo Gu

“…The diagnostic value of the identified key genes was evaluated using ROC curves, logistic regression analysis, and a nomogram. …”
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Supervised Injecting Room Cohort Study (SIRX): study protocol by Lisa Maher, Thomas Kerr, Matthew Hickman, Alexander Thompson, Peter Higgs, Paul Dietze, Paul A Agius, Nick Scott, Daniel O’Keefe, Mark A Stoové, Jack Stone, Dylan Vella-Horne, Ashleigh C Stewart, Amanda Roxburgh, Sione Crawford, Josephine Norman, Zachary Lloyd, Nico Clark

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Psychotropic medications: a descriptive study of prescription trends in Tabriz, Iran, 2021–2022 by Mostafa Farahbakhsh, Ali Fakhari, Ali Azimian, Amin Khameneh, Mahsa Matinkia, Ehsan Aghajani

“…We analyzed prescriptions in Tabriz from March 2021 to March 2022. Prescription data were categorized by medication category, physician specialty, age group, and sex. …”
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