Costs of Potential Medication Wastage Due to Switching Treatment Among People With Multiple Sclerosis by Darin T. Okuda, Achal Patel, Robert Schuldt, Ibraheem Abioye, Nicole G. Bonine

“…**Background:** Unused medications negatively impact healthcare resource utilization and environmental safety, contribute substantially to annual healthcare expenditures, and may ultimately affect patient health outcomes. …”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…Furthermore, E6020 is a single molecule, well-characterized fully synthetic TLR4 agonist constructed in eight synthetic steps from entirely crystalline starting materials and intermediates via an optimized high-yield synthetic route. …”
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Working Capital Management Practices and Performance of Small and Medium Enterprises in Western Uganda. by Sunday, Arthur, Turyahebwa, Abanis, Byamukama, Eliab Mpora

“…Small and medium Enterprises (SMEs) are the drivers of Ugandan economy; they are the engine of growth for the economic development, innovation, spur economic prosperity and wealth creation of Uganda. …”
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Assessing the Use of Crushed Rock Aggregate and Carbon Black for Laterite Soil Stabilization in Road Construction. by Turyamureeba, Emmanuel

“…The crushed rock aggregates of size ranging from 0.075mm-10mm were obtained from the hipped quarry at the faculty of engineering which is about 2km from Kabale town off Kabale-Kisoro Road. …”
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…Methods We performed RNA-sequencing (RNA-seq) on RWPE1 cells engineered to express ANO7 protein, alongside the analysis of a single-cell RNA-sequencing (scRNA-seq) dataset and RNA-seq from prostate tissues. …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

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Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting by Mekonnen Feyissa Senbu, Dereje Gulilat, Hiwot Tadesse Habtamu

“…Abstract Background Pneumonectomy, the surgical removal of an entire lung, was first performed in 1933 by Evarts A. …”
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Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018 by WenYi Xu, Li Zhang, Li Zhang, QianKun Yang, Ying Cao, Rui Rao, Li Lv, Qin Cen, Qiong Wei, LuLing Yang

“…In the fully-adjusted Cox regression model, in the entire cohort, higher PNI (≥46.5) was significantly associated with reduced risks for all-cause and CVD mortality. …”
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Temporal trends in guideline-recommended medical therapy after an acute heart failure decompensation event: an observational analysis from Generator Heart Failure DataMart by Antonio Gasbarrini, Giuseppe Patti, Filippo Crea, Giovanni Scambia, Domenico D'Amario, Vincenzo Valentini, Gianluigi Savarese, Alfredo Cesario, Jacopo Lenkowicz, Stefano Patarnello, Renzo Laborante, Agni Delvinioti, Andrada Mihaela Tudor, Chiara Iacomini, Antonio Iaconelli, Donato Antonio Paglianiti, Mattia Galli, Daniele Rodolico, Attilio Restivo, Giuseppe Ciliberti, Gaetano Rizzo, Emiliano Bianchini, Matteo Busti, Luca Sensini

“…Objectives To evaluate the trend of prescription of the four foundational therapies, and their impact on 30-day urgent re-admissions and all-cause death in patients with heart failure and reduced ejection fraction (HFrEF) following an acute decompensation event.Design Retrospective.Setting One tertiary referral centre.Participants 999 consecutively patients admitted with a primary diagnosis of HFrEF between January 2020 and June 2023 were identified through a validated, high‐performance technology infrastructure based on artificial intelligence. The entire cohort was divided into three time periods based on two time points: September 2021 (ie, the release of the latest European guidelines) and January 2022 (ie, reimbursement for sodium-glucose cotransporter 2 (SGLT2) inhibitors).Primary and secondary outcome measures Trends and predictors of the prescription of each of the four foundational therapies and of the composite of all-cause death and rehospitalisation for urgent causes at 30 days.Results Among the 999 included patients, β-blockers were prescribed in 93% of patients, ACE inhibitor (ACEi)/angiotensin receptor blocker (ARB)/angiotensin–neprilysin receptor inhibitor (ARNi) in 73%, mineralocorticoid receptor antagonist in 30% and SGLT2 inhibitors in 18%. …”
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China’s CBM exploration and production and associated technological advancements: A review and reflections by Jianping YE

“…Recent years have seen major advances in the accumulation mechanisms and modes of deep CBM, assessment methods for CBM exploration and production, and knowledge about CBM production regularity. The geology-engineering integration serves as an effective method for the prediction and assessment of play fairways, well deployment, and the research and development of adaptive technologies. …”
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FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

“…We utilized a random walk-based technique to discern genes associated with ossification. …”
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A dehazing and enhancement algorithm for heterogeneous images of underground mining environments in coal mines by Xuhui ZHANG, Yanbin XIE, Wenjuan YANG, Chao ZHANG, Jicheng WAN, Zheng DONG, Yanqun WANG, Jie JIANG, Long LI

“…The results indicate that compared to the above novel and excellent algorithms in terms of their optimal indicators, the proposed algorithm exhibited that: (1) The average gradients were approximately twice those obtained by CEEF, suggesting elevated image clarity. (2) The average information entropy decreased by approximately 1% compared to that of MRP, implying more information preserved. (3) The standard deviation increased by approximately 6% on average compared to OSFD, representing improved image contrast. (4) The average fog aware density evaluator (FADE) value by approximately 23% compared to CEEF, implying an effective reduction in the haze Therefore, the proposed algorithm can effectively improve the visual effects and quality of blurred images of underground mining environments in coal mines, exhibiting high utility in engineering.…”
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A novel TID + IDN controller tuned with coatis optimization algorithm under deregulated hybrid power system by Geetanjali Dei, Deepak Kumar Gupta, Binod Kumar Sahu, Mohit Bajaj, Vojtech Blazek, Lukas Prokop

“…Abstract Implementing a suitable load frequency controller to maintain the power balance equation for a multi-area system with many power generating units poses a challenge to a power system engineer. Incorporation of renewable energy sources along with non-renewable units is another challenge while maintaining the stability of the system. …”
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Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator by Rahma Aly, Shoukath Sulthana, Robert Beaudoin, Ayman K. Hamouda, Santosh Aryal

“…A biodegradable and biocompatible, the US-FDA-approved, poly(l-lactic-co-glycolic) acid (PLGA) was used to engineer nanoparticles (NPs) to solubilize CMPI in its hydrophobic core in an aqueous environment using the nanoprecipitation with the drug loading content of 10 ± 1.2% by weight of NPs. …”
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Genome Characteristic of NDM-5-Producing Klebsiella Quasipneumoniae and Klebsiella Pneumoniae in China by Chen L, Liu R, Ye H, Qian J, Lou D

“…Lifeng Chen,1,* Ruishan Liu,2,3,* Haowei Ye,2 Jiajie Qian,4 Danfeng Lou5 1Department of Clinical Engineering and Materials Supplies, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3Jinan Microecological Biomedicine, Shandong Laboratory, Jinan, People’s Republic of China; 4Department of Gastrointestinal Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 5Department of Infectious Diseases, Shulan (Hangzhou) Hospital, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Danfeng Lou, Department of Infectious Diseases, Shulan (Hangzhou) Hospital, No. 848 Dongxin Road, Hangzhou, People’s Republic of China, Email loudanfeng@126.com Jiajie Qian, Department of Gastrointestinal Surgery, The First Affiliated Hospital, College of Medicine Zhejiang University, No. 79 Qingchun Road, Hangzhou, People’s Republic of China, Email 1202058@zju.edu.cnAbstract: The global dissemination of carbapenem-resistant Enterobacteriaceae poses a significant threat to public health. …”
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Realising health justice in Palestine: beyond humanitarian voices by James Smith, Sara el-Solh, Layth Hanbali, Sawsan Abdulrahim, Sali Hafez, Samer Abuzerr, Bram Wispelwey, Mads Gilbert, Mohammed Seyam, Bassam Abu Hamad, Dorotea Gucciardo, Fahd Haddad, Rasha Khoury, Amira Nimerawi, David Mills, Ghassan Abu-Sittah

“…Accessed 8 November 2024], and as such have failed to elucidate the root causes of what manifests most immediately as an entirely manufactured humanitarian crisis. This in turn undermines the substance and utility of the recovery proposal as it has been presented. …”
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Study on sedimentary organic facies of coal-measure source rocks in Shuixigou Group, Taibei Sag, Tuha Basin by Hao LIANG, Tanguang FAN, Zhiyong WANG, Shu TAO, Yijie WEN, Haitian ZHENG, Zijian ZHANG

“…However, organic facies types of the coal-measure source rocks in the Shuixigou Group and their relationships with sedimentary environments remain unclear, hindering oil and gas exploration across the sag and the entire basin. To enable a detailed classification and evaluation of coal-measure source rocks in the Shuixigou Group of the Tuha Basin, geochemical analyses were conducted, including maceral composition, total organic carbon (TOC) content, and hydrocarbon generation potential (S1+S2). …”
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Impact of new coalbed methane wells on old well productivity and its controlling factors: a case study of Shizhuangnan block in Qinshui Basin by Xueting HAN, Shangzhi MENG, Guangjing LIU, Zhenyu REN, Shu TAO, Xinyang MEN, Ziyang WEI

“…From the geological and engineering perspectives, countermeasures and suggestions on well deployment were proposed. …”
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Cryoballoon ablation for atrial fibrillation in South Africa: One-year outcome from the Cryo Global Registry by A Stanley, K A van Bragt, V Obidigbo, B Vezi

“…The overall presence of baseline comorbidities in the SA cohort was relatively low compared with the entire Cryo Global Registry cohort. The acute PVI success rate was high (98.8%). …”
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Using Deep Learning to Identify High-Risk Patients with Heart Failure with Reduced Ejection Fraction by Zhibo Wang, Xin Chen, Xi Tan, Lingfeng Yang, Kartik Kannapur, Justin L. Vincent, Garin N. Kessler, Boshu Ru, Mei Yang

“…A sequential model architecture based on bi-directional long short-term memory (Bi-LSTM) layers was utilized. For DL models to predict HF hospitalizations and worsening HF events, we utilized two study designs: with and without a buffer window. …”
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