Limbal Epithelial Stem Cells Transplantation in Cases with Unilateral Limbal Stem Cell Deficiency Syndrome by B. E. Malyugin, S. A. Borzenok, O. N. Nefedova, M. Yu. Gerasimov

“…The review also considers options for new promising approaches to the possible solution of existing problems in the transplantation of limbal epithelial stem cells.…”
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Simple Limbal Epithelial Transplantation (SLET): case reports by João Pedro Gomes Henn da Silva, Mártin Luís Stival Marquezan, Ricardo Alexandre Stock, Elcio Luiz Bonamigo

“…The limbus is a transition zone between the cornea and the conjunctiva of the eye, housing epithelial stem cells responsible for maintaining and ensuring the proper functioning of the cornea. …”
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Mesenchymal stem cells and their secretome modulate stress and enhance lipogenesis in bovine mammary epithelial cells by Roni Tadmor-Levi, Lior Sharabi, Adi Koren, Sharon Schlesinger, Noam Tzirkel-Hancock, Nurit Argov-Argaman

“…Abstract Background Increased production of the modern dairy cow can induce a stress response by the mammary epithelial cells (MEC) and compromise production traits. …”
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Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model by Haley Masters, Shuxiong Wang, Christina Tu, Quy Nguyen, Yutong Sha, Matthew K. Karikomi, Pamela Shi Ru Fung, Benjamin Tran, Cristina Martel, Nellie Kwang, Michael Neel, Olga G. Jaime, Victoria Espericueta, Brett A. Johnson, Kai Kessenbrock, Qing Nie, Edwin S. Monuki

“…Abstract Despite the major roles of choroid plexus epithelial cells (CPECs) in brain homeostasis and repair, their developmental lineage and diversity remain undefined. …”
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Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering by Davide Adamo, Vincenzo Giuseppe Genna, Giulia Galaverni, Chiara Chiavelli, Alessia Merra, Fabio Lepore, Federica Boraldi, Daniela Quaglino, Jessica Evangelista, Filippo Lococo, Graziella Pellegrini

“…Conclusions Our results show that primary airway epithelial cell cultures can maintain stem cells together with their differentiation lineages in vitro. …”
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SNAI1 promotes epithelial-mesenchymal transition and maintains cancer stem cell-like properties in thymic epithelial tumors through the PIK3R2/p-EphA2 Axis by Haoran E, Lei Zhang, Zhenhua Yang, Long Xu, Tao Wang, Junhong Guo, Lang Xia, Juemin Yu, Heyong Wang, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao

“…The influence of the hub gene on promoting epithelial-mesenchymal transition (EMT), tumor progression, and regulating cancer stem cell-like properties was assessed both in vitro and in vivo. …”
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Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model by Zohreh Sharafian, Zohreh Sharafian, Paula T. Littlejohn, Paula T. Littlejohn, Paula T. Littlejohn, Christina Michalski, Christina Michalski, James A. Sousa, James A. Sousa, Janelle Cheung, Mariana Hill, Mariana Hill, Hannah Piper, Kevan Jacobson, Kevan Jacobson, Pascal M. Lavoie, Pascal M. Lavoie, Joannie M. Allaire, Bruce A. Vallance, Bruce A. Vallance

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Apoptotic extracellular vesicles carrying Mif regulate macrophage recruitment and compensatory proliferation in neighboring epithelial stem cells during tissue maintenance. by Safia A Essien, Ivanshi Ahuja, George T Eisenhoffer

“…While apoptotic cell-derived extracellular vesicles (AEVs) can transmit instructional cues to mediate communication with neighboring cells, the molecular mechanisms that induce cell division are not well understood. Here, we show that macrophage migration inhibitory factor (Mif)-containing AEVs regulate compensatory proliferation via ERK signaling in epithelial stem cells of larval zebrafish. …”
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Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells. by Engin Ulukaya, Fiona M Frame, Buse Cevatemre, Davide Pellacani, Hannah Walker, Vincent M Mann, Matthew S Simms, Michael J Stower, Veysel T Yilmaz, Norman J Maitland

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The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB by Ziyu Zhu, Leonie Schnell, Bastian Müller, Martin Müller, Panagiotis Papatheodorou, Holger Barth

“…Here, we tested the effect of bacitracin towards TcdB, a major virulence factor of C. difficile contributing to severe C. difficile-associated diseases (CDAD) including pseudomembranous colitis. Bacitracin protected stem cell-derived human intestinal organoids as well as human gut epithelial cells from intoxication with TcdB. …”
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A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial–mesenchymal transition and stemness in breast cancer by Saima Usman, William Andrew Yeudall, Muy-Teck Teh, Fatemah Ghloum, Hemanth Tummala, Ahmad Waseem

“…Functional transcriptomic studies confirmed the upregulation of EMT and mesenchymal markers, downregulation of epithelial markers, as well as acquisition of signatures associated with cancer stemness (CD56, POU5F1, PROCR, and CD49f), thus transforming MCF-7 cells from oestrogen-positive to triple-reduced (ESR1, PGR, and HER2) status. …”
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Safety and Efficacy of a Mesenchymal Stem Cell Secretome Therapy (KPI-012) for Persistent Corneal Epithelial Defects: A Phase 1b Trial by Valeria Sánchez Huerta, MD, Hugo Quiroz-Mercado, MD, Enrique O. Graue-Hernández, MD, MSc, Alejandro Navas, MD, MSc, Spencer Alford, PhD, Darius Kharabi, JD, MBA, Stephen Pflugfelder, MD

“…KPI-012 is a topical mesenchymal stem cell secretome therapy under investigation for PCED management. …”
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PAX3 expression patterns in ocular surface melanocytes by Eva Ulrich, Sebastian Kistenmacher, Gottfried Martin, Ursula Schlötzer-Schrehardt, Berthold Seitz, Claudia Auw-Hädrich, Günther Schlunck, Thomas Reinhard, Naresh Polisetti

“…This study investigated the expression patterns of PAX3 in the limbal stem cell niche, specifically in limbal epithelial progenitor cells (LEPC), limbal melanocytes (LM), and limbal mesenchymal stem cells (LMSC). …”
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Current research of the Notch pathway in hepatocellular carcinoma by Leiya Fu, Xinyu Gu, Na Lou, Juan Li, Chen Xue

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IGF2BP2: an m6A reader that affects cellular function and disease progression by Siyi Liu, Shan Liao, Junyu He, Yanhong Zhou, Qian He

“…This article aims to elucidate the effects of IGF2BP2 on cell ferroptosis, EMT, stemness, angiogenesis, inflammatory responses, and lipid metabolism, providing a new perspective for a comprehensive understanding of the relationship between IGF2BP2 and cell functions such as ferroptosis and EMT, as well as the potential for targeted IGF2BP2 therapy for tumors and other diseases.…”
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Cancer stem cells and mesenchymal stem cells in pancreatic ductal adenocarcinoma by V. O. Tumanskyi, I. S. Kovalenko

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer and chemotherapy resistant cancer, in the development of which poorly studied cancer stem cells (CSC) and mesenchymal stem cells (MSC) are of great importance. …”
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Epithelial architecture and signaling activity in the adult human esophagus by David Grommisch, Evelien Eenjes, Maeve L. Troost, Maria Genander

“…Furthermore, we review current models available to study the human esophageal epithelium, focusing predominantly on adult primary organoids and epithelioids as well as the generation of human developmental esophageal epithelial cells from induced pluripotent stem cells. …”
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CD44 staining of cancer stem-like cells is influenced by down-regulation of CD44 variant isoforms and up-regulation of the standard CD44 isoform in the population of cells that hav... by Adrian Biddle, Luke Gammon, Bilal Fazil, Ian C Mackenzie

“…CD44 is commonly used as a cell surface marker of cancer stem-like cells in epithelial tumours, and we have previously demonstrated the existence of two different CD44(high) cancer stem-like cell populations in squamous cell carcinoma, one having undergone epithelial-to-mesenchymal transition and the other maintaining an epithelial phenotype. …”
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Stemness regulation in prostate cancer: prostate cancer stem cells and targeted therapy by Hao Liang, Bin Zhou, Peixin Li, Xiaoyi Zhang, Shijie Zhang, Yaozhong Zhang, Shengwen Yao, Sifeng Qu, Jun Chen

“…These cells exhibit similar characteristics to those of normal stem cells in tissues; moreover, they are capable of self-renewal and differentiation, as well as high tumorigenicity and drug resistance. …”
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Intestinal Epithelial Organoids as Tools to Study Epigenetics in Gut Health and Disease by Judith Kraiczy, Matthias Zilbauer

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