Recognizing Epithelial Cells in Prostatic Glands Using Deep Learning by Liton Devnath, Puneet Arora, Anita Carraro, Jagoda Korbelik, Mira Keyes, Gang Wang, Martial Guillaud, Calum MacAulay

“…An integrated machine-learning network, named GlandNet, was developed to correctly recognize the epithelial cells within prostate glands using cell-centric patches selected from the core biopsy specimens. …”
Get full text

PD-L1 expression on tumor cells and tumor-infiltrating immune cells in thymic epithelial tumors detected with SP142 and SP263 antibodies. by Kei Chubachi, Hisashi Tanaka, Kageaki Taima, Sadatomo Tasaka, Akira Kurose

Get full text

S100A7 as a predictive biomarker in malignant transformation of oral epithelial dysplastic lesions by Jeffrey Soparlo, Lachlan McLean, Christina McCord, Linda Jackson-Boeters, Michael Shimizu, Michael Robinson, Wanninayake M. Tilakaratne, Mark R. Darling

Get full text

Anti-Migratory Activity of Brazilin Chemodiversification on Breast Cancer Cells by Alberto Hernández-Moreno, Dania A. Nava-Tapia, Miriam D. Zuñiga-Eulogio, Jorge Bello-Martínez, Monserrat Olea-Flores, Tadeo Hernández-Moreno, Mario Ordoñez, Ana E. Zacapala-Gómez, Miguel A. Mendoza-Catalán, Napoleón Navarro-Tito

“…Regarding biological assays, the MTT assay showed that these compounds showed cytotoxic effects on the MCF7 and MDA-MB-231 breast cancer cells at 20 µM but was not toxic in non-tumorigenic MCF10A mammary epithelial cells. …”
Get full text

Development of a Widely Accessible, Advanced Large-Scale Microfluidic Airway-on-Chip by Brady Rae, Gwenda F. Vasse, Jalal Mosayebi, Maarten van den Berge, Simon D. Pouwels, Irene H. Heijink

“…The model consists of two large polydimethylsiloxane (PDMS) cell culture chambers under an independent flow of medium or air, separated by a semi-permeable polyethylene (PET) cell culture membrane (23 μm thick, 0.4 μm pore size). …”
Get full text

Expression of CXCR-4 and CD 133 and it’s Correlation with Prognostic Pathologic Factors in Resectable Oral Squamous Cell Carcinoma: A Research Protocol by Nirlipta Swain, Arvind Shridhar Bhake

“…Markers such as Cluster of Differentiation 133 (CD133) and CXC Chemokine Receptor-4 (CXCR-4) are linked to poor prognosis in cancers, including Oral Squamous Cell Carcinoma (OSCC). CD133 promotes Epithelial-Mesenchymal Transition (EMT) and chemoresistance, while CXCR-4 enhances invasion via CXCL12 signalling. …”
Get full text

Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors. by Kathryn C Arbour, Jarushka Naidoo, Keith E Steele, Ai Ni, Andre L Moreira, Natasha Rekhtman, Paul B Robbins, Joyson Karakunnel, Andreas Rimner, James Huang, Gregory J Riely, Matthew D Hellmann

“…The expression of membranous PD-L1 on tumor cells, CD3+ and CD8+ tumor infiltrating lymphocytes (TILs), co-stimulatory (CD137, GITR, ICOS), and co-inhibitory immune checkpoint molecules (PD-1, CTLA-4, TIM-3) were assessed semi-quantitatively using immunohistochemistry.…”
Get full text

Adaptation to Arginine Deprivation Leads to a More Aggressive, Therapy-Resistant Phenotype in HNSCC Cells by Oleg Chen, Olena Vovk, Nikita Polishchuk, Oksana Mayevska, Galyna Shuvayeva, Melike Demir, Vasyl Lukiyanchuk, Leoni A. Kunz-Schughart, Anna Dubrovska, Oleh Stasyk

“…<i>Methods:</i> We applied repeated ADT and established a subline SAS-R9 of the human head and neck squamous cell carcinoma (HNSCC) cells semi-resistant to arginine (Arg) deprivation <i>in vitro</i>. …”
Get full text

Quantitative Histopathological Analysis of Cervical Intra-Epithelial Neoplasia Sections: Methodological Issues by Martial Guillaud, Dennis Cox, Anais Malpica, Gregg Staerkel, Jasenka Matisic, Dirk Van Niekirk, Karen Adler‐Storthz, Neal Poulin, Michele Follen, Calum MacAulay

Get full text

Prognostic Significance of RBM3 Expression in Epithelial Ovarian Cancer: A Tissue Microarray-Based Study by Hyeong Chan Shin, Hye Won Lee, So-Jin Shin, Sun Young Kwon

“…Tissue microarrays were constructed using paired 2 mm tumor cores, and RBM3 expression was assessed by immunohistochemistry. Nuclear staining was semi-quantitatively scored based on intensity and proportion, generating a nuclear score (NS). …”
Get full text

Semi-Field Evaluation and Genotoxicity of Chlorophyllin Applied Against <i>Aedes aegypti</i> Larvae (Diptera, Culicidae) by Magda H. Rady, Asmaa M. Ammar, Areej A. Al-Khalaf, Abdelwahab Khalil, May A. Azzam, Ayman A. Abdel-Shafi, Shaimaa M. Farag

“…Histopathological analysis demonstrated severe disruptions in chlorophyllin-treated larvae’s gut epithelial cells and muscle tissues, including epithelial detachment and irregular cell shapes. …”
Get full text

ArfGAP with the SH3 Domain, Ankyrin Repeat and PH Domain 1 Inversely Regulates Programmed Death-Ligand 1 Through Negative Feedback of Phosphorylated Epithelial Growth Factor Recept... by Chiba N, Menju T, Shimazu Y, Toyazaki T, Sumitomo R, Miyamoto H, Tamari S, Nishikawa S, Date H

“…In this study, we investigated the function of AMAP1 on PD-L1 expression using lung cancer cells.Methods: We used two non-small cell lung cancer cell lines. …”
Get full text

First detection of a cervidpoxvirus in Europe—disease occurrence in semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus) in Norway and Sweden by Ingebjørg H. Nymo, Cathrine Arnason Bøe, Javier Sánchez Romano, Hans Lian, Renate Thorvaldsen, Faisal Suhel, Mette Boye, Øivind Øines, Lars P. Folkow, Hans-Arne Solvang, Tomas Jinnerot, Jonas Johansson Wensman, Rebecca K. Davidson, Torill Mørk, Line Olsen, Morten Tryland, Ulrika Rockström, Bjørn Spilsberg

“…In vitro infection in Madin-Darby bovine kidney epithelial cells demonstrated cytopathic effect. It is unknown whether the emergence of this disease in semi-domesticated reindeer in Norway and Sweden is due to ecosystem changes facilitating altered disease dynamics, or if the virus has been recently introduced.IMPORTANCEThis study documents the first detection of a Cervidpoxvirus in Europe, causing disease in semi-domesticated reindeer in Norway and Sweden. …”
Get full text

Expression profiles of SGK-1 and α-ENaC in minor salivary glands of subjects with xerostomia by Mahmood S. Mozaffari, Rafik Abdelsayed

“…IntroductionEpithelial sodium channel (ENaC) is a major conduit for sodium transport across the cell membrane, and its activity is regulated by multiple factors/mechanisms, including the serum and glucocorticoid-regulated kinase-1 (SGK-1). …”
Get full text

Application of deep learning convolutional neural networks to identify gastric squamous cell carcinoma in mice by Yuke Ren, Yuke Ren, Shuangxing Li, Di Zhang, Yongtian Zhao, Yanwei Yang, Guitao Huo, Xiaobing Zhou, Xingchao Geng, Zhi Lin, Zhe Qu

“…After scanning into digital slides, semi-automated data annotation was performed. All images underwent preprocessing, including tissue extraction, artifact removal, and exclusion of normal epithelial regions. …”
Get full text

BIOCHEMICAL AND HISTOLOGICAL STUDY OF CYSTICERCUS TENUICOLLIS OF SHEEP IN DUHOK PROVINCE by saad M, Bayati

“…Histochemical study of parasite bladder revealed it composed from various kind of cells which are fibroblast , mesenchimal cell ,squamous epithelial like cell , and vacuolated undifferentiated cell with semi-gelatinous mucoid tissue.…”
Get full text

RECURRENT CORNEAL EROSION SYNDROME (a review) by S. V. Trufanov, S. A. Malozhen, E. G. Polunina, E. A. Pivin, L. Yu. Tekeeva

“…Ultrastructural changes in RCE include abnormalities of basal epithelial cells and epithelial basal membrane, absence or deficiency of semi-desmosomes, loss of anchor fibrils. …”
Get full text

OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. by Yan Cui, Ying Ying, Andrew van Hasselt, Ka Man Ng, Jun Yu, Qian Zhang, Jie Jin, Dingxie Liu, Johng S Rhim, Sun Young Rha, Myriam Loyo, Anthony T C Chan, Gopesh Srivastava, George S W Tsao, Grant C Sellar, Joseph J Y Sung, David Sidransky, Qian Tao

“…Instead, promoter methylation of OPCML was frequently detected in multiple carcinoma cell lines (nasopharyngeal, esophageal, lung, gastric, colon, liver, breast, cervix, prostate), lymphoma cell lines (non-Hodgkin and Hodgkin lymphoma, nasal NK/T-cell lymphoma) and primary tumors, but not in any non-tumor cell line and seldom weakly methylated in normal epithelial tissues. …”
Get full text

Morphological characteristics and ecological significance of Volga‐Caspian Basin fish tumors by V. V. Volodina, M. P. Grushko, N. N. Fedorova, E. A. Voronina, N. Yu. Terpugova, M. A. Gulyaeva

“…Epithelial papilloma was most often observed in catfish. …”
Get full text

Atrazine-Induced Intestinal Histopathology in Juvenile African catfish, Clarias gariepinus (Burchell, 1822) by P. A. Opute, F. E. Mbajiorgu

“…Other alterations in this category that were observed only in the 500 µg L−1 treatment group are: completely damaged epithelium (91.67%), leakage of cells into the lumen (79.17%), advanced epithelial hyperplasia (79.17%), massive dis-epithelialization (66.67%), and completely degenerated tunica muscularis (95.83%). …”
Get full text