Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

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Viral load suppression rate of third-line antiretroviral therapy and its association with gender among HIV patients after second-line treatment failure in Africa: a systematic revi... by Tilahun Degu Tsega, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Getaneh Atikilt Yemata, Rahel Mulatie Anteneh, Almaw Genet Yeshiwas, Getasew Yirdaw, Chalachew Yenew, Anley Shiferaw Enawgaw, Amare Genetu Ejigu, Ahmed Fentaw Ahmed, Zeamanuel Anteneh Yigzaw, Berhanu Abebaw Mekonnen, Meron Asmamaw Alemayehu, Abathun Temesgen, Abebaw Molla, Habitamu Mekonen, Assefa Andargie Kassa, Gashaw Melkie Bayeh

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Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

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Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study by Hirofumi Ohnishi, Yoshitaka Murakami, Katsuyuki Miura, Koji Tamakoshi, Hirotsugu Ueshima, Akira Okayama, Tomonori Okamura, Takayoshi Ohkubo, Toshiyuki Ojima, Yoshihiro Miyamoto, Maryam Zaid, Aya Kadota, Akira Fujiyoshi, Yosikazu Nakamura, Naoyuki Takashima, Atsushi Hozawa, Shigeyuki Saitoh, Yutaka Kiyohara, Fumiyoshi Kasagi, Nagako Okuda, Takehito Hayakawa, Hiroshi Akasaka, Yusuke Arai, Katsushi Yoshita, Kiyomi Sakata, Nobuo Nishi, Toru Izumi, Yasuhiro Matsumura, Hideaki Nakagawa, Yoshikuni Kita, Naomi Miyamatsu, Yasuyuki Nakamura, Kazunori Kodama

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Understanding experiences of neglected tropical diseases of the skin: a mixed-methods study to inform intervention development in Ethiopia by Michael Marks, David Mabey, Ruth Canter, Elizabeth Allen, Charles Opondo, Jennifer Palmer, Iris Mosweu, Jacob Novignon, Sinéad Langan, Maria Zuurmond, Catherine Pitt, Stephen L Walker, Dorothy Yeboah-Manu, Tara Mtuy, Rachel L Pullan, Richard Phillips, Daniel Okyere, Anthony Ablordey, Samantha Owen, Portia Boakye Okyere, Kidist Bobosha, Katherine Halliday, Steve Walker, Galana Mamo Ayana, Rachel Pullan, Mirgissa Kaba, Tara B Mtuy, Yaw Amoako, Adwoa Asante-Poku, Abigail Agbanyo, Eric Koka, Joseph Timothy, Yohannes Hailemichael, Abebaw Yeshambel Alemu, Teklu Cherkose, Getachew Kebebew, Fikregabrail Aberra Kassa, Tedros Nigusse, Kibur Engedawork, Zenebu Begna, Abay Waday, Saba Lambert, Katherine Elizabeth Halliday, Endalamaw Gadisa, Vanessa Yardley, Collins Ahorlu, Anita Achiaa Gyekye, Emmanuel Afreh, Esther Amon, Abraham Kwabena Anang, Ruth Dede Tuwor, Giulia D’Odorico, Kibur Engidawork, Mehari Getaneh, Bernadette Morkporkpor, Emmanuel Narh, Dorcas Opai-Tetteh, Yohannes Michael, Amel Mohammed, Fewzia Shikur Mohammed, Shimelis Doni Nigusse, Maja Niksic, Edmond Okloo, Michael Oppong, Lucy Owusu, Ishaque Siam, Ingrid Sobel, Feleke Tilahum, Joseph Tuffour, Abay Woday, Abebaw Yeshambel, Adelaide Forkuo- Boadu, Derrick Kontoh, Jojo Cobbinah

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Emergency Medicine Palliative Care Access (EMPallA): protocol for a multicentre randomised controlled trial comparing the effectiveness of specialty outpatient versus nurse-led tel... by Jeanne Cho, Michael Hill, Corita R Grudzen, Deborah J Shim, Abigail M Schmucker, Keith S Goldfeld, Lauren Southerland, Jeffrey M Caterino, Marie-Carmelle Elie, Robert Swor, Susan E Cohen, Arum Kim, Joseph Lowy, Jennifer S Scherer, Nancy E Bael, Ellin Gafford, Joshua Lakin, Paige Barker, Angela Chmielewski, Jennifer Kapo, Audrey Tan, Rebecca Yamarik, Susan Salz, Stephen Ryan, Anne Kim, Isabel Castro, Amelia Hargrove, Laura Stuecher, Nora Daut, Juanita Booker-Vaughns, Garrett K Chan, J Nicholas Dionne-odom, Patrick Dunn, Robert Galvin, Ernest A Hopkins III, Margaret M Maguire, Neha Reddy Pidatala, Dawn Rosini, Sally Welsh, Karen Jubanyik, Ada L Rubin, Kei Ouchi, Rebecca Murray, Nicole Tang, Marie Bakitas, Abraham Brody, Caroline Blaum, Mara Flannery, Richard Tamirian, Pamela Marsack, Jennifer Bonito, Romilla Batra, Donna C Sadasivan, Eric David Isaacs, Constance L Kizzie-Gillett, William K Vaughan, Pluscedia G Williams, Angela Young-Brinn

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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

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Obesity is South Africa’s new HIV epidemic by Nomathemba Chandiwana, Willem Venter, Jennifer Manne-Goehler, Alisha Wade, Carel le Roux, Nzama Mbalati, Angelika Grimbeek, Petronell Kruger, Eunice Montsho, Zukiswa Zimela, Anele Yawa, Sibongile Tshabalala, Ndivhuwo Rambau, Ngqabutho Mpofu, Sasha Stevenson, Bridget McNulty, Ntobeko Ntusi, Yogan Pillay, Joel Dave, Angela Murphy, Sue Goldstein, Karen Hfman, Sameera Mahomedy, Elizabeth Thomas, Busi Mrara, Jeff Wing, Jeanne Lubbe, Zack Koto, Marli Conradie-Smit, Sean Wharton, Wayne May, Ian Marr, Hilton Kaplan, Mariam Forgan, Graham Alexander, John Turner, V R Fourie, Jocelyn Hellig, Mandy Banks, Kim Ragsdale, Marisa Noeth, Farzahna Mohamed, Landon Myer, Limakatso Lebina, Salome Maswime, Yunus Moosa, Sumy Thomas, Mzamo Mbelle, Phumla Sinxadi, Linda-Gail Bekker, Sindeep Bhana, June Fabian, Eric Decloedt, Zaheer Bayat, Reyna Daya, Bilal Bobat, Fiona Storie, Julia Goedecke, Kathleen Kahn, Stephen Tollman, Brett Mansfield, Mark Siedner, Vincent Marconi, Aaloke Mody, Ntombifikile Mtshali, Elvin Geng, Suman Srinivasa, Mohammed Ali, Samanta Lalla-Edwards, Alison Bentley, Gustaaf Wolvaardt, Andrew Hill, Jeremy Nel

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Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology by Elliot Gould, Hannah S. Fraser, Timothy H. Parker, Shinichi Nakagawa, Simon C. Griffith, Peter A. Vesk, Fiona Fidler, Daniel G. Hamilton, Robin N. Abbey-Lee, Jessica K. Abbott, Luis A. Aguirre, Carles Alcaraz, Irith Aloni, Drew Altschul, Kunal Arekar, Jeff W. Atkins, Joe Atkinson, Christopher M. Baker, Meghan Barrett, Kristian Bell, Suleiman Kehinde Bello, Iván Beltrán, Bernd J. Berauer, Michael Grant Bertram, Peter D. Billman, Charlie K. Blake, Shannon Blake, Louis Bliard, Andrea Bonisoli-Alquati, Timothée Bonnet, Camille Nina Marion Bordes, Aneesh P. H. Bose, Thomas Botterill-James, Melissa Anna Boyd, Sarah A. Boyle, Tom Bradfer-Lawrence, Jennifer Bradham, Jack A. Brand, Martin I. Brengdahl, Martin Bulla, Luc Bussière, Ettore Camerlenghi, Sara E. Campbell, Leonardo L. F. Campos, Anthony Caravaggi, Pedro Cardoso, Charles J. W. Carroll, Therese A. Catanach, Xuan Chen, Heung Ying Janet Chik, Emily Sarah Choy, Alec Philip Christie, Angela Chuang, Amanda J. Chunco, Bethany L. Clark, Andrea Contina, Garth A. Covernton, Murray P. Cox, Kimberly A. Cressman, Marco Crotti, Connor Davidson Crouch, Pietro B. D’Amelio, Alexandra Allison de Sousa, Timm Fabian Döbert, Ralph Dobler, Adam J. Dobson, Tim S. Doherty, Szymon Marian Drobniak, Alexandra Grace Duffy, Alison B. Duncan, Robert P. Dunn, Jamie Dunning, Trishna Dutta, Luke Eberhart-Hertel, Jared Alan Elmore, Mahmoud Medhat Elsherif, Holly M. English, David C. Ensminger, Ulrich Rainer Ernst, Stephen M. Ferguson, Esteban Fernandez-Juricic, Thalita Ferreira-Arruda, John Fieberg, Elizabeth A. Finch, Evan A. Fiorenza, David N. Fisher, Amélie Fontaine, Wolfgang Forstmeier, Yoan Fourcade, Graham S. Frank, Cathryn A. Freund, Eduardo Fuentes-Lillo, Sara L. Gandy, Dustin G. Gannon, Ana I. García-Cervigón, Alexis C. Garretson, Xuezhen Ge, William L. Geary, Charly Géron, Marc Gilles, Antje Girndt, Daniel Gliksman, Harrison B. Goldspiel, Dylan G. E. Gomes, Megan Kate Good, Sarah C. Goslee, J. Stephen Gosnell, Eliza M. Grames, Paolo Gratton, Nicholas M. Grebe, Skye M. Greenler, Maaike Griffioen, Daniel M. Griffith, Frances J. Griffith, Jake J. Grossman, Ali Güncan, Stef Haesen, James G. Hagan, Heather A. Hager, Jonathan Philo Harris, Natasha Dean Harrison, Sarah Syedia Hasnain, Justin Chase Havird, Andrew J. Heaton, María Laura Herrera-Chaustre, Tanner J. Howard, Bin-Yan Hsu, Fabiola Iannarilli, Esperanza C. Iranzo, Erik N. K. Iverson, Saheed Olaide Jimoh, Douglas H. Johnson, Martin Johnsson, Jesse Jorna, Tommaso Jucker, Martin Jung, Ineta Kačergytė, Oliver Kaltz, Alison Ke, Clint D. Kelly, Katharine Keogan, Friedrich Wolfgang Keppeler, Alexander K. Killion, Dongmin Kim, David P. Kochan, Peter Korsten, Shan Kothari, Jonas Kuppler, Jillian M. Kusch, Malgorzata Lagisz, Kristen Marianne Lalla, Daniel J. Larkin, Courtney L. Larson, Katherine S. Lauck, M. Elise Lauterbur, Alan Law, Don-Jean Léandri-Breton, Jonas J. Lembrechts, Kiara L’Herpiniere, Eva J. P. Lievens, Daniela Oliveira de Lima, Shane Lindsay, Martin Luquet, Ross MacLeod, Kirsty H. Macphie, Kit Magellan, Magdalena M. Mair, Lisa E. Malm, Stefano Mammola, Caitlin P. Mandeville, Michael Manhart, Laura Milena Manrique-Garzon, Elina Mäntylä, Philippe Marchand, Benjamin Michael Marshall, Charles A. Martin, Dominic Andreas Martin, Jake Mitchell Martin, April Robin Martinig, Erin S. McCallum, Mark McCauley, Sabrina M. McNew, Scott J. Meiners, Thomas Merkling, Marcus Michelangeli, Maria Moiron, Bruno Moreira, Jennifer Mortensen, Benjamin Mos, Taofeek Olatunbosun Muraina, Penelope Wrenn Murphy, Luca Nelli, Petri Niemelä, Josh Nightingale, Gustav Nilsonne, Sergio Nolazco, Sabine S. Nooten, Jessie Lanterman Novotny, Agnes Birgitta Olin, Chris L. Organ, Kate L. Ostevik, Facundo Xavier Palacio, Matthieu Paquet, Darren James Parker, David J. Pascall, Valerie J. Pasquarella, John Harold Paterson, Ana Payo-Payo, Karen Marie Pedersen, Grégoire Perez, Kayla I. Perry, Patrice Pottier, Michael J. Proulx, Raphaël Proulx, Jessica L Pruett, Veronarindra Ramananjato, Finaritra Tolotra Randimbiarison, Onja H. Razafindratsima, Diana J. Rennison, Federico Riva, Sepand Riyahi, Michael James Roast, Felipe Pereira Rocha, Dominique G. Roche, Cristian Román-Palacios, Michael S. Rosenberg, Jessica Ross, Freya E. Rowland, Deusdedith Rugemalila, Avery L. Russell, Suvi Ruuskanen, Patrick Saccone, Asaf Sadeh, Stephen M. Salazar, Kris Sales, Pablo Salmón, Alfredo Sánchez-Tójar, Leticia Pereira Santos, Francesca Santostefano, Hayden T. Schilling, Marcus Schmidt, Tim Schmoll, Adam C. Schneider, Allie E. Schrock, Julia Schroeder, Nicolas Schtickzelle, Nick L. Schultz, Drew A. Scott, Michael Peter Scroggie, Julie Teresa Shapiro, Nitika Sharma, Caroline L. Shearer, Diego Simón, Michael I. Sitvarin, Fabrício Luiz Skupien, Heather Lea Slinn, Grania Polly Smith, Jeremy A. Smith, Rahel Sollmann, Kaitlin Stack Whitney, Shannon Michael Still, Erica F. Stuber, Guy F. Sutton, Ben Swallow, Conor Claverie Taff, Elina Takola, Andrew J. Tanentzap, Rocío Tarjuelo, Richard J. Telford, Christopher J. Thawley, Hugo Thierry, Jacqueline Thomson, Svenja Tidau, Emily M. Tompkins, Claire Marie Tortorelli, Andrew Trlica, Biz R. Turnell, Lara Urban, Stijn Van de Vondel, Jessica Eva Megan van der Wal, Jens Van Eeckhoven, Francis van Oordt, K. Michelle Vanderwel, Mark C. Vanderwel, Karen J. Vanderwolf, Juliana Vélez, Diana Carolina Vergara-Florez, Brian C. Verrelli, Marcus Vinícius Vieira, Nora Villamil, Valerio Vitali, Julien Vollering, Jeffrey Walker, Xanthe J. Walker, Jonathan A. Walter, Pawel Waryszak, Ryan J. Weaver, Ronja E. M. Wedegärtner, Daniel L. Weller, Shannon Whelan, Rachel Louise White, David William Wolfson, Andrew Wood, Scott W. Yanco, Jian D. L. Yen, Casey Youngflesh, Giacomo Zilio, Cédric Zimmer, Gregory Mark Zimmerman, Rachel A. Zitomer

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Prevalence and risk factors of heartburn in organized population of administrative centre of Khakasia republic by N. N. Butorin, O. S. Rzhavicheva, O. V. Khomenko, O. V. Shtygashyeva, V. V. Tsukanov

“…Ethnic features of clinical and epidemiologic characteristic of GERD were registered in studied populations.…”
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The role of nutritional fiber deficiency in the pathogenesis and course of gastroesophageal reflux disease by S. V. Morozov, Yu. A. Kucheryavyy, M. D. Kukushkina

“…The review contains data concerning influence of nutritional fiber on the pathogenetic mechanisms of GERD and illuminates results of epidemiological studies suggesting positive correlation between quantities of nutritional fiber in the patient’s diet and manifestations of the disease. …”
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Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association by V. T. Ivashkin, N. D. Yushchuk, I. V. Mayev, Tatyana L Lapina, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, A. S. Trukhmanov, A. A. Sheptulin, Ye. K. Baranskaya, O. S. Lyashenko, K. V. Ivashkin

“…Epidemiologic growth, risk of significant morbidity made C. difficile-associated disease a socially important disease. …”
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Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence by Camran R. Nezhat, Tomiko T. Oskotsky, Joshua F. Robinson, Susan J. Fisher, Angie Tsuei, Binya Liu, Juan C. Irwin, Brice Gaudilliere, Marina Sirota, David K. Stevenson, Linda C. Giudice

“…Herein, we present real-world perspectives on endometriosis and the importance of multidisciplinary collaboration in informing molecular, epidemiologic, and cell-specific data in the clinical and surgical contexts.…”
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Documenting Student Representation of Indigenous HIV/AIDS Information and Integration Into the School Curriculum by Denis, Sekiwu, Olivia Nina, Rugambwa

“…Often times, contemporary health and epidemiological practices ignore indigenous information on HIV prevention. …”
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Comparison of clinical metagenomics with 16S rDNA Sanger sequencing for the bacteriological diagnosis of culture-negative samples by Camille d’Humières, Skerdi Haviari, Marie Petitjean, Laurène Deconinck, Signara Gueye, Nathan Peiffer-Smadja, Lynda Chalal, Naima Beldjoudi, Geoffrey Rossi, Yann Nguyen, Charles Burdet, Ségolène Perrineau, Diane Le Pluart, Roza Rahli, Michael Thy, Piotr Szychowiak, Xavier Lescure, Véronique Leflon-Guibout, Victoire de Lastours, Etienne Ruppé

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Diarrhoea in Patients with COVID-19 by A. A. Sheptulin

“…Published evidence on the impact of diarrhoea on the course of COVID-19 is contradictory.Conclusion. Epidemiological and clinical aspects of this problem require further research.…”
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Advances in the study of apathy related to cerebral small vessel disease by Shuo-han Bu, Shuo-han Bu, Xin-zhu Hu, Zhe Su, Li-tao Li, Li-tao Li

“…This article describes the latest research advances in the concept, epidemiological features, pathogenesis, assessment and diagnosis, imaging and biomarkers, and treatment of CSVD-related apathy, aiming to serve as a reference for the clinical diagnosis and prevention of CSVD-related apathy.…”
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Sociology of the COVID-19 Lockdown: Critical Analysis of Its Effects on Private School Teacher Wellbeing by Denis, Sekiwu, Johnson, Ocan

“…Much of the research on COVID-19 is gleaned on epidemiological, virological, and medical outcomes of the global pandemic. …”
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Treatment compliance of patients with gastro-intestinal diseases by O. P. Alekseyeva, L. N. Kasimova, Ye. Ye. Goryacheva

“…Overall 151 patients (57 - with irritable bowel syndrome, 57 - with gastroesophageal reflux disease and 37 - with peptic ulcer of the stomach and duodenum) were investigated by structured interview method applying «the basic questionnaire for clinical and epidemiologic ethnocultural studies». Compliance was estimated by the universal validated Morisky medication adherence scale; the degree of treatment compliance was specified with the help of specially designed questionnaire. …”
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