Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stress by Purva V. Gade, Angela Victoria Rojas Rivera, Layla Hasanzadah, Sofie Strompf, Thomas Raymond Philipson, Matthew Gadziala, Atharva Tyagi, Arnav Bandam, Rithvik Gabbireddy, Fatah Kashanchi, Amanda Haymond, Lance A. Liotta, Marissa A. Howard

“…Using several types of cancer cells, we show that tumor cells treated with CCCP can be induced to switch over to secretory mitophagy by treatment with Bafilomycin A1, which blocks the fusion of mitophagosomes with lysosomes. Under these conditions, an increased number of PINK1 + EVs are exported. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Bintrafusp alfa (BA) is a bifunctional fusion protein that simultaneously blocks nonredundant immunosuppressive TGF-β and PD-(L)1 pathways.Methods This first-in-human, dose-escalation study in patients with advanced solid tumors (N=58; aged ≥18 years, ECOG PS≤1) evaluated M6223 alone (Part 1A, n=40; M6223 10–2400 mg every 2 weeks, n=32; M6223 2400 mg every 3 weeks, n=8) or with BA (Part 1B, n=18; M6223 300–1600 mg with BA 1200 mg; both every 2 weeks, intravenous). …”
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Site Assessment of Multiple-Sensor Approaches for Buried Utility Detection by Alexander C. D. Royal, Phil R. Atkins, Michael J. Brennan, David N. Chapman, Huanhuan Chen, Anthony G. Cohn, Kae Y. Foo, Kevin F. Goddard, Russell Hayes, Tong Hao, Paul L. Lewin, Nicole Metje, Jen M. Muggleton, Adham Naji, Giovanni Orlando, Steve R. Pennock, Miles A. Redfern, Adrian J. Saul, Steve G. Swingler, Ping Wang, Christopher D. F. Rogers

“…The multi-sensor platform is being developed in conjunction with a knowledge-based system that aims to provide information on how the properties of the ground might affect the sensing technologies being deployed. The fusion of data sources (sensor data and utilities record data) is also being researched to maximize the probability of location. …”
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Analisis Kinerja Augmented Reality HyperText Markup Language (ARHTML) Melalui Pemanfaatan Web Graphics Library dan OpenGl Shading Language untuk Pengembangan 3D by Multohadi Hamzaturrazak, Abdul Jabbar, Rizal Setya Perdana, Aryo Pinandito

“…Abstract In this digital era, technology has changed rapidly advancements, including the usage of augmented reality, which has become increasingly popular. The fusion of virtual and real-world elements by augmented reality creates memorable and dynamic user interactions. …”
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Whether Detection of Gene Mutations Could Identify Low- or High-Risk Papillary Thyroid Microcarcinoma? Data from 393 Cases Using the Next-Generation Sequencing by Lei Jin, Liang Zhou, Jian-Biao Wang, Li Tao, Xiao-Xiao Lu, Na Yan, Qian-Ming Chen, Li-Ping Cao, Lei Xie

“…The subsequent analysis did not uncover a significant distinction in the incidence of gene mutation or fusion between the cN0 and cN1 patient cohorts. The presence of BRAFV600E mutation and CLNM incidence rates were found to be positively correlated with larger tumor size in PTMC. …”
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DepITCM: an audio-visual method for detecting depression by Lishan Zhang, Lishan Zhang, Zhenhua Liu, Yumei Wan, Yunli Fan, Diancai Chen, Qingxiang Wang, Kaihong Zhang, Yunshao Zheng

“…This approach enables the capture of global features while emphasizing the fusion of temporal, channel, and spatial information in finer detail. …”
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Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration by Aurélie Fessard, Aliki Zavoriti, Natacha Boyer, Jules Guillemaud, Masoud Rahmati, Peggy Del Carmine, Christelle Gobet, Bénédicte Chazaud, Julien Gondin

“…Abstract Background Skeletal muscle is a plastic tissue that adapts to increased mechanical loading/contractile activity through fusion of muscle stem cells (MuSCs) with myofibers, a physiological process referred to as myonuclear accretion. …”
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A Case of Cardiac Arrest during C1 Laminectomy for Irreducible Atlantoaxial Subluxation by Yosuke Shibao, Masao Koda, Keita Nakayama, Tomoyuki Asada, Kosuke Sato, Mamoru Kono, Fumihiko Eto, Kentaro Mataki, Hiroshi Kumagai, Katsuya Nagashima, Kousei Miura, Hiroshi Noguchi, Hiroshi Takahashi, Toru Funayama, Tetsuya Abe, Masashi Yamazaki

“…Cardiac arrest occurred twice during the C1 laminectomy and occipito-cervical fusion (Occ-C3), and ROSC occurred without any treatment. …”
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Comorbidities and neurosurgical interventions in a cohort with connective tissue disorders by Ilene S. Ruhoy, Paolo A. Bolognese, Jared S. Rosenblum, Randall A. Dass, Navdeep S. Nayyer, Navdeep S. Nayyer, Jeffrey D. Wood, Jeffrey D. Wood, John B. Biggins, John B. Biggins

“…Of those who elected to undergo surgery (n = 612), 61% required craniocervical fusion (CCF). Notably, of the 460 individuals diagnosed with hEDS, 404 chose surgical intervention, of which, 73% required CCF for craniocervical instability.ConclusionIn this retrospective study of individuals referred to our institution for evaluation of CTDs potentially requiring neurosurgical intervention, we defined the frequency of presentation of specific comorbidities that we commonly encountered and revealed the rate at which they required neurosurgical intervention.…”
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Measurement-Based Prediction of mmWave Channel Parameters Using Deep Learning and Point Cloud by Hang Mi, Bo Ai, Ruisi He, Anuraag Bodi, Raied Caromi, Jian Wang, Jelena Senic, Camillo Gentile, Yang Miao

“…First, we introduce a novel measurement campaign for indoor mmWave channel at 60 GHz, where a light detection and ranging (LiDAR) sensor and panoramic camera were co-located with a channel sounder and then time-synchronized point clouds and images were captured to describe environmental information. Furthermore, a fusion method between the point clouds and images is proposed based on geometric relationship between the LiDAR and camera, to compress the size of the data collected. …”
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Cardiac Hemodynamics, Tissue Oxygenation, and Functional Capacity in Post-COVID-19 Patients by Elizane Poquiviqui do Nascimento, Larissa Fernanda Estevam do Nascimento, Lhara de Freitas Castro, Vilena Cavalcante de Barros, Emily Rachel Pereira Bandeira, Thiago Bezerra Wanderley e Lima, Matías Otto-Yáñez, Guilherme Augusto de Freitas Fregonezi, Vanessa Regiane Resqueti

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Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

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Producción y persistencia de una mezcla de alfalfa (Medicago sativa L.) y festuca alta (Festuca arundinacea Schreb.) bajo intensidades y frecuencias de pastoreo contrastantes by A. M. KLOSTER, G.A ZURBRIGGEN

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Transition from paediatric to adult neurological care: What do we know? by A. Valero-Mut, M.M. Rosselló-Vadell, M. Caner-Faig, J. Rubies-Olives, M. Carmona-Belda, E. Córdoba-Borrás, M.A. Grimalt-Calatayud, E. Miravet-Fuster

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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Lrp1 deficiency in these stem cells causes joint fusion, malformation of cartilage/bone template and markedly delayed or lack of primary ossification. …”
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Design of a Wearable Exoskeleton Piano Practice Aid Based on Multi-Domain Mapping and Top-Down Process Model by Qiujian Xu, Meihui Li, Guoqiang Chen, Xiubo Ren, Dan Yang, Junrui Li, Xinran Yuan, Siqi Liu, Miaomiao Yang, Mufan Chen, Bo Wang, Peng Zhang, Huiguo Ma

“…Through multi-domain mapping, the top-down process model, and modular design, this research effectively breaks through the design flexibility and functional adaptability bottleneck of traditional piano assistance devices while integrating neurological rehabilitation with music education, opening up a new application path for intelligent assistive devices in the fields of rehabilitation medicine and arts education, and providing a solution for cross-disciplinary technology fusion and innovative development.…”
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Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia by Zhenhua Li, Huanbin Zhao, Wenjian Yang, Maud Maillard, Satoshi Yoshimura, Yu-Chih Hsiao, Xin Huang, Yoshihiro Gocho, Lauren Rowland, Anthony Brown, Landon Choi, Kristine R. Crews, Charles G. Mullighan, Samuel W. Brady, Cheng Cheng, Ti-Cheng Chang, Gang Wu, Mignon L. Loh, Allen Eng Juh Yeoh, Federico Antillon-Klussmann, Sima Jeha, Hiroto Inaba, Jiyang Yu, Ching-Hon Pui, Seth E. Karol, William E. Evans, Jun J. Yang

“…Abstract ETV6::RUNX1 is the most common fusion gene in childhood acute lymphoblastic leukemia (ALL) associated with favorable prognosis, but the optimal therapy for this subtype remains unclear. …”
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Effect of static magnetic field on microstructure and mechanical property of AlSi10Mg alloy by laser directed energy deposition by Weiming Niu, Bingke Song, Jiasen Han, Haiou Yang, Zhaopu Yao, Hui Chen, Xin Lin

“…The magnetic field is effective in refining grain structures and promoting the columnar-to-equiaxed transition of LDED process, while its influence on fusion defects of pores is not remarkable. Due to the thermoelectric-magnetic effect, the volume force imposed on the dendrite is sufficient to fracture the dendrite arm and then reduce the dendrite spacing. …”
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<i>Rubus idaeus RiACS1</i> Gene Is Involved in Ethylene Synthesis and Accelerates Fruit Ripening in <i>Solanum lycopersicum</i> by Tiemei Li, Wenjiao Xin, Hang Zhang, Jiarong Jiang, Kunmiao Ding, Mengyu Liu, Nanyan Li, Guohui Yang

“…The subcellular localization analysis of the RiACS1 protein in the tobacco transient expression system revealed that the RiACS1-GFP fusion protein was mainly located in the nucleus. …”
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