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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition
Published 2025-01-01“…In addition, excessive ROS levels impaired autophagic degradation by inhibiting the fusion of autophagosomes with lysosomes. These abnormalities eventually induced apoptosis and inhibited testosterone synthesis in TM3 cells. …”
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4142
Intratumoral and peritumoral radiomics using multi-phase contrast-enhanced CT for diagnosis of renal oncocytoma and chromophobe renal cell carcinoma: a multicenter retrospective st...
Published 2025-02-01“…CMP models (AUC: 0.811–0.900) generally outperformed NP and fusion models (AUC: 0.728–0.756). SVM models (sensitivity: 62.50–88.89%; specificity: 63.16–77.78%; accuracy: 62.96–81.48%) outperformed manual diagnosis (sensitivity: 46.74–70.59%; specificity: 41.67–46.34%; accuracy: 52.27–59.78%). …”
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4143
Spatial mapping of the localized corrosion behavior of a magnesium alloy AZ31B tungsten inert gas weld
Published 2025-01-01“…The formation of an Al-Zn solidification network in the fusion zone (FZ) at and near the TIG weld epicenter differs from the outer heat-affected zone (HAZ), where intermetallic particles (IMPs) are the notable secondary phase from the magnesium matrix. …”
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4144
UAV Hyperspectral Remote Sensing Image Classification: A Systematic Review
Published 2025-01-01“…Furthermore, this article delves into cutting-edge research trends, such as lightweight model development, hyperspectral large models, multisource data fusion, and model interpretability, while also highlighting future trends for UAV hyperspectral remote sensing classification technology, particularly in real-time monitoring and intelligent applications.…”
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4145
First-principles calculations for the effect of irradiation-induced point defects on the hydrogen dissolution and diffusion in γ-Al2O3
Published 2025-03-01“…FeAl/Al2O3 is considered the most promising candidate material for tritium permeation barrier (TPB) due to numerous advantages. γ-Al2O3 phase structure is commonly found in FeAl/Al2O3, and is crucial to its effectiveness. In fusion reactors, high-energy neutrons generate a large number of irradiation-induced defects, significantly affecting the performance of γ-Al2O3. …”
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4146
Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in mice
Published 2025-01-01“…By treating pregnant mice with TCDD (40 μg/kg) at the vital craniofacial patterning stages (embryonic day 8.5, 10.5 and 12.5), and scanning and reconstructing the skulls at embryonic day 18.5 using microCT, we found that TCDD exposure at the earlier and later patterning stages induced variable craniofacial malformations, including premature fusion of metopic and coronal sutures, truncated palatal processes of maxillary and palatine bones, as well as opening oriented pterygoid processes. …”
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4147
Nuclear talin-1 provides a bridge between cell adhesion and gene expression
Published 2025-02-01“…To determine the functional impact of nuclear TLN1, we expressed a TLN1 fusion protein containing a nuclear localization signal. …”
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4148
MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder
Published 2024-02-01“…Eight-week-old male C57BL/6 mice had miR-451a overexpression in the medial prefrontal cortex (mPFC) via adeno-associated virus serotype 9 vectors encoding a pri-mmu-miR-451a-GFP fusion protein followed by behavioural and pathological analyses. …”
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4149
Global Elevation Inversion for Multiband Spaceborne Lidar: Predevelopment of Forest Canopy Height
Published 2025-01-01“…A high-precision multiband fusion algorithm (MBFA) is proposed for global geographic elevation inversion for multiband spaceborne lidar of China's Daqi-1 satellite (DQ-1), enhancing the ranging capability of the 1572 nm channel by approximately 5 times. …”
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4150
Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors
Published 2025-01-01“…Methods This study validated a Universal Fluorescence Multiplex PCR-based assay that assessed BCOR ITDs, BCOR::CCNB3, BCOR::MAML3 and YWHAE::NUTM2 fusions simultaneously. Results The assay achieved a detection threshold of 10 copies for fusion genes and 0.32 ng genomic DNA for BCOR ITDs. …”
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4151
Genomic and Pathogenic Characteristics of Virulent Newcastle Disease Virus Isolated from Chicken in Live Bird Markets and Backyard Flocks in Kenya
Published 2020-01-01“…Also, the polybasic amino acid sequence at the fusion-protein cleavage site had the motif 112RRQKRFV118. …”
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4152
USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression
Published 2025-01-01“…However, the nucleolar phase separation of DUBs and association with lung cancer development have remained incompletely investigated till now. Methods GFP-USP39 fusion proteins were analyzed for LLPS properties using immunofluorescence, fluorescence recovery after photobleaching (FRAP) and in vitro LLPS assays. …”
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4153
Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism
Published 2025-01-01“…Additionally, there was a decrease in osteo-facial fusion and calcified cartilage thickening in the knee joint. …”
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4154
TPDTNet: Two-Phase Distillation Training for Visible-to-Infrared Unsupervised Domain Adaptive Object Detection
Published 2025-01-01“…Next, to address small remote sensing target detection tasks, we construct a multidimensional progressive feature fusion detection framework, which initially fuses two adjacent low-level feature maps and then progressively incorporates high-level features to enhance the quality of fusing nonadjacent layer features. …”
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A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)
Published 2025-02-01“…According to our model, upon fusion of multivesicular bodies with autophagosomes, fragments of the autophagosomal inner membrane curl up to form LC3B positive ILVs of amphisomes, while CD63 positive small EVs are of multivesicular body origin. …”
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4160
Unity in diversity: navigating global connections through cultural exchange
Published 2025-01-01“…While globalization can erode local traditions, it also fosters cultural enrichment, seen in fusion cuisine, multilingualism and ethical fashion. …”
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