Transmission of the human respiratory microbiome and antibiotic resistance genes in healthy populations by Lili Ren, Jing Yang, Yan Xiao, Li Guo, Jian Rao, Chao Wu, Xinming Wang, Ying Wang, Linfeng Zhang, Li Zhang, Xiaoqing Jiang, Jiaxin Zhong, Jingchuan Zhong, Weizhong Yang, Chen Wang, Jianwei Wang, Mingkun Li

“…Abstract Background The human microbiome is transmissible between individuals, including pathogens and commensals with metabolic and immune-modulating effects, which could influence susceptibility, severity, and outcomes of both infection and non-infection diseases. …”
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Dietary Melatonin Supplementation Improved Intestinal Health and Immune Function of Pacific White Shrimp (<i>Litopenaeus vannamei</i>) Under High Alkali Stress by Yiming Li, Yucong Ye, Haojuan Yuan, Zongli Yao, Yan Li, Zhen Sun, Yuxing Wei, Yunlong Zhao, Qifang Lai

“…Experimental supplementation revealed dose-dependent outcomes: 82.7 mg/kg MT significantly improved survival rates without affecting growth parameters, while higher concentrations (329.2 mg/kg) induced elevated apoptosis (<i>p</i> < 0.05). …”
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Isocitrate Dehydrogenase-Wildtype Glioma Adapts Toward Mutant Phenotypes and Enhanced Therapy Sensitivity Under D-2-Hydroxyglutarate Exposure by Geraldine Rocha, Clara Francés-Gómez, Javier Megías, Lisandra Muñoz-Hidalgo, Pilar Casanova, Jose F. Haro-Estevez, Vicent Teruel-Martí, Daniel Monleón, Teresa San-Miguel

“…<b>Conclusions:</b> <i>IDH</i> mutation and 2HG modulate glioma cell biology, including cell cycle dynamics, proliferation rates, migration, and apoptosis. …”
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Population genetic analysis of clinical Mycobacterium abscessus complex strains in China by Xiangchen Li, Xiangchen Li, Yelei Zhu, Yewei Lu, Kunyang Wu, Yang Che, Xiaomeng Wang, Weixin Wang, Junli Gao, Junshun Gao, Zhengwei Liu, Zhengwei Liu, Zhuxian Zhou

“…An acquired erm(46) gene, likely obtained via phage-mediated horizontal gene transfer, was detected in one MabA strain.ConclusionThis study provides key genetic insights into the dynamics of MABC in China. The widespread distribution of DCCs, high genomic clustering rates, open pan-genome, and distinct resistance patterns between MabA and MabM, along with MGEs, highlight the need for targeted surveillance and tailored therapies to address emerging challenges in MABC infections.…”
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Rickettsia parkeri hypothetical protein RPATATE_1266, a homolog of exopolyphosphatase/guanosine pentaphosphate phosphohydrolase, regulates tick cell apoptosis by Dattatray V. Sawant, Nicole Y. Burkhardt, Haritha Katasani, Benjamin Cull, Ulrike G. Munderloh, Xin-Ru Wang

“…We found that the RPATATE_1266 mutant had reduced infection rates, growth, and plaque formation compared to wild-type R. parkeri in tick and mammalian cells. …”
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Tracing the evolutionary pathway of SARS-CoV-2 through RNA sequencing analysis by Mostafa Rezapour, Sean V. Murphy, David A. Ornelles, Patrick M. McNutt, Anthony Atala

“…Our first objective was to examine differences in gene expression dynamics using Generalized Linear Models with Quasi-Likelihood F-tests and the Magnitude-Altitude Scoring (GLMQL-MAS) technique, followed by Gene Ontology (GO) and pathway analyses. …”
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Impact of Split Nitrogen Topdressing on Rhizobacteria Community of Winter Wheat by Yu An, Yang Wang, Shuangshuang Liu, Wei Wu, Weiming Wang, Mengmeng Liu, Hui Xiao, Jing Dong, Hongjie Ren, Huasen Xu, Cheng Xue

“…Previous research on soil bacteria focused on refining the nitrogen (N) rates during the wheat (<i>Triticum aestivum</i> L.) growth cycle. …”
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PDGFR-β/Cav1-induced autophagy via mTOR/FIP200/ATG13 activation in cancer-associated fibroblasts promotes the malignant progression of breast cancer by Lifang Zhang, Keqin Wang, Jianbo Zhang, Xianzhe Qian, Xiaoan Zhang, Yi Wang, Quan Hu, Ziyi Zhan, Wending Hu, Hui Lin, Xiaoming Liu, Lixia Xiong

“…Abstract Background Breast cancer incidence rates have been increasing globally. Cancer-associated fibroblasts (CAFs), key stromal components of the tumor microenvironment (TME), play crucial roles in tumor growth by dynamically interacting with cancer cells. …”
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Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway by Zheng Zhang, Zheng Zhang, Zheng Zhang, Yufang Zhang, Yufang Zhang, Xiaofang Zou, Jiake Li, Yunfei Chi, Hailiang Bai, Bin Wei, Huiting Yun, Huiting Yun, Quanxi Zhang, Quanxi Zhang, Weihua Cao, Haiyan Liu, Hongjie Duan

“…Mechanistically, irisin activated AMP-activated protein kinase (AMPK) and Sirtuin 1(SIRT1), to suppress the expression of dynamin-related protein 1 (Drp1) and fission protein 1 (Fis1), while upregulating mitofusin 1 (Mfn1). This modulation of mitochondrial dynamics preserved cardiomyocyte mitochondrial membrane potential (MMP), ATP production, and structural integrity. …”
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Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. by Ananya Datta, Xin Yi Li, Manshul Nagpaul

“…However, its specific roles in modulating ocular surface dynamics and immune responses in diabetes remain unexplored. …”
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Effect of perioperative ONS combined with intestinal microecology in patients with colorectal cancer: a randomized clinical trial by Xuanjun Liu, Weixu Mao, Guowei Zhao, Juan Liao, Qigang Li, Gan He

“…The time to first defecation was significantly shorter in the test group (4.5 ± 1.8 vs. 5.9 ± 1.7 days, t = 3.132, p = 0.003).ConclusionPerioperative ONS combined with intestinal microbiota interventions improves postoperative nutritional status, modulates inflammatory dynamics, and accelerates intestinal function recovery. …”
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International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB) by John A. Rathmacher, Lisa M. Pitchford, Jeffrey R. Stout, Jeremy R. Townsend, Ralf Jäger, Richard B. Kreider, Bill I. Campbell, Chad M. Kerksick, Patrick S. Harty, Darren G. Candow, Brandon M. Roberts, Shawn M. Arent, Douglas S. Kalman, Jose Antonio

“…HMB may be effective in countering muscle disuse atrophy during periods of inactivity due to illness or injury. The modulation of mitochondrial dynamics and lipid metabolism by HMB may be a potential mechanism for preventing disuse atrophy and aiding rehabilitation beyond HMB’s effects on rates of muscle protein synthesis and degradation. 12. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT by Biza Stenfert Kroese, Gemma Unwin, Richard Hastings, Andrew Jahoda, Rachel McNamara, David Gillespie, Jeremy Segrott, Kate Ingarfield, Myrsini Gianatsi, Elizabeth Randell, Zoe Mather, Barbara Barrett, Poushali Ganguli, John Rose, Mariam Sahle, Emily Warren, Nathan Da Cruz

“…It is likely that the pandemic resulted in reduced capacity and interest of schools to participate in research, higher staff and pupil absence in schools, increased pressure on school management, teachers, children and parents/carers, difficult family dynamics and poorer response rates of teachers and parents/carers. …”
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