Five-Year Sales Trends of Osteoporosis Medications in Korea: A Market Analysis Based on IMS Health Sales Audit Data (2018–2023) by Jung Yoon Park, Youn-Jee Chung, Mee-Ran Kim, Jae-Yen Song

“…Meanwhile, denosumab, a receptor activator of the nuclear factor-κB ligand inhibitor, showed a remarkable growth rate of 957.6% from 2018 to 2023, surpassing bisphosphonates in their market share. …”
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A complex remodeling of cellular homeostasis distinguishes RSV/SARS-CoV-2 co-infected A549-hACE2 expressing cell lines by Claudia Vanetti, Irma Saulle, Valentina Artusa, Claudia Moscheni, Gioia Cappelletti, Silvia Zecchini, Sergio Strizzi, Micaela Garziano, Claudio Fenizia, Antonella Tosoni, Martina Broggiato, Pasquale Ogno, Manuela Nebuloni, Mario Clerici, Daria Trabattoni, Fiona Limanaqi, Mara Biasin

“…Concurrent infections with two or more pathogens with analogous tropism, such as RSV and SARS-CoV-2, may antagonize or facilitate each other, modulating disease outcome. Clinically, discrepancies in the severity of symptoms have been reported in children with RSV/SARS-CoV-2 co-infection. …”
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The Jahn–Teller distortion‐induced electronic structure regulation of Mn‐doped Co3O4 for enhanced acetone detection by Liang Zhao, Congcong Xin, Chengchao Yu, Yunpeng Xing, Zefeng Wei, Hongda Zhang, Teng Fei, Sen Liu, Haiyan Zhang, Tong Zhang

“…As expected, Mn‐Co3O4 exhibits a high response value of 46.7 toward 100 ppm acetone, low limit of detection of 0.75 ppb, high selectivity, and high stability, which are overwhelmingly superior to previous Co3O4‐based acetone sensors. The dynamics and thermodynamics analysis demonstrate that the Mn doping improves sensing reaction rate, reduces reaction barrier, and promotes the charge transfer. …”
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Anti-Inflammatory effects of Lactobacillus helveticus and Arthrospira platensis on colonic cells inflamed by Crohn’s disease-associated Escherichia coli by Samira Alipour, Hossein Halimi, Nastaran Asri, Mohammad Rostami-Nejad, Leila Pishkar, Hamidreza Houri

“…The anti-invasion/adhesion properties of L. helveticus and/or HA-A. platensis were investigated by assessing the CD-associated E. coli invasion/adhesion rate (%). Signaling molecules (NF-κB, STAT3, NOD2) were analyzed via qPCR to capture pathway activation dynamics, while cytokines (TNF-α, IL-1β, IL-8, IL-10) were quantified by ELISA to assess secreted functional proteins. …”
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Skin Micrograph Protector in a Burn Wound: Alloderm or Hydrogel Coating? by I. Yu. Arefyev, M. G. Ryabkov, V. V. Beschastnov, M. L. Bugrova, K. S. Petrova, P. V. Peretyagin, L. B. Timofeeva, A. A. Karpenko, A. A. Tulupov, N. A. Koloshein

“…AIM OF STUDY Was to compare the dynamics of engraftment of skin micrographs in a burn wound when using protectors from an allodermal graft and from a hydrogel coating.MATERIAL AND METHODS The experimental study was conducted on 18 rats with a scab formed 3 days after modeling a deep burn with an area of 20% of the body surface. …”
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Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…Abstract Background The modulation of tumor microenvironments through immune checkpoint pathways is pivotal for the development of effective cancer immunotherapies. …”
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Exploring the Molecular Mechanism of 1,25(OH)₂D₃ Reversal of Sorafenib Resistance in Hepatocellular Carcinoma Based on Network Pharmacology and Experimental V... by Zhiyan Long, Xiangyi Wu, Tianxin Luo, Xiaomei Chen, Jian Huang, Shu Zhang

“…In vitro experiments demonstrated the synergistic effects of 1,25(OH)₂D₃ and sorafenib, significantly inhibiting the viability and colony formation rate of sorafenib-resistant hepatocellular carcinoma cells. …”
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International Natural Uranium Price Prediction Based on TF-CNN-BiLSTM Model by YANG Jingzhe, XUE Xiaogang

“…The training process was optimized with learning rate reduction and early stopping callbacks to prevent overfitting. …”

PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling by Caterina Mancini, Giulia Lori, Gianluca Mattei, Marta Iozzo, Dayana Desideri, Fabio Cianchi, Laura Fortuna, Federico Passagnoli, Daniela Massi, Filippo Ugolini, Luca Messerini, Salvatore Piscuoglio, Antonio Pezone, Francesca Magherini, Alessio Biagioni, Tiziano Lottini, Demetra Zambardino, Giuseppina Ivana Truglio, Elena Petricci, Alberto Magi, Annarosa Arcangeli, Luisa Maresca, Barbara Stecca, Erica Pranzini, Maria Letizia Taddei

“…Abstract Background Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors. …”
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Climate Change and Vegetation Greening Jointly Promote the Increase in Evapotranspiration in the Jing River Basin by Luoyi Yao, Rong Wu, Zijun Wang, Tingyi Xue, Yangyang Liu, Ercha Hu, Zhongming Wen, Haijing Shi, Jiaqi Yang, Peidong Han, Yinghan Zhao, Jingyao Hu

“…Radiation is found to govern most ET changes across the region, while radiation and precipitation notably affected ET by modulating air temperature. In summary, these radiant energy changes directly affect the evaporation rate and total evapotranspiration of surface water. …”
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Precision therapy targeting CAMK2 to overcome resistance to EGFR inhibitors in FAT1-mutated oral squamous cell carcinoma by Yumeng Lin, Yibo Huang, Bowen Yang, You Zhang, Ning Ji, Jing Li, Yu Zhou, Ying-Qiang Shen, Qianming Chen, Xiangxiang Pan

“…Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer with a high mortality rate in its late stages. One of the major challenges in OSCC treatment is the resistance to epidermal growth factor receptor (EGFR) inhibitors. …”
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Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling by Joseph Hanna, Yacine Touahri, Alissa Pak, Lauren Belfiore, Edwin van Oosten, Luke Ajay David, Sisu Han, Yaroslav Ilnytskyy, Igor Kovalchuk, Deborah Kurrasch, Satoshi Okawa, Antonio del Sol, Robert A Screaton, Isabelle Aubert, Carol Schuurmans

“…Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. …”
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Hemoglobin state-flux: A finite-state model representation of the hemoglobin signal for evaluation of the resting state and the influence of disease. by Randall L Barbour, Harry L Graber, San-Lian S Barbour

“…Accessible phenomenology includes measures of the kinetics and probabilities of network dynamics, which we treat as surrogates for the actions of feedback mechanisms that modulate tissue-vascular coupling.…”
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Microsaccades: Empirical Research and Methodological Advances by Susana Martinez-Conde, Ralf Engbert, Rudolf Groner

“…Krueger et al discover that microsaccade rates modulate with visual attention demands and report that “Microsaccades distinguish looking from seeing”. …”
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Emotional Evaluations from Partners and Opponents Differentially Influence the Perception of Ambiguous Faces by Danyang Ran, Yihan Zhang, Bin Hao, Shuaixia Li

“…Thirty-five participants rated the valence of surprised faces. An advanced mass univariate statistical approach was utilized to analyze the ERP data. …”
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Poly(vinyl alcohol boric acid)-Diclofenac Sodium Salt Drug Delivery Systems: Experimental and Theoretical Studies by Daniela Ailincai, Alexandra Maria Dorobanțu, Bogdan Dima, Ștefan Andrei Irimiciuc, Cristian Lupașcu, Maricel Agop, Orzan Olguta

“…To explain such dynamics involved multifractal self-modulation in the form of period doubling, quasiperiodicity, intermittency, etc., as well as multifractal self-modulation of network type. …”
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Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors by Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl

“…To understand gating and lipid modulation, we generated two ensembles of molecular dynamics simulations of apo α7 nAChRs, with or without cholesterol. …”
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Functional architecture of intracellular oscillations in hippocampal dendrites by Zhenrui Liao, Kevin C. Gonzalez, Deborah M. Li, Catalina M. Yang, Donald Holder, Natalie E. McClain, Guofeng Zhang, Stephen W. Evans, Mariya Chavarha, Jane Simko, Christopher D. Makinson, Michael Z. Lin, Attila Losonczy, Adrian Negrean

“…We systematically quantify the modulation of local event rates by locomotion in distinct dendritic regions, report an advancing gradient of dendritic theta phase along the basal-tuft axis, and describe a predominant hyperpolarization of the dendritic arbor during sharp-wave ripples. …”
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Ultrafast strong-field terahertz nonlinear nanometasurfaces by Cai Jiahua, Chen Sai, Geng Chunyan, Li Jianghao, Quan Baogang, Wu Xiaojun

“…In this work, we obtain the nonlinear modulation dynamics of a “THz-nano” metasurface on silicon substrates using a time-resolved strong-field THz-pump THz-probe (TPTP) with a thousand orders local field enhancement through confining THz waves into nano-gaps (15 nm, λ/33,000). …”
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An Exploratory Analysis of Long-Term Effects of Role-Model Volunteering on Young Adults by Sharon Kukla-Acevedo, Emma Powell

“…Although previous research indicates a relationship between concurrent parental and child volunteering, there is very little work that explores the long-term effect of parental volunteering (during a child’s adolescent years) on their adult children. We merged several modules of the Panel Study of Income Dynamics that allowed for significant granularity to explore this question. …”
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