A novel computational model of swine ventricular myocyte reveals new insights into disease mechanisms and therapeutic approaches in Timothy Syndrome by Alessandro Trancuccio, Carmen Tarifa, Rossana Bongianino, Silvia G. Priori, Demetrio J. Santiago

“…Introducing 22% of TS1-mutated LTCCs, the model faithfully reproduced key disease features, including marked AP prolongation, steeper rate-dependent adaptation of AP duration, $$\hbox {Ca}^{2+}$$ Ca 2 + overload, and CaMKII-mediated decreased upstroke velocity. …”
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Effects of fluconazole and amphotericin B in the control of cryptococcal pneumonia in vivo by Zhao Yu, Zhihao Liu, Jiaojiao Qian, Yuanyuan Qian

“…Its incidence is increasing, driven by evolving pathogen dynamics and heightened susceptibility among patient populations. …”
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Research on the construction and application of pathology knowledge graph by Hong Wei, Xue Liu, Huiling Cao, Weiqi Qin, Qun Ma, Lingling Kong

“…Results The MKG-O-PIRTAS group achieved significantly higher adjusted exam scores (76.14 vs. 73.72, p = 0.033) and 86% lower misdiagnosis rate in high performers (p = 0.015). Cognitive load diverged markedly (57.5 vs. 75.5, p = 0.007), with high performers dynamically contextualizing MKG nodes into clinical reasoning, while novices required scaffolded pathways. …”
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Feeding and Growth in the Ephyra Stage of <i>Aurelia coerulea</i>: An In Situ Study by Seo Yeol Choi, Kyoung Yeon Kim, Seok Hyun Youn

“…These results indicate that in situ feeding and growth rates are lower than laboratory rates, and that early-stage predation by ephyrae is modulated by prey availability and environmental history. …”
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Polyamine-Mediated Growth Regulation in Microalgae: Integrating Redox Balance and Amino Acids Pathway into Metabolic Engineering by Leandro Luis Lavandosque, Flavia Vischi Winck

“…This review advances a comprehensive perspective of microalgae growth, integrating polyamine dynamics, amino acid metabolism, and redox balance. …”
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High average power nanosecond pulsed single longitudinal mode diamond Raman laser in the 1.6 µm waveband by Weifeng Tan, Yisen Wang, Peining Chen, Rongzhuo Chen, Siqi Zhu, Hao Yin, Zhen Li, Zhenqiang Chen, Shibo Dai

“…By exploiting the subtly designed dynamically stable resonator and the thoroughly optimized acousto-optic modulator, excellent beam quality and substantial power improvement have been confirmed. …”
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Ornithine decarboxylase antizyme 2 (OAZ2) in human colon adenocarcinoma: a potent prognostic factor associated with immunity by Yiheng Liu, Shengjie Zhang, Wenjie Liao, Jun Qian, Cuihua Lu, Li Jin

“…Overexpression of OAZ2 in RKO colorectal cancer cells significantly reduced their proliferation rate and impaired migration, confirming the functional impact of OAZ2 dysregulation in COAD. …”
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Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors by Folorunsho Bright Omage, José Augusto Salim, Ivan Mazoni, Inácio Henrique Yano, Luiz Borro, Jorge Enrique Hernández Gonzalez, Fabio Rogerio de Moraes, Poliana Fernanda Giachetto, Ljubica Tasic, Raghuvir Krishnaswamy Arni, Goran Neshich

“…Existing computational methods for predicting allosteric sites on proteins often rely on static protein surface pocket features, normal mode analysis or extensive molecular dynamics simulations encompassing both the protein function modulator and the protein itself. …”
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Boundary Layers of Circumplanetary Disks around Spinning Planets. II. Global Modes with Azimuthal Magnetic Fields by Zhihao Fu, Shunquan Huang, Cong Yu

“…Our prior studies have revealed two distinct global wave modes for circumplanetary disks with BLs exhibiting opposite behaviors in spin modulation. We perform a detailed analysis of the effects of magnetic fields on these global modes, highlighting how magnetic resonances and turning points could complicate the wave dynamics. …”
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Zinc toxicity induces intestinal cell death via inhibiting NAD+ synthesis in mice and IPEC-J2 cells by Lingjun Chen, Feifei Huang, Leilei Zhu, Xin Tian, Mohan Zhou, Jie Feng

“…We next determined the dynamics of oxidative stress and energy metabolism in Zn overload treatment IPEC-J2 cells. …”
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Dual associations of gut and oral microbial networks with kidney transplantation by Siming Qu, Yuzheng Gu, Xiaoxue Hou, Min Wei, Mengmeng Wang, Yuya Su, Yinglei Miao, Jinlong Yang, Yang Sun, Zhong Zeng

“…These network changes were significantly correlated with clinical indicators, especially with estimated glomerular filtration rate, suggesting that microbial networks contributed to regulating kidney function and host health from dual dimensions. …”
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Elucidating the role of earthworms on the fate of fertilizer N with synthetic and organic fertilizer application by Rong Hao, Yupeng Wu, Hong Di, Yunfeng Chen, Weiguo Cheng, Ronggui Hu, Wenfeng Tan

“…This study underscores the pivotal role of earthworms in modulating fertilizer N dynamics, with organic fertilizer offering superior ecosystem services compared to synthetic fertilizer. …”
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Dietary Tribulus Terrestris as a functional food combined with blood flow restriction to enhance the jump performance of basketball athletes: a randomized crossover study by Junhao Kong, Jinda Li, Mingchen Xu, Tao Liu, Zhiyu Xie, Tianhe Li, Yapu Liang

“…CMJ performance was assessed at 0, 4-, 8-, 12-, and 16-min post-activation, measuring jump height (H(v)), peak/relative peak power (PP/RPP), maximum/relative force (MCF/MRF), peak rate of force development (PRFD), and modified reactive strength index (RSImod). …”
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UAV Trajectory Control and Power Optimization for Low-Latency C-V2X Communications in a Federated Learning Environment by Xavier Fernando, Abhishek Gupta

“…Due to the limited battery power and coverage range of UAV, the quality of service (QoS) requirements such as coverage rate, UAV flying time, and fairness of vehicle selection are adversely impacted. …”
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Alkali Induction Strategy for Artificial Photosynthesis of Hydrogen by TiO2 Heterophase Homojunctions by Minghua Xu, Xiaowen Ruan, Malik Zeeshan Shahid, Depeng Meng, Guozhen Fang, Chunsheng Ding, Wei Zhang, Jing Leng, Songcan Wang, Sai Kishore Ravi, Xiaoqiang Cui

“…Unlike traditional heterojunction photocatalysts, homojunction features different energy bandgaps with interchangeable compositions that can significantly trigger charge carrier dynamics, but their precise construction remains an ongoing challenge owing to quick lattice‐level modulations. …”
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The Impact of Litter from Different Belowground Organs of <i>Phragmites australis</i> on Microbial-Mediated Soil Organic Carbon Accumulation in a Lacustrine Wetland by Chong Chen, Yong Wang, Liu Yang, Yongen Min, Keming Yue, Sitong Lu, Hongfeng Bian, Xue Wang, Leilei Zhang

“…Although belowground litter decomposition critically influences lacustrine wetland soil carbon dynamics, the organ-specific microbial mechanisms driving soil organic carbon (SOC) accumulation remain unclear. …”
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Synergistic impacts of bisphenol A and elevated temperatures on Oryza sativa development and rhizosphere microbiome in diverse cultivars by Mehmood Jan, Mengyun Xu, Muhammad Afzal, Weicai Jin, Faisal Islam, Wenhao Zhong, Qiang Yue, Waqar Ahmed, Wenyi Wang

“…Furthermore, HTR-1 exhibited higher ABA levels, a lower transpiration rate, and reduced BPA accumulation in seedlings under stress conditions, resulting in superior growth compared to HTS-5. …”
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Terahertz Wave Alleviates Comorbidity Anxiety in Pain by Reducing the Binding Capacity of Nanostructured Glutamate Molecules to GluA2 by Zihua Song, Yuankun Sun, Pan Liu, Hao Ruan, Yuanyuan He, Junkai Yin, Chun Xiao, Jing Ma, Yun Yu, Shaomeng Wang, Yubin Gong, Z. W. Lin, Zhi Zhang, Chao Chang, Maojun Yang

“…Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy and carry a risk of side effects. …”
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Effects of pH on Oat Protein Isolate and Pickering Emulsion Stabilized by the Protein by Jing WANG, Yingxue JIAO, Wei GAO, Lipeng FAN, Sunshuo LIANG, Huiting WANG, Lijuan LU, Wenhui QI, Zhisheng ZHANG

“…Lipid oxidation kinetics were significantly decelerated, emulsion stability was augmented through steric hindrance mechanisms, and free fatty acid release rate was elevated to 70.27% during in vitro digestion simulations. …”
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Higher Soil Mesofauna Abundance and Microbial Activities Drive Litter Decomposition in Subtropical Forests by Hong Lin, Qin Kong, Xinyu Xu, Xingbing He, Yonghui Lin, Zaihua He, Yuehong Gao, Xiangshi Kong

“…However, how this effect is modulated by the microenvironment needs further investigation. …”
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