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The delaying effect of toripalimab on disease progression in patients with advanced hepatocellular carcinoma and changes in serum tumor markers
Published 2025-07-01“…Primary endpoints included objective response rate (ORR) and overall survival (OS); secondary endpoints encompassed tumor marker dynamics, liver function parameters, T lymphocyte subsets, and safety. …”
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303
Reducing power ripple for multi-rotor wind energy systems using FOPDPI controllers
Published 2025-04-01Get full text
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304
Assessing immunotherapy response: going beyond RECIST by integrating early tumor growth kinetics
Published 2024-12-01“…Tumor size measurements up to two follow-up time points were used to fit a novel Gompertz model and estimate growth rate (GR) and kinetic parameters representing depth of response (A), speed of response (B), and long-term modulation (M). …”
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Therapeutic efficacy and mechanisms of Xuebijing in Acinetobacter baumannii infection based on meta-analysis and integrated pharmacology approaches
Published 2025-05-01“…Meta-analysis demonstrated that XBJ significantly improved clinical outcomes, with a higher overall effective rate (RR = 1.20, 95% CI: 1.13–1.27, P < 0.01) and enhanced bacterial clearance (RR = 1.44, 95% CI: 1.23–1.68, P < 0.01) compared to conventional treatment alone. …”
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Joint Effects of Submesoscale Lateral Dispersion and Biological Reactions on Biogeochemical Flux
Published 2025-04-01“…By parameterizing the effects of dispersion due to lateral stirring on flux within an eastern boundary current region, we show that enhanced dispersion yields a near‐linear increase in cross‐shore flux, modulated by phytoplankton growth rates and ambient nutrient availability. …”
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309
Comparative impacts of climate change and human activities on spatiotemporal changes of bare land in the Turpan-Hami Basin (1985–2020)
Published 2025-07-01“…Moreover, the soil organic carbon influenced bare land stability, though its effects were modulated by climate-human interactions. This study demonstrates the synergistic interactions between climate change and human activities in driving bare land dynamics. …”
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310
Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro,...
Published 2024-12-01“…Phosphorylation causes a 2-3 fold decrease of affinity of cTn for Ca2+ associated with a higher rate of Ca2+ dissociation from cTnC leading to a faster relaxation rate of the cardiac muscle (lusitropy). …”
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311
Hispidulin: a potential alternative to vorinostat against HDAC1 for acute myeloid leukemia
Published 2025-07-01“…Abstract Acute myeloid leukemia (AML) has a survival rate of only 30%, predominantly affecting the bone marrow. …”
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312
Targeting mitochondria: a novel approach for treating platinum-resistant ovarian cancer
Published 2024-10-01“…Mutations in mtDNA can modulate tumor chemosensitivity through various mechanisms, including DNA damage responses, shifts in energy metabolism, maintenance of Reactive Oxygen Species (ROS) homeostasis, and alterations in mitochondrial dynamics. …”
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313
Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation
Published 2025-08-01“…Conclusions These findings underscore the role of the skeletal muscle pump in modulating venous return and cardiac output during PCMs. …”
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314
Analysis of Precision Regulation Pathways for Thermal Substation Supply–Demand Balance
Published 2025-05-01“…A quality regulation strategy is systematically implemented to stabilize circulation flow rates through temperature modulation by establishing a supply–demand equilibrium model under bypass conditions. …”
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315
Research on voltage fluctuation suppression in coal mine AC/DC hybrid distribution network based on directly-coupled energy storage control
Published 2025-01-01“…The battery charge/discharge rate was controlled at 0.628C, meeting the fast-response requirements. …”
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316
Processing streams in a monitoring cloud cluster
Published 2020-01-01“…In the conditions of high dynamics of changes in the bit rate of information generation from the source, a model of the bit rate of Discretized Stream (DStream) formation is proposed, which has a common application. …”
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317
Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i>
Published 2024-12-01“…Integrating reverse virtual docking, molecular dynamics simulations, and cellular thermal shift assays ultimately focused on HSP90AA1 as the target of PCC. …”
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318
Simulation of Interference Effects of UWB Pulse Signal to the GPS Receiver
Published 2021-01-01Get full text
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319
Analysis of Irrigation, Crop Growth and Physiological Information in Substrate Cultivation Using an Intelligent Weighing System
Published 2025-05-01“…The monitored values from the intelligent weighing system’s pressure-type module were used to calculate irrigation start–stop times, frequency, volume, drainage volume, drainage rate, evapotranspiration, evapotranspiration rate, and stomatal conductance. …”
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320
Path planning algorithm for logistics autonomous vehicles at Cainiao stations based on multi-sensor data fusion.
Published 2025-01-01“…[Formula: see text]), and obstacle avoidance success rate (98.7% vs. 85.4%), especially in complex dynamic environments. …”
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