Discovery and Characterization of Novel Esterases with Ethyl Carbamate-Hydrolyzing Activity by LIU Qingtao, ZHU Sibao, WANG Tianwen, LI Chuang, QIAN Senhe, ZHANG Wenqing, CHENG Fan, TIAN Shufang

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Artificial intelligence and 3D subsurface interpretation for bright spot and channel detections by Yasir Bashir, Muhammad Afiq Aiman Bin Zahari, Abdullah Karaman, Doğa Doğan, Zeynep Döner, Ali Mohammadi, Syed Haroon Ali

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Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler, Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, Ibrahim Akin

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized. …”
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LHC Signals of the Next-to-Lightest Scalar Higgs State of the NMSSM in the 4τ Decay Channel by M. M. Almarashi

“…It is found that while the h2 discovery is impossible through the latter channel, the former one in the 4τ final state is a promising channel to discover the h2 with masses up to around 250 GeV at the LHC. …”
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A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli by Mallory Wright, Mandeep Kaur, Laura K. Thompson, Georgina Cox

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Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation by Sung Eun Kim, Geehoon Chung, Sun Kwang Kim

“…In this regard, we summarize the discovery and characterization of pain-relieving phytochemicals from herbal medicine, and we discuss their mechanisms of action and their potential to mimic or enhance the effects of conventional analgesics through ion channel modulation.…”
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Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance by Liang Liu, Xian Zhang, Yan Chai, Jianning Zhang, Quanjun Deng, Xin Chen

“…Abstract The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. …”
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TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets by Nelson S. Yee, Ada S. Chan, Julian D. Yee, Rosemary K. Yee

“…Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. …”
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Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention by Sonia Youhanna, Aurino M. Kemas, Shane C. Wright, Yi Zhong, Britta Klumpp, Kathrin Klein, Aikaterini Motso, Maurice Michel, Nicole Ziegler, Mingmei Shang, Pierre Sabatier, Aimo Kannt, Hongda Sheng, Nuria Oliva‐Vilarnau, Florian A. Büttner, Brinton Seashore‐Ludlow, Jonas Schreiner, Maike Windbergs, Martin Cornillet, Niklas K. Björkström, Andreas J. Hülsmeier, Thorsten Hornemann, Jesper V. Olsen, Yi Wang, Roberto Gramignoli, Michael Sundström, Volker M. Lauschke

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Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1 by David A. Close, V. Blair Journigan, Paul A. Johnston

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Genetics and pathophysiology of low-renin arterial hypertension by A. L. Markel

“…Also, several oligogenic forms of low-renin hypertension were studied, some of which are associated with the hyperproduction of aldosterone, but in the others the development of low-renin hypertension was associated with mutations of genes involved in regulation of the functioning of the kidney ion channels. The discovery of some types of arterial hypertension with known mechanisms of their development is of paramount importance for medicine, as it allows for targeted efective therapy and in some cases for achieving a complete cure. …”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

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The History of Cystinosis: Lessons for Clinical Management by Paul Goodyer

“…Major conceptual break-throughs include (a) its discovery in 1903, (b) recognition of the renal Fanconi syndrome, (c) realization that tissue accumulation of cystine reflects a defective channel in the lysosomal membrane, (d) translation of this discovery to trials of cysteamine, (e) discovery of the CTNS gene, and (f) report of successful stem cell therapy in the cystinotic mouse. …”
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Découverte d’une canalisation antique sur la colline de Fourvière à Lyon by Philippe Dessaint

“…The existence of tanks in this sector is mentioned without being precisely located.However, other factors, such as the discovery of a channel against a wall to the west of Place de Fourvière during work at the end of the 19th century, prompt us to propose another hypothesis. …”
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Fully automated CFD simulation system research based on design scheme tree by Zijun Liu

“…Abstract Compared with the remarkable achievements of computer-aided drug discovery systems for drug discovery, the role of computational fluid dynamics (CFD) in flow channel design requires further development. …”
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Morphology Effect of Surface Structures on Microchannel Flow Using Lattice Boltzmann Method by Ge Zhang, Bo Liu, Aiguo Xu, Yiming Shan, Yingjun Li

“…This discovery is furtherly ensured numerically by a test on a channel created with the profile of a rough rock surface. …”
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Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature by Abbi Lulsegged, Christina Wlodek, Michela Rossi

“…Thyrotoxic periodic paralysis (TPP) is a rare but potentially serious complication of thyrotoxicosis resulting in temporary but severe muscle weakness. Recent discovery of a novel mutation in the KCNJ18 gene which codes for an inwardly rectifying potassium channel and is controlled by thyroid hormones may provide greater insight into the pathogenesis of TPP.…”
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Microspectrometer-Enabled Real-Time Concentration Monitoring in the Microfluidic Protein Enrichment Chip by Dong-Li Li, Wen-Shu Huang, Yi Hung Wu, Chun-Ping Jen

“…The device employs electrokinetic principles for efficient protein preconcentration in a PDMS and Nafion film channel. Using FITC-labeled BSA as a model protein, the system demonstrated a linear correlation between protein concentration and absorbance at 491 nm. …”
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Kajian Perancangan dan Evaluasi PLTMH Jorong Patamuan Kabupaten Pasaman dalam Mengatasi Kekurangan Listrik Pedesaan by N Nusyirwan

“…The Maximum head for this micro hydro generator is 8 meters and the net loss of 0.4 m. The main channel is composed of a trunk made of concrete channels open with a size of 40 x 40 x 40 cm and a pipeline for rapid pipeline with a length of 28 m using the pipe 8 inches or 20 cm. …”
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Intelligent Digital Currency and Dynamic Coding Service System Based on Internet of Things Technology by Shanshen Li, Xin Jing

“…Otherwise, it will cache the message and attach its own neighbor node list to the signal-to-noise ratio of the channel link, update the RREQ message, and broadcast it. …”
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