An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants by Bruce Nmezi, Guillermo Rodriguez Bey, Talia DeFrancesco Oranburg, Kseniia Dudnyk, Santana M. Lardo, Nathan Herdman, Anastasia Jacko, Sandy Rubio, Emanuel Loeza-Alcocer, Julia Kofler, Dongkyeong Kim, Julia Rankin, Emma Kivuva, Nicholas Gutowski, Katherine Schon, Jelle van den Ameele, Patrick F. Chinnery, Sérgio B. Sousa, Filipe Palavra, Camilo Toro, Filippo Pinto e Vairo, Jonas Saute, Lisa Pan, Murad Alturkustani, Robert Hammond, Francois Gros-Louis, Michael S. Gold, Yungki Park, Geneviève Bernard, Raili Raininko, Jian Zhou, Sarah J. Hainer, Quasar S. Padiath

“…Most cases of ADLD are caused by tandem genomic duplications involving the lamin B1 gene (LMNB1) while a small subset are caused by genomic deletions upstream of the gene. Utilizing data from recently identified families that carry LMNB1 gene duplications but do not exhibit demyelination, ADLD patient tissues, CRISPR edited cell lines and mouse models, we have identified a silencer element that is lost in ADLD patients and that specifically targets expression to oligodendrocytes. …”
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Strategi Penanganan Imbalance Class Pada Model Klasifikasi Penerima Kartu Indonesia Pintar Kuliah Berbasis Neural Network Menggunakan Kombinasi SMOTE dan ENN by Zaqiatud Darojah, Ronny Susetyoko, Nana Ramadijanti

“…Furthermore, the sample-selected deletion method is applied to the majority sub-classes that have a very significant distance from the minority class. …”
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IMPACT OF FISH WASTE PROTEIN ENZYMETIC HYDROLYSATE ON GROWTH OF SOME OF Lactobacillus sp. AND Bifidobacterium sp. by A. S. Mohammed

“…Two type protein concentrates were prepared from defatted carp fish waste powder, the first at pH 2/4.5 and the second at pH 12/4.5. …”
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Integrity of Best-Answer Assignments in Large Enrollment Classes; the role of Compulsory Attribution by Kurt Schmitz, Veda Storey

“…A unique feature that makes this method well-suited to large enrollment classes is the ability to secure and, when necessary, to delete stolen work, thereby precluding misappropriation. …”
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DYNAMICS OF AFRICAN TRADITIONAL AND CULTURAL PRACTICE AS A SOCIAL CONTROL MECHANISM: A DETERRENT THEORETICAL ANALYSIS ON THE ALEKWU BELIEF SYSTEM AMONG THE IDOMA PEOPLE IN NIGERIA by Daniel, Rosemary Onchi

“… Strong traditional and cultural convictions prevalent in many African communities place a premium on deference to established rules and refraining members from abominable or deviant behaviour. …”
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis by Phuong T.T. Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T. Izzo, Laura V. Pinheiro, Hayley A. Affronti, Gabriel Gugiu, Shivani Ghaisas, Joyce Y. Liu, Jordan C. Harris, Charles W. Bradley, John T. Seykora, Xiaolu Yang, Taku Kambayashi, Clementina Mesaros, Brian C. Capell, Kathryn E. Wellen

“…ACLY-deficient skin upregulates the acetyl-CoA synthetase ACSS2; deletion of both Acly and Acss2 from the skin exacerbates skin abnormalities, with differential effects on two major lipid-producing skin compartments. …”
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Analysis of Amelogenin and Sex-determining Region on Y Chromosome Genes Obtained from Pulpal Tissue for Sex Estimation by using Multiplex Polymerase Chain Reaction by Mohammed Taha Ahmed Baban, Dena Nadhim Mohammad, Natheer Al-Rawi

“…Nevertheless, the amplification of both of these genes encounters limitations in determining sex, primarily due to deletions observed in certain racial groups and the influence of genetic disorders on these genes. …”
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DC-DC Boost Converter Design With Analog Feedback Control for Cryogenic Applications by Danilo Santoro, Niccolo Gallice, Marco Bassani, Paolo Cova, Nicola Delmonte, Massimo Lazzaroni, Valeria Trabattoni, Andrea Zani

“…However, in the Deep Underground Neutrino Experiment (DUNE) Vertical Drift design, the Photon Detection System (PDS) electronic readout and bias circuits and sensors must be installed on the cathode plane, which is biased at a high DC voltage (-300 kV). …”
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Waveform characteristics in thoracic paravertebral space: a prospective observational study [version 2; peer review: 2 approved] by Pattika Subsoontorn, Lalinthip Vareesunthorn, Amorn Vijitpavan, Sivaporn Termpornlert

“…Results 98 typical regular respiratory waveforms with a mean pressure of ≤ 25 mmHg were detected in the TPVS of 50 patients. The sensitivity of the combined ultrasound and pressure waveform measurement technique to identify the TPVS was 95.45% (95% confidence interval, 84.527–99.445). …”
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The Impact of Zinc Supplementation on the Course of Infections by Justyna Woźniak, Ewelina Kopczyńska, Piotr Kulej, Wiktor Biesiada, Justyna Weronika Kmieć, Anna-Mariia Chernysh, Aleksandra Dusińska, Jakub Waszczyński, Kamila Fuczyło, Karolina Stankevič

“…Introduction Zinc plays a vital role in immune function, enhancing defense mechanisms and reducing infection duration and severity. …”
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Rib suppression-based radiomics for diagnosis of neonatal respiratory distress syndrome in chest X-rays by Yudong Wang, Zongjin Qu, Zhengjun Dai, Yuhong Li, Yanyan Liu, Wei Wang, Lianxiang Xiao, Yi Zhang

“…Abstract This study aims to refine a radiomics-based diagnostic approach for detecting neonatal respiratory distress syndrome (NRDS) and examines the influence of rib suppression on the diagnostic precision of radiomics models using neonatal chest X-ray (CXR) images. …”
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New insights into the mechanism of triphenyl phosphate and its metabolite diphenyl phosphate in diabetic kidney disease by Ting Fang, Qiaoyan Liu, Xinxin Huangfu, Hongkai Zhu, Hongwen Sun, Liming Chen

“…Toxicity analysis showed that TPHP could cause dose-dependent toxicity in mouse podocyte clone 5 (MPC5) and mouse mesangial cells (MES13). The study also detected mRNA expression of core targets molecularly docked with TPHP and DPHP using real-time-PCR. …”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…Background and Aims: This study aims to conduct a comprehensive quantitative analysis of various nonalcoholic fatty liver disease (NAFLD) therapeutics, utilizing magnetic resonance (MR)-detected liver fat content (LFC) as the efficacy endpoint, and to identify biomarkers correlated with changes in LFC based on published literature. …”
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Energy-Optimized Monitoring System for Underground Cave Environments Based on Long Preamble LoRa by Mattia Ragnoli, Gianluca Barile, Alfiero Leoni, Stefano Ricci, Vincenzo Stornelli

“…The presented monitoring system is based on an asynchronous LoRa network that leverages Channel Activity Detection (CAD) for in-cave communication. This study is part of a pre-commercial survey in sight of a future fixed installation in the aforementioned location. …”
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Congenital Chylothorax: Case Report by Egemen Tolunay, Bulut Varlı, Fırat Tülek, Emre Pabuçcu, Şerife Esra Çetinkaya, Korhan Kahraman, Acar Koç

“…Patient with 31 weeks of gestation has detected to have a fetal pleural effusion by routine ultrasonographic imaging. …”
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Clinical Guidelines of the Russian Society of Surgeons, the Russian Gastroenterological Association, the Association of Surgeons-Hepatologists and the Endoscopic Society “REndO” o... by V. T. Ivashkin, A. G. Kriger, A. V. Okhlobystin, M. A. Anischenko, S. S. Kardasheva, S. A. Alekseenko, S. F. Bagnenko, M. I. Bykov, S. A. Budzinskiy, I.  M. Buriev, V. A. Vishnevskiy, E. I. Galperin, V. P. Glabay, V. R. Goltsov, T. G. Dyuzheva, G. G. Karmazanovskiy, M. P. Korolev, D. M. Krasilnikov, Yu. A. Kucheryavy, I. V. Maev, N. A. Maystrenko, M. F. Osipenko, M. I. Prudkov, V. I. Simanenkov, E. G. Solonitsin, A. V. Fedorov, E. D. Fedorov, I. B. Khlynov, M. V. Chikunova, A. V. Shabunin, S. G. Shapovalyants, A. A. Sheptulin, O. S. Shifrin

“…The criteria for establishing the diagnosis of CP include typical attacks of abdominal pain and/or clinical and laboratory signs of exocrine, endocrine insufficiency with the mandatory detection of characteristic morphological changes (calcifications in the parenchyma and pancreatic ductal stones, dilatation of the main pancreatic duct and its branches). …”
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Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis by Amirhossein Shahsavand Davoudi, Hamid Harandi, Reza Samiee, Shayan Forghani, Keyhan Mohammadi, Maryam Shafaati

“…Its severe manifestations like thrombocytopenia and plasma leakage are associated with increased mortality. Ultrasound-detected gallbladder wall thickening (GBWT) has been suggested as a potential indicator of the severity of the disease. …”
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Mixture of Bacillus Amyloliquefaciens and Bacillus Pumilus Modulates Community Structures of Rice Rhizosphere Soil to Suppress Rice Seedling Blight by Jiang Nan, Qiu Jiehua, Tian Dagang, Shi Huanbin, Liu Zhiquan, Wen Hui, Xie Shuwei, Chen Huizhe, Wu Meng, Kou Yanjun

“…The mixture of the T40 and T208 strains also significantly increased the expression of defense-related genes. In conclusion, the mixture of the T40 and T208 strains effectively modulates microbial community structures, enhances microbial network stability, and boosts the resistance against rice seedling blight. …”
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Vitamin D deficiency and intracranial aneurysms: Systematic Review by Lívio Pereira de Macêdo, Glaudir Donato, Maria Eduarda d’Almeida Lins Regis, Isabela Fernandes de Melo Pereira, Gustavo Rodrigues Paulo, Kamilla Azevedo Bringel, Gabriel Carvalho Andrade Gadelha, Fábio Antônio Serra de Lima Júnior, Yally Dayanne Oliveira Ferreira, Renata de Castro Tavares, Arlindo Ugulino Netto, Kauê Franke, Pierre Vansant Oliveira Eugênio, Auricélio Batista Cezar-Junior, Igor Vilela Faquini, Eduardo Vieira de Carvalho Júnior, Nivaldo Sena de Almeida, Francisco Alfredo Bandeira e Farias, Marcelo Moraes Valença, Hildo Rocha Cirne Azevedo-Filho

“…A relationship between low vitamin D levels and IA incidence was detected in all studies. In terms of rupture and complications, there was a tendency of association with hypovitaminosis. …”
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Inferring 3D displacement time series through InSAR measurements and potential field theory in volcanic areas by Andrea Barone, Maurizio Fedi, Antonio Pepe, Pietro Mastro, Pietro Tizzani, Raffaele Castaldo

“…Abstract Interferometric SAR (InSAR) techniques allow the detection of ground displacements along the satellite line-of-sight (LOS) directions. …”
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