IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

“…Integrated analysis of transcriptomes and chromatin accessibility, supported by CRISPR-Cas9 mediated deletion, shows that AP-1 transcription factors constitute a key regulatory node of the IL-23 pathway in MAIT cells. …”
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A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice by Guohao Han, Dan Li, Haisen Zhang, Chao Li, Luda Yang, Tiantian Ma, Xuerong Wang, Bairong Ma, Xiaodie Wu, Yang Tao, Ziang Wang, Aihua Wang, Hsu-Wen Chao, Yaping Jin, Huatao Chen

“…To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected liver tissues from global and liver-specific Bmal1 knockout mice, along with their respective control groups, at two circadian time points (CT2 and CT14) and used them for transcriptome sequencing analysis. …”
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The occurrence and safety evaluation of phthalic acid esters in Oasis agricultural soils of Xinjiang, China by Hejiang Liu, Xiuting Liu, Kai Wang, Xingwang Ma, Haihe Gao, Xuejun Liu, Changrong Yan

“…The most abundant PAEs detected were Di (2-ethylhexyl) phthalate (DEHP), diisobutyl phthalate (DIBP), and diethyl phthalate (DEP), which accounted for 49.82 %, 23.74 %, and 20.96 % of the total, respectively. …”
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Improving clinical care of patients in Nipah outbreaks: moving beyond ‘compassionate use’ by Md Zakiul Hassan, Amanda Rojek, Piero Olliaro, Peter Horby

“…To improve NiVD care, we propose four key strategies: 1) Enhance early case detection, 2) optimize supportive care to improve outcomes and create a standard for future trials, 3) adopt a syndromic approach centered on encephalitis, and 4) explore innovative trial designs tailored to low case numbers as an alternative to ‘compassionate use’. …”
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Orientation, dendrites and precipitates in Hastelloy C276 alloy fabricated by laser and arc hybrid additive manufacturing by Qingwen Deng, Yugang Miao, Zhibin Yang, Yuyang Zhao, Ji Liu, Huijun Li, Bintao Wu

“…Further heat treatment (LHAM-HT) results in reduced texture strength, equiaxed grains with annealing twins and no precipitates detected. The LHAM-HT specimens show lower hardness and yield strength (190.33 HV and 338 MPa) due to dislocation annihilation, but enhanced elongation and tensile strength (63.5% and 713 MPa) owing to fine grain size and absence of precipitates. …”
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Comparative analysis of microbial contamination in diesel fuels using MALDI-TOF MS by Agnieszka Ludwiczak, Tomasz Zieliński, Ewelina Sibińska, Grażyna Czeszewska-Rosiak, Michał Złoch, Joanna Rudnicka, Andrzej Tretyn, Paweł Pomastowski

“…Therefore, we aimed to identify the microbiological contaminants using two MALDI-TOF MS systems (Bruker Daltonik GmbH and Zybio Inc.). Detection and characterization of microbiological contamination in fuels were performed with further validation by 16 S rRNA gene sequencing. …”
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Genomic insights into ecological adaptation of oaks revealed by phylogenomic analysis of multiple species by Tian-Rui Wang, Xin Ning, Si-Si Zheng, Yu Li, Zi-Jia Lu, Hong-Hu Meng, Bin-Jie Ge, Gregor Kozlowski, Meng-Xiao Yan, Yi-Gang Song

“…In addition, we identified expansion and tandem repetitions within gene families that contribute to plant physical and chemical defense (e.g., cuticle biosynthesis and oxidosqualene cyclase genes), which may represent the foundation for the ecological adaptation of oak species. …”
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Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

“…Abstract Type I-E CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated proteins) system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes, providing defense against foreign genetic elements. Unlike the previously characterized Cas3 nuclease, which exhibits progressive DNA cleavage in the typical type I-E system, a recently identified HNH-comprising Cascade system enables precise DNA cleavage. …”
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Vehicle maneuver recognition and correction algorithm for road quality measurement system optimization by Roland Nagy, István Szalai

“…We introduce a novel, computationally efficient soft-sensor algorithm that detects and isolates aggressive maneuvers using sensor data from existing road quality measurement systems, classifying them into four categories. …”
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A Patient with Uncontrollable Belching: What to Do? by I. V. Maev, Yu. A. Kucheryaviy, E. V. Barkalova, M. A. Ovsepyan

“…Supragastric belching is not a reflex process; rather, it is considered to be a manifestation of behavioural disorders. 24-hour pH-impedancemetry and high-resolution esophageal manometry are highly informative methods for detecting various types of belching (gastric and supragastric), as well as their mechanisms. …”
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Ion suppression correction and normalization for non-targeted metabolomics by Iqbal Mahmud, Bo Wei, Lucas Veillon, Lin Tan, Sara Martinez, Bao Tran, Alexander Raskind, Felice de Jong, Yiwei Liu, Jibin Ding, Yun Xiong, Wai-kin Chan, Rehan Akbani, John N. Weinstein, Chris Beecher, Philip L. Lorenzi

“…Across the broad range of conditions tested, all detected metabolites exhibit ion suppression ranging from 1% to >90% and coefficients of variation ranging from 1% to 20%, but the Workflow and companion algorithms are highly effective at nulling out that suppression and error. …”
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Evaluation of Pathology Results of Patients with a History of Breast Cancer who were Operated on for Gynecological Pathologies or Prophylaxis by Necim Yalcin, Isin Ureyen, Aysun Alci, Mustafa Gokkaya, Alper Kahraman, Gorker Sel, Gulsum Ekin Sari, Tayfun Toptaş

“…Benign pathologies were detected in the majority of patients with a history of breast cancer, this rate was found to be 87.7%. …”
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Causal relationship between educational attainment and the occurrence of venous thromboembolism by Sitong Guo, Sitao Tan, Shiran Qin, Dandan Xu, Henghai Su, Xiaoyu Chen

“…Results were consistent in all sensitivity analyses and no horizontal pleiotropy was detected. Conclusions The MR technique instructed a potential inverse causative relationship between EA and occurrence of VTE. …”
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Ambient Atmospheric Aerosol Extinction Coefficient Reconstruction from PM2.5 Mass Concentrations and Application to Haze Identification in China by Lina Gao, Peng Yan, Jietai Mao, Xiaochun Zhang, Xiaoling Zhang, Yongxue Wu, Junshan Jing, Jianming Xu, Xuejiao Deng, Wenxue Chi

“…Finally, we assessed the bias in the predicted number of hours with haze for 61 stations in China by comparing the estimates derived from different values for the model’s parameters with those derived from the reference values and found a relative bias of less than 15% for approximately 99.8% of the stations, indicating the feasibility of our approach for detecting haze.…”
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Difficulties the Conservative Treatment of Crohn’s Disease Complicated by Autoimmune Hemophilia A by E. L. Belyaeva, O. I. Filippova, A. V. Koloskov, A. A. Naydenov, F. D. Albegova

“…A 7 % decrease in the FVIII level and the presence of FVIII antibodies were detected. The patient was diagnosed with autoimmune hemophilia A. …”
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Spectrum of Chronic Gastritis Based on Morphological Examination of Gastric Biopsies by А. S. Tertychnyy, Т. L. Lapina, D. Р. Nagornaya, N. V. Pachuashvili, А. Р. Kiryukhin, А. А. Fedorenko, Р. V. Pavlov, D. D. Protsenko, V. Т. Ivashkin

“…The most frequently diagnosed type was active H. pylori-associated gastritis (36.7 %), followed by chronic atrophic gastritis with intestinal metaplasia in cases where H. pylori infection was not detected (28.4 %), including immunohistochemical examination, classified as gastritis after successful H. pylori eradication. …”
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Effect of biannual azithromycin on respiratory pathogens among symptomatic children: results from the randomised Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résista... by Jie Liu, Thomas M Lietman, Jeremy D Keenan, Kieran S O'Brien, Elodie Lebas, Amza Abdou, Benjamin F Arnold, James A Platts-Mills, Eric R Houpt, Stephanie A Brennhofer, Elizabeth T Rogawski McQuade, Ramatou Maliki, Jixian Zhang, Suzanne Stroup, Suporn Pholwat, Ahmed M Arzika

“…Swabs were tested by quantitative PCR using a customised TaqMan Array Card that included assays for 19 respiratory pathogens.Results Nasopharyngeal detection of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae was common in both azithromycin and placebo communities. …”
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The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study by Run Peng, Xiaoxin Wang, Wei Wang, Zeqin Li, Yuze Sun, Mingliang Yang

“…No significant estimates of heterogeneity or pleiotropy were detected. Conclusion Our study emphasizes the causal relationship between CSF metabolites and LBP risk, providing reference for clinical treatment and prognosis of LBP.…”
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New method for cytological evaluation using direct nipple discharge without aspiration by Jiang Zhu, Han Cong, Xiaotong Zhang, Xiaoya Dong, Song Zhao, Chaolu Hu, Jude Ranchu Maimo, Yawen Wang, Kai Zhang, Jianli Wang, Pengyu Li, Rong Ma

“…Therefore, LBC provides a new and better diagnostic method for early detection of breast tumors with nipple discharge.…”
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Comparative efficacy of Doppler-guided hemorrhoidal artery ligation with mucopexy and hemorrhoidectomy by A. Yu. Titov, Maryana V. Abritsova, L. P. Orlova, O. Yu. Fomenko, Yu. L. Trubacheva, D. A. Mtvralashvili

“…At anorectal manometry decrease of mean resting anal canal pressure after dearterialization with mucopexy was detected, and became comparative to post-hemorrhoidectomy level. …”
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