Myocardial Perfusion Imaging with Cardiovascular Magnetic Resonance in Nonischemic Cardiomyopathies: An In-Depth Review of Techniques and Clinical Applications by Ilir Sharka, Giorgia Panichella, Chrysanthos Grigoratos, Matilda Muca, Carmelo De Gori, Petra Keilberg, Giovanni Novani, Valerio Barra, Hana Hlavata, Matteo Bianchi, Denisa Simona Zai, Francesca Frijia, Alberto Clemente, Giancarlo Todiere, Andrea Barison

“…Microvascular dysfunction—present in approximately 50–60% of dilated cardiomyopathy (DCM), 40–80% of hypertrophic cardiomyopathy (HCM), and >95% of cardiac amyloidosis (CA) patients—has emerged as a key driver of adverse outcomes. Perfusion defects appear early, often preceding overt hypertrophy or fibrosis, and provide incremental prognostic value beyond conventional CMR metrics. …”
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Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P by François Charles Wang, François Charles Wang, Olivier Bouquiaux, Olivier Bouquiaux, Isabelle Lievens, Bernard Lakaye, Laura Vandries, Margaux Poleur, Samira Abdou Ide, Nurcan Inci, Vincent Seutin

“…Whole-cell recordings allowed to pinpoint the biophysical defects of L1436P. Thus, this mutation induced a significant slowing down of fast inactivation of the Nav current at several voltages, but this effect was less marked than in R1448H. …”
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Improving the charge transport of perovskite nanocrystal light-emitting-diodes through Benzylammonium ligand exchange by Minsik Gong, Dong Gyu Lee, Gwang Yong Shin, Yun Seop Shin, Donghwan Yun, Yunhye Jeong, Sang Wook Park, Chan Beom Park, Yung Jin Yoon, Sung Yong Bae, Yun-Hi Kim, Jin Young Kim, Tae Kyung Lee, Gi-Hwan Kim

“…The result is that ligand exchange significantly impacts the LHP NCs' characteristics due to overlapped orbitals between the NC surface and π-bonds of the aromatic ring, enhancing charge injection and transport while reducing surface defects. …”
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Composite scintillators based on ZnWO4:Me+ micropowders obtained by solid-state synthesis by V.S. Tinkova, I.A. Tupitsyna, A.G. Yakubovskaya, L. Yu. Sidelnikova, S.O. Tretiyak, O.D. Opolonin

“…The paper considers the possibility of using the method of heterovalent doping to improve the functional characteristics (light output and afterglow level) of composite scintillators based on ZnWO4 micropowder obtained by solid-stase synthesis. …”
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New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024 by WANG Ting, QIN Yi, XU Xiaowu, YU Xianjun

“…In basic research, a branched organ simulation system that mimics the unique structural characteristics of pancreatic cancer provides a new model for in vitro studies of pancreatic cancer. …”
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Acousto-Electric Conversion Fiber Networks via Regional Activation of Schwann Cell-Derived Exosomes for Neurogenic Bone Regeneration by Weiwei Yi, Xiaoyu Han, Fan Wang, Qiuyu Tang, Huzhe Liu, Bo Liao, Jieliang Shen, Juan Wang, Wenguo Cui, Dingqun Bai

“…The incorporation of the piezoelectric polymer glycine imparts superior piezoelectric characteristics to the fiber network, while the conjugated π-electron motion within the conductive graphene network enhances internal electron transfer efficiency, thereby facilitating electrical conductivity. …”
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Development and Validation of a New LC-MS/MS Method for Simultaneous Quantification of Ivacaftor, Tezacaftor and Elexacaftor Plasma Levels in Pediatric Cystic Fibrosis Patients by Alessandro Mancini, Raffaele Simeoli, Luca Cristiani, Sara Cairoli, Fabiana Ciciriello, Alessandra Boni, Federico Alghisi, Chiara Rossi, Giacomo Antonetti, Carlo Dionisi Vici, Alessandro Giovanni Fiocchi, Renato Cutrera, Bianca Maria Goffredo

“…<b>Background</b>: “CFTR modulators” (also named “caftor”) have been developed and introduced into clinical practice to improve the functionality of defective CFTR protein. Therapeutic drug monitoring (TDM) is not currently used for CFTR modulators in routine clinical practice and there is still much to learn about the pharmacokinetic/pharmacodynamic (PK/PD) and the safety profiles of these drugs in a real-world setting. …”
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Comparison of the Clinical Profile of Patients with Glaucoma Between Private and Government Clinics in the Philippines by Edgar Felipe U. Leuenberger, MD, DPBO, Marie Joan Therese D. Balgos, MD, DPBO, Shalam Siao-Mariano, MD, DPBO, Denise Polly Chao-Po, MD, DPBO, Irene R. Felarca, MD, DPBO, Rainier Victor A. Covar, MD, DPBO, Nilo Vincent FlorCruz, MD, DPBO, John Mark S. De Leon, MD, DPBO, Jose Ma. D. Martinez, MD, DPBO, Joseph Anthony J. Tumbocon, MD, DPBO, Maria Imelda Yap-Veloso, MD, DPBO, Robert Edward T. Ang, MD, DPBO, James Paul S. Gomez, MD, DPBO, Noel D. Atienza, MD, DPBO

“…Objective: To describe the demographic and clinical characteristics of patients with glaucoma managed at private and government institutions in the Philippines between 2009 and 2014. …”
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INDICATORS OF BIOELECTRICAL ACTIVITY OF THE PROPER MASSETER MUSCLES WITH THEIR DIFFERENT MASS IN MALES by O.V. Rybalov, Yu.I. Semenenko, P.I. Yatsenko, O.I. Yatsenko, O.S. Ivanytska

“…That is why it is reasonable to search solutions of problems on the objectification of the leading characteristics of bioelectric activity of the masseter muscles for people having no dental pathologies in spite of adequate comparison them to various diseases of the muscle and joint complex for their clinical and pathogenetic treatment. …”
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Comparison of Placental Vitamin D Receptor Target Gene Expression in Idiopathic Foetal Growth Restriction Pregnancy and Gestational Age-matched Healthy Controls: A Case-control Stu... by Priya Sharma, Richa Aggarwal, BD Banerjee, Priyanka Gogoi, Richa Sharma

“…However, no correlation was found with maternal Vitamin D levels, suggesting defects in the placental VDR pathway as an etiological factor in FGR.…”
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Advancements and future prospects in the fundamental theories of rock blasting research Ⅲ—Interaction mechanism between blast waves and cracks by Peng XU, Renshu YANG, Cheng CHEN, Chenxi DING, Yanbing WANG

“…The “three relationships (the relationship between rock failure characteristics and blast loading, the superposition effect between blast waves and explosion gas, and the interaction between blast waves and cracks)” are important contents of the rock blasting theory. …”
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ON DISCRETE STRUCTURE OF GEOLOGIC MEDIUM AND CONTINUAL APPROACH TO MODELING ITS MOVEMENTS by Sh. A. Mukhamediev

“…The paper considers actual difficulties encountered in studies using the continuity model, specifically in coordinated descriptions of the medium containing mobile defects, as well as the medium that is subject to deformation due to movements on its structure, while this structure is hierarchical at any scale level, down to the zero level (which, in particular, concerns the fractal structure). …”
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Clinical-neurologic, cytogenetic and molecular aspects of the Prader-Willi and Angelman Syndromes Aspectos clínico-neurológicos, citogenéticos e moleculares das síndromes de Prader... by João M. de Pina-Neto, Victor Evangelista F. Ferraz, Greice Andreotti de Molfetta, Jess Buxton, Sarah Richards, Sue Malcolm

“…The predominant genetic defects in PW are 15q 11-13 deletions of paternal origin and maternal chromosome 15 uniparental disomy. …”
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<i>Ab initio</i> Calculations of the Electronic-Energy Structure and Optical Properties of Lanthanum and Neodymium Pyrozirconates by A. A. Lavrentyev, B. V. Gabrelian, Vu Van Tuan, K. F. Kalmykova

“…Compounds with lanthanum and neodymium (La2Zr2O7 and Nd2Zr2O7) have low thermal conductivity, high permittivity and melting point, stability and resistance to defects. They can be used for thermal insulation of metal components in turbines and air engines. …”
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Biomimetic Targeted Co‐Delivery System Engineered from Genomic Insights for Precision Treatment of Osteosarcoma by Tianqi Luo, Zhijin Fan, Anyu Zeng, Anqi Wang, Yuanwei Pan, Yanyang Xu, Hongmin Chen, Weiqing Chen, Dingmeng Nie, Jiaming Lin, Anfei Huang, Ming Gong, Yufeng Huang, Yun Ding, Xiaojun Zhu, Lang Rao, Jin Wang

“…Herein, a comprehensive genomic analysis is conducted, and identified two prominent characteristics of osteosarcoma: significant cyclin‐dependent kinases 4 (CDK4) amplification and homologous recombination repair deficiency. …”
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Impact of PECVD deposition on dielectric charge and passivation for n-GaN/SiOx interfaces by Olivier Richard, Ali Soltani, Rahma Adhiri, Ali Ahaitouf, Hassan Maher, Vincent Aimez, Abdelatif Jaouad

“…Controlling properties of GaN/dielectric interfaces is crucial for determining the characteristics of MOS-HEMT devices and their stability. …”
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Molecular assessment of splicing variants in a cohort of patients with inborn errors of immunity: methodological approach and interpretation remarks by Laura Miguel Berenguel, Carla Gianelli, Carla Gianelli, Carla Gianelli, Elisabet Matas Pérez, Teresa del Rosal, Ana Méndez Echevarría, Ángel Robles Marhuenda, Marta Feito Rodríguez, Maria Teresa Caballero Molina, Maria Teresa Caballero Molina, Lorena Magallares García, Brenda Sánchez Garrido, Samantha Hita Díaz, Luis Allende Martínez, Luis Allende Martínez, Pilar Nozal Aranda, Pilar Nozal Aranda, Pilar Nozal Aranda, Carmen Cámara Hijón, Carmen Cámara Hijón, Carmen Cámara Hijón, Eduardo López Granados, Eduardo López Granados, Eduardo López Granados, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, Rebeca Rodríguez Pena, María Bravo García-Morato, María Bravo García-Morato, María Bravo García-Morato

“…All of them needed molecular validation, with the exception of two patients, whose variants had previously been well characterized in the medical literature.ConclusionThis study shows the proportion of splicing variants in a cohort of IEI patients, providing their clinical phenotypic characteristics and the methodology used to validate the splicing defects. …”
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Whole exome sequencing enhances diagnosis of hereditary bronchiectasis by Wangji Zhou, Yixuan Li, Haixia Zheng, Miao He, Miaoyan Zhang, Qiaoling Chen, Christopher Situ, Yaqi Wang, Ting Zhang, Keqi Chen, Jinrong Dai, Shuzhen Meng, Xueqi Liu, Aohua Wu, Yaping Liu, Kai-Feng Xu, Xinlun Tian, Xue Zhang

“…Clinicians should recommend WES for patients exhibiting these characteristics, in combination with accessible non-genetic testing methods, to maximize diagnostic accuracy. …”
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Research on component compatibility and aging behavior of chemically toughened high-performance asphalt by Bin Huang, Bin Huang, Chenxi Wang, Yi Yang, Yi Yang, Yuchen Wang, Yuchen Wang, Yanan Zhao, Ruiyao Jiang

“…IntroductionFrequent cracks, potholes, and other defects, as well as a decline in the durability of asphalt pavements, are specific manifestations of the deterioration of road performance caused by asphalt aging. …”
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Polishing inner wall of crossed deep micropores using magnetic microabrasive jet technology by Zezhi WANG, Jie WANG, Xiaogang MA, Fan LI, Xinya FAN, Yan CHEN

“…However, due to the limitations of manufacturing technology, precision parts with complex shapes, such as cross micro-holes, may have defects such as burrs, scratches, and nodules during the manufacturing process. …”
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