The role of tumor stem cells and the immune microenvironment in the pathogenesis of lung cancer: mechanisms of interaction and research prospects by D. A. Kharagezov, A. A. Antonyan, E. Yu. Zlatni, A. B. Sagakyants, E. A. Mirzoyan, T. G. Ayrapetova, I. A. Leyman, A. G. Milakin, O. N. Stateshny, K. D. Iozefi, M. A. Homidov, E. A. Alekseev

“…Various approaches to treating lung cancer targeting CSCs, focusing on targeted therapy aimed at specific molecular targets, are highlighted.The important role of the tumor immune microenvironment in the pathogenesis of lung cancer and its impact on CSCs is emphasized. …”
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Efficacy and Safety of the Low-molecular Heparin in Treatment and Prevention of the Acute Coronary Syndrome by Katerenchuk I., Tsyhanenko I., Katerenchuk O.

“…For a long time, the main medication for treating and preventing of thrombotic complications was unfractionated heparin (UFH). …”
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A Weighted Voting Approach for Traditional Chinese Medicine Formula Classification Using Large Language Models: Algorithm Development and Validation Study by Zhe Wang, Keqian Li, Suyuan Peng, Lihong Liu, Xiaolin Yang, Keyu Yao, Heinrich Herre, Yan Zhu

“…To further advance this task, TCM formulas can be classified using various approaches, including manual classification, machine learning, and deep learning. Additionally, large language models (LLMs) are gaining prominence in the biomedical field. …”
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Bilateral Upper Extremity DVT in a 43-Year-Old Man: Is It Thoracic Outlet Syndrome?! by Hadoun Jabri, Sarbajit Mukherjee, Devang Sanghavi, Shyam Chalise

“…We are presenting a 43-year-old man who was diagnosed with left upper extremity deep vein thrombosis (UEDVT) and was treated with anticoagulation and surgical decompression in 2004. 9 years later, he presented with right arm swelling and was diagnosed with right UEDVT using US venous Doppler. …”
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Transcriptome and translatome profiling of Col-0 and grp7grp8 under ABA treatment in Arabidopsis by Jing Zhang, Yongxin Xu, Jun Xiao

“…In this study, RNA-seq and Ribo-seq analyses were conducted on 3-day-old Col-0 and grp7grp8 seedlings of Arabidopsis thaliana, treated with either ABA or mock solutions. These analyses facilitated deep sequencing of total mRNA and mRNA fragments protected by translating ribosomes. …”
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Social Factors Affecting Religious Institutions in the Maintenance of Peace and Harmony in East Hararghe Zone: The Case of Selected Religious Institutions by Abreham Belachew, Birhanu Midakso

“…A purposive sampling technique was employed to select informants who have sufficient knowledge in the area. The study employed thematic analysis to sort-out important themes. …”
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How beliefs in traditional healers impact on the use of allopathic medicine: In the case of indigenous snakebite in Eswatini. by Sarah Nann

“…Deep-seated cultural beliefs were the most important reason for choosing traditional medicine, the success of which is largely attributed to the 'placebo effect' and positive expectations. …”
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Harnessing Multiscale Topographic Environmental Variables for Regional Coral Species Distribution Models by Annie S. Guillaume, Renata Ferrari, Oliver Selmoni, Véronique J. L. Mocellin, Hugo Denis, Melissa Naugle, Emily Howells, Line K. Bay, Stéphane Joost

“…For this, we obtained and processed three distinct bathymetric digital depth models that we treat as DEMs, which are available across the GBR extent: (i) Allen Coral Atlas (ACA) at 10 m, (ii) DeepReef at 30 m and (iii) DeepReef at 100 m. …”
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Self-Correlation Network With Triple Contrastive Learning for Hyperspectral Image Classification With Noisy Labels by Kwabena Sarpong, Mohammad Awrangjeb, Md. Saiful Islam, Islam Helmy

“…However, current deep learning approaches typically employ conventional convolution methods that treat all spatial frequency components uniformly, neglecting the exploration of feature-dependent knowledge, significantly affecting learning with noisy labels. …”
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Peripheral ulcerative keratitis in Sweet syndrome by Denise Ramona Carbonell, MD, Maria Cecilia Gertrudis Agdeppa, MD, Mararita Nahleen N. Mejia, MD

“…Conclusion: PUK is a potentially blinding disorder that can be seen in Sweet syndrome. With proper knowledge of the underlying disease, close monitoring and management, PUK can be treated and cured.…”
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Causal Layered Analysis: Towards a Theory of the Multiple by Marcus Bussey

“… Causal layered analysis (CLA) is a key tool for Deep Futures approach, which is seen by numerous experts as a prospective trend in evolution of Foresight studies. …”
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Design of an Improved Model Using Neuro-Symbolic Encoding and Federated Meta-Adaptation for Plant Disease Detection and Explanation Process by Kurhe Prajakta, Dashore Pankaj

“…The conventional methods in deep learning are exceedingly accurate, but they fail to capture phenotypic subtlety within the limit of the context of fixed settings. …”
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Challenges in the development of treatment guidelines for bipolar disorder by Konstantinos N. Fountoulakis, Nikolaos K. Fountoulakis, Diomidis Antoniadis

“…This task demands an exhaustive review of the existing literature, searching for unpublished data and digging deep into them to comprehend their nature. It also needs to manage to synthesize the fragmented research picture that refers to isolated faces of the disorder, into a comprehensive network of decision-making that will incorporate the knowledge of the past with decisions for the present by having the mind in the future (the three-fingers rule).…”
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Diabetic Patients’ Perception of Diabetic Foot Ulcers: A Qualitative Study by Leila Mardanian Dehkordi, Raheleh Javanbakhtian

“…Accordingly, this study aimed to rely on deep insight and knowledge to explain diabetic patients’ perception of DFU and identify appropriate care and support practices to prevent and manage it.Methods: This descriptive study was conducted using qualitative content analysis. …”
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High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization by Beatriz Fernández Rubio, Fernando Docobo Pérez, Laura Herrera Hidalgo, Luis Eduardo López-Cortés, Rafael Luque Márquez, José Manuel Lomas Cabezas, Luis Fernando López-Cortés, Marta Mejías Trueba, Ana Belén Guisado Gil, Alicia Gutiérrez Valencia, Arístides de Alarcón González, María Victoria Gil Navarro

“…The design of a ceftriaxone regimen suitable for OPAT requires deep knowledge of ceftriaxone pharmacokinetics (PK). …”
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Psoriasis as a risk factor of pulmonary embolism - case report by Milić Rade, Šarac Sanja, Lazović-Popović Biljana, Dinić Miroslav

“…Introduction. Deep vein thrombosis and pulmonary embolism, known as venous thromboembolism, constitute a major global burden of disease. …”
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The Design & Pitch Challenges in STEM: A Theoretical Framework for Centering Mathematics Learning in Entrepreneurial Pitch Competitions by Michael Belcher, Jere Confrey, Erin E. Krupa, Margaret L. Borden

“…This means leveraging frameworks that emphasize practices and ways of thinking that support students to build and justify solutions that create value for users, while also creating a need for disciplinary content knowledge. This is especially necessary for mathematics, a discipline that is often treated insufficiently in interdisciplinary STEM activities. …”
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Subcutaneous Histiocytoid Sweet Syndrome Associated with Crohn Disease in an Adolescent by Rosa María Fernández-Torres, Susana Castro, Ana Moreno, Roberto Álvarez, Eduardo Fonseca

“…A skin biopsy specimen showed deep dermal and predominantly septal inflammatory infiltrate in the subcutaneous tissue composed of polymorphonuclears, eosinophils, and mononuclear cells of histiocytic appearance. …”
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Impact of the on-site fish workshop in gaining children’s understanding and support for coastal zone management: leverage points and human-nature connection perspectives by Takuro Uehara, Sawako Tachibana, Takeshi Hidaka

“…The preliminary findings indicate that the workshop had diverse impacts, from shallow (parameters) to deep leverage points (Information flows, Rules, Goals, and Paradigms), including HNC, support for ongoing management measures, and pro-SES attitudes and intentions. …”
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Protein C and antithrombin III deficiency in an elderly patient presenting with pulmonary embolism by R. Khan, N. Mahiyuddin, R. Tasnim, M. M. Rishad, Q. T. Islam

“… Pulmonary embolism is a life-threatening condition, which if not detected and treated timely may lead to death. It is usually a consequence of deep vein thrombosis, which itself may occur due to several risk factors like prolonged immobilisation, surgery, long haul flights, obesity, previous or family history of thrombosis, intravenous drug abuse, oral contraceptive pills and conditions like antiphospholipid syndrome, paroxysmal nocturnal haemoglobinuria or myeloproliferative disorders. …”
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