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Increase in quinolones prescriptions for children (0–10 years old) in Brazil
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In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage
Published 2025-08-01“…Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered by neuro‐glial units for persistent neuroinflammation, oxidative damage and programmed neuronal cell death. Single‐target and traditional multi‐target therapies, derived from individual drugs, show limited efficacy in addressing these interconnected events, due to spatiotemporal heterogeneity of action in single‐target components. …”
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Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade
Published 2022-03-01“…The benefit of immunotherapies based on T cell immunoreceptor with Ig and ITIM domains (TIGIT) and Programmed cell death protein 1 (PD-1) immune checkpoint blockade following ATRi/RT treatment was assessed in the MOC2 model and confirmed in another HPV-negative murine oral squamous cell carcinoma model called SCC7. …”
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Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation
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MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
Published 2025-05-01“…Initial responses in both, gemcitabine resistant and sensitive cells, reflect known targeted effects by gemcitabine on ribonucleotide reductase and DNA damage responses. However, later responses diverge dramatically where sensitive cells show induction of characteristic CETSA signals for early apoptosis, while resistant cells reveal biochemical modulations reflecting transition through a distinct DNA-damage signaling state, including opening of cell cycle checkpoints and induction of translesion DNA synthesis programs, allowing bypass of damaged DNA-adducts. …”
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Assessing the effectiveness of air pollution control programs in Tehran using air quality trend analysis
Published 2019-03-01“…Undoubtedly, one of the most important ways to reduce environmental pollution is the use of control programs and measures. Therefore, this study aims to evaluate the effectiveness of some plans and programs to reduce the air pollution of a metropolis (Tehran). …”
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The impact of a disaster medicine clinical training program on medical students’ disaster literacy
Published 2025-01-01“…Result The DLS scores of the experimental group showed significant improvement after the training program compared to their pretest scores (Total Scale: p < 0.001, Damage Mitigation: p = 0.002, Preparation: p < 0.001, Response: p < 0.001, and Relief: p = 0.004). …”
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Organizational Management Of The Arabic Language Course Program At Boarding School Al Hidayah Batu
Published 2024-04-01“…This study aims to describe the organizational management in the Arabic language course program at Pondok Pesantren Al-Hidayah Batu. This research uses qualitative research methods, case study type. …”
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Cell cycle regulation and cytoskeletal remodelling are critical processes in the nutritional programming of embryonic development.
Published 2011-01-01“…While these describe processes leading from nutritional insult to development of the actual pathology, the initial underlying cause of the programming effect remains elusive. To establish the primary drivers of programming, this study aimed to capture embryonic gene and protein changes in the whole embryo at the time of nutritional insult rather than downstream phenotypic effects. …”
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