NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice by Cher-Chia Chang, Yea-Hwey Wang, Jiin-Cherng Yen, Chia-Ching Liaw, Keng-Chang Tsai, Wen-Chi Wei, Wen-Fei Chiou, Chun-Tang Chiou, Kuo-Tong Liou, Yuh-Chiang Shen, Yi-Chang Su

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Effect and Mechanism of Massage Manipulation on Rats with Skeletal Muscle Overuse Injury Based on Wnt/β-catenin Signaling Pathway by DUAN Miaomiao, HUANG Bo, RUAN Lei, MU Panpan, CHEN Yiming, PENG Liang

“…Armstong centrifugal exercise program was used to establish the rat skeletal muscle overuse injury model in the model group and the intervention group, except for the blank group. …”
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Intratumoral delivery of mRNA encoding the endogenous TLR2/6 agonist UNE-C1 induces immunogenic cell death and enhances antitumor activity by Uijoo Kim, Uijoo Kim, Sunkyo Hwang, Seongmin Cho, Hyeong Yun Kim, Hyeong Yun Kim, Hamin Ban, Hamin Ban, Joohee Park, Jeongwon Mun, Jeongwon Mun, Nayoung Kim, Ji Hun Suh, Jihye Choi, Yungyeong Shin, Sang Bum Kim, Ina Yoon, Ina Yoon, Hyuk-Sang Kwon, Hyuk-Sang Kwon, Sunghoon Kim, Sunghoon Kim, Sunghoon Kim, Sunghoon Kim

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Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response by Zhuo Wang, Wendong Guo, Xiaowen Zhang, Yufei Wei, Wanying Zhang, Ning Du, Chunlu Li, Xuan Wu, Fei Yi, Tingting Zhou, Xiang Dong, Qiqiang Guo, Hongde Xu, Erli Wang, Na Li, Rong Cheng, Ziwei Li, Xiaoyu Song, Yingxian Sun, Xun Sun, Liu Cao

“…Summary: Sirtuin-1 (SIRT1) is a classical histone deacetylase well known for its roles in intracellular pathways such as energy metabolism, DNA damage response, and genome stability maintenance. …”
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Discovery and early validation of serum protein signatures in untreated multiple sclerosis patients: identification of candidate biomarkers for diagnosis and stratification by Isabel Brichette-Mieg, Isabel Brichette-Mieg, Ana Alonso-Torres, Ana Alonso-Torres, Pablo Aliaga-Gaspar, Pablo Aliaga-Gaspar, José-Luis Rodríguez-Bada, Virginia Reyes-Garrido, Virginia Reyes-Garrido, Patricia Urbaneja-Romero, Patricia Urbaneja-Romero, Carmen Muñoz, María Díaz-Sánchez, Elisa Martín-Montañez, María-del-Rosario Cabello-Porras, Begoña Oliver-Martos, Begoña Oliver-Martos, Laura Leyva, Laura Leyva

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BLASTING BEYOND THE OBVIOUS: IDENTIFICATION OF OVERLOOKED PREDICTIVE FACTORS FOR LEUKEMIC CONVERSION IN MYELODYSPLASTIC NEOPLASMS by PRC Passos, RDB Dias, SCC Carneiro, IB Nogueira, JMGF Lima, RC Venâncio, ACG Lavor, JVG Gama, RF Pinheiro, SMM Magalhães

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Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations by Jie Yang, Fanyan Ou, Binbin Li, Lixiong Zeng, Qiuli Chen, Houyu Gan, Jianing Yu, Qian Guo, Jihua Feng, Jianfeng Zhang

“…Programmed Cell Death (PCD) can regulate the enrichment of effector immune cells or regulatory immune cells, providing a new perspective for immunotherapy. …”
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A triple-targeting “nano-brake” remodeling the impaired immune microenvironment in skin lesions for psoriasis treatment by Ruijie Chen, Baiqun Duan, Shize Li, Yixuan Zhu, Zihao Huang, Dingchao Shen, Zhanzheng Ye, Yuqi Yan, Chenyu Qiu, Haoxiong Guan, Yinsha Yao, Jie Dong, Fugen Wu, Xinyu Jiang, Xianbao Shi, Longfa Kou

“…Immune checkpoint pathways, particularly the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) signaling axis, are instrumental in establishing and sustaining self-tolerance and regulating immune responses. …”
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Basophil-derived exosomes exacerbate systemic lupus erythematosus by regulating B-cell proliferation via miR-24550 by Jiaxuan Chen, Shuzhen Liao, Jiaqi Lun, Xing Lu, Bitang Huang, Xiaoxian Liu, Xiaowei Xu, Lawei Yang, Fengbiao Guo, Liuyong You, Haiyan Xiao, Hua-Feng Liu, Qingjun Pan

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Cellular effects of splenectomy on liver regeneration after 70% resection by Andrey Elchaninov, Andrey Elchaninov, Polina Vishnyakova, Polina Vishnyakova, Elena Gantsova, Elena Gantsova, Miroslava Chirkova, Victoria Karyagina, Larkin Anatoliy, Evgeniya Kananykhina, Maria Kuznetsova, Ibrahim Atabekov, Evgeny Karpulevich, Silachev Denis, Dmitry Trofimov, Dmitry Goldshtein, Timur Fatkhudinov, Timur Fatkhudinov, Gennady Sukhikh

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CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer by Shini Liu, Peng Deng, Zhaoliang Yu, Jing Han Hong, Jiuping Gao, Yulin Huang, Rong Xiao, Jiaxin Yin, Xian Zeng, Yichen Sun, Peili Wang, Ruizi Geng, Jason Yongsheng Chan, Peiyong Guan, Qiang Yu, Bin‐Tean Teh, Qingping Jiang, Xiaojun Xia, Ying Xiong, Jianfeng Chen, Yongliang Huo, Jing Tan

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Eradication of Biofilms on Catheters: Potentials of <i>Tamarix ericoides</i> Rottl. Bark Coating in Preventing Catheter-Associated Urinary Tract Infections (CAUTIs) by Mohammed H. Karrar Alsharif, Muhammad Musthafa Poyil, Salman Bin Dayel, Mohammed Saad Alqahtani, Ahmed Abdullah Albadrani, Zainab Mohammed M. Omar, Abdullah MR. Arafah, Tarig Gasim Mohamed Alarabi, Reda M. Fayyad, Abd El-Lateef Saeed Abd El-Lateef

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IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model by Alyne Riani Moreira, Camila Uchoa da Silva, Leticia de Paula Costa Mattos, Jussara Jesus Simão, Veronica Camargo Berti, Luan Henrique Vasconcelos Alves, Alex Ferreira da Silva, Franciele Jesus Lima, Suellen Karoline Moreira Bezerra, Cintia Nascimento Silva, Maria Isabel Cardoso Allonso- Vale, Iolanda de Fatima Lopes Calvo Tiberio, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Fernanda Degobbi Tenorio Quirino dos Santos Lopes

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APPLICATION ELEMENTS OF LITHOTHERAPY IN COMPLEX TREATMENT OF NEUROPATHY FACIAL NERVE by V.L. Melnik, V.K Shevchenko, E.V. Shevchenko, I.V. Melnik

“…To achieve stabilization process the individual rehabilitation program developed for each patient was taken into account – Chinese Tuyna facial massage, techniques qigong therapy, exercise of wellness gymnastics. …”
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Genetic risk factors underlying white matter hyperintensities and cortical atrophy by Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van der Auwera, Thomas H. Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F. Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V. Roshchupkin, M. Arfan Ikram, Hans J. Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova

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Case Study of the Characteristics and Dynamic Process of July 10, 2013, Catastrophic Debris Flows in Wenchuan County, China by Guisheng Hu, Ningsheng Chen, Javed Iqbal Tanoli, Yong You, Jun Li

“…In the five years since the earthquake, there have been many large-scale individual and group catastrophic debris flows that have caused lots of damage to the resettled population and the reconstruction efforts. …”
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A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy by Haitao Yuan, Xiaoxian Wang, Xin Sun, Di Gu, Jinan Guo, Wei Huang, Jingbo Ma, Chunjin Fu, Da Yin, Guohua Zeng, Ying Long, Jigang Wang, Zhijie Li

“…Collectively, photodynamic immunotherapy with PFBT@Rox Lip nanoparticles efficiently program TME through the induction of immunogenicity and oxygenation, and effectively suppress tumor growth through immunogenic cell death and enhanced anti-tumor immunity.…”
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TMTP1-modified polymeric micelles for the inhibition of ovarian cancer metastasis and recurrence through enhanced photothermal-immunotherapy by Ling Wang, Jie Li, Danya Zhang, Songwei Tan, Guiying Jiang, Xueqian Wang, Fei Li, Ying Zhou, Pingbo Chen, Rui Wei, Ling Xi

“…Moreover, PTT with TP1-IM nanomicelles in combination with programmed cell death ligand 1 (PD-L1) checkpoint blockade could induce strong anti-tumor immune responses, relieve the immunosuppressive tumor microenvironment, and thus effectively inhibit the metastasis of OC. …”
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Pathogenic germline variants in small cell lung cancer: A systematic review and meta-analysis by Sami Ul Haq, Aleem Aamir, Chloe Mighton, Katrina Hueniken, Vivek Philip, Raymond H. Kim, Geoffrey Liu, Peter Sabatini, Scott V. Bratman, Benjamin H. Lok

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An urgent call for more ambitious ocean literacy strategies in marine protected areas: a collaboration project with small-scale fishers as a case study by Janire Salazar, Janire Salazar, Sílvia Gómez, Begoña Vendrell-Simón, Begoña Vendrell-Simón, Begoña Vendrell-Simón, Miroslav Pulgar, Núria Viladrich, Núria Viladrich, Núria Viladrich, Stefano Ambroso, Stefano Ambroso, Stefano Ambroso, Patricia Baena, Andreu Santín, Andreu Santín, Maria Montseny, Maria Montseny, Marina Biel-Cabanelas, Josep-Maria Gili

“…In this context, passive and active restoration measures are crucial to avoid their damage and disappearance, which might cause the consequent loss of complexity and biodiversity of marine benthic communities. …”
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