Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis by Rui Huang, Rui Huang, Dawei Chu, Jiandang Shi, Ruiqing Xu, Kun Wang

“…Ferroptosis is a new form of programmed cell death characterized by iron-dependent accumulation of lethal lipid oxidation, which provides a potential alternative intervene for the OS treatment. …”
Get full text

Evaluation of rock slope stability using field, laboratory, and numerical methods: A case study of critical road sections from Morka- Chencha, in Southern Ethiopia by Hayat Abdela, Bayisa Regassa, Tola Garo, Addisu Bekele

“…Further stability analysis via the RocPlane program revealed that the crucial rock slope sections at RS2 are unstable under all anticipated conditions. …”
Get full text

Stereotactic radiosurgery in pituitary metastases: a systematic review and meta-analysis by Bardia Hajikarimloo, Salem M. Tos, Mohammadamin Sabbagh Alvani, Alireza Kooshki, Ibrahim Mohammadzadeh, Dorsa Najari, Mohammad Amin Habibi

“…The meta-analysis, sensitivity analysis, publication bias evaluation, and meta-regression were conducted using the R program. Results Seven studies with 79 individuals with PMs were included. …”
Get full text

Targeted Inhibition of CHD1L by OTI-611 Reprograms Chemotherapy and Targeted Therapy-Induced Cell Cycle Arrest and Suppresses Proliferation to Produce Synergistic Antitumor Effects... by Hector Esquer, Qiong Zhou, Daniel V. LaBarbera

“…CHD1L is a novel oncogenic protein involved in regulating chromatin remodeling, DNA damage repair, epithelial-mesenchymal transition (EMT), and programmed cell death via PARthanatos. …”
Get full text

Anticancer Mechanisms of Ginsenoside Compound K: A Review by Yu-Po Lee, Hui-Ting Chan, Tzu-Hsuan Li, Lichieh (Julie) Chu, Sheau-Long Lee, Yu-Quan Chang, Robert YL Wang

Get full text

Influence of blue and violet LED and infrared laser on the temperature of bleaching protocols in different concentrations of hydrogen peroxide by Elma Vieira Takeuchi, Joatan Lucas de Sousa Gomes Costa, Carmem Lúcia de Arroxelas Silva, Antonia Patricia Oliveira Barros, Barbara Leite Machado, Heitor Hussni Casarin, João Felipe Besegato, Milton Carlos Kuga, Cecy Martins Silva

Get full text

The modulation of immune cell death in connection to microRNAs and natural products by Ya-Ting Chuang, Ching-Yu Yen, Ching-Yu Yen, Jen-Yang Tang, Jen-Yang Tang, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Tsu-Ming Chien, Tsu-Ming Chien, Tsu-Ming Chien, Hsueh-Wei Chang, Hsueh-Wei Chang, Hsueh-Wei Chang

Get full text

Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients by Carlos Ricardo Maneck Malfatti, Leandro Tibiriçá Burgos, Alexandre Rieger, Cássio Luiz Rüdger, Janaína Angela Túrmina, Ricardo Aparecido Pereira, João Lang Pavlak, Luiz Augusto Silva, Raul Osiecki

Get full text

Penilaian Konsekuensi Beban Lalu Lintas Terhadap Pengurangan Umur Rencana Jalan by Ni Kadek Ari Gita Cahyani, Anak Agung Gede Sumanjaya, Putu Aryastana

Get full text

Fluoxetine and agomelatine mitigate anhedonic and hepatic changes in chronic restraint stress rat model by Wedad S. Sarawi, Norah K. Algarzae, Nada M. Alharbi, Ahlam M. Alhusaini, Layan M. Akkam, Reem E. Alsharidah, Latifah S. Alrasheed, Hala A. Attia, Iman H. Hasan

Get full text

The ER Stress Induced in Human Neuroblastoma Cells Can Be Reverted by Lumacaftor, a CFTR Corrector by Michela Pecoraro, Adele Serra, Maria Pascale, Silvia Franceschelli

“…Accordingly, the UPR is a cellular reaction to an ER stress state that, if left unchecked for an extended period, results in apoptosis and irreversible damage. The identification of caspase 4, which is in the ER and is selectively activated by apoptotic stimuli caused by reticular stress, further demonstrated the connection between reticular stress and programed cell death. …”
Get full text

Investigating the Effect of Aerobic training on the Gene Expression of AKT and FOXO in the Sarcopenia Signaling Pathway, Beclin-1 and LC3 Genes in the Autophagy Pathway, and Inflam... by Mohammad Hossein Rabbani, Parvin Farzanegi, Mohammad Ali Azarbayjani

“…The exercise group underwent a moderate-intensity treadmill running program for eight weeks, five sessions per week. Gene expression levels of AKT, FOXO3, Beclin-1, LC3, TNF-α, and IL-1β in the soleus muscle tissue were measured using quantitative real-time PCR. …”
Get full text

Analysis Mortality in Patients with HIV-infection on Example of a Region with a High Prevalence of Infection by V. Ya. Rosenberg, Yu. K. Plotnikova, E. E. Voronin

“…Relevance The HIV epidemic, registered worldwide since the early 1980s, is currently continuing its development in most countries, and, according to the Joint United Nations Program on HIV/AIDS (UNAIDS, 2016), covers more than 36 million people (including 1.8 million children) AIDS mortality is a key indicator of the effectiveness of the response to the HIV epidemic. …”
Get full text

The prevalence, results, and treatments of the patients followed up with a diagnosis of metabolic disease in the pediatric intensive care unit: A single-center experience by Gültaç Evren, Ayşe Ergül Bozacı

“…Late diagnosis and delays in intervention can result in acute metabolic decompensation, progressive neurological damage, or death. IEM patients are responsible for significantly increased morbidity and mortality in intensive care units. …”
Get full text

Experimental evaluation of the diagonal tension test of hollow clay blocks strengthening with (AR) glass fibers by Delaram Ostad, Jalil Shafaei, Farshid Jandaghi Alaee

“…To investigate this, an experimental program comprising 33 diagonal tension tests was conducted on masonry wallettes with nominal dimensions of 650 × 650 × 100 mm. …”
Get full text

Efficacy of n-tyrozol medication for regeneration stimulation of lip mucous membrane at experimental stomatitis by Nataliia N. Baitinger, Elena Yu. Varakuta, Liliia R. Mustafina, Anastasiia D. Koniaeva, Sergei V. Logvinov, Mark B. Plotnikov, Alexandr V. Gerasimov, Alexei V. Potapov

“…The local application of the gel based on n-tyrosol was carried out three times a day for 12 days.Histological and macroscopic examination was performed on the 3rd, 7th and 12th days. The extent of damage was recorded by measuring the area of the lesion in square millimeters (mm2 ). …”
Get full text

Chronic hepatitis B and risk of kidney involvement by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…First of all, it is HBV-associated glomerulonephritis developed as systemic manifestation of infection and presented, as a rule, by membranous nephropathy in children and mesangiocapillary glomerulonephritis in adults, resulting in chronic renal failure (CRF) in 30% of cases, while program hemodialysis is required in 10% of patients. …”
Get full text

Optimizing Multi-Echelon Delivery Routes for Perishable Goods with Time Constraints by Manqiong Sun, Yang Xu, Feng Xiao, Hao Ji, Bing Su, Fei Bu

“…The model aims to minimize total costs, including transportation, fixed, refrigeration, goods damage, and penalty costs, while measuring customer satisfaction by the start time of service at each demand node. …”
Get full text

Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer by Hyeonyeob Seo, Gun-Hee Lee, Jiwoo Park, Dong-Yeong Kim, Yeonzu Son, Semin Kim, Kum Seok Nam, Congqi Yang, Joonhee Won, Jae-Young Bae, Hyunjun Kim, Seung-Kyun Kang, Steve Park, Jiheong Kang, Seongjun Park

Get full text

Research on the Flame-Retardant Performance of Antioxidant Gel Foam in Preventing Spontaneous Coal Combustion by Hu Wen, Ziqi Wang, Maoxia Liu

“…Multi-scale experiments, including FTIR, leakage air testing, programmed temperature rise, and small-scale fire extinction, were conducted to evaluate its performance. …”
Get full text