Decreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infant... by Shuhua Liu, Shuhua Liu, Shuhua Liu, Liping Xu, Yan Cheng, Dehong Liu, Dehong Liu, Dehong Liu, Bin Zhang, Bin Zhang, Bin Zhang, Xianxia Chen, Xianxia Chen, Xianxia Chen, Mingming Zheng, Mingming Zheng, Mingming Zheng

“…We hypothesize that the poor intrauterine environment in pregnant women with GDM may lead to chromosomal DNA damage and telomere damage in umbilical cord blood cells, providing evidence of an association between intrauterine programming and increased long-term metabolic disease risk in offspring.MethodsWe measured telomere length (TL), serum telomerase (TE) activity, and oxidative stress markers in umbilical cord blood mononuclear cells (CBMCs) from pregnant women with GDM (N=200) and healthy controls (Ctrls) (N=200) and analysed the associations of TL with demographic characteristics, biochemical indicators, and blood glucose levels.ResultsThe length of telomeres in umbilical CBMCs in the GDM group was significantly shorter than that in the Ctrl group (P<0.001), and the shortening of telomeres in male infants in the GDM group was more significant than that in the Ctrl group (P<0.001) after adjustment for Pre-pregnancy body mass index (PBMI), Pregnancy weight gain (PGW), and Triglyceride (TG) as confounding factors. …”
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Guideline towards sustainable infrastructure in new urban communities – Egypt by Hend A. Elhawy, Laila Mohamed Khodeir, Ahmed Khaled

“…As a result, the study found that the main challenges facing the residents of these areas and their impacts are:1) Lack of regular maintenance. 2) Health risks to the population. 3) Damaging of public parks and gardens. 4) Pollution of the surrounding environment, including soil and water. 5) Lack of state funding for maintenance and Limited financial resources available for projects in this type of housing. 6) Lack of government engagement in preparing programs to raise population awareness and clarity in environmental goals and quality of life policies. 7) Lack of community initiatives to participate in decision-making. 8) Lack of political guidance on planning processes for sustainable infrastructure.…”
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Effect of Sound Absorption on Noise Reduction in the Automotive Industry by Cüneyt Kurtay, Muammer Yaman

“…Industrial noise is one of the most common physical factors that cause annoyance and damage to workers' health in the long term. Precautions should be taken to reduce noise and to improve acoustic performance in industrial working environments. …”
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Numerical simulations and experimental analysis of high-speed turnout rails wear models by Jincheng Li, Min Hu, Hao Wu, Hao Zhong

“…In addition, different wear models, update steps, wear superposition, and filtering methods are investigated in the turnout area. A simulation program in the turnout area for rail wear damage is established and compared with experimental data. …”
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The power of restorative apologies (real and imagined) for victims and offenders by Walker Lorenn, Tarutani Cheri, Furman Ben

“…The purpose of this paper is to show how the confidential apology program can help people address harm and shame. …”
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Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study by Alessandra Bortoluzzi, Marcello Govoni, Dimitrios T Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, George Bertsias, Konstantinos Parperis, Argyro Repa, Ettore Silvagni, Myrto Nikoloudaki, Nestor Avgoustidis, Sofia Pitsigavdaki, Antonio Marangoni, Irini Flouri, Spyridon Katechis

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Unravelling inflammation-driven mechanisms in hepatocellular carcinoma: therapeutic targets and potential interventions by Dhrubajyoti Sen, Sonia Bisht, Sangeetha Gupta

“…While PD-L1 inhibits anti-tumor immunity by interacting with programmed cell death protein (PD-1) on T cells, the NLRP3 inflammasome controls innate immune activation. …”
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Exploring Hydraulic Behavior of Weir Using HEC-RAS at Semangir River Jember Regency by Sefti Aryani Retnaningtias, Entin Hidayah, Gusfan Halik

“… Flooding significantly impacts communities living along riverbanks, causing severe damage to infrastructure and properties. The flood event on January 9, 2022, in Bumi Mangli Permai and Mangli Residence Housing, heavily damaged access roads. …”
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BASIC INTRACELLULAR MECHANISMS OF FORMATION OF MORPHOLOGICAL CHANGES OF INTERNAL ORGANS IN FLUOROSIS (LITERATURE REVIEW) by Мария Сергеевна Бугаева, Олег Иванович Бондарев

“…Since the main manifestation of fluorosis is damage to the teeth and skeleton, researchers traditionally focus their attention on studying mainly the pathology of these tissues. …”
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A new system to the spectroscopy analysis with multiple X-ray of free electron laser by Thair Abdulkareem Khalil Al-Aish, Hanady Amjed Kamil

“…The working mechanism is summed up by obtaining two laser pulses with specific specifications within the x-ray range, by creating an executive program (SAMXFEL) using the MATLAB program for the purpose of simulation. …”
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Study of the Effect of Ice Seeding on Slow Freezing of Ovarian Tissue by 叶娜, 徐强, 刘晨曦, 曹裕坤, 周新丽

“…The results showed that the optimized cooling procedure with ice seeding reduced the damage to ovarian tissues。When ice seeding was triggered at -11°C with a cooling rate of 1°C/min after nucleation, follicle survival was 88.02%. …”
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Numerical Study on Pipeline Pressure Surge of the Large Aircraft Fuel System by Yi Tu, Xuanren Chen, Liang Yin, Qiuyun Zheng, Yu Zeng

“…In serious cases, it will cause severe damage to the pipeline. The pressure surge in the pipeline can be affected by many design factors. …”
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Triggering Pyroptosis in Cancer by Daniel E. Johnson, Zhibin Cui

“…Pyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. …”
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Intelligent Over-vibration Protection Modeling & Simulation For Three Phase Induction Motor by Ayman Eissa

“…Three phase induction motor is widely used in industry because they are rugged, reliable and economical.Monitoring and over-vibration protection of machines can avoid consequential damage and avoid its consequences.The effect of three main different abnormal operating cases which are rotor unbalance,shaft coupling misalignment and torque pulsations on the rotor vibration are examined.The results are collected and evaluated for motor status. …”
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The Sea-Based Waste Collection Routing Problem Using a Novel Value Recovery Function by Ricardo C. Alindayu II, Jayne Lois San Juan, Charlle L. Sy

“…The Asia-Pacific region has been implicated as a major hotspot for plastic pollution in the world’s oceans, causing environmental and economic damage to marine ecosystems and maritime industries. …”
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Cut-Through Fractured Seepage Properties and Numerical Simulation of Sandstone after Different Temperature Treatments by Haopeng Jiang, Annan Jiang

“…Second, the macroscopic fractured state of sandstone after different temperature treatments was analyzed, and it is concluded that the inclination angle of the fracture surface decreases with the applied thermal temperature, the fracture surface gradually develops into a single shear failure surface, and the damage degree becomes more and more serious. Finally, the theoretical formula for the calculation of fractured seepage was introduced, and the FLAC3D embedded fish language was used to compile the seepage-stress coupling calculation program of the fractured sandstone after different temperature treatments. …”
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FATIGUE STRENGTH ANALYSIS OF HIGH-STRENGTH JOINT BOLTS UNDER MULTIAXIAL NONPROPORTIONAL LOADING SPECTRUM by CAO FaJun

“…And third,the fatigue damage of the nodal location was calculated according to the VDI2230 standard under the consideration of the bolt material S-N curve. …”
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Application of Serial Crystallography for Merging Incomplete Macromolecular Crystallography Datasets by Ki Hyun Nam

“…However, collecting a complete experimental dataset using a single crystal is frequently unsuccessful due to poor crystal quality or radiation damage, resulting in the collection of multiple incomplete datasets. …”
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Digitalization and Cyber Risks by V. G. Khalin, G. V. Chernova

“…Since they can have a negative impact on digitalization, considered both in a broad and narrow sense, there is a problem of allocating cyber risks and managing them in order to reduce possible losses and damage caused by the implementation of these cyber risks. …”
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Intransigent Vowel-Consonant Position in Korean Dysgraphia: Evidence of Spatial-Constructive Representation by HyangHee Kim, Duk L. Na, Eun Sook Park

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