Multi-omics characterization of oncosis in spinal cord injury by Zhipeng Jiang, Youwei Guo, Zihan Wang, Jinhao Ouyang, Hailong Huang, Haoxuan Huang, Tianqian Shen, Lei Wang, Wen Yin, Xingjun Jiang, Caiping Ren

“…Spinal cord injury (SCI) initiates a cascade of complex secondary damage processes, prominently involving programmed cell death (PCD). …”
Get full text

Immunogenic Cell Death Traits Emitted from Chronic Lymphocytic Leukemia Cells Following Treatment with a Novel Anti-Cancer Agent, SpiD3 by Elizabeth Schmitz, Abigail Ridout, Audrey L. Smith, Alexandria P. Eiken, Sydney A. Skupa, Erin M. Drengler, Sarbjit Singh, Sandeep Rana, Amarnath Natarajan, Dalia El-Gamal

“…Previously, we have demonstrated how a three-carbon-linker spirocyclic dimer (SpiD3) promotes futile activation of the unfolded protein response (UPR) in CLL cells through immense misfolded-protein mimicry, culminating in insurmountable ER stress and programmed CLL cell death. <b>Method:</b> Herein, we used flow cytometry and cell-based assays to capture the kinetics and magnitude of SpiD3-induced damage-associated molecular patterns (DAMPs) in CLL cell lines and primary samples. …”
Get full text

THE RESEARCH OF THE RAILWAY RAIL FOR ANALYSIS OF SURFACE INITIATED ROLLING CONTACT FATIGUE CRACKS by Pavlo Protsenko, Yurii Borodii, Andrii Petryshyn, Janis Thalau, Pavlo Lypovka, Eckart Uhlmann, Volodymyr Horbyk, Viktor Hlukhovskyi

“…Provides a hydraulic system. For testing, a test program was developed, which provides for two-hour tests, after which tests for the presence of defects (micro cracks) on the rail are conducted. …”
Get full text

INVESTIGATION ON FINITE ELEMENT MODELING METHOD OF WITH TRIPLE JUNCTION POLYCRYSTALLINE INTERGRANULAR FRACTURE by SHI JunLin, ZHAO JianPing

“…Cohesive zone model was used to simulate polycrystalline intergranular fracture at the grain level model,the finite element model build-ing reflected the actual situation is a difficult point.In this paper,Mixed Programming of Matlab,Python and Abaqus,An algorithm was presented which can easily and quickly generated Voronoi geometric model and the grain sizes distribution agrees with lognormal distribution.Realized the automatically insert the zero-thickness cohesive interface element by writing nodes and elements at crystal boundary,firstly solved the void zone at the intersection of the three zerothickness cohesive element,which is the triple junction,And to make up the defect of cohesive zone model.The whole process of the finite element analysis was performed automatically by secondary development,including the assignation material properties,material orientation,load application,model solution.Finally,polycrystalline aluminum was used as an example to simulate the intergranular fracture process without the initial damage.The results show that the method is more effectively and practically,which can be used to simulate polycrystalline intergranular crack initiation and propagation in random microscopic grains.…”
Get full text

Penggunaan Kendaraan Listrik di Indonesia dan Relevansinya dengan Ajaran Konservasi Lingkungan dalam al-Qur’an by Muhammad Akbar Zulkarnain

“…To address this, the Indonesian government has introduced the Electric Motor Vehicle Acceleration Program, which aims to reduce emissions and conserve resources through the adoption of electric vehicles (EVs). …”
Get full text

Features of road safety project implementation until 2024 in Omsk region by E. A. Safronov, K. E. Safronov

Get full text

Prospects for the development of adaptive medical immunology by I. V. Nesterova, N. S. Tataurschikova

“…Another task of adaptive medical immunology is the creation of promising innovative diagnostic technologies and, on this basis, the development of new integration programs for targeted restoration of damage to the immune system, as well as the nervous and endocrine systems in immunocompromised patients suffering from various immune-dependent diseases.…”
Get full text

Multicomponent Agents for Prevention and Treatment of Digestive Diseases by E. V. Ferubko

“…To assess the pharmacotherapeutic effect of the developed agents «Pentafit» hepatoprotective activity studied in experimental models tetrachloromethane and D-galactosamine hepatitis, «Octafit» gastroprotective activity studied in models of acute aspirins, neurogenic and chronic butadione ulcer, сholeretic activity of «Hexafit» as studied in models of experimental cholecystitis and toxic liver damage using laboratory animals. The results of the studies processed statistically using the Statistica 10 program.Results and discussion. …”
Get full text

On-Site Investigation and Diagnosis of Hazardous Street Section in Erbil Street Network by Abdulhakim Othman Salih kozapanky

“… Accidents place a significant burden on the national economy due to their potential to cause disability, death, health issues, property damage, social distress, and environmental harm.         …”
Get full text

Resveratrol alleviates testicular toxicity induced by anti-PD-1 through regulating the NRF2-SLC7A11-GPX4 pathway by Halahati· Tuerxun, Yixin Zhao, Yawen Li, Xingyu Liu, Shuhui Wen, Yuguang Zhao

“…Immune checkpoint inhibitors (ICIs), including anti-programmed cell death protein 1 (anti-PD-1), have become a standard therapeutic approach for various malignancies. …”
Get full text

RESEARCH ON ACCELERATED LOAD SPECTRUM FOR FATIGUE TEST OF PHEV SUBFRAME WELDS by ZHAO Lihui, WEI Xuguo, LIANG Shan, WENG Shuo, FENG Jinzhi, ZHANG Dongdong

“…The numerical simulation results show that the program load spectrum can reproduce the damage of dangerous points and has a high acceleration coefficient, which verifies the effectiveness of the accelerated test spectrum.…”
Get full text

The role of immune checkpoints PD-1 and CTLA-4 in cardiovascular complications leading to heart failure by Shoulian Huang, Shoulian Huang, Yu Kang, Ting Liu, Yan Xiong, Zixuan Yang, Qing Zhang

Get full text

ALTRUISTIC DEATH, EVOLUTIONARY SOLUTION TO SAVE THE SPECIES by Laura Catalina Dragomir

Get full text

Detection of PD-L1 expression levels in malignant pleural mesothelioma with a targeted MRI nanoprobe in vivo by Zhenghua Zhang, Yang Tian, Wenjun Gao, Yubin Hu, Liangping Luo, Lichang Lei, Shasha Shen, Dan Han

“…It was well dispersed in serum and saline and showed no cytotoxicity or organ damage in vivo. The probe selectively accumulated in PD-L1-expressing MPM cells, especially MSTO-211H, and exhibited significantly higher uptake in high PD-L1-expressing H460 cells (930.22 ± 11.75 ng/mL) compared to low PD-L1-expressing A549 cells (254.89 ± 17.33 ng/mL, P &lt; 0.05). …”
Get full text

Imaging features and prognostic significance of immune checkpoint inhibitor–related pneumonitis in NSCLC by Xueqi Wang, Jingyi Yang, Jiahui E, Fan Liu, Qiliang Wang, Yuwei Zhang, Jing Wang, Ying Liu

“…Methods A total of 102 NSCLC participants who received immunotherapy with programmed cell death protein-1 (PD-1) inhibitors and then developed CIP were retrospectively enrolled in this study. …”
Get full text

Federal Directorate for Safe Storage and Destruction of Chemical Weapons – 30th Anniversary by V. P. Kapashin, V. G. Mandych, S. I. Samarin, I. N. Isaev, I. V. Kovalenko, V. L. Veriga

“…The main results of the completed process of destruction of chemical weapons are that no human life has been lost and no damage has been done to the environment. Currently, the Federal Directorate is implementing measures within the framework of the departmental project «Liquidation of the consequences of the activities of storage facilities and facilities for the destruction of chemical weapons in the Russian Federation» of the state program of the Russian Federation «Development of industry and increasing its competitiveness».…”
Get full text

Impact of voids on the solder joint integrity and fatigue life of IGBT power module by Sunday E. Nebo, Emeka H. Amalu, David J. Hughes

“…Combined elliptical and spherical voids induced the highest damage while elliptical voids induced the highest plastic strain of 0.045 µm/µm magnitude in the joints. …”
Get full text

Load spectrum construction of a jack-up offshore platform lifting system by MAI Zhihui, ZHOU Zhanpeng, TIAN Chengquan, WAN Zhenping

“…The fatigue life of the climbing gear in the lifting system was analyzed based on the load spectrum.ResultsThe position with the maximum damage degree was the contact area of the climbing gear’s positive tooth surface, with a damage degree of only 1.55×10⁻³ and a fatigue life of approximately 1.29×10⁶ h, which far exceeds the design life.…”
Get full text

Economic Evaluation of Losses From Invalidism of the Population in Russia: Approaches and Methods by Olga I. Goleva

Get full text

Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast by Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo

Get full text