Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…Western blot results revealed enhanced PI3K/Akt/mTOR pathway activity, with upregulated Bcl-2 expression (P < 0.01), downregulated Bax expression (P < 0.01), and decreased Caspase3 and Caspase9 levels (P < 0.05). Additionally, CyclinD2 and P70S6 K expression were significantly increased in treated groups, suggesting enhanced cell cycle progression and protein synthesis. …”
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Review and Prospect of Research on Urban Walking Safety and Environmental Influencing Factors Thereof by Lin LI, Yu YE, Yong CHEN

“…New data and technologies support the analysis of core environmental factors influencing walking safety. 3) Based on CNKI database, the analysis of keywords shows that domestic research focuses on the spatial quality of walking environment and the special needs of vulnerable walkers, and it is urgent to establish a walking safety environment evaluation system in China. In addition, the keyword analysis also shows that the impact of built environment on pedestrian safety accidents and pedestrian safety perception has become a focus of attention. …”
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Inflammatory Gene Signature Identified by Machine Algorithms Reveals Novel Biomarkers of Coronary Artery Disease by Liu X, Zhang Y, Wang Y, Xu Y, Xia W, Liu R, Xu S

“…Furthermore, increased levels of ADM, NUPR1, PTGER1, and PYDC2 were validated in PBMCs isolated from CAD patients. In addition, ADM, NUPR1, and PTGER1 were upregulated in the mouse atherosclerotic aorta.Conclusion: Our findings revealed novel inflammatory gene signatures of CAD that could be potential biomarkers for the early diagnosis of CAD.Keywords: inflammation, coronary artery disease, machine learning, immune infiltration…”
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Diabetes distress among immigrants of south Asian descent living in New York City: baseline results from the DREAM randomized control trial by Farhan Mohsin, Laura Wyatt, Hayley Belli, Shahmir Ali, Deborah Onakomaiya, Supriya Misra, Yousra Yusuf, Shinu Mammen, Jennifer Zanowiak, Sarah Hussain, Haroon Zafar, Sahnah Lim, Nadia Islam, Naheed Ahmed

“…Abstract Background Type 2 diabetes (T2D) disproportionately affects individuals of South Asian descent. Additionally, diabetes distress (DD) may lead to complications with diabetes management. …”
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Administration of Sex Hormone Preparations as a Risk Factor in the Development of Intrahepatic Cholestasis of Pregnancy and Biliary Sludge in Pregnant Women by Yu. B. Uspenskaya, I. V. Kuznetsova, A. A. Sheptulin, N. V. Goncharenko, A. N. Gerasimov, M. M. Amiraslanova

“…The use of sex hormone preparations and ART programs are shown to be additional factors contributing to the emergence of ICP and BS during pregnancy. …”
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The role of the TAPSE/sPAP ratio as a predictor of mortality in Pulmonary Arterial Hypertension: Its value for patient risk stratification by Paul Palacios-Moguel, MD, Guillermo Cueto-Robledo, MD, Héctor González-Pacheco, MD, Jorge Ortega-Hernández, MD, María Berenice Torres-Rojas, MD, Dulce Iliana Navarro-Vergara, MD, Marisol García-Cesar, MD, Cinthia Alejandra González-Nájera, MD, Carlos Alfredo Narváez-Oríani, MD, Julio Sandoval, MD

“…Clinical, functional, echocardiographic, and haemodynamic variables, along with the TAPSE/sPAP ratio, were analysed based on etiological PAH subgroups and outcomes. Additional statistical measures, such as the area under the curve (AUC), net reclassification index (NRI), and integrated discrimination improvement, assessed the predictive ability of TAPSE/sPAP in combination with the ESC/ERS risk score, and other risk assessment strategies (COMPERA and Reveal Lite 2). …”
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Antimicrobial Resistance Surveillance of Skin and Soft Tissue Infections: Hospital-Wide Bacterial Species and Antibiograms to Inform Management at a Zonal Tertiary Hospital in Mwan... by Justine BN, Mushi MF, Silago V, Igembe Z, Muyombe J, Kishengena PP, Michael Jnr NS, Maganga MG, Massenga A, Tegete F, Massaga FA, Seni J

“…Revisiting SSTIs treatment guidelines at BMC and inclusion of SSTIs in the on-going AMR surveillance in Tanzania are recommended.Plain Language Summary: Tanzania National Action Plan on combating resistant bugs is exclusively focused on urinary tract infections and blood stream infections despite enormous impact conferred by skin and soft tissue infections.Bugs which are resistant to commonly used antibiotics were found more among patients admitted in the hospital in contrast to those attending outpatient clinics.This study highlights a pressing need to develop treatment guidelines based on generated local research-evidence to foster favorable patients’ outcomes.Keywords: skin and soft tissue infections, antimicrobial resistance, surveillance, Tanzania…”
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Mental health in public safety personnel with workplace injuries requiring surgery: a longitudinal population-wide administrative data study in Manitoba, Canada by Tracie O Afifi, Jitender Sareen, Dan Chateau, Alyson Mahar, Jordan Nantais, James Bolton, Allen Kraut, Sarvesh Logsetty, Thomas Turgeon, Brenda Comaskey, Justin Gawaziuk, Rae Spiwak, Lauren Burton, Anthony Wightman, Jai Sareen, Natalie Mota

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SMART SPECIALISATION AS A BASIC COMPONENT OF SOCIO-ECONOMIC DEVELOPMENT by Olena Guzenko, Svitlana Nikolaichuk, Dmytro Ivanenko

“…Furthermore, the implementation of these strategies can also generate additional financial opportunities to support regional development. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Conditional deletion of Nrf2 in CD8TILs abrogates mTORC1 activation and antitumor immunity by Met. …”
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CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

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Assessing the comparative effectiveness of ECHO and coaching implementation strategies in a jail/provider MOUD implementation trial by Todd Molfenter, Jessica Vechinski, Jee-Seon Kim, Jingru Zhang, Lionel Meng, Jessica Tveit, Lynn Madden, Faye S. Taxman

“…Results Jail sizes ranged from 24% with < 100 and 24% with > 500 daily population, and community-based treatment providers ranged from 63% with < 50 and 7% with > 500 average monthly OUD intakes. …”
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Multiple Comorbidities, Psychiatric Disorders, Healthcare Resource Utilization and Costs Among Adults with Essential Tremor: A Retrospective Observational Study in a Large US Comme... by Dingwei Dai, Ali Samiian, Joaquim Fernandes, Henriette Coetzer

“…**Background:** Essential tremor (ET), the most common movement disorder, often impairs patients’ ability to perform activities of daily living, mental health, and quality of life. …”
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Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis by Eric S. Donkor, Abdul-Halim Osman, Bill Clinton Aglomasa, Aaron Awere-Duodu, Alex Odoom, Bismark Opoku-Asare, Gilbert Lazarus

“…Antibiotic consumption for inpatients has a pooled estimate of 620.03 defined daily dose (DDD) per 100 bed-days (confidence interval [CI] 0.00–1286.67; I2 = 100%) after accounting for outliers while prescribing appropriateness ranged from 2.5% to 93.0% with a pooled estimate of 50.09 ([CI: 22.21–77.92%], I2 = 99.4%). …”
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Factors associated with caffeine intake among undergraduates: a cross-sectional study from Palestine by May Hamdan, Souzan Zidan, Fatima Al-Amouri, Hiba Niroukh, Manar Abu Dawod, Sajeda Ashour, Shahd Sameer Dweik, Manal Badrasawi

“…Caffeine consumption was assessed using a semi-quantitative food frequency questionnaire (FFQ) developed by the research team. The content validity of the FFQ was done by three reviewers. Also, a questionnaire was used to collect data related to sociodemographic characteristics, medical history, lifestyle habits, sleeping quality, physical activity, and psychological status. …”
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Perancangan Aplikasi Tanggap Api Berbasis Android Menggunakan Metode Design Sprint by Agus Tedyyana, Muhammad Fauzi, Depandi Enda, Fajar Ratnawati, Elgamar Syam

“…Proses sebuah iterasi design sprint hanya memakan waktu lima hari. Dari hasil pengujian prototype di iterasi terakhir dalam proses design sprint di penelitian ini didapatkan hasil bahwa prototype yang dirancang mendapatkan skor rata-rata 68,21 berdasarkan skor System Usability Scale (SUS), dan berada di kategori good berdasarkan adjective rating. …”
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Evaluasi Usability Aplikasi Elektronik-Kesehatan Ibu dan Anak (e-KIA) by Fitra Abdurrachman Bachtiar, Retno Indah Rokhmawati, Fajar Pradana, Intan Yusuf Habibie

“…Aplikasi e-KIA yang sudah dibangun saat ini masih belum diketahui tingkat usabilitas dari penggunaan aplikasi tersebut. Pengujian usability ini penting untuk dilakukan sebelum aplikasi tersebut digunakan oleh masyarakat secara luas dan dapat digunakan sebagai early warning untuk mendeteksi kemungkinan-kemungkinan kesalahan yang terjadi. …”
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The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression by Callan L. Attwell, Inés Maldonado-Lasunción, Ruben Eggers, Bastiaan A. Bijleveld, Ward M. Ellenbroek, Natascha Siersema, Lotte Razenberg, Dédé Lamme, Nitish D. Fagoe, Ronald E. van Kesteren, August B. Smit, Joost Verhaagen, Matthew R. J. Mason

“…Gene expression profiling revealed that unexpectedly, the MEF2-VP16 construct used had little transcriptional activity in vivo, suggesting additional steps may be required to achieve full MEF2 activity. …”
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Akuisisi Foreground dan Background Berbasis Fitur DTC pada Matting Citra secara Otomatis by Meidya Koeshardianto, Eko Mulyanto Yuniarno, Mochamad Hariadi

“… Teknik pemisahan foreground dari background pada citra statis merupakan penelitian yang sangat diperlukan dalam computer vision. …”
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Evaluation of the Clinical Efficacy of Prednisolone in the Treatment of Inflammatory Bowel Diseases with Different Dosage Methods by O. P. Alekseeva, S. V. Krishtopenko, A. A. Alekseeva

“…All patients were treated with prednisolone at an initial daily dose from 30 to 60 mg with a subsequent tapering of dose. …”
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