Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…To achieve that, we applied CirComPara2 pipeline to publicly available datasets to identify the differently expressed circRNAs in the LNCaP cell lines pre- and post-transdifferentiation. After that, validation and functional analysis by RNA-interference was applied to a selected circRNA to explore its role during NED. …”
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Early weight gain after stopping smoking: a predictor of overall large weight gain? A single-site retrospective cohort study by Alexandra Pankova, Eva Kralikova, Kamila Zvolska, Lenka Stepankova, Milan Blaha, Petra Ovesna, Paul Aveyard

“…A receiver operating curve analysis showed that patients gaining more than 0.98% of their baseline weight during first 3 months had a sensitivity of 66% and specificity of 44% for gaining 7% or more weight by 12 months. In addition, lower body mass index and an increase in appetite at 3 months after quitting were associated with greater weight gain, while using nicotine replacement therapy was associated with less weight gain at 1-year follow-up.Conclusions People who stop smoking and gain a larger amount of weight early after quitting are not more likely to gain excessively at 1 year.…”
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Development of a machine learning model related to explore the association between heavy metal exposure and alveolar bone loss among US adults utilizing SHAP: a study based on NHAN... by Jiayi Chen

“…In the future, more advanced algorithms should be developed to validate these results and related parameters can be tuned to improve the accuracy of the model. …”
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El impacto demográfico de la COVID-19 durante 2020 y sus diferencias regionales. ¿Cómo afectará la pandemia al futuro de la población española? by Miguel González Leonardo, Jeroen Spijker

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Bioinformatics insights into mitochondrial and immune gene regulation in Alzheimer's disease by Tian Meng, Yazhou Zhang, Yuan Ye, Hui Li, Yongsheng He

“…After platform removal, there was a notable increase in the path complexity and time required to reach the target quadrant, suggesting a reduction in spatial memory capacity in AD mice. Moreover, qRT-PCR validation confirmed that the mRNA expression of the five biomarkers was consistent with bioinformatics results. …”
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Bibliotherapy Services in Public Libraries: the Case of Lithuania by Jurgita Girčienė, Miglė Damijonaitytė

“…The article presents the results of a quantitative empirical study based on the synthesis of multidisciplinary bibliotherapy research, which allowed to determine the librarians’ own possibilities to provide biblio­therapy services, revealing the state of bibliotherapy services provision in Lithuanian public libraries in 2022. In addition, the article provides a comparative analysis of this study and secondary sources, which showed the evolution and development possibilities of the provision of bibliotherapy services in Lithuanian public libraries. …”
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The effect of depth data and upper limb impairment on lightweight monocular RGB human pose estimation models by Gloria-Edith Boudreault-Morales, Cesar Marquez-Chin, Xilin Liu, José Zariffa

“…The models were trained, validated and tested using the CMU Panoptic and Human3.6 M data sets as well as a custom data set. …”
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Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…It restored the kidney hypertrophy index, stabilized biochemical parameters, enhanced histopathological outcomes, and increased beta-cell count. Additionally, (PTE+PSE)-NLC led to a 30.53-fold more significant reduction in blood glucose levels than free (PTE+PSE) extracts. …”
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Does macrolide use confer risk of out-of-hospital cardiac arrest compared with penicillin V? A Danish national case-crossover and case–time–control study by Lars Køber, Freddy Lippert, Charlotte Andersson, Peter E Weeke, Gunnar H Gislason, Frederik Boetius Hertz, Aksel Jensen, Jenny D Knudsen, Magnus Arpi, Christian Torp–Pedersen

“…Compared with penicillin-V treatment, specific macrolides were not associated with increased risk of OHCA: roxithromycin (OR=0.97; 95% CI 0.74 to 1.26), erythromycin (OR=0.68; 95% CI 0.44 to 1.06), clarithromycin (OR=0.95; 95% CI 0.61 to 1.48) and azithromycin (OR=0.85; 95% CI 0.57 to 1.27).Similar results were obtained using case–time–control models: overall macrolide use (OR=0.81; 95% CI 0.62 to 1.06) and specific macrolides (roxithromycin (OR=0.70; 95% CI 0.49 to 1.00), erythromycin (OR=0.67; 95% CI 0.38 to 1.18), clarithromycin (OR=0.75; 95% CI 0.41 to 1.39) or azithromycin (OR=1.17; 95% CI 0.70 to 1.95)).Conclusion The risk of OHCA during treatment with macrolides was similar to that of penicillin V, suggesting no additional risk of OHCA associated with macrolides.…”
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Airborne Levels of Lung Carcinogens at an Ascon Manufacturing Site by Kyeongmin Lee, Sungwon Choi, Miyeon Kim, Dongwoo Song, Ki-Youn Kim

“…The drying process removes moisture from the aggregate and maintains the required temperature for combining the aggregate, asphalt, and additives into ascon during the mixing stage. Finally, the ascon is disgorged from an outlet on the mixing machine and loaded onto dump trucks. …”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Despite this, it is underused or rarely evaluated in the context of vaccination. Additionally, the success of RVP implementation in vaccination clinics hinges on the motivation of vaccination staff, which remains critical even with stable contextual factors. …”
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Desmoid-type fibromatosis of the breast: a case report and literature review by Zijun Zhao, Qingyao Shang, Chenxuan Yang, Jiaxiang Liu, Shanqing Liu, Xiaoqian Li, Xiyu Kang, Jiaxian Yue, Xin Wang, Xiang Wang

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Nonlinear associations of the hs-CRP/HDL-C index with metabolic dysfunction-associated steatotic liver disease and advanced liver fibrosis in US adults: insights from NHANES 2017–2... by Bin Liang, Xue Qiu, Jiansheng Huang, Yequan Lu, Hairong Shen, Jianchao Ma, Yongyu Chen

“…Smooth curve fitting and threshold effect analyses revealed nonlinear relationships of hs-CRP/HDL-C index with MASLD and advanced liver fibrosis, with inflection points at 0.8 for MASLD and 1.2 for advanced liver fibrosis. Additionally, significant interactions were observed between MASLD and covariates such as gender, smoking status, chronic kidney disease (CKD), and cancer. …”
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Effects of poultry by-product meal and complete replacement of fish oil with alternative oils on growth performance and gut health of rainbow trout (Oncorhynchus mykiss): a FEEDNETICS™ validation study by Imam Hasan, Simona Rimoldi, Biagina Chiofalo, Marianna Oteri, Micaela Antonini, Rosangela Armone, Violeta Kalemi, Laura Gasco, Genciana Terova

“…The validation of the model for fish growth resulted in a Mean Absolute Percentage Error (MAPE) of 8%. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Weighted Gene Co-expression Network Analysis (WGCNA) was employed to screen the DN-related genes, then the differential CSRGs (DCSRGs) were identified, followed by protein–protein interaction (PPI) network construction. In addition, key biomarkers were acquired by two machine learning algorithms, then immune infiltration analysis, Gene Set Enrichment Analysis (GSEA), and potential drugs screening were conducted. …”
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L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005–2016 by Xiaotong Chen, Haiwei Chen, Yuling Chen, Lixin Tang, Jiaqi Liu, Yu-Hua Ou

“…To statistically assess this relationship, we utilized weighted multivariate logistic regression models. Additionally, we implemented smooth curve fitting and threshold effect analysis, to delineate the complex, nonlinear association between iron intake and HPV infection. …”
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Variations of microbiota and metabolites in rhizosphere soil of Carmona microphylla at the co-contaminated site with polycyclic aromatic hydrocarbons and heavy metals by Ying Zhang, Fanghan Qian, Yanyu Bao

“…As the results showed, among three pollution levels, a medium level of pollution was favorable to increase the richness and diversity of soil bacterial community, while high level of pollution greatly decreased special OTUs number. In addition, HMs were the most significant factors driving bacterial community structure, especially for Cd. …”
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Impacts of National Reimbursement Drug Price Negotiation on drug accessibility, utilization, and cost in China: a systematic review by Zheng Zhu, Jiawei Zhang, Zhihu Xu, Quan Wang, Yu Qi, Li Yang

“…It has been suggested that the NRDPN was conducive to narrowing disparities in availability and affordability across regions, hospital levels, and types of health insurance. In addition, it was associated with the increased drug expenditure by 61% due to the increased use of successful-negotiated drugs. …”
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Association between Dysfunctional Beliefs and Coping Strategy among Persons Suffering from Substance Use Disorder by Prosenjit Ghosh, Saptarshi Paul Choudhury, Subho Panja

“…Materials and Methods: The population of this descriptive and cross-sectional study were 44 patients who were admitted under psychiatry ward and consented to the study. …”
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Cohort profile: Born in Wales—a birth cohort with maternity, parental and child data linkage for life course research in Wales, UK by Amrita Bandyopadhyay, Sarah Davies, Michaela James, Sinead Brophy, Sam Dredge, Hope Jones, Mike J Seaborne, Natasha L Kennedy, Adele Battaglia

“…This comprehensive dataset comprises over 400 000 child electronic records. Additionally, survey responses about health and well-being from a cross-section of the population including 2500 parents and 30 000 primary school children have been collected for enriched personal responses and linkage to the data spine.Findings to date The electronic cohort comprises all children born in Wales since 2011, with follow-up conducted until they finish primary school at age 11. …”
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