FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

“…Downregulation of FOXA1 markedly augmented the expression of osteoblast-specific genes and proteins, activated the ERK1/2 signaling pathway, intensified ALP activity, and promoted mineral deposition. In addition, excessive expression of FOXA1 significantly reduced ALP activity and mineral deposits. …”
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MECHANISMS FOR ENSURING THE ECONOMIC DEVELOPMENT OF RURAL AREAS THROUGH THE FORMATION OF THEIR ENERGY DEPENDENCE BASED ON THE INTENSIFICATION OF BIOFUEL PRODUCTION by Yuliia Okhota, Denys Titov, Svitlana Dotsiuk

“…The study examines biomass as a resource with significant potential to meet local energy needs, create additional jobs and stimulate economic growth in rural areas. …”
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Effects of dietary chlorogenic acid supplementation on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens by Haitong Zhao, Lianxiang Guo, Ming Yan, Yue Sun, Yan Hong, Mingkun Zhu

“…Meanwhile, CGA treatment significantly upregulated hepatic Nrf2 and SOD2 gene expression while downregulating Keap1 gene expression. Additionally, 600 and 800 mg/kg CGA treatment significantly decreased serum TG, T-CHO, and LDL-C levels, as well as liver TG and T-CHO levels, while increasing serum lipoprotein lipase activity. …”
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Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain by Chen Y, Tang G, Lu J, Tang S, Xiong X, Chen C, Pei L, Shi J

“…Pain threshold of rats was measured by thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT), Elisa was used to detect the expression level of inflammatory factors, qRT PCR and Western blotting were used to detect astrocyte polarization markers, C/EBP-β, TGF-β 1, p-smad2 and p-smad3.Results: Following Vincristine administration, the TWL and MWT of rats exhibited a decrease. Additionally, there was an increase in A1 polarization of astrocytes, while A2 polarization remained relatively unchanged. …”
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Causal machine learning models for predicting low birth weight in midwife-led continuity care intervention in North Shoa Zone, Ethiopia by Wudneh Ketema Moges, Awoke Seyoum Tegegne, Aweke A. Mitku, Esubalew Tesfahun, Solomon Hailemeskel

“…The estimated ATE for the S-learner was 0.284, which is lower than the true ATE of 0.216. Additionally, the estimated ITE for both the T-learner and X-learner was less than -0.5, indicating that mothers would not choose to participate in the MLCC program. …”
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Comparing survival outcomes of localized tumor destruction, sublobar resection, and pulmonary lobectomy in stage IA non-small cell lung cancer: a study from the SEER database by Lin Cheng, Sheng-Wei Li, Xiao-Guang Li

“…Comparison between groups was performed separately after 1:1 proportional propensity score matching (PSM) with a caliper value of 0.1. Kaplan–Meier analysis was performed to compare survival outcomes between groups. …”
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Chemical Composition Characteristics and Source Apportionment of PM2.5 in Ceramic Industrial Base during Winter by Xiang Tu, Xiaozhen Fang, Hansun Fang, Changlin Ye, Zugen Liu, Xuehui Jia, Dan He, Jinliang Wang, Hong Huang, Changwei Zou, Chenglong Yu

“…Water-soluble ions and total carbon contributed about 48.7% and 13.9% of the PM2.5 mass, respectively. In addition, the SO42−/NO3− ratio in the ambient PM2.5 during the sampling period was 1.16, indicating that it was the result of primarily emissions from stationary sources. …”
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Understanding Citizens’ Response to Social Activities on Twitter in US Metropolises During the COVID-19 Recovery Phase Using a Fine-Tuned Large Language Model: Application of AI by Ryuichi Saito, Sho Tsugawa

“…A total of 47,111 unique users authored these posts. In addition, for privacy considerations, any identifiable information, such as author IDs and usernames, was excluded, retaining only the text for analysis. …”
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Use of Anabolic-Androgenic Steroids and Male Fertility: A Systematic Review and Meta-analysis by Prashant Motiram Mulawkar, Pankaj N. Maheshwari, Vineet Gauhar, Sumeet Gopal Agrawal, Taofiq Olayinka Mohammed, Abhishek Gajendra Singh, Gopal Ramdas Tak, Utsav Shailesh Shah, Deepali Parthsarthi Shukla, Deepali Mamankar

“…Most AAS users need additional medications to mitigate detrimental effects on fertility. …”
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Sexual distress among men with cancer – a cross-sectional study by Jonas Nahavandipour, Christoffer Johansen, Annamaria Giraldi, Bolette Skjøft Rafn, Annika von Heymann

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Effects of E-Cigarette Liquid Ratios on the Gravimetric Filter Correction Factors and Real-Time Measurements by Austin Close, Jane Blackerby, Heather Tunnell, Jack Pender, Eric Soule, Sinan Sousan

“…ECIG aerosols were generated inside a controlled exposure chamber using a diaphragm pump and a refillable ECIG device for all the ratios. In addition, the aerosol size distribution and mass median diameter were measured for all five ECIG ratios. …”
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Oakland score to identify low-risk patients with lower gastrointestinal bleeding performs well among emergency department patients by Daniel D. DiLena, Sean C. Bouvet, Madeline J. Somers, Maqdooda A. Merchant, Theodore R. Levin, Adina S. Rauchwerger, Dana R. Sax

“…The Oakland Score composite outcome includes re-bleeding, defined as additional blood transfusion requirements and/or a further decrease in hematocrit (Hct) >/= 20% after 24 h in clinical stability; red blood cell transfusion; therapeutic intervention to control bleeding, including surgery, mesenteric embolization, or endoscopic hemostasis; in-hospital death, all cause; and re-admission with further LGIB within 28 days. …”
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Efficacy and prognosis of dapagliflozin in the treatment of patients with acute myocardial infarction complicated with type 2 diabetes in Xining area by Jinping Chai, Delian Li, Yanmin Liu, Xiaoling Su

“…KaplanMeier survival analysis showed that the primary endpoint of survival was significantly higher in the dapagliflozin group than in the control group (P < 0.05). In addition, the overall survival rate of the dapagliflozin group was significantly higher than that of the control group, and the difference was statistically significant (P < 0.05).ConclusionsDapagliflozin is safe and reliable in the treatment of patients with acute myocardial infarction and type 2 diabetes, and can effectively reduce the incidence of cardiovascular events and improve the overall survival rate of patients.…”
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Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway by Zihan Song, Zijun Zhao, Xuehua Liu, Yiran Song, Siyu Zhu, Ziyang Jia, Yijie Li, Zairan Wang, Boyu Sun, Qianxu Jin, Shiyang Zhang, Zongmao Zhao, Liqiang Liu

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Predictors of food security status among informal caregivers of older adults residing in slums in Ghana by Dina Adei, Williams Agyemang-Duah, Bright Osei Boateng, Anthony Acquah Mensah

“…The study revealed that participants without formal education (β = 0.661, p <.05) and those aged 29 years or younger (β = 26.927, p <.001), 30–39 years (β = 27.453, p <.001), and 40–49 age group (β = 26.710, p <.001) statistically significantly exhibited an increased food security status compared to their counterparts. Additionally, participants identifying as Akan (β = -0.421, p <.05), Christians (β = -0.828, p <.001), married individuals (β = -0.500, p <.05), those who reported never being ill (β = -2.617, p <.001), those without chronic non-communicable diseases (NCDs) (β = -0.638, p <.001), and those not enrolled in the national health insurance scheme (β = -0.422, p <.01) statistically significantly experienced a decreased food security status compared to their counterparts. …”
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Evaluation of the Effectiveness of Soil Improvement Measures in Apple Orchards on the Loess Plateau: A Meta-Analysis by DUAN Shunxia, LIU Jiayuan, ZHAO Hongxiang, LI Yangyang

“…[Results] The results indicated that grass mulching, plastic film mulching, straw mulching, and gravel mulching effectively reduced soil bulk density by 6.63%, 5.96%, 6.04%, and 6.40%, respectively. Additionally, grass mulching and straw mulching also significantly increased soil nutrient contents. …”
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Beyond borders: investigating the impact of the 2023 conflict in Gaza on generalized anxiety disorders and associated somatic symptoms and wellbeing among the Kuwait population: a... by Musaed Z. Alnaser, Hamad Alhamad, Naser Alotaibi, Nadia Alhamdan, Fahad Manee

“…Generalized anxiety disorder, associated somatic symptoms, and wellbeing were examined among the Kuwait population during the Gaza Conflict in 2023, in addition to exploring the provoking factors.MethodsA descriptive, correlational cross-sectional design was used in this study. …”
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Analysis of the predictive value of the prostate-specific antigen-to-neutrophil ratio for the diagnosis of prostate cancer by Yuxuan Chen, Haisheng Yan, Yaoqin Xu, Kexin Chen, Runqin Yang, Jiali Yang, Ruian Zhu, Rui Lin, Jiang Wang, Jie Liu, Pingsheng Gao, Lei Pang, Lexin Wang

“…Patients within this range need to be further evaluated using additional parameters such as PSA ratio, PSA density, and other indices to determine the necessity of prostate biopsy (PBx). …”
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The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota by Jingda Zhang, Lin Hou, Shanxiang Lei, Yan Li, Guogang Xu

“…Still, more in vivo and in vitro work should be carried out to validate the precise effect and molecular mechanisms of the gut microbiome.…”
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Efficacy and Safety of Cataract Surgery Combined with Ab Interno Canaloplasty and Micro-Trabecular Bypass Stent Surgery in Open-Angle Glaucoma by Porter MS, Flowers A, Wood BP, Gallardo MJ

“…IOP reduced to 12.8± 2.4 (p=0.005) at 12 months while the number of medications did not show any statistically significant change: 1.9± 1.6 (p=0.4). No eyes underwent additional glaucoma surgery in the study period.Conclusion: Canaloplasty combined with microtrabecular bypass stent surgery following cataract extraction demonstrated efficacy in reducing IOP and medication burden up to 24 months postoperatively. …”
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