Engineered CAF-cancer cell hybrid membrane biomimetic dual-targeted integrated platform for multi-dimensional treatment of ovarian cancer by Yuwei Yao, Jiarui Zhang, Kexin Huang, Yingying Peng, Shuangshuang Cheng, Shuangge Liu, Ting Zhou, Jinhua Chen, Haojia Li, Yingchao Zhao, Hongbo Wang

“…Abstract Background The efficacy of current therapies for ovarian cancer is limited due to the multilevel and complex tumor microenvironment (TME), which induces drug resistance and tumor progression in a single treatment regimen. Additionally, poor targeting and insufficient tissue penetration are important constraints in ovarian cancer treatment. …”
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Growth performance and meat quality of medium-growing chickens fed with live black soldier fly larvae by Cristina Tognoli, Sara Bellezza Oddon, Luisa Zaniboni, Ilaria Biasato, Niko Gioacchino Zeni, Manuela Renna, Laura Gasco, Stefano Paolo Marelli, Annalaura Lopez, Achille Schiavone

“…As concern growth performance, the diets influenced the average daily feed intake (p = 0.039) and FCR, which was lower in insect-fed birds (p < 0.001). …”
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Pengaruh Penggunaan Aplikasi Wattpad terhadap Kemampuan Menulis Cerita Pendek Siswa SMPN 1 Siak Hulu by Pristi Dian Nova, Rhani Febria

“…Dengan demikian, Ha diterima, sedangkan H0 ditolak. Dengan demikian, dapat disimpulkan bahwa pemanfaatan aplikasi Wattpad berpengaruh terhadap kemampuan menulis cerita pendek siswa SMPN 1 Siak Hulu. …”
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Clinical observation of VR virtual reality rehabilitation training combined with acupuncture in the treatment of mild cognitive impairment by Ying Fu, Hui Wang

“…This directly affects the patient's motor function, daily living ability, and social adaptability, and brings many difficulties to the patient's reintegration into society. …”
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Are Artificial Sweeteners a Healthier Alternative to Sugar? by Julia Buszek, Piotr Czerniak, Adrianna Antoszewska, Weronika Bargiel, Dominika Bąk, Halszka Wajdowicz, Mateusz Warzocha, Michał Medygrał, Sylwia Buszek, Aldona Sokołowska, Maciej Rumian, Alicja Kosel

“…Regulatory bodies like the FDA deem approved sweeteners safe within recommended daily limits. Despite their advantages, further research is needed to fully understand their long-term impact. …”
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Barriers and facilitators to data-based decision making in Australian early childhood education and care: A qualitative study by Shauna Sherker, Karen Villanueva, Ruth Beatson, Caitlin M. Macmillan, Wan Yi Lee, Olivia Hilton, Carly Molloy, Sharon Goldfeld

“…To be of benefit to all children, ECEC must deliver on three key areas: availability (quantity), quality and participation (reach and dose). …”
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Selfitis: An Analysis on Prevalence and Attitude among College Students by MG Sreejamol, R Radhika, Rajalakshmi Reghuvaran

“…Introduction: Our daily lives now mostly revolve around our smartphones. …”
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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Results demonstrated a significant reduction in mitochondrial superoxide anion levels without affecting mitochondrial membrane potential, indicating enhanced cellular resilience to oxidative stress. Additionally, CCRE decreased UVB-induced IL-6 expression and IKK phosphorylation, which play a crucial role in inflammaging. …”
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Combined effects of Macleaya cordata extract and antimicrobial peptides on reproductive performance and oviduct microbiota in Xuefeng black-bone chickens by Hui Wan, Fu Yin, Guihua Chen, Yaling Yao, Qiongtao Zi, Yuxuan Zhou, Lixia Yan, Peng Li, Jingzhe Huang, Ning He, Meichun Li, Songchang Guo

“…Moreover, group E exhibited a significant increase in average daily egg weight (p < 0.05), and all experimental groups showed a significant reduction in abnormal egg rates (p < 0.05). (2) Groups B and C exhibited significantly thicker oviduct epithelium compared to group A (p < 0.05). (3) At the phylum level, all dietary treatment groups showed a higher relative abundance of Firmicutes compared to group A, with the highest levels found in group B (p < 0.05). (4) At the genus level, the relative abundance of Faecalibacterium in groups C and E was significantly higher than in group A (p < 0.05).…”
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The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…Participants received KN046 5 mg/kg every 3 weeks and lenvatinib 12 or 8 mg once daily. The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), and objective response rate (ORR) according to RECIST v1.1. …”
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Modeling of drying kinetics and chemical analysis for optimal preservation of pitahaya, aguaymanto and pineapple fruits using a parabolic solar dehydrator in the Amazon region - Pe... by Merbelita Yalta Chappa, Wildor Gosgot Angeles, Luz Quispe-Sanchez, Diana Carina Mori Servan, Homar Santillan Gomez, Manuel Oliva-Cruz, Miguel Ángel Barrena Gurbillón

“…Five mathematical models were used to determine the drying curve, with the criterion of selection the best model with the coefficient of determination (R2) and model efficiency (EF); in addition, pH and titratable acidity were evaluated during the dehydration period. …”
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Gastrointestinal complaints in patients with anorexia nervosa in the timecourse of inpatient treatment by Caroline Riedlinger, Caroline Riedlinger, Nazar Mazurak, Nazar Mazurak, Norbert Schäffeler, Andreas Stengel, Andreas Stengel, Andreas Stengel, Katrin Elisabeth Giel, Katrin Elisabeth Giel, Stephan Zipfel, Stephan Zipfel, Paul Enck, Paul Enck, Isabelle Mack, Isabelle Mack

“…Diarrhea and reflux were, on average, not pathological at admission and remained stable during treatment. In addition to treatment time, the strongest predictors were ED pathology at admission for the development of abdominal pain, constipation, reflux, and total GI symptoms; stress for the development of constipation and total GI symptoms; and depression for constipation.ConclusionsInforming patients with AN about the course of GI symptoms and their improvement during weight rehabilitation may help support compliance during treatment.…”
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Potential of Lactiplantibacillus Plantarum 20174 for Vitamin B12 Production in Pineapple: An Enhanced Nutritional Quality and Storage Stability of Processed Jelly by Mayuri Rastogi, Bushra Shaida, Vandana Singh, Zoobiya Islam, Saleem Siddiqui

“…The vitamin B12 content of FPJ was stable during storage and sufficient enough to fulfil an individual’s daily requirement. Conclusion: The developed fermented pineapple jelly can be recommended as an excellent vegan source of vitamin B12.…”
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Evaluasi Kualitas Proyek Sistem Informasi Pelayanan Pemerintah Daerah Menggunakan Project Management Body of Knowledge by Gde Brahupadhya Subiksa, Made Pasek Agus Ariawan, , Ida Bagus Adisimakrisna Peling

“…Peneliti juga menggunakan Capability Maturity Model (CMM) guna membantu mendefinisikan maturity level dari manajemen proyek sistem pelayanan perijinan tersebut. …”
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Emission Characteristics of Volatile Organic Compounds from Typical Coal Utilization Sources: A Case Study in Shanxi of Northern China by Yang Xu, Hualong Yu, Yulong Yan, Lin Peng, Rumei Li, Cheng Wang, Zhiyong Li

“…Among the detected VOCs, the results identified 1-butene as the most abundant species for both the power plants (36.7%) and the residential stoves (41.7%) as well as a significant contributor at the steel plants (7.3%), and alkenes, alkanes, and aromatics composed the largest groups for the power plants (42.0%) and residential stoves (60.2%); steel plants (59.2%); and coking plants (66.1%), respectively. Additionally, the VOC profiles for power plants employing the same coal source or combustion technology exhibited strong similarities, although the BTEX ratios varied more between plants using different coal sources than those using different combustion technologies. …”
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Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma by Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

“…We identified eight distinct tumor-associated collagen signatures (TACS1-8) from multiphoton images of PDAC tissues and developed an optical biomarker, TACS-score, based on the TACS1-8 using ridge regression analysis. Additionally, we also extracted 142 microscopic TACS (M-TACS) from second-harmonic generation (SHG) images and constructed a new robust biomarker, M-TACS-score, using the least absolute shrinkage and selection operator (LASSO) regression analysis. …”
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Investigation of the effects of combined exercises and self-management education, with and without functional exercises, on pain and functional outcomes in patients with avascular... by Zohreh Gholami, Seyedeh Tahereh Faezi, Elham Madreseh, Raghad Mimar

“…This degeneration is causing pain and limited function in daily activities over time. This study will plan to enrol 53 male and female participants, aged 18–50 years, who have been diagnosed with AVNFH. …”
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The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

“…Specifically, NSUN2 could stabilize PKM2 mRNA by increasing the m5C level of the m5C site C773 in the 3′-UTR of PKM2 mRNA. In addition, rescue assays revealed that NSUN2 promotes HCC glycolysis and progression by upregulating PKM2. …”
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The Relationship Between Screen Time, Sleep and Obesity by Dominika Lewandowska, Dominika Rosińska-Lewandoska, Zofia Podraza, Dominika Strep, Julia Grabowska, Jakub Rosiński, Zofia Głowniak, Maciej Kwiatkowski, Izabela Kwiatkowska, Malwina Soja

“… Introduction Excessive screen time has emerged as a major public health concern, particularly due to its association with sleep disturbances and the rising prevalence of obesity. Digital technologies have become deeply integrated into daily life, leading to prolonged exposure to screens and subsequent health challenges. …”
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Oral dydrogesterone versus oral micronized progesterone in threatened miscarriage: protocol paper for a randomized controlled trial by Alka Kriplani, Gouri Shankar Kamilya, T Ramani Devi, Ashima Taneja, Amol Pawar, Gayathri Karthik Nagesh, Tapan Pattanaik, Tanusree Gupta, Mahima Jain, Monjori Mitra

“…Scheduled visits after enrollment will be conducted during 6–13, 8–14, 18–20 and 24–26 weeks of gestation, in addition to a visit at the end of treatment at 14 weeks and another after parturition. …”
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