Meiotic recombination modulates the structure and dynamics of the synaptonemal complex during C. elegans meiosis. by Divya Pattabiraman, Baptiste Roelens, Alexander Woglar, Anne M Villeneuve

“…During meiotic prophase, a structure called the synaptonemal complex (SC) assembles at the interface between aligned pairs of homologous chromosomes, and crossover recombination events occur between their DNA molecules. Here we investigate the inter-relationships between these two hallmark features of the meiotic program in the nematode C. elegans, revealing dynamic properties of the SC that are modulated by recombination. …”
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Enhancing Cervical Cancer Screening: New Diagnostic Methodologies, Triage, and Risk Stratification in Prevention and Treatment by Nazira Kamzayeva, Gauri Bapayeva, Milan Terzic, Berik Primbetov, Balkenzhe Imankulova, Yevgeniy Kim, Arailym Sultanova, Kuralay Kongrtay, Nazira Kadroldinova, Talshyn Ukybassova

“…Advances in diagnostic methodologies, including E6/E7 oncoprotein detection, DNA methylation, and microRNA-based assays, are examined in the context of improving screening accuracy and early detection. …”
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Decoding the complete mitochondrial genome of Hydrangea chinensis maxim.: insights into genomic recombination, gene transfer, and RNA editing dynamics by Kang Ye, Jun Qin, Hu Yonghong

“…Furthermore, the genome harbors 23 plastid-derived DNA fragments (MTPTs) spanning 11,059 bp—evidence of chloroplast-to-mitochondrial gene transfer with potential evolutionary implications. …”
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Prevalence and genotypic distribution of high-risk human papillomavirus (HPV) among ever-married women in coastal regions of Bangladesh. by Snigdha Chakraborty, Ashrafun Nessa, Noor-E Ferdous, Mohammad Mosiur Rahman, Mohammad Harun Ur Rashid, Asma Akter Sonia, Md Foyjul Islam

“…These findings hold significant implications for policy makers, providing guidance for targeted screening strategies and vaccination programs.…”
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Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB by Yongzhan Sun, Quan Zou, Huizheng Yu, Xiaoping Yi, Xudan Dou, Yu Yang, Zhiheng Liu, Hong Yang, Junya Jia, Yupeng Chen, Shao-Kai Sun, Lirong Zhang

“…Interestingly, we found that MMPP effectively inhibits a cyst-promoting gene program downstream of the cAMP-CREB pathway, a crucial signaling pathway implicated in ADPKD progression. …”
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Complete mitochondrial genome sequence analysis revealed double matrilineal components in Indian Ghoongroo pigs by Pranab Jyoti Das, Satish Kumar, Manasee Choudhury, Seema Rani Pegu, K. Meera, Rajib Deb, Sunil Kumar, Santanu Banik, Vivek Kumar Gupta

“…This study underscores the significance of mitochondrial DNA analysis in uncovering hidden genetic diversity within seemingly uniform populations. …”
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INVESTIGATION OF CANDIDATE GENE POLYMORPHISMS IN AN IMMUNE RESPONSE AS MARKERS FOR THE RISK OF DEVELOPING RHEUMATOID ARTHRITIS AND PRODUCING AUTOANTIBODIES by I. A. Guseva, N. V. Demidova, N. E. Soroka, E. L. Luchikhina, A. A. Novikov, E. N. Aleksandrova, G. V. Lukina, E. V. Fedorenko, E. S. Aronova, E. Yu. Samarkina, D. Yu. Trofimov, D. E. Karateev, E. L. Nasonov

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MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor-associated, macrophages-mediated immunosuppression in primary glioblastomas by Ying Zhang, Zheng Wang, Zheng Zhao, Tao Jiang, Shou-Wei Li, Yong-Jian Zhu, Qiang-Wei Wang, Li-Hua Sun, Zhi-Liang Wang, Kuan-Yu Wang, Guan-Zhang Li, Jian-Bao Xu, Chang-Yuan Ren, Wen-Ping Ma, Hong-Jun Wang, Zhao-Shi Bao

“…Chromatin immunoprecipitation-PCR assay showed enrichment of STAT4 in the PD-L1 DNA. Transwell co-culture and chemotaxis assays revealed that knockdown of MET in GBM cells inhibited macrophage chemotaxis. …”
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Molecular characteristics of human adenovirus isolated from the 2024 influenza-like illness outbreaks in Suzhou City, China by Jia Zang, Yueping Xing, Hongkai Zhang, Yanshi Wu, Xuerong Ya, Qiang Shen, Zefeng Dong

“…Abstract Background Human adenoviruses (HAdV) comprises a genetically diverse group of double-stranded DNA viruses strongly associated with influenza-like illness (ILI) and acute respiratory illnesses (ARI) outbreaks. …”
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Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome by Leonardo Josué Castro-Muñoz, Davide Maestri, Leena Yoon, Bhanu Chandra Karisetty, Italo Tempera, Paul Lieberman

“…The histone variant H2A.Z.1 has been implicated in chromatin structures associated with the initiation of transcription and DNA replication. …”
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Human lung cancer neutrophils generate NETs with preserved anti-tumor cytotoxicity but impaired anti-migratory activity by Nuha Alsharif, Nuha Alsharif, Mohamad Qaisi, Merav Shaul, Naomi Kaisar-Iluz, Naomi Kaisar-Iluz, Dan Padawer, Dan Padawer, Osnath Bouhanna, Osnath Bouhanna, Yael Volman, Yael Volman, Zvi G. Fridlender, Zvi G. Fridlender

“…Neutrophil extracellular traps (NETs) are DNA-protein structures released during a form of programmed neutrophil death known as NETosis. …”
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Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study by Beyazyuz M, Kufeciler T, Bulut L, Unsal C, Albayrak Y, Soydas Akyol E, Baykal S, Kuloglu M, Hashimoto K

“…Murat Beyazyüz,1 Tarkan Küfeciler,2 Leyla Bulut,3 Cüneyt Ünsal,1 Yakup Albayrak,1 Esra Soydaş Akyol,4 Saliha Baykal,1 Murat Kuloglu,5 Kenji Hashimoto61Department of Psychiatry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 2Department of Emergency Medicine, Çekirge State Hospital, Bursa, Turkey; 3Department of Biochemistry, Okmeydani Education and Research Hospital, Istanbul, Turkey; 4Department of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey; 5Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey; 6Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, JapanBackground: Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including schizophrenia. …”
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Emerging Ferroptosis Involvement in Amyotrophic Lateral Sclerosis Pathogenesis: Neuroprotective Activity of Polyphenols by Annamaria Russo, Stefano Putaggio, Ester Tellone, Antonella Calderaro, Santa Cirmi, Giuseppina Laganà, Silvana Ficarra, Davide Barreca, Giuseppe Tancredi Patanè

“…Indeed, many pathways implicated in the disease are hallmarks of ferroptosis, a recently discovered type of iron-dependent programmed cell death characterized by increased reactive oxygen species (ROS) and lipid peroxidation. …”
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California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of AC... by Lauren Y. Kim, Sophia Miryam Schüssler-Fiorenza Rose, Summer Mengelkoch, Daniel P. Moriarity, Jeffrey Gassen, Jenna C. Alley, Lydia G. Roos, Tao Jiang, Arash Alavi, Durga Devi Thota, Xinyue Zhang, Dalia Perelman, Tamar Kodish, Janice L. Krupnick, Michelle May, Katy Bowman, Jenna Hua, Yaping Joyce Liao, Alicia F. Lieberman, Atul J. Butte, Patricia Lester, Shannon M. Thyne, Joan F. Hilton, Michael P. Snyder, George M. Slavich

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Environmental arsenic hijacks DDX5-mediated FANCA splicing to impair R-loops resolution and drive ovarian aging by Tuo Zhang, Jin Niu, Lu Yang, Yuanyuan Yu, Meina He, Changfa Wu, Zengmei Cheng, Mei Pan, Zerui Hong, Jian Sun, Yuan Gao, Tengxiang Chen, Zhengrong Wang, Wei Pan

“…Arsenic, a widespread environmental toxicant, is increasingly implicated in female reproductive dysfunction. Long-term exposure to low concentrations of arsenic leads to diminished ovarian reserve. …”
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Investigating the Relationship between Changes in the Expression Level of the CLU Gene and the Prognosis of Gastric Cancer Patients by Arezoo Farhadi, Erfan Cheraghi, Nastaran Farahani, Fatemeh Khodabandehloo, Mohammad Foad Heidari, Reza Heydari, Mehdi Ghorbani, Mahmood Vahidi, Javad Behroozi

“…Gene expression changes are also implicated in other diseases, such as heart disease, autoimmune disorders, and diabetes. …”
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