Plasmodium falciparum Clinical Isolates Reveal Analogous Circulation of 3D7 and FC27 Allelic Variants and Multiplicity of Infection in Urban and Rural Settings: The Case of Adama a... by Temesgen File, Lemu Golassa, Hunduma Dinka

“…Analysis of the block 3 region of the msp-2 gene of P. falciparum provides strong molecular evidence to evaluate the real picture of malaria epidemiology to fine-tune the ongoing control and elimination programs in the region. Thus, this study was aimed at examining the status of such polymorphic gene and its implications in Adama and its surroundings. …”
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Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns by Tyler D. Noble, Courtney G. Sansam, Kimberlie A. Wittig, Blanka Majchrzycka, Christopher L. Sansam

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Reversible proliferative arrest induced by rapid depletion of RNase MRP by Yuan Liu, Shiyang He, Kawon Pyo, Reuben Franklin, Ibrahim B. Maaz, Chen Cai, Kriti Shah, Sihem Cheloufi, William F. Marzluff, Jernej Murn

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High frequency of benzimidazole resistance polymorphisms and age-class differences in trichostrongyle nematodes of ranched bison from the south-central United States by Kaylee R. Kipp, Elizabeth M. Redman, Joe L. Luksovsky, Dani Claussen, John S. Gilleard, Guilherme G. Verocai

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Metabolomic Profiling and Anti-<i>Helicobacter pylori</i> Activity of <i>Caulerpa lentillifera</i> (Sea Grape) Extract by Chananchida Thacharoen, Thisirak Inkaewwong, Watthanachai Jumpathong, Pornchai Kaewsapsak, Thiravat Rattanapot, Tippapha Pisithkul

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Epigenetic Regulation in Wilms Tumor by Annabelle Bolitho, Hongbing Liu

“…This review examines the various epigenetic mechanisms implicated in WT, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA-mediated regulation. …”
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MIAT: A pivotal oncogenic long noncoding RNA tunning the hallmarks of solid malignancies by Monica M. Rostom, Alaa A. Rashwan, Christina D. Sotiropoulou, Sama Z. Hozayen, Abdelhamid M. Abdelhamid, Miriam Mokhtar Abdelhalim, Omar Eltahtawy, Hadir M. Emara, Noha M. Elemam, Christos K. Kontos, Rana A. Youness

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Clinical and molecular characterization of TP53-mutant acute lymphoblastic leukemia in adults by Ethan J. Harris, Diren Arda Karaoglu, Madina Sukhanova, Yasmin Abaza, Theodoros Karantanos, Ann-Kathrin Eisfeld, Clare Anderson, Chenyu Lin, Yenny A. Moreno Vanegas, Talha Badar, Alexander Coltoff, Todd C. Knepper, Neval Ozkaya, Hamed Rahmani Youshanlouei, Sinan Cetin, Anand A. Patel, Adam S. DuVall, Michael W. Drazer, Peng Wang, Melissa Tjota, Jeremy P. Segal, Girish Venkataraman, Sandeep Gurbuxani, Jason X. Cheng, Daniel A. Arber, Richard A. Larson, Olatoyosi Odenike, Jonathan Webster, Bijal Shah, Wendy Stock, Caner Saygin

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Mechanisms of <i>Salmonella typhimurium</i> Resistance to Cannabidiol by Iddrisu Ibrahim, Joseph Atia Ayariga, Junhuan Xu, Daniel A. Abugri, Robertson K. Boakai, Olufemi S. Ajayi

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Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis by Lingzhi Huang, Xinyi Chen, Yawen Shao, Shujun Deng, Chen Wang, Jianqiao Chen, Yongsheng Xie, Siming Yuan, Liqin Tang

“…Subsequently, we evaluated the impact of ISG15 on pyroptosis, a form of programmed cell death, to understand its potential role in DKD pathology. …”
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Reexamining a Host-Associated Genomic Diversity of Bean Golden Mosaic Virus (BGMV) Isolates from <i>Phaseolus</i> Species and Other Fabaceae Hosts by Luciane de Nazaré Almeida dos Reis, Josiane Goulart Batista, Maria Luiza Fernandes de Oliveira, Maria Esther de Noronha Fonseca, Josias Corrêa de Faria, Francisco José Lima Aragão, Leonardo Silva Boiteux, Rita de Cássia Pereira-Carvalho

“…The host prevalence and genomic differences suggest that most <i>P. lunatus</i> isolates are currently misclassified as BGMV strains, being more likely samples of a closely related (but distinct) <i>Begomovirus</i> species. Hence, the implications of this BGMV diversity should be taken into consideration by classical and biotech breeding programs aiming for large-spectrum viral resistance in <i>Phaseolus</i> species.…”
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Low-dose hydralazine during gestation reduces renal fibrosis in rodent offspring exposed to maternal high fat diet. by Benjamin P Larkin, Sonia Saad, Sarah J Glastras, Long T Nguyen, Miao Hou, Hui Chen, Rosy Wang, Carol A Pollock

“…DNA methylation has been proposed as a key mechanism by which fetal programming occurs and is implicated in CKD progression. …”
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First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation by Handoko, Adham M, Rachmadi L, Tobing DL, Asmarinah A, Fadilah F, Dai W, Lee AWM, Gondhowiardjo SA

“…Enriched KEGG pathways included PI3K-Akt signalling, ECM–receptor interaction, and focal adhesion. The presence of EBV DNA was confirmed in all samples, implicating its role in influencing methylation patterns.Discussion: This study provides comprehensive insights into the epigenetic landscape of NPC, underscoring the role of CpG methylation in tumour suppressor gene silencing. …”
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Cross-laboratory replication of pseudomyxoma peritonei tumor microbiome reveals reproducible microbial signatures by Victoria F. Nieciecki, Faith C. Blum, Ryan C. Johnson, Traci L. Testerman, Tom J. McAvoy, Mary Caitlin King, Vadim Gushchin, Jeannette M. Whitmire, Kenneth G. Frey, Lindsay Glang, Dessiree Peña-Gomez, Kimberly A. Bishop-Lilly, Armando Sardi, D. Scott Merrell, Jessica L. Metcalf

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Assessing HIV-1 subtype C infection dynamics, therapeutic responses and reservoir distribution using a humanized mouse model by Snehal Kaginkar, Leila Remling-Mulder, Ashashree Sahoo, Tejaswini Pandey, Pranay Gurav, Jyoti Sutar, Amit Kumar Singh, Ella Barnett, Sivasankar Panickan, Ramesh Akkina, Vainav Patel

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A network-based approach to overcome BCR::ABL1-independent resistance in chronic myeloid leukemia by Valeria Bica, Veronica Venafra, Giorgia Massacci, Simone Graziosi, Sara Gualdi, Gessica Minnella, Federica Sorà, Patrizia Chiusolo, Maria Elsa Brunetti, Gennaro Napolitano, Massimo Breccia, Dimitrios Mougiakakos, Martin Böttcher, Thomas Fischer, Livia Perfetto, Francesca Sacco

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Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications by Jinxin Tang, Yan Zhuang, Yibo Zhang, Hongkun Hu, Hua Wang, Haodong Xu, Yintao Li, Chao Tu

“…Abstract Necroptosis represents a distinct form of programmed cell death that exhibits characteristics of both necrosis and apoptosis. …”
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The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation by Adel S. Girgis, Yujun Zhao, Angel Nkosi, Nasser S. M. Ismail, Mohamed S. Bekheit, Dalia R. Aboshouk, Marian N. Aziz, M. Adel Youssef, Siva S. Panda

“…The p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the MDM2 protein (murine double minute 2, also known as HDM2 in humans). …”
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Genetic surveillance of Plasmodium–Anopheles compatibility markers during Anopheles stephensi associated malaria outbreak by Elizabeth Waymire, Dejene Getachew, Isuru Gunarathna, Joseph Spear, Grace Lloyd, Madison Follis, Avery A. Kaye, Said Ali, Solomon Yared, Tamar E. Carter

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STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans. by Patricia P Peterson, Sarah Croog, Yeseul Choi, Sheng Sun, Joseph Heitman

“…Transcriptomic profiling of pph22Δ and far8Δ mutants revealed dysregulation of genes involved in nuclear organization, DNA replication and repair, RNA processing, cell cycle progression, and morphogenesis, suggesting that STRIPAK disruption broadly impairs cellular programs important for faithful sexual reproduction. …”
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