Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice by Lauren J. Tracey, Mahmoud El-Maklizi, Dustin J. Sokolowski, Miki S. Gams, Travis Brooke-Bisschop, Julie Ruston, Christine Taylor, Alexandra Khozin, Sujeetha A. Rajakumar, Michael D. Wilson, Cynthia J. Guidos, Monica J. Justice

“…Together, our data show that Prdm14 can initiate premature T and B cell cancer programs when expressed in hematopoietic progenitor cells.…”
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Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology by Marwa Shekfeh, Mariam M. Konaté, Julia Krushkal

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The recombinases Rad51 and Dmc1 play distinct roles in DNA break repair and recombination partner choice in the meiosis of Tetrahymena. by Rachel A Howard-Till, Agnieszka Lukaszewicz, Josef Loidl

“…Repair of programmed DNA double-strand breaks (DSBs) by meiotic recombination relies on the generation of flanking 3' single-stranded DNA overhangs and their interaction with a homologous double-stranded DNA template. …”
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Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer by Borja Ruiz-Fernández de Córdoba, Karmele Valencia, Connor Welch, Haritz Moreno, Susana Martínez-Canarias, Carolina Zandueta, Eduardo Gómez, Alfonso Calvo, Nerea Otegui, Mirari Echepare, Ignacio Garzón, Daniel Ajona, David Lara-Astiaso, Elisabeth Guruceaga, Laura Guembe, Rubén Pío, Ignacio Melero, Silve Vicent, Fernando Pastor, Rafael Martínez-Monge, Fernando Lecanda

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Maternal Nutrient Excess Induces Stress Signaling and Decreases Mitochondrial Number in Term Fetal Baboon Skeletal Muscle by Xu Yan, Carolina Tocantins, Mei-Jun Zhu, Susana P. Pereira, Min Du

“…Maternal obesity programs the fetus for increased risk of chronic disease development in early life and adulthood. …”
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Molecular heterogeneity of CD30+ peripheral T-cell lymphoma with prognostic significance and therapeutic implications: a retrospective multi-centre studyResearch in context by Yu-Jia Huo, Shu Cheng, Hong-Mei Yi, Ting Niu, Lei Fan, Guo-Hui Cui, Fu-Ling Zhou, Xian-Min Song, Fei Li, Ou Bai, Xiao-Jing Yan, Jun Shi, Ming-Ci Cai, Yao-Hui Huang, Lei Dong, Jie Xiong, Song Hu, Yu-Ran Qiu, Yan Zhao, Peng-Peng Xu, Li Wang, Min Lu, Hong-Mei Jing, Wei-Li Zhao

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WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer by Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M Virshup, Babita Madan

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Exploring RPA1-ETAA1 axis via high-throughput data analysis: implications for PD-L1 nuclear translocation and tumor-immune dynamics in liver cancer by Gaofeng Qin, Gaofeng Qin, Zengkuan Chen, Zengkuan Chen, Weihong Tian, Hongbo Chen, Yu Zhang, Yu Zhang, Wangzhi Wei, Wangzhi Wei

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Epigenetic Alterations in Cancer: The Therapeutic Potential of Epigenetic Drugs in Cancer Therapy by Preeti Gupta

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Decoding disease–specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validationResearch in context by Pan Li, Jijun Zhu, Shenghan Wang, Haowen Zhuang, Shunjie Zhang, Zhongting Huang, Fuqiang Cai, Zhijian Song, Yuxin Liu, Weixin Liu, Sebastian Freidel, Sijia Wang, Emanuel Schwarz, Junfang Chen

“…SW received funding from the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant no. …”
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The role of mitochondria in iron overload-induced damage by Yangyang Zhao, Mengjiao Yang, Xiaoxue Liang

“…This review examines the mechanisms by which mitochondria are implicated in iron overload-induced damage, including increased oxidative stress, mitochondrial DNA damage, and disruptions in energy metabolism. …”
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Genetic and neuro-epigenetic effects of divergent artificial selection for feather pecking behaviour in chickens by Elske N. de Haas, Fábio Pértille, Joergen B. Kjaer, Per Jensen, Carlos Guerrero-Bosagna

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Tumor Necrosis Factor-Alpha’s Role in the Pathophysiology of Colon Cancer by Saleha Khan, Yara Aldawood, Ayesha Hanin Shaikh, Aleena Zobairi, Urwa Nabilah, H. M. Alqahtani, Mansoor-Ali Vaali-Mohammed

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A polyvalent DNA prime with matched polyvalent protein/GLA-SE boost regimen elicited the most robust and broad IgG and IgG3 V1V2 binding antibody and CD4+ T cell responses among 13... by Zoe Moodie, Shuying Sue Li, Elena E. Giorgi, LaTonya D. Williams, One Dintwe, Lindsay N. Carpp, Shiyu Chen, Kelly E. Seaton, Sheetal S. Sawant, Lu Zhang, Jack Heptinstall, Shuying Liu, Nicole Grunenberg, Frank Tomaka, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Julie A. Ake, Sandhya Vasan, Giuseppe Pantaleo, Ian Frank, Lindsey R. Baden, Paul A. Goepfert, Michael Keefer, Mike Chirenje, Mina C. Hosseinipour, Kathryn Mngadi, Fatima Laher, Nigel Garrett, Linda-Gail Bekker, Stephen De Rosa, Erica Andersen-Nissen, James G. Kublin, Shan Lu, Peter B. Gilbert, Glenda E. Gray, Lawrence Corey, M. Juliana McElrath, Georgia D. Tomaras

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35th Australian and New Zealand Society for Neuropathology (ANZSNP) Scientific Meeting - Meeting Abstracts, August 31st - September 1st, 2024 by The Australian and New Zealand Society for Neuropathology (ANZSNP)

“…Prof David Capper delivered the plenary lecture on “DNA methylation profiling and its practical implications” during the combined session with AWCBR attendees. …”
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The cold immunological landscape of ATM-deficient cancers by Fresia Pareja, Stephen Morris, Sonali Sinha, Lorenzo Galluzzi, Fatemeh Derakhshan, Jennifer Ma, Jorge Reis-Filho, Nadeem Riaz, Shu Yazaki, Victor Ng, Ardijana Novaj, Yingjei Zhu, Xin Pei, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Kevin Ma, Anne Roulston, Maria Koehler, Simon Powell, Ezra Rosen, Atif Khan

“…Altogether, our results have important implications for the design of novel combination therapies for ATM null tumors and highlight the importance of antigenicity in the immunological consequences of defective DNA repair.…”
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Transcriptome sequencing reveals significant RNA variation in human sperm samples by Weiming Chen, Lei Yu, Zhenyu Jia, Jianguo Zhu

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Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction by David Nicolas Giuseppe Huebert, Atefeh Ghorbani, Shaw Yick Brian Lam, Mani Larijani

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Serological and Molecular Prevalence and Associated Risk Factors in Caprine Brucellosis, Northeastern Thailand by Sarinya Rerkyusuke, Sawarin Lerk-u-suke, Peerapol Sukon, Patchara Phuektes

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Identification of a novel SNP mutation causing drop-out alleles in a paternity test using combined nest and touch-down PCR with Sanger sequencing by Hongbo Wang, Botong Shi, Liang Guo, Yingnan Zou, Bo Liu, Jun Yao, Baojie Wang, Zhengdong Wang, Xin Li, Gang Mu, Fu Ren

“…This variation was found to be responsible for the drop-out alleles observed in the samples.Conclusion Our findings have important implications for optimising primer design and constructing DNA databases for forensic analysis.…”
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