Beyond the genome: the role of functional markers in contemporary plant breeding by Tae-Chun Park, Tae-Chun Park, Pransiskudura Chamara Silva, Pransiskudura Chamara Silva, Thomas Lübberstedt, Thomas Lübberstedt, M. Paul Scott, M. Paul Scott

“…FMs can be used in genomic selection (GS) and modern plant breeding programs by improving selection efficiency and accuracy. …”
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Prognostic and predictive molecular biomarkers of colorectal cancer by A. D. Shakhmatova, E. D. Mirlina, G. M. Butrovich, O. A. Vostriukhina, V. N. Verbenko

“…лукиан самосаткийThe search and application of genetic prognostic and predictive biomarkers in colorectal cancer (CRC) are aimed at identifying the characteristics of colorectal tumors for choosing a therapy strategy. …”
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A sex-specific molecular marker in Mulloway (Argyrosomus japonicus) by L.P. Dennis, T. Ventura, A.E. Elizur, D.S. Fielder

“…These markers, validated on both adult broodstock and juveniles, offer a reliable and efficient means of sex determination, contributing to the optimisation of breeding programs and sustainable management of Mulloway. The identification of the 95 bp deletion in the male sequence of dmrt1 increases understanding of Mulloway sex determination, the application extends beyond aquaculture management, offering insights into the life history and molecular mechanism underlying sex determination in this endangered species.…”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

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Taiwan Green Propolis Nanoparticles Induce Antiproliferation and Apoptosis in Oral Cancer Cells by Wen-Da Huang, Shu-Fen Peng, Nai-Wen Tsao, Sheng-Yang Wang, Shu-Ling Tzeng, Nien-Jen Hu

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Predictive biomarkers in the era of immunotherapy for gastric cancer: current achievements and future perspectives by Fujing Sun, Xiaozhuo Gao, Wentao Wang, Xiaoyan Zhao, Xiaoyan Zhao, Jingdong Zhang, Yanmei Zhu

“…Various biomarkers, such as the expression of programmed death ligand-1 (PD-L1), the microsatellite instability (MSI) status, tumor mutational burden (TMB), and Epstein–Barr virus (EBV) infection, demonstrate potential to predict the effectiveness of immunotherapy in treating GC. …”
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DArTseq-based silicoDArT and SNP markers reveal the genetic diversity and population structure of Kenyan cashew (Anacardium occidentale L.) landraces. by Dennis Wamalabe Mukhebi, Pauline Wambui Gachanja, Diana Jepkoech Karan, Brenda Muthoni Kamau, Pauline Wangeci King'ori, Bicko Steve Juma, Wilton Mwema Mbinda

“…Understanding cashew genomics through the application of SilicoDArT and SNP markers is crucial for advancing cashew genomic breeding programs aimed at improving yield and nut quality, and enhancing resistance or tolerance to biotic and abiotic stresses. …”
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Modular and efficient assembly of CRISPR vectors and construction of an apple gene editing efficiency evaluation system by HOU Feifan, HUANG Chuanmi, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo, JIAO Jian

“…[Objective] The CRISPR/Cas gene editing technology has demonstrated a broad application prospect for diverse applications in genetic improvement programs targeting apple (Malus domestica) and other perennial fruit crops. …”
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MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

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The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells by Jianghong Xiang, Yihan Lai, Zuping He

“…In addition, the cohesin complex ensures faithful DNA replication and sister chromatid cohesion, which indirectly supports genetic and epigenetic programs. …”
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Serplulimab combined with gemcitabine, nab-paclitaxel and stereotactic body radiotherapy as the first-line treatment for patients with metastatic pancreatic adenocarcinoma in China... by Dan Cao, Ke Cheng, Chenyan Zhang, Deying Kang, Ruizhen Li, Chen Chang, Heqi Yang, Junjie Xiong, Du He, Xi-Jiao Liu

“…Introduction Patients with pancreatic ductal adenocarcinoma (PDAC) remain a poor prognosis despite the development of chemotherapy. Although programmed cell death 1 (PD-1) blockade has shown great efficacy in various solid tumours, its application in treating PDAC is limited. …”
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Development of a Mammalian Cell Line for Stable Production of Anti-PD-1 by Erika Csató-Kovács, Pál Salamon, Szilvia Fikó-Lászlo, Krisztina Kovács, Alice Koka, Mónika András-Korodi, Emőke Antal, Emília Brumă, Brigitta Tőrsők, Szilárd Gudor, Ildikó Miklóssy, Kálmán Csongor Orbán, Csilla Albert, Emese Éva Bálint, Beáta Albert

“…<b>Background/Objectives:</b> Immune checkpoint blockade, particularly targeting the programmed cell death 1 (PD-1) receptor, is a promising strategy in cancer immunotherapy. …”
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An Impedimetric Genosensor for Ultrasensitive Detection of SARS-Cov-2 Genome Based on 3D Reduced Graphene Oxide and Gold Nanoparticle Composite by Zahra Izadi, Mahdi Ghasemi-Varnamkhasti, Mostafa Shakhsi-Niaei, Gh. Mobini

“…Therefore, in this research, we introduce an electrochemical genosensor based on a DNA probe that can hybridize directly to the viral genome or its transcripts and therefore does not need cDNA synthesis following RNA extraction from patient samples, a necessary and challenging step in routine RNA virus detection methods like Real-time PCR. …”
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Streamlining of Simple Sequence Repeat Data Mining Methodologies and Pipelines for Crop Scanning by Subramaniam Geethanjali, Palchamy Kadirvel, Mahender Anumalla, Nithyananth Hemanth Sadhana, Anandan Annamalai, Jauhar Ali

“…Over the past 50 years, DNA markers have rapidly changed, moving from hybridization-based and second-generation-based to sequence-based markers. …”
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The interplay of cellular senescence and reprogramming shapes the biological landscape of aging and cancer revealing novel therapeutic avenues by Fuan Ding, Ying Yu, Jiangqi Zhao, Shibo Wei, Yan Zhang, Jung Ho Han, Zhuo Li, Hong-Bo Jiang, Dongryeol Ryu, Minkyoung Cho, Sung-Jin Bae, Wonyoung Park, Wonyoung Park, Ki-Tae Ha, Ki-Tae Ha, Bo Gao

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Association Analysis of <i>SLC11A1</i> Polymorphisms with Somatic Cell Score in Chinese Holstein Cows by Kai Liu, Yufang Liu, Tuo Li, Qiuling Li, Jinyu Wang, Yongfu An, Yuze Yang, Kaiyang Li, Mingxing Chu

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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Additionally, de novo DNA methylation programs promote T cell exhaustion, which poses a significant limitation for CAR-T cell therapy applications.MethodsHigh-throughput liquid protein chip and CBA analyses were utilized to determine the expression levels of inflammatory factors. …”
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Identification of a novel InDel locus within the <i>ACSL5</i> gene and its association with body measurement traits in goats by A. Wang, A. Wang, A. Wang, X. Wu, X. Wu, Q. Xu, B. Wang, T. Xiao, Y. Liu, W. Li

“…Therefore, This study investigated the spatiotemporal expression pattern of <i>ACSL5</i> in goats and the association between its polymorphism and growth traits, aiming to identify useful DNA markers and provide a basis for the application of marker-assisted selection (MAS) in goat breeding. …”
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Quantum bioelectrochemical (QBIOL) software based on point stochastic processes by Simon Grall, Ignacio Madrid, Aramis Dufour, Helen Sands, Masaki Kato, Akira Fujiwara, Soo Hyeon Kim, Arnaud Chovin, Christophe Demaille, Nicolas Clément

“…Abstract Bioelectrochemistry is crucial for understanding biological functions and driving applications in synthetic biology, healthcare, and catalysis. …”
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Exploring the chemotypic variability of Silybum marianum and Silybum eburneum by biochemical and genetic characterization by Marianna Pasquariello, Marianna Pasquariello, Tommaso Martinelli, Roberta Paris, Roberta Paris, Anna Moschella, Roberto Colombo, Alice Di Bello, Jessica Frigerio, Jessica Frigerio, Abdenour Kheloufi, Mohammad Amin Mirzaabolghasemi, Damiano Puglisi, Damiano Puglisi, Salvatore Esposito, Salvatore Esposito, Stefano Scalercio, Stefano Scalercio, Nino Virzì, Pasquale De Vita, Pasquale De Vita, Nicola Pecchioni, Laura Bassolino, Laura Bassolino

“…These findings significantly expand our knowledge of the global biodiversity of the Silybum genus and provide valuable insights for future breeding programs and potential applications in nutrition and human health sciences.…”
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