Novel Insights into the Regulatory Role of N6-Methyladenosine in the Pathogenesis and Clinical Treatment of Osteoarthritis: Research Status and Prospect by He M, Liu J, Sun Y, Fang Y, Wang F

“…Finally, the application and future development prospects of m6A modification in the clinical treatment of OA were further discussed.Keywords: osteoarthritis, m6A, DNA methylation, pathogenesis, clinical treatment…”
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Clinical applications of and molecular insights from RNA sequencing in a rare disease cohort by Jamie C. Stark, Neta Pipko, Yijing Liang, Anna Szuto, Chung Ting Tsoi, Megan A. Dickson, Kyoko E. Yuki, Huayun Hou, Sydney Scholten, Kenzie Pulsifer, Meryl Acker, Meredith Laver, Harsha Murthy, Olivia M. Moran, Emily Bonnell, Nicole Liang, Jashanpreet Sidhu, Lucie Dupuis, Mohammad M. Ghahramani Seno, Care4Rare Canada Consortium, Marisa Chard, Rebekah K. Jobling, Jessie Cameron, Rose Chami, Michal Inbar-Feigenberg, Michael D. Wilson, David A. Chitayat, Kym M. Boycott, Lianna Kyriakopoulou, Roberto Mendoza-Londono, Christian R. Marshall, James J. Dowling, Gregory Costain, Ashish R. Deshwar

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Correlation study and full management of metabolic syndrome and sperm DNA fragmentation index, a regional multicentre prospective long term follow-up study from Anhui, China by Dongsheng Ma, Jianhong Xi

“…Univariate-multivariate logistic regression analyses were performed to build a predictive model using R Programming Language (4.42), and to plot the Nomogram, Calibration Curve, Decision Curve Analysis (DCA) Curve, and Clinical impact curve (CIC) to assess the consistency between the predicted probability of the model and the actual occurrence probability, as well as to evaluate the practicality and applicability in clinical decision-making.ResultsIntergroup comparison between the observation and control groups in this study showed no statistical difference between the two groups in terms of baseline information and fertility assessment (P > 0.05). …”
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Application of four molecular markers for breeding peach aphid (Myzus persicae Sülzer) resistance by CHEN Xuejia, LIU Mingjie, WU Jinlong, WANG Xinwei, CHEN Changwen, LI Yong, WANG Lirong

“…For each plant in the surveyed population, tender leaves were sampled, and genomic DNA was extracted via the Cetyltrimethylammonium Bromide (CTAB) method. …”
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Engineering the Salmonella type III secretion system to export spider silk monomers by Daniel M Widmaier, Danielle Tullman‐Ercek, Ethan A Mirsky, Rena Hill, Sridhar Govindarajan, Jeremy Minshull, Christopher A Voigt

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Cleaved Amplified Polymorphic Sequence Markers in Horticultural Crops: Current Status and Future Perspectives by Krishnanand P. Kulkarni, Richmond K. Appiah, Umesh K. Reddy, Kalpalatha Melmaiee

“…DNA markers have broad applications, including marker-assisted selection (MAS) for breeding new cultivars. …”
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Evaluation of a test-and-cull strategy to control bovine paratuberculosis based on the detection of Mycobacterium avium ssp. paratuberculosis DNA using the high-throughput Johne's... by A.A. Garcia, K.M. Plain, J.-A.L.M.L. Toribio, R.J. Whittington

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Interplay between pioneer transcription factors and epigenetic modifiers in cell reprogramming by Gerardo Mirizio, Samuel Sampson, Makiko Iwafuchi

“…Despite significant advances, many direct reprogramming processes remain inefficient, which limits their reliability for clinical applications. In this review, we discuss the molecular mechanisms underlying pioneer TF-driven reprogramming, with a focus on their interactions with epigenetic modifiers, including Polycomb repressive complexes (PRCs), nucleosome remodeling and deacetylase (NuRD) complexes, and the DNA methylation machinery. …”
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Decoding disease–specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validationResearch in context by Pan Li, Jijun Zhu, Shenghan Wang, Haowen Zhuang, Shunjie Zhang, Zhongting Huang, Fuqiang Cai, Zhijian Song, Yuxin Liu, Weixin Liu, Sebastian Freidel, Sijia Wang, Emanuel Schwarz, Junfang Chen

“…SW received funding from the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant no. …”
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Exploring regulatory roles of putrescine-doped zinc oxide nanoentities on ethylene signaling, redox imbalance, and programmed cell death in drought-stressed rice (Oryza sativa L.)... by Abir Das, Tibor Janda, Sudipta Kumar Sil, Malay Kumar Adak

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A ribodepletion and tagging protocol to multiplex samples for RNA-seq based virus detection: application to the cassava virome by Daniel H. Otron, Justin S. Pita, Murielle Hoareau, Fidèle Tiendrébéogo, Jean-Michel Lett, Pierre Lefeuvre

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Tumor Necrosis Factor-Alpha’s Role in the Pathophysiology of Colon Cancer by Saleha Khan, Yara Aldawood, Ayesha Hanin Shaikh, Aleena Zobairi, Urwa Nabilah, H. M. Alqahtani, Mansoor-Ali Vaali-Mohammed

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The generation of novel epialleles in plants: the prospective behind re-shaping the epigenome by Alessio Baldini, Filippo Battaglia, Giorgio Perrella

“…The promising results obtained by altering the expression state of targets involved in flowering time and abiotic stress resistance are crucial not only for elucidating the molecular interactions that underly chromatin dynamics, but also for future applications in breeding programs as an alternative route to genetic manipulation towards the achievement of higher quality crops particularly in terms of nutritional properties, yield and tolerance.…”
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An Effective and Safe Maize Seed Chipping Protocol Using Clipping Pliers With Applications in Small-Scale Genotyping and Marker-Assisted Breeding by Brian Zebosi, John Ssengo, Lander Geadelmann, Erica Unger-Wallace, Erik Vollbrecht

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A noninvasive method to detect Mexican wolves and estimate abundance by Antoinette J. Piaggio, Chip A. Cariappa, Dyan J. Straughan, Melissa A. Neubaum, Margaret Dwire, Paul R. Krausman, Warren B. Ballard, David L. Bergman, Stewart W. Breck

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SYSTEMIC APPROACH TO TEACHING BIOPHYSICS TO STUDENTS OF MEDICAL INSTITUTIONS OF HIGHER EDUCATION by Anatolii Yehorenkov

“…Taking into account the results of the analysis of the use of the principle of systematization for solving problems in medicine and biological physics, structural-logical knowledge schemes, test tasks, computer programs, and video applications have been developed to support interdisciplinary integration of knowledge in molecular biophysics of DNA, medical genetics, and bioinformatics, as well as for propaedeutics in the formation of the foundations of clinical thinking.…”

Exploring the potential of fungal proteases in aquatic environments of the Tapajós Basin, Brazil by Aline Lima de Aguiar, Ana Luiza Figueira da Silva, Rayane Bonfim Ferreira Xavier, Marcos Diones Ferreira Santana, Dávia Marciana Talgatti, Fernando Abreu Oliveira, Carlos Ivan Aguillar-Vildoso, Érica Simplício de Souza, Márcio Barreto Rodrigues, João Paulo Alves Silva, Lívia Melo Carneiro, Clarice Maia Carvalho, João Vicente Braga de Souza, Eveleise Samira Martins Canto

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Изучение биоразнообразия PYRICULARIA ORYZAE CAV. в рисосеющих зонах юга России на основе методов ПЦР by E. V. Dubina, P. I. Kostylev, M. G. Ruban, Yu. V. Aniskina, I. A. Shilov, N. S. Velishaeva, L. V. Esaulova

“…The study has found the genes of pathogen tolerance, greatly efficient in the south of Russia, which can be recommended for the breeding programs for growing rice varieties resistant to rice blast.…”
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KASP Markers for Identifying Roselle (<i>Hibiscus sabdariffa</i> L.) Key Varieties Based on Genetic Polymorphisms Revealed by ddRAD-Seq by Shih-Jie Huang, Jheng-Yang Ou, Yao-Cheng Lin, Jing-Wen Chen, Kai-Yi Chen, Yu-Lin Wu, Chun-Hao Hu, Ju-Yin Lee, Jia-Wei Wu, Fu-Chiun Hsu

“…In conclusion, this research contributes novel insights into the genetic relationships among roselle varieties, and establishes a robust framework utilizing ddRAD-seq and KASP markers for improved genetic resource identification and application in breeding programs.…”
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Aplicación del análisis de rango reescalado R/S para la predicción de genes en el genoma vegetal Rescaled range R/S analysis application for genes prediction in the plant genome by Martha Isabel Almanza Pinzón, Karina López López, Carlos Eduardo Téllez Villa

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